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Modeling cells spreading,motility,and receptors dynamics:a general framework

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Acta Mechanica Sinica 2021年第6期37卷 1013-1030,I0003页

作者： Mattia Serpelloni matteo Arricca Claudia Bonanno Alberto Salvadori Universitàdegli Studi di Brescia DIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DRIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DICACIM-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly

The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different *** this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for“rheology”or“mechanical response”.Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible *** of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.

关键词： Mechanobiology Receptor dynamics Cell motility

Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport

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World Journal of Gastroenterology 2010年第47期16卷 5958-5964页

作者： matteo Pedrelli Camilla Pramfalk Paolo Parini Division of Clinical Chemistry Department of Laboratory Medicine Molecular Nutrition Unit Biosciences and Nutrition Karolinska Institutet at Karolinska University Hospital Huddinge

Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. Thyroid hormones (THs) affect growth, develop- ment, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRα and TRβ, and several isoforms (e.g. TRα1, TRα2, TRβ1, and TRβ2). Activation of TRα1 affects heart rate, whereas activation of TRβ1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRβ1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRβ1-modulating thyromimetics on RCT in various animal models and in humans.

关键词： Cardiovascular disease Cholesterol Lipoprotein metabolism Reverse cholesterol transport Thyroid hormones Thyroid hormone receptors

Static Analysis of Anisotropic Doubly-Curved Shell Subjected to Concentrated Loads Employing Higher Order Layer-Wise Theories

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Computer Modeling in Engineering & Sciences 2023年第2期134卷 1393-1468页

作者： Francesco Tornabene matteo Viscoti Rossana Dimitri Department of Innovation Engineering School of EngineeringUniversity of SalentoLecce73100Italy

In the presentmanuscript,a Layer-Wise(LW)generalizedmodel is proposed for the linear static analysis of doublycurved shells constrained with general boundary conditions under the influence of concentrated and surface *** unknown field variable is modelled employing polynomials of various orders,each of them defined within each layer of the *** a particular case of the LW model,an Equivalent Single Layer(ESL)formulation is derived *** approaches are outlined for the assessment of external forces,as well as for non-conventional *** doubly-curved shell is composed by superimposed generally anisotropic laminae,each of them characterized by an arbitrary *** fundamental governing equations are derived starting from an orthogonal set of principal ***,generalized blending functions account for the distortion of the physical *** implementation of the fundamental governing equations is performed bymeans of the Generalized Differential Quadrature(GDQ)method,whereas the numerical integrations are computed employing theGeneralized IntegralQuadrature(GIQ)*** the post-processing phase,an effective procedure is adopted for the reconstruction of stress and strain through-the-thickness distributions based on the exact fulfillment of three-dimensional equilibrium equations.A series of systematic investigations are performed in which the static response of structures with various curvatures and lamination schemes,calculated by the present methodology,have been successfully compared to those ones obtained fromrefined finite element three-dimensional *** though the present LW approach accounts for a two-dimensional assessment of the structural problem,it is capable of well predicting the three-dimensional response of structures with different characteristics,taking into account a reduced computational cost and pretending to be a valid alternative to widespread numerical implementations.

关键词： Concentrated load doubly-curved shells generalized differential quadrature laminated anisotropic materials layer-wise theory mapping technique

Static Analysis of Doubly-Curved Shell Structures of Smart Materials and Arbitrary Shape Subjected to General Loads Employing Higher Order Theories and Generalized Differential Quadrature Method

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 719-798页

作者： Francesco Tornabene matteo Viscoti Rossana Dimitri Department of Innovation Engineering School of EngineeringUniversity of SalentoLecce73100Italy

The article proposes an Equivalent Single Layer(ESL)formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions.A parametrization of the physical domain is provided by employing a set of curvilinear principal *** generalized blendingmethodology accounts for a distortion of the structure so that disparate geometries can be *** layer of the stacking sequence has an arbitrary orientation and is modelled as a generally anisotropic *** addition,re-entrant auxetic three-dimensional honeycomb cells with soft-core behaviour are considered in the *** unknown variables are described employing a generalized displacement field and pre-determined through-the-thickness functions assessed in a unified ***,a weak assessment of the structural problem accounts for shape functions defined with an isogeometric approach starting fromthe computational *** has been proposed to define two-dimensional distributions of static surface *** the same way,boundary conditions with three-dimensional features are implemented along the shell edges employing linear *** fundamental relations are obtained from the stationary configuration of the total potential energy,and they are numerically tackled by employing the Generalized Differential Quadrature(GDQ)method,accounting for nonuniform computational *** the post-processing stage,an equilibrium-based recovery procedure allows the determination of the three-dimensional dispersion of the kinematic and static *** case studies have been presented,and a successful benchmark of different structural responses has been performed with respect to various refined theories.

关键词： 3D honeycomb anisotropic materials differential quadrature method general loads and constraints higher order theories linear static analysis weak formulation

Perturbed initial orbit determination

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Astrodynamics 2024年第3期8卷 401-416页

作者： Alberto Fossà matteo Losacco Roberto Armellin Institut Supérieur de l’Aéronautique et de l’Espace Toulouse31400France Te PūnahaĀtea-Space Institute The University of AucklandAuckland1010New Zealand

An algorithm for robust initial orbit determination (IOD) under perturbed orbital dynamics is presented. By leveraging map inversion techniques defined in the algebra of Taylor polynomials, this tool returns a highly accurate solution to the IOD problem and estimates a range centered on the aforementioned solution in which the true orbit should lie. To meet the specified accuracy requirements, automatic domain splitting is used to wrap the IOD routines and ensure that the local truncation error, introduced by a polynomial representation of the state estimate, remains below a predefined threshold. The algorithm is presented for three types of ground-based sensors, namely range radars, Doppler-only radars, and optical telescopes, by considering their different constraints in terms of available measurements and sensor noise. Finally, the improvement in performance with respect to a Keplerian-based IOD solution is demonstrated using large-scale numerical simulations over a subset of tracked objects in low Earth orbit.

关键词： initial orbit determination(IOD) range radar Doppler radar optical telescope differential algebra(DA)

Characterization of machine tools and measurement system for micromilling

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Nanotechnology and Precision Engineering 2019年第1期2卷 23-28页

作者： Andrea Abeni matteo Lancini Aldo Attansio Department of Mechanical and Industrial Engineering University of Brescia

Technological progress has led to increased demand for small components with tiny features, which cannot be achieved through conventional machining. Industrial application of processes based on microcutting is limited by some issues concerning the geometrical scale. The process performance is significantly affected by milling machine, tool holder, tool, workpiece material microstructure, workpiece fixtures, and process parameters. At present, an ultimate micromachining assessment procedure is not available. This study aims to propose and conduct an experiment on a testing procedure for micromilling. The set up to be implemented and the output to be considered are defined and described. Three major stages are identified: estimation of the effective bandwidth of the load cell–tool holder system, the milling machine natural frequency measurement, and micromilling test execution. The entire procedure is performed, and its robustness is demonstrated.

关键词： Micromilling Machine tool performance test Tool run-out Force analysis Modal analysis

S. V. Kovalevskaya system, its generalization and discretization

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Frontiers of Mathematics in China 2013年第5期8卷 1047-1065页

作者： matteo PETRERA Yuri B. SURIS Institut fiir Mathematik MA 7-2 Technische Universitat Berlin Str. des 17. Juni 13610623 Berlin Germany

We consider an integrable three-dimensional system of ordinary differential equations introduced by S. V. Kovalevskaya in a letter to G. Mittag- Leffler. We prove its isomorphism with the three-dimensional Euler top, and propose two integrable discretizations for it. Then we present an integrable generalization of the Kovalevskaya system, and study the problem of integrable discretization for this generalized system.

关键词： Birational map integrable map algebraically integrable system

Microstructure and Thermal Conductivity of Al–Graphene Composites Fabricated by Powder Metallurgy and Hot Rolling Techniques

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Acta Metallurgica Sinica(English Letters) 2017年第7期30卷 675-687页

作者： Abdollah Saboori matteo Pavese Claudio Badini Paolo Fino Department of Applied Science and Technology Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Turin Italy

The objective of this research is to improve the thermal conductivity and mechanical properties of Al/GNPs（graphene nanoplatelets） nanocomposites produced by classical powder metallurgy and hot rolling techniques. The microstructural evaluation confirmed the uniform dispersion of GNPs at low content and agglomeration at higher contents of GNPs. The structure of graphene was studied before and after the mixing and the Raman spectrum proofs that the wet mixing has a great potential to be used as a dispersion method. There was no significant peak corresponding to the Al_4C_3 formation in both the differential scanning calorimetry curves and X-ray diffraction patterns. The microstructural observation in both fabrication techniques showed grain refinement as a function of the GNPs content. Moreover, the introduction of the GNPs not only improved the Vickers hardness of the composites but also decreased their density. The thermal conductivity investigations showed that in both the press-sintered and hot-rolled samples, although the thermal conductivity of composites was improved at low GNPs contents, it was negatively affected at high GNPs contents.

关键词： Aluminum Graphene Thermal conductivity Powder metallurgy Microstructure

Minimal crystallographic descriptors of sorption properties in hypothetical MOFs and role in sequential learning optimization

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npj Computational Materials 2022年第1期8卷 1154-1167页

作者： Giovanni Trezza Luca Bergamasco matteo Fasano Eliodoro Chiavazzo Department of Energy Politecnico di TorinoC.so Duca degli Abruzzi 24Torino10129Italy

We focus on gas sorption within metal-organic frameworks(MOFs)for energy applications and identify the minimal set of crystallographic descriptors underpinning the most important properties of MOFs for CO_(2)and H_(2)O.A comprehensive comparison of several sequential learning algorithms for MOFs properties optimization is performed and the role played by those descriptors is *** energy transformations,thermodynamic limits of important figures of merit crucially depend on equilibrium properties in a wide range of sorbate coverage values,which is often only partially accessible,hence possibly preventing the computation of desired objective *** propose a fast procedure for optimizing specific energy in a closed sorption energy storage system with only access to a single water Henry coefficient value and to the specific surface *** are thus able to identify hypothetical candidate MOFs that are predicted to outperform state-of-the-art water-sorbent pairs for thermal energy storage applications.

关键词： functions sorption optimization