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Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker matt Cross Keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP *** may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

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Thirteen-year growth response of ponderosa pine plantations to dominant shrubs(Arctostaphylos and Ceanothus)

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Journal of Forestry Research 2020年第4期31卷 1445-1451页

作者： Jianwei Zhang matt d.Busse Gary O.Fiddler Ed Fredrickson USdA Forest Service Pacific Southwest Research Station3644 Avtech ParkwayReddingCA 96002USA USdA Forest Service Pacific Southwest Region3644 Avtech ParkwayReddingCA 96002USA Thunder Road Resources 21169 Falling Leaf RdReddingCA 96003USA

Thirteen-year growth response of ponderosa pine to various manipulations of understory vegetation was studied to determine if a threshold of understory cover can be established for plantation productivity and whether nitrogen-fixing Ceanothus species benefit plantation growth compared to non N-fixing Arctostaphylos species,given their ability to improve site *** showed that completely controlling competing vegetation increased plantation growth,as was universally expected,but the effects of partial shrub control on plantation performance was *** did not find a benefit of nitrogenfixing shrubs on tree growth,as young plantation growth was slightly better in the non N-fixing plots compared to the N-fixing plots due to differences in shrub *** understory cover threshold for tree growth was not *** to the overriding effect of shrub competition,controlling herbaceous species had little effect on plantation growth even though it benefited tree seedling survival.A long-term value of N-fixing shrubs at these sites,if there is one,must be balanced by successful plantation establishment and rapid early growth.

关键词： Competing vegetation control Manzanita Nitrogen-fixing Ceanothus Pinus ponderosa growth Shrub cover

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Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort

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World Journal of Gastroenterology 2021年第7期27卷 609-623页

作者： Kento Imajo Louise Tetlow Andrea dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine kelly matt d.kelly Rajarshi Banerjee Atsushi Nakajima department of Gastroenterology and Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan Innovation PerspectumOxford OX42LLUnited Kingdom Centre for Inflammation Research University of EdinburghEdinburghUnited KingdomEdinburgh EH164TJUnited Kingdom department of Cellular Pathology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Anatomic and Clinical Pathology department Yokohoma City University HospitalYokohoma 236-0004Japan department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUNd Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver *** multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2d Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver *** To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH *** From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and *** were subsequently biopsied,and samples were scored by three independent *** diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard *** between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa *** N=145 patients with mean age of 60(Sd:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the *** identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AU

关键词： Corrected T1 Fibro-inflammation Non-invasive imaging Non-alcoholic steatohepatitis Multiparametric magnetic resonance imaging Non-alcoholic fatty liver disease

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Phonon imaging in 3d with a fibre probe

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Light(Science & Applications) 2021年第6期10卷 1007-1019页

作者： Salvatore La Cavera III Fernando Perez-Cota Richard JSmith matt Clark Optics and Photonics Group Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG72RDUK

We show for the first time that a single ultrasonic imaging fibre is capable of simultaneously accessing 3d spatial information and mechanical properties from microscopic *** novel measurement system consists of two ultrafast lasers that excite and detect high-frequency ultrasound from a nano-transducer that was fabricated onto the tip of a single-mode optical fibre.A signal processing technique was also developed to extract nanometric in-depth spatial measurements from GHz frequency acoustic waves,while still allowing Brillouin spectroscopy in the frequency ***-free and non-contact imaging performance was demonstrated on various polymer *** singular device is equipped with optical lateral resolution,2.5μm,and a depth-profiling precision of 45 nm provided by *** endoscopic potential for this device is exhibited by extrapolating the single fibre to tens of thousands of fibres in an imaging *** a device catalyses future phonon endomicroscopy technology that brings the prospect of label-free in vivo histology within reach.

关键词： fibre equipped acoustics

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Energy Balance and Body Weight Regulation

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中国运动医学杂志 2006年第5期25卷 608-615页

作者： Chris Melby matt Hickey dept .of Food Science and Human Nutrition Nutrition and Metabolic Fitness LaboratoryColorado State University Fort Collins CODr .P.H. Human Performance/Clinical Research Lab Department ofHealth and Exercise ScienceColorado State University Fort Collins COPh.D.

Thermodynamic laws dictate that an excess of food energy intake relative to energy expenditure will lead to energy storage-an accumulation of fat. Conversely, a deficit of energy intake relative to expenditure will le... 详细信息

关键词： body than

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deep brain stimulation for dystonia

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Translational Neurodegeneration 2014年第1期3卷 6-10页

作者： Wei Hu matt Stead department of Neurology Mayo Clinic College of Medicine200 First Street SWRochesterMN 55901USA

deep brain stimulation(dBS)is an effective surgical treatment for medication-refractory movement disorders,and has been approved by the United States Food and drug Administration for treatment of *** success of dBS in the treatment of dystonia depends on our understanding of the anatomy and physiology of this disorder and close collaboration between neurosurgeons,neurologists,clinical neurophysiologists,neuroradiologists and ***,pallidal dBS is an established treatment option for medically refractive *** review is intended to provide a comprehensive review of the use of dBS for dystonia,focusing mainly on the surgical aspects,clinical outcome,MRI findings and side effects of dBS.

关键词： dystonia deep brain stimulation Surgical outcomes Neuromodulation Globus pallidus

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Variation in decomposition stages and carrion insect succession in a dry tropical climate and its effect on estimating postmortem interval

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Forensic Sciences Research 2020年第4期5卷 327-335页

作者： Kirsty Griffiths matt N.Krosch Kirsty Wright Scientific Section Forensic Services GroupQueensland Police ServiceBrisbaneQueenslandAustralia Quality Management Section Forensic Services GroupQueensland Police ServiceBrisbaneQueenslandAustralia Genomics Research Centre Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneQueenslandAustralia

Insects have an important role in minimum postmortem interval(PMImin)*** accurate PMImin estimation relies on a comprehensive study of the development and succes-sion of local carrion *** published research on carrion insect succession exists for tropical north *** address this,we aimed to obtain preliminary observational data concerning the rate of decomposition and insect succession on pig carcasses in Townsville and compare these with other regions of Australia and *** insects were collected daily from three pig carcasses for 30d during summer and identified to fa-mily *** of decomposition rate were made each day and progression through the stages of decomposition were *** insects were identified to family and their presence/absence used as a proxy for arrival at/departure from the remains,*** preliminary data highlight several interesting trends that may be inform-ative for forensic PMImin *** was rapid:all carcasses were at the dry/remains stage by day 5,which was substantially quicker than all other regions in the *** were also observed in the presence/absence of insect families and their arrival and departure *** the rapid progression through early decomposition,we argue that later-arriving coleopteran taxa may be more forensically informative in tropical Australia,in contrast with temperate regions where diptera appear most *** research contributes preliminary observational data to understanding insect succession pat-terns in tropical Australia and demonstrates the critical need for comprehensive local succes-sion data for each climatic region of Australia to enable accurate PMImin *** data will inform future research targeted at gaining a more comprehensive understanding of insect succession in the Australian tropics.

关键词： Forensic sciences forensic entomology postmortem interval diptera Coleoptera decomposition

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A murine model of tuberculosis/type 2 diabetes comorbidity for investigating the microbiome,metabolome and associated immune parameters

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Animal Models and Experimental Medicine 2021年第2期4卷 181-188页

作者： Harindra d.Sathkumara Janet L.Eaton matt A.Field Brenda L.Govan Natkunam Ketheesan Andreas Kupz Centre for Molecular Therapeutics Australian Institute of Tropical Health and MedicineJames Cook UniversityCairns&TownsvilleQLDAustralia College of Public Health Medical and Veterinary SciencesJames Cook UniversityTownsvilleQLDAustralia Centre for Tropical Bioinformatics and Molecular Biology James Cook UniversityCairnsQLDAustralia John Curtin School of Medical Research Australian National UniversityCanberraACTAustralia Science and Technology University of New EnglandArmidaleNSWAustralia

Tuberculosis(TB)is one of the deadliest infectious diseases in the *** meta-bolic disease type 2 diabetes(T2d)significantly increases the risk of developing ac-tive *** new TB vaccine candidates and novel therapeutic interventions are required to meet the challenges of global TB *** evidence suggests that the microbiota plays a significant role in how the host responds to infection,in-jury and neoplastic *** models that closely reflect human physiology are crucial in assessing new treatments and to decipher the underlying immunological defects responsible for increased TB susceptibility in comorbid *** this study,using a diet-induced murine T2d model that reflects the etiopathogenesis of clinical T2d and increased TB susceptibility,we investigated how the intestinal microbiota may impact the development of T2d,and how the gut microbial composition changes following a very low-dose aerosol infection with Mycobacterium tuberculosis(Mtb).Our data revealed a substantial intestinal microbiota dysbiosis in T2d mice compared to non-diabetic *** observed differences were comparable to previous clini-cal reports in TB patients,in which it was shown that Mtb infection causes rapid loss of microbial ***,diversity index and principle component analyses demonstrated distinct clustering of Mtb-infected non-diabetic mice ***-infected T2d *** findings support a broad applicability of T2d mice as a tractable small animal model for studying distinct immune parameters,microbiota and the immune-metabolome of TB/T2d *** model may also enable answers to be found to critical outstanding questions about targeted interventions of the gut mi-crobiota and the gut-lung axis.

关键词： gut microbiota host microbe interaction infectious diseases tuberculosis type 2 diabetes

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developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

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Asian Journal of Andrology 2021年第3期23卷 231-235页

作者： Keiran d Clement Lizzy day Helen Rooney matt Neilson Fiona Birrell Mark Salji Elizabeth Norm an Ross Clark Amit Patel John Morrison Hing Y Leung departm ent of Urology Queen Elizabeth University Hospital1345 Govan RdGlasgow G514TFUK department of Urology Ayr University HospitalDalmellington RdAyr KA66DXUK CRUK Beatson Institute for Cancer Research Garscube EstateBearsdenGlasgow G611BDUK lnstitute of Cancer Sciences University of GlasgowBearsdenGlasgow G611BDUK department of Radiology NHS Greater Glasgow and ClydeGlasgow G514TFUK.

Lack of investment for magnetic resonance(MR)fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic *** developed a coordinate-based method to support cognitive targeted prostate biopsies and then performed an audit on cancer detection and the location of *** each patient,the prostate is considered as two separate hemiprostates,and each hemiprostate is divided into 4×4×4 *** unit is therefore defined by a three-dimensional *** prospectively applied our coordinates approach to target 106 prostatic lesions in 93 *** 45(of 106;42.5%)lesions positive for cancer,27 lesions(60.0%)harbored clinically significant *** density was significantly higher in patients with proven cancer(median:0.264 ng ml^(-2))when compared to the noncancer group(median:0.145 ng ml-2;P=0.003,Wilcoxon ranksum test).Lesions with Prostate Imaging-Reporting and data System(PIRAdS)score of 5 were found to have a cancer incidence of 65.2%,while PI RAdS 4 and 3 lesions have a lower risk of cancer detection,as expected,at 37.3%and 31.3%,*** probability of a lesion being cancerous in our series significantly decreases as we go from the“apex-to-base”dimension(odds ratio[OR]:2.62,95%confidence interval[Cl]:1.55-4.44,P=0.00034).Our analysis also indicates that the probability of cancer decreases as the prostate volume increases(OR:1.03,95%Cl:1.01-1.05,P=0.00327).Based on this feasibility study,the use of coordinates to guide cognitive targeted prostate biopsies warrants future validation study in additional centers.

关键词： cognitive targeted prostate biopsies coordinates magnetic resonance imaging prostate cancer

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I_(c) measurement of twisted multifilamentary MgB_(2) wires with non-magnetic sheath over a wide range of temperatures and fields

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Superconductivity 2023年第4期8卷 84-89页

作者： Yukai Qiao matt Rindfleisch Mike Tomsic Michael d.Sumption Naoyuki Amemiya Rodney A.Badcock Nicholas M.Strickland Zhenan Jiang Robinson Research Institute Victoria University of WellingtonWellingtonLower Hutt 5012New Zealand Hyper Tech Research Inc ColumbusOH 43228USA department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA department of Electrical Engineering Kyoto UniversityKyoto 615-8510Japan

All‐superconducting rotating machines have the potential for meeting the high power density and high efficiency required for electrical aircraft ***,very high AC loss encountered in superconducting armature windings could hinder their *** MgB_(2) wires are one of the promising candidates for the stator windings,due to their potentially low AC loss properties with small filament size and twist *** the first step,the dependence of critical current and n‐value on magnetic fields and temperatures I_(c)(B,T)and n(B,T),which are basic input parameters for AC loss simulation,needs to be *** this work,we present transport I_(c)measurements in three non‐magnetic multifilamentary MgB_(2) wires(MgB_(2)/Nb/CuNi/CuZn):one large wire with a 0.70 mm diameter and 25 mm twist pitch,and two small wires with a 0.48 mm diameter each and a 10 mm and 30 mm twist pitch respectively.A four‐probe direct current method is used to measure I_(c) of the MgB_(2) wires with variations in temperature(15-35 K)and magnetic field(0-5.5 T).Full I_(c) data for the small wire with 10 mm twist pitch was obtained,and the n‐values were mostly less than *** the I_(c) data for the large wire at low fields was more limited due to heating,the n‐values were higher and could be up to around *** difference is attributed to the different filament *** also found that there is no significant hysteresis in the transport critical current measured by decreasing or increasing magnetic fields due to the non‐magnetic *** non‐hysteretic characteristic is critical for lowering AC loss because the additional losses from magnetic sheaths can be *** the magnetic‐field dependence of critical current density,an empirical expression has been developed that provides suitable extrapolations to lower fields for the large wire.

关键词： Transport critical current MgB_(2)wire A four‐probe direct current method

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