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Mitigation of Deane and Hamill phenomenon in gallium nitride high-voltage power supply for electric propulsion system application

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High Voltage 2024年第1期9卷 252-265页

作者： Minghai Dong Hui Li Shan Yin kye Yak See Yingzhe Wu Xiong Xin School of Aeronautics&Astronautics University of Electronic Science and Technology of ChinaChengduChina School of Electrical&Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Innoscience(Shenzhen)Semiconductor Co.Ltd. ShenzhenChina

The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power *** bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant ***,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)*** oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency *** authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be *** facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with *** relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH ***,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.

关键词： power resonant high

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Water hammer in the pump-rising pipeline system with an air chamber

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Journal of Hydrodynamics 2014年第6期26卷 960-964页

作者： KIM Sang-Gyun LEE kye-Bock KIM Kyung-Yup Korea Water Resources Corporation School of Mechanical Engineering Chungbuk National University School of Mechanical Engineering Korea Polytechnic University

Water hammer following the tripping of pumps can lead to overpressure and negative pressure. Reduction in overpressure and negative pressure may be necessary to avoid failure, to improve the efficiency of operation and to avoid fatigue of system components. The field tests on the water hammer have been conducted on the pump rising pipeline system with an air chamber. The hydraulic transient was simulated using the method of characteristics. Minimizing the least squares problem representing the difference between the measured and predicted transient response in the system performs the calibration of the simulation program. Among the input variables used in the water hammer analysis, the polytropic exponent, the discharge coefficient and the wave speed were calibrated. The computer program developed in this study will be useful in designing the optimum parameters of an air chamber for the real pump pipeline system. The correct selection of air chamber size and the effect of the inner diameter of the orifice to minimize water hammer have been investigated by both field measurements and numerical modeling.

关键词： air chamber design parameter field test pump pipeline system water hammer

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Management of obstructive colon cancer:Current status,obstacles,and future directions

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1850-1862页

作者： Ri-Na Yoo Hyeon-Min Cho Bong-Hyeon kye Division of Colorectal Surgery Department of SurgerySt.Vincent’s HospitalThe Catholic University of KoreaSuwon 442-723South Korea

Approximately 10%–18%of patients with colon cancer present with obstruction at the initial *** active screening efforts,the incidence of obstructive colon cancer remains ***,emergency surgery has been indicated to treat patients with obstructive colon ***,compared to patients undergoing elective surgery,the morbidity and mortality rates of patients requiring emergency surgery for obstructive colon cancer are *** the advancement of colonoscopic techniques and equipment,a self-expandable metal stent(SEMS)was introduced to relieve obstructive symptoms,allowing the patient’s general condition to be restored and for them undergo elective *** the use of SEMS placement is growing,controversies about its application in potentially curable diseases have been *** this review,the short-and longterm outcomes of different treatment strategies,particularly emergency surgery vs SEMS placement followed by elective surgery in resectable,locally advanced obstructive colon cancer,are described based on the location of the obstructive cancer *** regarding each treatment strategy are *** overcome current obstacles,a potential diagnostic method using circulating tumor DNA and further research directions incorporating neoadjuvant chemotherapy are introduced.

关键词： Colonic neoplasms Self-expandable metallic stents Intestinal obstruction Survival rate Morbidity Mortality

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Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature

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World Journal of Stem Cells 2022年第4期14卷 303-309页

作者： Hyunjun Ahn Sang Yeon Lee Won-Ju Jung kye-Ho Lee Stem Cell Treatment and Research Institute(STRI) bio Beauty and Health Company(bBHC)Seoul 04420South Korea Stem Cell Treatment 97.7 Beauty and Health ClinicSeoul 04420South Korea

BACKGROUND Syringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain,paresthesia,and urination and defecation disorders,and in severe cases causes various ***,there are only surgical methods for the treatment of syringomyelia,but these methods carry the possibility of failure,recurrence,and side *** SUMMARY The patient was a 59-year-old woman who suffered from pain due to *** treatment,the patient received transplant of uncultured umbilical cord-derived mesenchymal stem *** intended,the patient's pain was relieved after ***,an additional benefit was found in that the size of the cavity also *** 2 years from the last treatment,the patient's cavity had almost completely disappeared and her syringomyelia was deemed *** Using uncultured umbilical cord-derived mesenchymal stem cells may be a new treatment alternative for syringomyelia.

关键词： Syringomyelia Umbilical cord mesenchymal stem cells Cell therapy Allogenic stem cells Chiari malformations Case report

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Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells:Three case reports and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3741-3751页

作者： Hyunjun Ahn Sang Yeon Lee Won Ju Jung kye-Ho Lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair *** appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune *** this reason,preclinical and case studies of AA and related diseases using MSCs have been *** SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the *** was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 *** AA gradually improved 3 mo after the first *** patient was cured,and AA did not *** 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the *** was given two rounds of MM-UC-MSCs over 1 *** AA immediately improved after the first *** patient was cured,and AA did not *** 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 *** hair began to grow about 3 mo after the first *** patient was cured,and alopecia universalis did not *** MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.

关键词： Alopecia areata Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation:A case report

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World Journal of Stem Cells 2021年第8期13卷 1151-1159页

作者： Hyunjun Ahn Sang Yeon Lee Won Ju Jung kye-Ho Lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Stroke is one of the major causes of disability and death *** treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the ***,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been *** SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower *** intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d *** 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse *** MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.

关键词： Acute ischemic stroke Behavioral disorder Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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A 75 kDa glycoprotein isolated from Cudrania tricuspidata Bureau induces colonic epithelial proliferation and ameliorates mouse colitis induced by dextran sulfate sodium

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Chinese Journal of Natural Medicines 2021年第1期19卷 46-55页

作者： Park Jeong-Bae Kim Do-Wan Lim kye-Tack Oh Sejong Lee Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610South Korea Division of Animal Science Chonnam National UniversityGwangju 61186South Korea

Cudrania tricuspidata Bureau(CTB),a species of the Moraceae plant,has been used as a bruise recovery *** study aimed to determine whether the 75 kDa phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease(IBD).We found that CTB glycoprotein significantly induces the proliferation of human colon epithelial HT-29 cells by activating protein kinase *** glycoprotein stimulated the phosphorylation of c-Jun N-terminal kinase and transcription factor nuclear factor-κB,which are responsible for the expression of cell-cycle-related proteins(CDK2,CDK4,cyclin D1 and cyclin E)during its promotion of cell *** colitis was induced in mice by adding dextran sulfate sodium to their drinking water at a concentration of 4%(W/V)for seven *** found that CTB glycoprotein ameliorates the pathological process of IBD and lowers the disease activity index score,which was composed of body weight change,diarrhea,and hematochezia in ICR mice treated with dextran sulfate ***,we suggest that CTB glycoprotein has the ability to prevent IBD by promoting cell proliferation signaling events via the activation of PKC,JNK and NF-κB in colon epithelial cells.

关键词： Cell cycle Cell proliferation Colon epithelial cells Cudrania tricuspidata Glycoprotein Inflammatory bowel disease Protein kinase C

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Surgical Management of Symptomatic Adventitial Cystic Disease of the Popliteal Artery as a Cause of Deep Vein Thrombosis

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Chinese Medical Journal 2018年第17期131卷 2141-2142页

作者： Jong Seok Lee Jeong kye Hwang Sun Cheol Park Sang Dong Kim Department of Surgery Division Medical Detachment Ministry of National Defense Gangwon-do 24151 Korea Department of Surgery Division of-Vascular and Transplant Surgery College of Medicine The Catholic University of Korea Seoul 06591 Korea

To the Editor： A 67-year-old female was referred for persisted swelling in right leg despite of anticoagulation during 2 months for deep vein thrombosis （DVT） of the right popliteal vein （PV）. Initial duplex ultrasonography of local clinic at 2 months ago showed the acute DVT of right PV with thrombus and dilated vein [Figure 1a].

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Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercholesterolemic Men

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Biomedical and Environmental Sciences 2008年第2期21卷 91-97页

作者： SOO YEON KIM SUN YOON SOO MI KWON kye SOOK PARK YANG CHA LEE-KIM Graduate School of Human Environmental Science Department of Food and Nutrition College of Human Ecology Yonsei Health Center Yonsei University 134 Shinchon-dong Sudaemun-ku 120-749 Seoul Korea

Objective To evaluate the effect of 3-month kale （Brassica oleracea acephala） juice supplementation on coronary artery disease risk factors among hypercholesterolemic men. Methods Thirty-two men with hypercholesterolemia （〉 200 mg/dL） were recruited after annual health examinations among the faculty and staff at university. The subjects consumed 150 mL of kale juice per day for a 12-week intervention period. Dietary and anthropometric assessments were performed and blood samples were collected to evaluate biochemical profiles before and after supplementation. Results Serum concentrations of HDL-cholesterol, and HDL- to LDL-cholesterol ratio were significantly increased by 27% （P〈0.0001） and 52% （P〈0.0001）, respectively. The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 10% （P=0.0007） and 24.2% （P〈0.0001）, respectively without affecting body mass index, waist and hip circumferences, or nutrient intakes after three months of supplementation. While there was no difference in the concentration of malondialdehyde, significant increase in glutathione peroxidase activity （P=0.0005） were accompanied by a significant increase in the serum selenium level （P=0.0132）. It was also found that the responses of these risk factors to kale juice administration were dependent on smoking status. Conclusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems, and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia.

关键词： Kale juice Hyperlipidemia Coronary artery disease Lipid profile Antioxidant system

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Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing

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Chinese Journal of Natural Medicines 2020年第10期18卷 738-748页

作者： KIM Ji-Yun LEE Young-Min PARK Jong-Pil LIM kye-Taek LEE Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610Republic of Korea Department of Food Science and Technology Chung-Ang UniversityAnseong 17546Republic of Korea Division of Animal Science Chonnam National UniversityGwangju61186Republic of Korea

Dioscorea batatas Decne(DBD)has been used to heal various illnesses of the kidney and intestine as an herbal medicine in *** a source of therapeutic agents,many glycoproteins have been isolated from mushrooms and plants,but the functional role of glycoprotein in intestinal epithelial wound healing has not been understood *** the present study,we investigated the wound healing potentials of the 30 kDa glycoprotein(DBD glycoprotein)isolated from DBD in human intestinal epithelial(INT-407)*** found that DBD glycoprotein(100μg·mL^-1)significantly increased the motility of INT-407 cells for 24 h by activating protein kinase C(PKC).DBD glycoprotein stimulated the activation of p38 mitogen-activated protein kinase(MAPK),which is responsible for the phosphorylation of NF-κB inhibitorα(IκBα).DBD glycoprotein increased the level of profilin-1(PFN1),α-actinin and F-actin expression via activation of transcription factor,nuclear factor-kappa B(NF-κB)during its promotion of cell *** mouse colitis was induced by adding dextran sulfate sodium(DSS)to the drinking water at a concentration of 4%(W/V)for 7 *** figured out that administration of DBD glycoprotein(10 and 20 mg·kg-1)lowers the levels of disease activity index and histological inflammation in DSS-treated ICR *** this regard,we suggest that DBD glycoprotein has ability to promote the F-actin-related migration signaling events via activation of PKC and NF-κB in intestinal epithelial cells and prevent inflammatory bowel disease.

关键词： Cell migration Dioscorea batatas Decne(DBD)glycoprotein Intestinal epithelial cells p38 MAPK F-actin Mouse colitis

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