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small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias schwab Alexandra Kretz Computational Biology and systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALs)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALs),most cases are considered sporadic(sALs).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

solution of shallow-water equations using least-squares finite-element method

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Acta Mechanica sinica 2008年第5期24卷 523-532页

作者： s.j. Liang j,-H, Tang M.-s. Wu Department of Marine Environmental Informatics National Taiwan Ocean UniversityKeelung 20224 Taiwan China Department of Bioenvironmental Engineering Chung-Yuan Christian University Chung-Li 32023 Taiwan China Department of Geographic Information systems Feng Chia University Taichung 40724 Taiwan China

A least-squares finite-element method （LsFEM） for the non-conservative shallow-water equations is presented. The model is capable of handling complex topography, steady and unsteady flows, subcritical and supercritical flows, and flows with smooth and sharp gradient changes. Advantages of the model include：（1） sources terms, such as the bottom slope, surface stresses and bed frictions, can be treated easily without any special treatment; （2） upwind scheme is no needed; （3） a single approximating space can be used for all variables, and its choice of approximating space is not subject to the Ladyzhenskaya-Babuska-Brezzi （LBB） condition; and （4） the resulting system of equations is symmetric and positive-definite （sPD） which can be solved efficiently with the preconditioned conjugate gradient method. The model is verified with flow over a bump, tide induced flow, and dam-break. Computed results are compared with analytic solutions or other numerical results, and show the model is conservative and accurate. The model is then used to simulate flow past a circular cylinder. Important flow charac-teristics, such as variation of water surface around the cylinder and vortex shedding behind the cylinder are investigated. Computed results compare well with experiment data and other numerical results.

关键词： Least-square finite-element method,shallow-water equations Dam-break Vortex shedding

Optimization of wear parameters of binary Al-25Zn and Al-3Cu alloys using design of experiments

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International journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1465-1472页

作者： sreejith j s.Ilangovan Department of Mechanical Engineering Amrita School of Engineering

Zinc-aluminum alloys have been used as bearing materials in the past. In recent years, binary Al-Zn alloys and Al-Zn-Cu alloys are being used as an alternative to the Zn-Al alloys for bearing applications. In this study, both binary Al-25 Zn and Al-3 Cu were prepared using stir casting process. Homogenization of the as-cast alloys was performed at 350oC for 8 h and then, the alloys were furnace-cooled to 50oC. The homogenization led to the removal of the dendritic structure of the as-cast alloys. After homogenization, wear parameters optimization was carried out using Taguchi technique. For this purpose, L9 orthogonal array was selected, and the control parameters selected are load, velocity, and sliding distance. The optimum parametric condition was obtained using signal-to-noise(s/N) ratio analysis, and specific wear rate(sWR) is the selected response. The "smaller-the-better" is the goal of the experiment for s/N ratio analysis. After the optimization, confirmation tests were carried out using analysis of variance(ANOVA) from the developed regression equation. Finally, wear mechanism studies were conducted using scanning electron microscopy(sEM) and energy-dispersive X-ray spectroscopy(EDX) images.

关键词： specific wear rate micro-hardness Taguchi technique signal-to-noise ratio analysis of variance aluminum-zinc alloy aluminum-copper alloy

NUMERICAL sIMULATION OF FLOWs FOR sECOND-ORDER VIsCOELAsTIC FLUID COUPLED WITH HEAT TRANsFER BY DIFFERENTIAL QUADRATURE METHOD

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journal of Hydrodynamics 2005年第2期17卷 209-215页

作者： AL-sAIF A.s.j. shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

The problem of two-dimensional steady flow of an incompressible second-order viscoelastic fluid coupled with heat transfer between parallel plates was considered. A viscous dissipation function was included in the energy equation. When the elastic property of the fluid is weaker, the zeroth-order and first-order approximate governing equations were obtained by means of the perturbation method. To understand the behavior of flow near the tube wall, the half-domain was divided into two sub-domains, in which one is a thin layer near the wall called the inner domain and the remainder is called the outer domain. The governing equations in the inner domain and in the outer domain were discretized respectively by using the Differential Quadrature Method (DQM). The matching conditions at the interface between the inner and outer domains were presented. An iterative method for solving these discretized equations was given in this paper. The numerical results obtained agree with existing results.

关键词： momentum equations heat equation second-order viscoelastic fluid Differential Quadrature Method (DQM)

small Zeros of Additive Forms in several Variables

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Acta Mathematica sinica,English series 1998年第1期14卷 57-66页

作者： j. s. Hwang Institute of Mathematics Academia Sinica Taipei Taiwan 11529 China

Let f（X） be an additive form defined by f（X）=f（x1. x2,…,xs）=σ1α1x1k+σα2x2k+…+σsαsxsk, where αo≠0 is integer, i=1, 2,…, s. In 1979, schmidt proved that if ε>0 then there is a large constant C（k, ε）... 详细信息

Let f（X） be an additive form defined by f（X）=f（xsub>1sub>. xsub>2sub>,…,xsub>ssub>）=σsub>1sub>αsub>1sub>xsub>1sub>sup>ksup>+σsub>αsub>sub>2sub>xsub>2sub>sup>ksup>+…+σsub>ssub>αsub>ssub>xsub>ssub>sup>ksup>, where αsub>osub>≠0 is integer, i=1, 2,…, s. In 1979, schmidt proved that if ε>0 then there is a large constant C（k, ε） such that for s≥C（k, ε） the equation f（X）=0 has a nontrivial integer solution in σsub>1sub>. σsub>2sub>,…σsub>ssub>, xsub>1sub>, xsub>2sub>…,xsub>ssub> satisfying σsub>isub>=±1 and |xsub>isub>|≤Asup>εsup>, i=1, 2.…,s where A=max|ai|. schmidt did not estimate this constant C（k. ε） since it would be extremely large. In this paper, we prove the following result: Theorem 1 If log A≤1/ε,then C（k,ε）≤max （2/ε,20）; if log A>1/ε,A is sufficiently larye and 1/2A≤5≤|asub>isub>|≤A,i=1. 2,…, s, then C（k,ε）≤csub>1sub>csub>2sub>sup>psup> and if the last condition is omitted, then C（k. ε）≤[4/ε]csub>1sub>csub>2sub>,where csub>1sub>={2k+1 for≤k≤11 [5ksup>2sup>log k] for k≥12, csub>2sub>=100csub>1sub>ksup>2sup>2sup>ksup>+csub>1sub>sup>2sup> and p=2[log 2csub>1sub>/ε]. We note that the inequality in the first case is sharp but not in the second case.

关键词： Additive form subset sums small zeros

Numerical solution to the Falkner-skan equation:a novel numerical approach through the new rational α-polynomials

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Applied Mathematics and Mechanics(English Edition) 2021年第10期42卷 1449-1460页

作者： s.ABBAsBANDY j.HAjIsHAFIEIHA Department of Applied Mathematics Faculty of ScienceImam Khomeini International UniversityQazvin 34148-96818Iran

The new rationalα-polynomials are used to solve the Falkner-skan *** polynomials are equipped with an auxiliary *** approximated solution to the Falkner-skan equation is obtained by the new rational a-polynomials with unknown *** find the unknown coefficients and the auxiliary parameter contained in the polynomials,the collocation method with Chebyshev-Gauss points is *** numerical examples show the efficiency of this method.

关键词： Falkner-skan equation rational Chebyshev polynomial mapping parameter collocation method singular sturm-Liouville problem

seismic behavior of batter pile groups embedded in liquefiable soil

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Earthquake Engineering and Engineering Vibration 2021年第3期20卷 583-604页

作者： j.s.Rajeswari Rajib sarkar Department of Civil Engineering Indian Institute of Technology(ISM)DhanbadDhanbad 826004India

A comparative study of the seismic performance of 2×1 pile groups considering different degrees of batter(0°for vertical,10°and 20°)embedded in single homogeneous liquefiable sand through fully coupled three-dimensional dynamic analyses is *** effects of inertial interaction are considered with structures having two different *** performance of pile groups is investigated for the fixed and pinned pile to cap connections for both floating and end bearing types of pile *** ratios of piles were also varied to enable a comprehensive *** have been carried out for three earthquake motions having varied dominant *** is observed that batter pile groups in liquefiable soils provide beneficial effects on piles and superstructure responses for both fixed and pinned head pile to cap connections for long period ***,for short period structures,a beneficial effect is most evident for fixed head connection.

关键词： batter pile liquefaction period of structure pile to cap connection slenderness ratio

INTRODUCTION TO INCONEL ALLOY 740: AN ALLOY DEsIGNED FOR sUPERHEATER TUBING IN COAL-FIRED ULTRA sUPERCRITICAL BOILERs

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Acta Metallurgica sinica(English Letters) 2005年第4期18卷 479-488页

作者： s.j. Patel special Metals Corporation Huntington WV 25705 USA

Chinese utilities as well as those worldwide are facing increased demand for additional electricity, reduced plant emissions and greater efficiency. To meet this challenge will require increasing boiler temperature, pressure and coal ash corrosion resistance of the materials of boiler construction of future coal-fired boilers. A new nickel-based tube alloy, INCONEL^R alloy 740, is described aiming at meeting this challenge. Emphasis will be on describing the alloy＇ s mechanical properties, coal-ash and steam corrosion resistance. Microstructural stability as a function of temperature and time is addressed as well as some of the early methodology em- ployed to arrive at the current chemical composition.

关键词： ultrasupercritical boiler tubing INCONEL coal-fired

Evaluating Wharton’s jelly-derived stem cell therapy in autism:Insights from a case study

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World journal of Methodology 2025年第2期15卷 174-176页

作者： Muzamil Akhtar Abdulqadir j Nashwan College of Medicine Gujranwala Medical CollegeGujranwala 52250PunjabPakistan Department of Nursing and Midwifery Research Hamad Medical CorporationDoha 3050Qatar

Autism spectrum disorder(AsD)is a complex neurodevelopmental disorder affecting over 2%of the global population,marked by social communication deficits and repetitive *** et al explored the efficacy and safety of Wharton’s jelly-derived mesenchymal stem cell(Wj-MsC)therapy in a 4-year-old child with *** the childhood autism rating scale and Denver II develop-mental screening test,significant improvements were seen after six Wj-MsC sessions,with no adverse events over 2 *** promising results,the study’s single-case design limits ***,multi-center trials are needed to validate the findings and assess long-term effects of Wj-MsC therapy in AsD.

关键词： Autism spectrum disorder stem cell therapy Neuroinflammation Neuro-developmental disorders Wharton jelly derived mesenchymal stem cell