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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

NON-QUASI-NEWTON UPDATES FOR UNCONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 1995年第2期13卷 95-107页

作者： YUAN, YX byrd, RH ACAD SINICA CTR COMPBEIJING 100080PEOPLES R CHINA UNIV COLORADO DEPT COMP SCIBOULDERCO 80309

In this report we present some new numerical methods for unconstrained optimization. These methods apply update formulae that do not satisfy the quasi-Newton equation. We derive these new formulae by considering different techniques of approximating the objective function. Theoretical analyses are given to show the advantages of using non-quasi-Newton updates. Under mild conditions we prove that our new update formulae preserve global convergence properties. Numerical results are also presented.

关键词： NON-QUASI-NEWTON UPDATES FOR UNCONSTRAINED OPTIMIZATION Th

THE TEKOA BOYS’HOME A Melding of Vision,Functionality,and Sustainability

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Journal of Green Building 2011年第3期6卷 33-45页

作者： Melissa byrd James Ruhland 不详 Community Design Studio(a wholly owned subsidiary of Community Housing Partners)

INTRODUCTION Community Housing Partners(CHP)is a 501(c)(3)community development corporation that serves the needs of low-income and low-wealth individuals and families in the ***’s mission is to create affordable,green,sustainable housing opportunities and services for the people and communities they *** 1975,CHP has served over 206,000 people,including the elderly,women and children in transition,formerly homeless people,single female heads-of-household.

关键词： charrette collaborative design construction waste management ENERGY STAR® geothermal heat pump LEED group home Indoor Air Quality(IAQ) integrated design native landscaping residential treatment center storm water management Solar Reflectance Index(SRI) sustainable

ADC evaluation boards design and test framework for LCLS-Ⅱ precision receiver

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Nuclear Science and Techniques 2016年第5期27卷 200-207页

作者： Jin Yang Gang Huang Qiang Du Lawrence Doolittle John byrd Lawrence Berkeley National Laboratory BerkeleyCA 94720 USA Department of Engineering Physics Tsinghua UniversityBeijing 100084 China

In the low-level RF control field,ADC acquisition accuracy and noise set the boundary of our control ability,making it important to develop low-noise acquisition *** the design to test stage,all the noise terms should be understood and *** specific need addressed here is the precision acquisition system for the second Linac Coherent Light Source(LCLS-Ⅱ),led by SLAC National Accelerator *** circuit boards for the LTC2174 and AD9268 ADCs are designed and fabricated by *** ADC test framework based on FPGA evaluation board to assess performance has been *** ADC test framework includes both DSP(Digital Signal Processing) firmware and processing *** is useful for low-level RF control and other synchronization *** the clock jitter between two channels give us an understanding of that noise *** with the test framework,the raw ADC data are transferred to a computer through a Gigabit Ethernet *** short-term error signal can be calculated based on a sine wave *** changing low-pass filter bandwidth,relative long-term performance can also be *** jitter and differential phase jitter are the key issues for *** paper will report the test results for LTC2174 and AD9268 *** integral amplitude jitter is smaller than 0.003%,and the integral phase noise is smaller than 0.0015°(measured at 47 MHz RF,100 MHz clock,bandwidth 1 Hz to 100 kHz) for both ADC chips.

关键词： ADC芯片测试框架电路板设计评估接收机千兆以太网接口直线加速器

Alterations in gastric mucin synthesis by Helicobacter pylori

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World Journal of Gastroenterology 2000年第4期6卷 475-482页

作者： James C. byrd Robert S. Bresalier Gastrointestinal Cancer Research Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Gastrointestinal Cancer Research Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Department of MedicineUniversity of Michigan School of MedicineAnn ArborMIUSA

INTRODUCTIONHelicobacter pylori is recognized as a cause of chronicactive gastritis,gastric and duodenal ulcers,and gastriccancer,though the mechanisms of pathogenesis for ***-associated diseases are not yet well *** ... 详细信息

关键词： gastric mucin Helicobacter pylori

Nitrogen further promotes a dominant salt marsh plant in an increasingly saline environment

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Journal of Plant Ecology 2012年第4期5卷 429-441页

作者： Amelia byrd Ryan Katharyn E.Boyer Romberg Tiburon Center for Environmental Studies San Francisco State University3152 Paradise DriveTiburonCA 94920USA Department of Biology San Francisco State University1600 Holloway AvenueSan FranciscoCA 94132 USA

Aims Human alterations of the environment are combining in unprecedented ways,making predictions of alterations to natural communities a difficult and pressing *** systems have been subject to a high degree of modification,including increased nitrogen(N)inputs and altered salinity,factors important in shaping estuarine plant *** human populations increase and the climate changes,both N and salinity levels are likely to increase in these coastal *** objective was to evaluate the interactive effects of N and salinity on USWest Coast salt marsh species;in particular,the performance of the dominant species Sarcocornia pacifica(pickleweed)alone and in mixed species *** expected increased salinity to favor *** but that N enrichment could help maintain greater species richness through use of N in salinity tolerance *** We crossed treatments of N(added or not)and salinity(salt added or not)in a field experiment at a salt marsh in the San Francisco Estuary,California,USA,in each of three habitats:(i)monotypic pickleweed on the marsh plain,(ii)monotypic pickleweed along channels and(iii)mixed assemblages along *** a greenhouse experiment,we crossed treatments of N(added or not)and salinity(at three levels to simulate brackish to saline conditions)in(i)pots of pickleweed only and(ii)the same species mix as in the *** Findings Naddition doubled *** biomass and branching in both channel and marsh plain habitats regardless of salinity and greatly increased its dominance over Distichlis spicata and Jaumea carnosa in mixed assemblages along *** the greenhouse,*** biomass increased 6-to 10-fold with N addition over the range of salinities,while *** and *** biomass increased with N addition only at lower salinity ***,while localized management could influence outcomes,expected overall increases in both N and salinity with human population growth and climat

关键词： Distichlis eutrophication Jaumea salinity Sarcocornia

Facilitating spectral analyses,simplification,and new tools through deep neural networks

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Magnetic Resonance Letters 2022年第1期2卷 56-58,I0003页

作者： Fa-An Chao Yue Zhang R.Andrew byrd NCI RAS Initiative Cancer Research Technology ProgramFrederick National Laboratory for Cancer ResearchLeidos Biomedical ResearchFrederickMD21701-4907United States Center for Structural Biology Center for Cancer ResearchNational Cancer InstituteFrederickMD21702-1201United States

In a recent publication it was shown that homonuclear scalar couplings in directly detected protein NMR spectra can be“decoupled”using deep neural networks,including cases where existing methods fail[1].The work harkens back to the introduction of maximum entropy and non-uniform sampling,and it elegantly illustrates how new approaches can be devised in the conceptualization of NMR experiments,freeing researchers from conventional thinking and *** work opens up a new era in biomolecular NMR spectroscopy,where experimental design is tailored towards processing with deep neural networks.(https://***/10.1021/jacs.1c04010).

关键词： entropy illustrate scalar

Evaluation of method performance for osteometric sorting of commingled human remains

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Forensic Sciences Research 2018年第4期3卷 343-349页

作者： John E.byrd Carrie B.LeGarde Laboratory Defense POW/MIA Accounting AgencyJoint Base Pearl Harbor-HickamHIUSA

Evaluation of method performance involves the consideration of numerous factors that can contribute to error.A variety of measures of performance can be borrowed from the signal detection literature and others are drawn from statistical *** article demonstrates the principles of performance evaluation by applying multiple measures to osteometric sorting models for paired elements run against data from known *** indicate that false positive rates are close,on average,to expected *** assemblage size grows,the false positive rate becomes unimportant and the false negative rate becomes *** disparity among the commingled individuals plays a significant role in method performance,showing that case-specific circumstances(*** size and size disparity)will determine method power.

关键词： Forensic sciences forensic anthropology statistics test method method performance error signal detection osteometric sorting