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Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy

World Journal of Gastrointestinal Oncology 2012年第2期4卷 22-25页

作者： Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave Digestive and Liver Disease Unit Second Medical School"La Sapienza" UniversityS. An-drea Hospital00189 RomeItaly Nursery Science Second Medical School "La Sapienza" University00189 RomeItaly Radiology Unit "La Sapienza" University00189 RomeItaly Oncology Unit "La Sapienza" University00189 RomeItaly General Surgery Unit "La Sapienza" University00189 RomeItaly Digestive Endoscopy Unit Catholic University000192 RomeItaly Radiotheraphy Unit "La Sapienza" Uni-versity00189 RomeItaly

Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological *** include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous *** date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated *** hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct *** surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and *** was effective in decreasing the mass size and in resolving subsequent *** is also the f irst reported case of IPMN-B successfully treated with *** should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery.

关键词： Intraductal papillary neoplasm Bile duct Simultaneous Pancreatic intraductal papillary mucinous neoplasm

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The duration of the conventional chemoembolization for hepatocellular carcinoma:factors affecting the procedural time

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Hepatoma Research 2022年第1期8卷 313-326页

作者： matteo Renzulli Mattia Gentilini Giovanni Marasco Nicolo Brandi Alessandro Granito Silvia Lo Monaco Anna Maria Ierardi Antonio De Cinque Francesco Tovoli Laura Bartalena Daniele Spinelli Fabio Piscaglia Rita Golfieri Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Internal Medicine and Digestive Physiopathology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Division of Internal Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Diagnostic and Interventional Radiology Department Fondazione IRCCS CàGranda Ospedale Maggiore PoliclinicoUniversitàdegli Studi di Milano MilanMilan 20122Italy

Aim:The present study evaluated the duration of chemoembolization in patients with hepatocellular carcinoma,analyzing possible factors affecting the procedural ***:In total,175 patients who underwent chemoembolization have been prospectively *** procedural length was considered the time between the insertion and the removal of the angiographic *** features related to the tumor burden and angiographic procedures,which could be related to the procedural time,were ***:The chemoembolization time resulted in a mean of 58.1 *** longer procedural time was associated with a number of nodules treated per patient≥2(P<0.001),a number of segments with nodules≥2(P<0.001),the presence of more than 1 nodule in the same segment(P<0.001),the location of the tumor in the left lobe(P=0.001),the exclusion from the Milan criteria(P<0.001),and a number of segments treated≥2(P<0.001).Only the number of nodules treated per patient resulted significantly in multivariate analysis(OR 2.927,95%CI:2.015-4.251,P<0.001).Conclusion:The factors related to longer procedural time are the number of nodules treated≥2,the number of segments with nodules≥2,the involvement of the left lobe,the tumor burden outside the Milan criteria,and the number of segments treated≥*** these characteristics,known in the pre-procedural phase,represent useful tools for a correct planning of the angiographic room’s workflow during the pandemic era as well as in the future to reduce downtime and increase productivity.

关键词： Chemoembolization hepatocellular carcinoma procedural time angiographic room management

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在超声引导下做颈内静脉穿刺置管时，头正中位与头侧偏45°体位相比是否更安全——来自于随机对照的临床试验结果

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麻醉与镇痛 2013年第3期9卷 65-73页

作者： Mas simo Lamperti matteo Subert Paolo Cortellazzi Davide Vailati Paola Borrelli Cris tina Montomoli Giovanni D' Onofrio, MD Dario Caldiroli, MD Department of Neuroanesthesia Neurological Institute Besta Milan Department ofApplied Sciences Medical Statistics and Epide-miology Universit6 di Pavia Pavia Italy

背景在颈内静脉（internal jugularvein，IJV）置管时，颈部的最佳偏转角度仍然不确定，因为之前的研究建议使用超声，但是没有做静脉穿刺。我们评估了在超声}I导下进行颈内静脉穿刺置管时，头正中位（neutralposition，NP，0°）是否... 详细信息

背景在颈内静脉（internal jugularvein，IJV）置管时，颈部的最佳偏转角度仍然不确定，因为之前的研究建议使用超声，但是没有做静脉穿刺。我们评估了在超声}I导下进行颈内静脉穿刺置管时，头正中位（neutralposition，NP，0°）是否比钙。的头侧偏位更安全。主要观察指标是两种体位穿刺时严重并发症的发生率。同时将评估总体并发症、进入静脉所需时间以及操作过程中的困难程度。方法在第三神经外科中心进行了前瞻性的随机对照非盲法研究。接受择期神经外科大手术且需中心静脉置管的患者被随机分为两组，用平面外定位的方法进行超声引导下的颈内静脉置管。结果我们评估了1424例患者，排除了92例，670例患者被纳入头侧偏组，662例患者入头中位组。穿刺置管的成功率为100％。除颈内静脉位置外，两组人口统计学数据相似。共发生10例严重并发症：6例在头正中位组，4例在45°头侧偏组，其发生率在两组之间没有显著差异。总体并发症发生率为13％，主要见于女性、A．姐分级≥II级、静脉直径较小或者是静脉位置很深且在侧面或前外侧者。总体并发症的增加与进入静脉的时间增加有关。操作过程的困难程度两组之间没有统计学差异。结论在超声BI导下做颈内静脉穿刺置管时，头正中位和45°头侧偏位同样安全。发生严重及轻微并发症的几率和进入静脉所需时间在两组间是相似的。在进行颈内静脉穿刺置管时，超声引导能帮助确定头侧偏的最佳角度。

关键词：颈内静脉穿刺置管超声引导随机对照中位临床试验安全体位并发症发生率

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Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score:is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)?

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 52-66,I0007,I0008页

作者： Ivan Capobianco Karl J.Oldhafer Mohammed-Hossein Fard-Aghaie Ricardo Robles-Campos Roberto Brusadin Henrik Petrowsky Michael Linecker Arianeb Mehrabi Katrin Hoffmann Jun Li Asmus Heumann Roberto Hernandez-Alejandro Mauro Enrique Tun-Abraham Elio Jovine matteo Serenari Bergthor Bjornsson Per Sandström Ruslan Alikhanov Mikhail Efanov Paolo Muiesan Andrea Schlegel Thomas M.van Gulik Pim B.Olthof Gregor Alexander Stavrou Lina Maria Serna-Higuita Alfred Königsrainer Silvio Nadalin Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenTübingenGermany Department of General and Abdominal Surgery Asklepios Hospital BarmbekHamburgGermany Department of Surgery Virgen de la Arrixaca Clinic and University HospitalMurciaSpain Swiss HPB and Transplantation Center Department of SurgeryZurich University HospitalZurichSwitzerland Department of General Visceraland Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany General Visceral and Thoracic Surgery Department and ClinicHamburg-Eppendorf University Medical CenterHamburgGermany Division of Transplantation and Hepatobiliary Surgery University of RochesterRochesterNYUSA Division of HPB Surgery and Liver Transplantation Department of SurgeryLondon Health Sciences CentreLondonCanada General and Emergency Surgery Unit Azienda Ospedaliero-Universitaria di BolognaMaggiore HospitalBolognaItaly General Surgery and Transplantation Unit Azienda Ospedaliero-Universitaria di BolognaSant’Orsola-Malpighi HospitalBolognaItaly Department of Surgery in Linköping and Department of Biomedical and Clinical SciencesLinköping UniversityLinköpingSweden Department of Hepatopancreatobiliary Surgery Moscow Clinical Scientific CenterMoscowRussia Liver Unit Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham NHS Foundation TrustBirminghamUK Department of Surgery Amsterdam UMC(Location AMC)University of AmsterdamAmsterdamThe Netherlands Department of General Abdominal and Thoracic SurgerySurgical OncologySaarbruecken General HospitalSaarbrueckenGermany Department of Clinical Epidemiology and Applied Biometry University of TübingenTübingenGermany

Background:Preoperative patient selection in Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)is not always reliable with currently available scores,particularly in patients with primary liver *** study aims to(I)to determine whether comorbidities and patients characteristics are a risk factor in ALPPS and(II)to create a score predicting 90-day mortality ***:Thirteen high-volume centers participated in this retrospective multicentric study.A risk analysis based on patient characteristics,underlying disease and procedure type was performed to identify risk factors and model the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score.A nonparametric receiver operating characteristic analysis was performed to estimate the predictive ability of our score against the Charlson Comorbidity Index(CCI),the age-adjusted CCI(aCCI),the ALPPS risk score before Stage 1(ALPPS-RS1)and Stage 2(ALPPS-RS2).The model was internally validated applying ***:A total of 451 patients were *** was 14.4%.The CAPRA score is calculated based on the following formula:(0.1×age)−(2×BSA)+1(in the presence of primary liver tumor)+1(in the presence of severe cardiovascular disease)+2(in the presence of moderate or severe diabetes)+2(in the presence of renal disease)+2(if classic ALPPS is planned).The predictive ability was 0.837 for the CAPRA score,0.443 for CCI,0.519 for aCCI,0.693 for ALPPS-RS1 and 0.807 for *** 1,000 cycles of bootstrapping the C statistic was *** accuracy plot revealed a cut-off for optimal prediction of postoperative mortality of ***:Comorbidities play an important role in ALPPS and should be carefully considered when planning the *** assessing the patient’s preoperative condition in relation to ALPPS,the CAPRA score has a very good ability to predict postoperative mortality.

关键词： Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS) comorbidity mortality prediction model patient selection

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嵌入式AI可用于广泛的终端市场,ST助力工程师克服三道难关

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电子产品世界 2021年第9期28卷 12-12页

作者： matteo MARAVITA 意法半导体亚太区人工智能技术创新中心

1 AI技术可用于广泛的终端市场在ST(意法半导体)产品覆盖的所有终端市场中(诸如工业、个人电子产品、家用电器、医疗保健、汽车等等),人工智能(AI)技术在其中的应用率一直在增长。ST已发布了一些基于32位微控制器、MPU和MEMS传感器的AI... 详细信息

1 AI技术可用于广泛的终端市场在ST(意法半导体)产品覆盖的所有终端市场中(诸如工业、个人电子产品、家用电器、医疗保健、汽车等等),人工智能(AI)技术在其中的应用率一直在增长。ST已发布了一些基于32位微控制器、MPU和MEMS传感器的AI解决方案,这些方案被大量地采用,市场热度高昂。我们的解决方案可以在所有这些市场应用用例和许多其他用例中为客户提供支持。

关键词：意法半导体 MEMS传感器电子产品终端市场医疗保健 32位微控制器市场热度应用率

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在中国最美好的回忆

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文化交流 2021年第11期 55-57页

作者：马提欧·普利比安卡

我在中国的时候,一些最美好的回忆是有关老年人的。在中国,不仅仅是年轻人,老年人更是充满活力,对人十分友好。只要在晚上6点左右去散步,或者在夏天晚上8点以后,你就会看到他们在充满激情地跳舞。我喜欢他们的态度,他们不在乎自己会不...

我在中国的时候,一些最美好的回忆是有关老年人的。在中国,不仅仅是年轻人,老年人更是充满活力,对人十分友好。只要在晚上6点左右去散步,或者在夏天晚上8点以后,你就会看到他们在充满激情地跳舞。我喜欢他们的态度,他们不在乎自己会不会跳舞,他们享受生活。当然,即使在一个外国人的眼里,也能理解年轻人和老年人之间的关系,和他们父母之间的关系,一点也不简单。

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Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy

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World Journal of Methodology 2014年第3期4卷 189-196页

作者： Laura Petrarca Raffaella Nenna Gerarda Mastrogiorgio matteo Florio Manuela Brighi Stefano Pontone Department of Pediatrics "Sapienza" University of Rome Department of Surgical Sciences "Sapienza" University of Rome

The prevalence of dyspepsia is up to 40% in population-based study. Functional dyspepsia is an exclusion diagnosis and it is classified as a chronic abdominal pain-related functional disorder, characterized by the presence of persistent or recurrent pain or discomfort centered in the upper abdomen, neither relief by defecation, nor association with the onset of a change in stool frequency or form. Celiac disease(CD) is a common autoimmune enteropathy, with a prevalence around 1% in the general population. Its diagnosis includes a serological screening and an upper gastrointestinal endoscopy with multiple biopsies. Gluten-free diet is the only effective treatment. CD diagnosis is often delayed in asymptomatic patients or in individuals with less clinical gastrointestinal symptoms. Several studies performed coeliac disease screening in patients with symptoms suggestive of dyspepsia, showing a biopsy-proved prevalence that ranged from 0.5% to 2%. The typical endoscopic markers of villous atrophy are not sufficiently sensitive, so some endoscopic techniques, such as "water immersion" and confocal endomicroscopy were proposed to improve the diagnosticsensitivity and target biopsies. A recent meta-analysis estimated that the prevalence of CD was higher in patients with dyspepsia, but not in a statistically significant way. However this assumption should be confirmed further larger studies.

关键词： Dyspepsia Coeliac disease Upper endoscopy Villus atrophy Screening

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Electrochemotherapy and heart function:Treatment in a patient with implantable cardioverter defibrillator/pacemaker

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World Journal of Anesthesiology 2013年第2期2卷 14-17页

作者： Maurizio Marandola Alida Albante Raffaele Quaglione Claudia Lucci matteo Chiaretti Luigi Tritapepe Department of Cardiovascular RespiratoryNephrologicAnesthesiologic and Geriatric Sciences"Sapienza" UniversityPoliclinico Umberto I00161 RomeItaly Department of Heart and Great Vessels " A.Reale" "Sapienza" UniversityPoliclinico Umberto I00161 RomeItaly

Electrochemotherapy(ECT) is a recently described therapy that relies on the permeation of cancer cell membranes by electrical pulses to enhance cytotoxic drug penetration. It has been successfully used in the treatment of primary and metastatic skin cancer. Systemic chemotherapy is the most commonly used therapeutic strategy, and the prevailing orientation calls for the administration of the maximum tolerated dose; however, considerable limitations exist including toxicities to healthy tissues and low achievable drug concentrations at tumor sites. We reported a case of an 83-years-old patient with a laterocervical metastasis of a squamous epidermoidal lip cancer. The patient had a complex medical history and an implantable cardioverter defibrillator(ICD)/pace-maker. The lesion was localized in the supraclavicular right side with a distance from the pace-maker/ICD about 5 cm, but the nodule was not deeply located. The ECT was performed un-der general anesthesia and particular attention we put on the interference with the functioning of the heart. The synchronization algorithm currently implemented in Clinoporator Vitae device coupled with the external triggering device Accu Sync proved to be effective in preventing external stimulation of the heart during the so-called vulnerable period of the ventricles. As a result all electroporation pulses in our study were delivered outside the vulnerable period and no heart arrhythmias or any other pathological morphological changes were observed. The safety of treatment was demonstrated also by absence of side effects during and after ECT.

关键词： General anesthesia Electrochemotherapy Pace-maker Implantable cardioverter defibrillator Tumor ablation Metastatic skin cancer

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Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation

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World Journal of Gastroenterology 2015年第13期21卷 3912-3920页

作者： Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone Department of Medical and Surgical Sciences University of Bologna and Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’Orsola Malpighi40138 BolognaItaly Department of Gastroenterology Azienda Ospedaliero-Universitaria and University of Modena and Reggio Emilia41124 ModenaItaly Department of Hepatology and Gastroenterology Niguarda Hospital20162 MilanItaly Hepatobiliopancreatic and General Surgery Unit Regina Elena Institute00186 RomeItaly Department of General Surgery and Transplantation Niguarda Hospital20162 MilanItaly

AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic ***: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders"(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

关键词： Hepatitis C Liver transplantation Hepatitis C viru

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设计师要在整合资源的能力和表达的野心之间取得平衡

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设计 2022年第24期35卷 42-45页

作者：马泰欧·英格拉姆刘源张弛米兰理工大学不详

《设计》:近年来,米兰理工大学***设计学院(以下简称***)学生们倾向于什么方向的毕业课题?马泰欧·英格拉姆:近年来,***的毕业设计方向确实发生了变化,并且这些变化已经尽早融入了学生们的专业教学。这些课题倾向于在设计学科相关语境... 详细信息

《设计》:近年来,米兰理工大学***设计学院(以下简称***)学生们倾向于什么方向的毕业课题?马泰欧·英格拉姆:近年来,***的毕业设计方向确实发生了变化,并且这些变化已经尽早融入了学生们的专业教学。这些课题倾向于在设计学科相关语境之下展开思考与讨论,将设计与日常生活(daily life)相结合,与用户们的生活方式相结合。

关键词：思考与讨论整合资源米兰理工大学毕业课题毕业设计英格拉姆

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