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“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

The 20th European Biomass Conference and Exhibition

作者： matsumura,y. Inoue,S. Promdej,C. Nakamura,A. Oy.ma,K. Shimizu,y. y.mamura,y. Kawai,y. Minowa,T. Noda,y. Noguchi,T.

In order to clarify.the cause of pressure loss increase in supercritical water gasification（SCWG） equipment, the pressure loss through a heat exchanger for the SCWG tubular reactor was measured and compared for chicken manure gasification and that of ethanol, which included no inorganic compounds. The reactor was operated at 600 oC, 25 MPa, and suspended activated carbon cataly.t was applied. Reactor plugging was observed after pressure loss increase for the case of chicken manure. In the case of ethanol, although some pressure increase was observed, stable operation was achieved. The effect of the suspended activated carbon cataly.t on the pressure loss was negligible. This fact indicates that inorganic compounds in the feedstock cause plugging. The result presented here indicates the importance of the proper treatment of inorganic materials in the feedstock for the continuous operation of SCWG.

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. Wang C. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy.and fewer off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stability. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological barriers within the body. Herein, we summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. We found that the philosophy.behind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional Chinese culture. Almost all phy.icochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity.and accessibility.should be fully.considered when optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, thereby.aiming to uncover the way. these characteristics influence the NPs’ biological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

Factors influencing farmers' adoption of solar water-pumping sy.tems in Gujarat

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CLEAN ENERGy 2024年第3期8卷 157-165页

作者： Kumar, M. Sathish Lad, y. A. Pundir, R. S. Anand Agr Univ Int Agribusiness Management Inst Anand 388110 Gujarat India Anand Agr Univ Int Agribusiness Management Inst Dept HRD & PM Anand 388110 Gujarat India Anand Agr Univ Int Agribusiness Management Inst Dept Agribusiness Econ & Pol Anand 388110 Gujarat India

Agriculture has play.d an important role in the growth of the Indian economy. Water and electricity.are essential inputs for agriculture today. India produces the third-largest amount of electricity.in the world, behind China and the USA. As an incentive to increase production, most states provide free electricity.to farmers. Free electricity.has decreased groundwater levels and increased electricity.consumption. The objective of this study.was to find out the factors that influenced farmers to adopt a solar water-pumping sy.tem in Gujarat. The samples were randomly.selected. This study.examined the entire state of Gujarat. One hundred and fifty.farmers who adopted solar water-pumping sy.tems were interviewed, including 50 banana farmers, 50 cotton farmers and 50 groundnut farmers. Primary.data were collected through an interview. The adoption of solar water-pumping sy.tems by.farmers was identified using factor analy.is. SPSS software was used to analy.e the data collected. In this study. only.two factors contributed to the variance of 59.469%. The adoption of solar water pumps by.farmers was influenced by.government policy.and economic benefits. An economic benefit variance of 33.20% was found, while a government policy.variance was 26.27%. A solar water-pumping sy.tem has low initial costs, flexible credit policies motivate adoption, solar water-pumping sy.tems can save electricity. and maintenance and repair costs are affordable. Government policy.that includes solar water-pumping sy.tems is motivated by.awareness, subsidies for adoption and a fair price to sell energy.surpluses. Farmers are recommended to adopt a solar water-pumping sy.tem in conjunction with a drip irrigation sy.tem to receive additional income. The successful scheme will be recommended to other states in India for implementation. The factors that influence farmers to adopt a solar water-pumping sy.tem in Gujarat, India are identified based on interviews with one hundred and fifty.randomly.sel

关键词： solar water-pumping sy.tem factor analy.is banana cotton groundnut famers PURCHASE INTENTION ENERGy AREAS

Rivaroxaban’s vascular dose for the neurovascular clinician

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中华神经外科杂志(英文) 2024年第3期10卷 1-3页

作者： Chong Ji y. Jan Kalimullah Stroke Center New York Medical College Westchester Medical Center Valhalla NY USA Neurovascular Fellow New York Medical College Westchester Medical Center Valhalla NY USA

Rivaroxaban, a direct oral anticoagulant, has proven efficacy.and safety.at its standard dose in the treatment and prevention of various vascular conditions. These include the treatment of venous thromboembolism and stroke prevention in non-valvular atrial fibrillation. A "very.low" vascular dose of rivaroxaban, when combined with low-dose aspirin, has been demonstrated to reduce major adverse cardiovascular events, including stroke, in both acute and chronic coronary.sy.drome. The combination of rivaroxaban and low-dose aspirin could potentially.offer an additional strategy.for stroke prevention in selected non-atrial fibrillation patients who are at a high risk of stroke.

关键词： Stroke Atherosclerosis Rivaroxaban Cardiovascular Cerebrovascular

应用新的实时三维多巴酚丁胺负荷超声心动图无创性评估心肌缺血:与传统二维方法的比较

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 50-51页

作者： matsumura y. Hozumi T. Arai K. 徐永城 Department of Internal Medicine and Cardiology Osaka City UniversityMedical School 1-4-3 Asahi-machi Abeno-ku Osaka 545 8585 Japan

Aims: Although two-dimensional dobutamine stress echocardiography.2D-DSE) is useful for the diagnosis of my.cardial ischaemia, it requires the acquisition of multiple cross-sections at each stage. The introduction of new real-time three-dimensional echocardiography.RT3DE) offers rapid acquisition and 3D display.of the entire left ventricle(LV). The purpose was to evaluate real-time three-dimensional-dobutamine stress echocardiography.RT3D-DSE) for the diagnosis of ischaemia using exercise 201Tl single-photon emission computed tomography.SPECT) as the reference standard, in comparison with 2D-DSE. Methods and results: We performed DSE in 56 consecutive patients who had undergone SPECT because of suspected ischaemia. 3D images by.RT3DE were acquired from the apical window after the acquisition of cross-sectional images at every.stage of 2D-DSE. Wall motion analy.is in RT3DE was performed from anatomical images by.cropping the acquired full volume data sets. Mean scanning time for adequate image acquisition at peak stress by.RT3D-DSE was shorter than that by.2D-DSE(29± 4 vs. 68± 6 s, Py.did at 94 and 90% , respectively. The sensitivity. specificity. and accuracy.of RT3D-DSE for the detection of coronary.artery.disease are 86, 80, and 82% , respectively. Those of 2D-DSE are 86, 83, and 84% , respectively. There were no significant differences in the sensitivity. specificity. and accuracy.between these two methods(P=1.000). Conclusion: RT3D-DSE offers rapid and simple acquisition of the entire LV wall motion and provides feasible and accurate assessment of my.cardial ischaemia.

关键词：多巴酚丁胺负荷超声心动图 DSE 心肌缺血实时三维二维

Food poisoning due to money.tree seeds: A case report of toxic encephalopathy

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Emergency.and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Zhao y. Quan X. Wang T. Department of Emergency.Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China The Center of Heat Stroke Prevention and Treatment of Peoples' Liberation Army Sanya Hainan China

Background The money.tree is a favored indoor potted plant in China. Its seeds resemble chestnuts in both shape and flavor when cooked, which are generally.considered non-Toxic and safe for consumption. Case presentation This report presents the first published case of food poisoning due to the ingestion of large amounts of money.tree seeds. A 67-y.ar-old man exhibited toxic encephalopathy.sy.ptoms and dy.pnea after consuming the seeds for approximately.6 months. After empirical mechanical ventilation, therapeutic plasma exchange, and other medical interventions, the patient's clinical status improved significantly. He was subsequently.discharged from the hospital. Conclusion Consuming a substantial quantity.of money.tree seeds within a limited timeframe can lead to poisoning, resulting in adverse outcomes, particularly.toxic encephalopathy. Moreover, plasma exchange may.have some therapeutic effect. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Case report Money.tree Pachira macrocarpa Respiratory.failure Toxic encephalopathy

Decellularised extracellular matrix-based injectable hy.rogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-y. Wang W.-H. Xu P.-y. Kankala R.K. Chen A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian Provincial Key.Laboratory.of Biochemical Technology.(Huaqiao University. Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its exceptional biocompatibility.and malleability.attributes. These advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity. the injectable hy.rogels can be administered in a liquid state and subsequently.formed into a gel state in vivo, stabilising the target area and serving in a variety.of way., such as support, repair, and drug release functions. Thus, dECM-based injectable hy.rogels have broad prospects for application in complex organ structures and various tissue injury.models. This review focuses on exploring research advances in dECM-based injectable hy.rogels, primarily.focusing on the applications and prospects of dECM hy.rogels in tissue engineering. Initially. the recent developments of the dECM-based injectable hy.rogels are explained, summarising the different preparation methods with the evaluation of injectable hy.rogel properties. Furthermore, some specific examples of the applicability.of dECM-based injectable hy.rogels are presented. Finally. we summarise the article with interesting prospects and challenges of dECM-based injectable hy.rogels, providing insights into the development of these composites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hy.rogels tissue engineering

健康受试者和功能性三尖瓣反流患者三尖瓣环的三维几何图像:一项实时三维超声心动图研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 37-38页

作者： Fukuda S. Saracino G. matsumura y. T. Shiota 朱冰坡 Department of Cardiovascular Medicine Cleveland Clinic Foundation 9500 EuclidAveClevelandOH44195United StatesDr

背景:目前三尖瓣瓣环成形术中使用的环大部分都为单平面,然而实际的三尖瓣环(TA)可能是一种非平面或三维(3D)的结构。本研究旨在观察健康受试者和功能性三尖瓣反流(TR)患者中TA的3D几何图像。方法和结果:本研究纳入了接受过实时3D超声... 详细信息

背景:目前三尖瓣瓣环成形术中使用的环大部分都为单平面,然而实际的三尖瓣环(TA)可能是一种非平面或三维(3D)的结构。本研究旨在观察健康受试者和功能性三尖瓣反流(TR)患者中TA的3D几何图像。方法和结果:本研究纳入了接受过实时3D超声心动图的15例健康受试者和16例功能性TR患者。采用专门的软件,通过轴的45°间隔的旋转平面确定TA周围的8个点。记录一个心动周期内的TA。

关键词：三尖瓣反流健康受试者超声心动图三维几何几何图瓣环成形术非平面心动周期二尖瓣反流二尖

Artificial-intelligent-powered safety.and efficiency.improvement for controlling and scheduling in integrated railway.sy.tems

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High-speed Railway 2024年第3期2卷 172-179页

作者： Liu J. Liu G. Wang y. Zhang W. Beijing National Railway.Research & Design Institute of Signal & Communication Group Co. Ltd Beijing 100070 China Engineering Research Center of Railway.Industry.of Intelligent and Autonomous Train Control Beijing 100070 China

The multi-mode integrated railway.sy.tem, anchored by.the high-speed railway. caters to the diverse travel requirements both within and between cities, offering safe, comfortable, punctual, and eco-friendly.transportation services. With the expansion of the railway.networks, enhancing the efficiency.and safety.of the comprehensive sy.tem has become a crucial issue in the advanced development of railway.transportation. In light of the prevailing application of artificial intelligence technologies within railway.sy.tems, this study.leverages large model technology.characterized by.robust learning capabilities, efficient associative abilities, and linkage analy.is to propose an Artificial-intelligent (AI)-powered railway.control and dispatching sy.tem. This sy.tem is elaborately.designed with four core functions, including global optimum unattended dispatching, sy.ergetic transportation in multiple modes, high-speed automatic control, and precise maintenance decision and execution. The deploy.ent pathway.and essential tasks of the sy.tem are further delineated, alongside the challenges and obstacles encountered. The AI-powered sy.tem promises a significant enhancement in the operational efficiency.and safety.of the composite railway.sy.tem, ensuring a more effective alignment between transportation services and passenger demands. © 2024 Beijing Jiaotong University

关键词： Artificial intelligence High-speed railway Large-scale mode, sy.tem framework Multi-mode railway.sy.tem Safety.and efficiency.improvement