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Preclinical Evaluation of the Antidiabetic Effect and Phytochemical HPLC-MS ESI-QTOF Analysis of Sclerocarya birrea (A. Rich) Hoscht Bark of Trunk Aqueous Extract in Alloxan-Induced Diabetic Wistar Rat

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Pharmacology & Pharmacy 2024年第11期15卷 364-387页

作者： Ida Valerie Yasmina Ga San Nintie Traoré Lazare Belemnaba Windingoudi Rimwagna Christian Ouedraogo Boukaré Kaboré Rémy Kindanloun Bationo Bonéwendé Mohamed Belemlilga Souleymane Compaoré Wendinmi Bertrand Florent Goumbri Salfo Ouedraogo Moumouni Koala mathieu nitiéma Unit de Formation et de Recherche en Sciences de la Sant (UFR-SDS) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Dpartement Mdecine et Pharmacope Traditionnelles - Pharmacie (MEPHATRA-PH) Institut de Recherche en Sciences de la Sant/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Dpartement Substances Naturelles Institut de Recherche en Sciences Appliques et Technologique/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso

Introduction: Diabetes is a serious public health problem requiring complex treatment. Numerous ethnopharmacological studies have reported the traditional use of Sclerocarya birrea in managing diabetic patients. This study aims to demonstrate, preclinically, the antidiabetic effects of the aqueous decoction of S. birrea trunk bark. Methods: Phytochemical analysis was performed by HPLC-MS. The effects of the extracts (Sb5 and Sb25) and 0.9% NaCl on the normal blood glucose levels of the animals were determined. Diabetes induction was performed intraperitoneally by administering a single dose of alloxan (150 mg/kg) in normoglycemic rats. The antidiabetic effects of the extracts (Allox + Sb5, Allox + Sb25) and glibenclamide (Allox + Glib5) were determined in Alloxan-induced diabetic animals for four weeks. Results: Interpretation of mass spectra obtained by HPLC-MS allowed the tentative identification of vanillic acid-4-sulfate and rhamnetin in Sb extract. Investigated doses of Sb extract showed an antidiabetic impact similar to the reference, glibenclamide, with a return to normal blood glucose in all treated rats only after 4 days of treatment. Furthermore, Sb extract treatments reduced weight loss in diabetic rats. Sb had no negative impact on the balance of total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Conclusion: The present study demonstrated the antidiabetic efficacy and, to some extent, the beneficial effects of Sb extract on Alloxan-induced diabetic rats’ health. Detection of antidiabetic phytochemicals such as vanillic acid-4-sulfate and rhamnetin would justify this pharmacological property of the aqueous decoction of S. birrea trunk bark.

关键词： Preclinical Study Sclerocarya birrea Antidiabetic Effect Alloxan HPLC-MS

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Anti-Inflammatory and Antioxidant Properties of the Aqueous Extracts of the Leaves of Opilia amentacea (Opiliaceae)

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Pharmacology & Pharmacy 2023年第9期14卷 329-347页

作者： Rainatou Boly Abdoul Gilchrist Laurent Boly Wendkouni Leila marie Esther Belem-Kabré Kadiatou Tata Traoré Boukaré Kaboré Ollo Youl Latifatou Sawadogo mathieu nitièma Moumouni Koala Noufou Ouédraogo Estella Noëla Hoho Youl maminata Traoré-Coulibaly Laboratoire de Recherche-Développement/Phytomédicaments et Médicaments (LR-D/PM) Institut de Recherche en Sciences de la Santé (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Ecole Doctorale Sciences et Technologie Laboratoire de Chimie Organique et Physique Appliquée (LCOPA) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Ecole Doctorale Sciences et Techniques Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Ecole Doctorale Sciences de la Santé Laboratoire de Développement du Médicament (LADME) Centre de Formation de Recherche et d’Expertises en Sciences du Médicament (CEA-CFOREM) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Opilia amentacea (Opiliaceae) is a woody plant with multiple medicinal claimed effects. The present study aimed to assess the anti-inflammatory and antioxidant activities of the decoction and macerate extracts from the leaves of Opilia amentacea. Moreover, acute toxicity and phytochemical analysis were performed. The acute toxicity was evaluated on NMRI mice at 2000 mg/kg bw. The anti-inflammatory activity was studied using the carrageenan-induced mouse paw edema and the lipoxygenase inhibition assay. The radical scavenging (DPPH and ABTS), ferric-reducing antioxidant power (FRAP), and lipid peroxidation (LPO) assays were used to measure the antioxidant capacity of the extracts. Qualitative and quantitative methods served for identifying and quantifying the extract’s phytoconstituents. The decoction demonstrated low acute toxicity;the lethal dose was therefore estimated to be superior to 2000 mg/kg bw. The extracts significantly reduced the mouse paw’s thickness at 600 mg/kg bw. The extracts developed weak radical scavenging and lipid peroxidation inhibitory effects. However, the macerate showed a high ability (664.90 ± 0.71 mol Ascorbic Acid Equivalent/g dry extract) to reduce the ferric ions. Saponins, sterols, triterpenes, and flavonoids were qualitatively detected in the two extracts. Total phenolics (TP) and total flavonoids (TF) were found abundant in the extracts, especially the decoction (TP content (TPC) = 94.03 ± 2.66 mg GAE/g;TF content (TFC) = 35.05 ± 0.32 mg QE/g). Strong positive correlations existed between ferric-reducing capacity and TPC (r = 0.959) for the macerate, while TFC was mainly involved in the DPPH radical scavenging of the two extracts. Instead, most correlations were negative between the polyphenol compounds and the anti-inflammatory assays. The results indicate potent in vivo anti-inflammatory and in vitro antioxidant effects of the aqueous extracts from the leaves of Opilia amentacea. Further studies are needed to find the anti-inflamm

关键词： Opilia amentacea Aqueous Extracts Acute Toxicity Anti-Inflammatory Antioxidant

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Phytochemical Profile, Antioxidant, and Anti-Inflammatory Activities, Safety of Use and Spasmolytic Effects of Aqueous Decoction Extract of Diospyros mespiliformis Leaves Hochst. ex A. DC. (Ebenaceae) on the Isolated Duodenum of Rat

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Pharmacology & Pharmacy 2023年第12期14卷 513-529页

作者： mathieu nitiéma Pegdwendé Esther Ouédraogo Tata Kadiatou Traoré Oumarou maman Noura Boukaré Kaboré Wendkouni Leila marie Esther Bélem-Kabré Windingoudi Rimwagna Christian Ouédraogo Moumouni Koala Bruno Nébié Abdel magid Arsène Ouoba makumbu Joseph makaya Sylvain Ilboudo Lazare Belemnaba Noufou Ouédraogo Sylvin Ouédraogo Laboratoire de Recherche-Développement des Phytomédicaments et Médicaments (LR-D/PM) Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Initiative Pour la Résilience et la Gouvernance (IRG) Ouagadougou Burkina Faso International Research Laboratory 3189 Environnement Santé Sociétés (IRL 3189 ESS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso UFR/Science et Technologie Université Aube Nouvelle Ouagadougou Burkina Faso Laboratoire du Développement du Médicament (LADME) école Doctorale Sciences et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Doctorale Sciences et Techniques Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Diospyros mespiliformis Hochst. ex A. DC. (Ebenaceae) is a multi-use plant, including for therapeutic purposes. It is used in alternative medicine in Burkina Faso to treat conjunctivitis, menorrhagia, dysentery, and diarrhea. The aim of our study was to evaluate the chemical profile, antioxidant and anti-inflammatory activities, safety of use and spasmolytic effects of the aqueous decoction of Diospyros mespiliformis leaves. Phytochemical screening by HPTLC and assay of compounds of interest were carried out. Four methods were used to assess antioxidant activity. Inhibitory activity against 15-lipoxygenase and phospholipase A2 was assessed. Acute oral toxicity of the extract was tested on female mice (NMRI). Following these tests, the extract contained bioactive compounds of interest such as flavonoids, tannins, sterols, triterpenes, and saponosides. The total phenolic and flavonoid contents of the aqueous decoctate were 70.59 ± 3.20 mg EAT/g and 31.57 ± 0.78 mg EQ/g respectively. The extract was less active than Trolox with inhibitory concentrations of 50% (IC50) for the ABTS, DPPH, FRAP, and LPO tests of 7.53 ± 0.08 μg/mL, 29.47 ± 0.06 μg/mL, 1128.83 ± 4.82 mol EAA/g, and 32.30 ± 1.60 μg/mL respectively. The extract has an anti-inflammatory effect with inhibition of phospholipase A2 compared to betamethasone. In addition, the aqueous extract produced an antispasmodic effect with Emax of 70% and 80% respectively during contractions induced by BaCl2 and ACh. Finally, this study provided basic scientific data and could justify the use of D. mespiliformis leaves in the treatment of diarrhea.

关键词： Diospyros mespiliformis Phytoconstituents Antioxidants Acute Oral Toxicity Spasmolytic Leaves

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Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from Lannea microcarpa Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca²⁺ Mobilization

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Pharmacology & Pharmacy 2023年第12期14卷 530-549页

作者： mathieu nitiéma Bertrand Kafando Windingoudi Rimwagna Christian Ouédraogo Bibata Sawadogo Boukaré Kaboré Wendkouni Leila marie Esther Bélem-Kabré Tata Kadiatou Traoré Jean Claude Romaric Pingdwindé Ouédraogo Salfo Ouédraogo Lazare Belemnaba Aristide Traoré Moussa Ouédraogo Noufou Ouédraogo Bondo Félix Kini Sylvin Ouédraogo Laboratoirede Recherche-Développement de Phytomédicaments et Médicaments Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique Ouagadougou Burkina Faso Laboratoirede Développement du Médicament (LADME)/CEA-CFOREM Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Lannea microcrapa Engl. & K. Krause (Anacardiaceae) is a fruit and medicinal plant widely used in Burkina Faso. This plant is traditionally used in the treatment of hypertension. The aim of the present study was to evaluate the vasorelaxant effects of the hydroethanolic extract from Lannea microcarpa trunk barks (HE_ELM) on the aorta isolated from NMRI mice. Phytochemical screening by HPTLC, assay of phenolic and flavonoid compounds, assessment of antioxidant activity (DPPH, ABTS, FRAP, and LPO), and myography of HE_ELM (1 - 2000 μg/mL) on mice thoracic aortas in the presence and absence of endothelium were carried out. Endothelium-dependent and endothelium-independant vasodilation were assessed by cumulative addition of Ach (1 nM - 10 μM) on aortic rings precontracted with the thromboxane analogue A2 agonist, 9,11-dideoxy9α,11α-methanoepoxy PGF2α (U46619). L-NAME was used to verify the involvement of NO production in the relaxation mechanism of the extract. Acute oral toxicity of HE_ELM was also evaluated. A phytochemical study revealed the presence of tannins, flavonoids, sterols and triterpenes, saponosides, and high levels of total phenolics and flavonoids. These compounds are thought to be responsible for the extract’s antioxidant and vasorelaxant properties. HE_ELM demonstrated significant antioxidant potential and induced aortic relaxation. Indeed, pharmacological parameters gave EC50 values ranging from 596.45 ± 95.82 μg/mL to 749.48 ± 133.40 μg/mL and Emax values from 85.51% ± 9.59% to 96.81% ± 8.60% for the three conditions of vasodilation of the extract (p > 0.05). A complete antagonism of the contractile effect of U46619 was noted with 1 mg/mL HE_ELM. These results suggest that HE_ELM induces aortic relaxation through a concentration-dependent, endothelium-independent mechanism, possibly involving intracellular calcium mobilization of vascular cells. Acute oral toxicity tests of HE_ELM (2000 mg/kg) showed no mortality or adverse effects, sugge

关键词： Lannea macrocarpa Hydroethanolic Extract Phytoconstituents Antioxidant Vasorelaxant Effects Safety

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Anti-Inflammatory and Antioxidant Properties of the Aqueous Extracts of the Leaves of Opilia amentacea (Opiliaceae)

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Pharmacology & Pharmacy（药理与制药） 2023年第9期

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Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from Lannea microcarpa Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas:Possible Involvement of Intracellular Ca2+ Mobilization

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Pharmacology & Pharmacy（药理与制药） 2023年第12期

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Pharmacology & Pharmacy（药理与制药） 2023年第12期

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Biphasic (Lu,Gd)_(3)Al_(5)O_(12)-based transparent nanoceramic color converters for high-power white LED/LD lighting

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Journal of Advanced Ceramics 2023年第12期12卷 2331-2344页

作者： Jie Fu Ying Zhang Shaowei Feng mathieu Allix Cécile Genevois Emmanuel Veron Zhibiao ma Wenlong Xu Linghan Bai Ruyu Fan Yafeng Yang Hui Wang Jianqiang Li School of materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China CNRS CEMHTI UPR 3079Univ.OrléansOrléans 45071France University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory for Advanced Powder Metallurgy and Particulate materials University of Science and Technology BeijingBeijing 100083China

Ce doped Lu_(3)Al_(5)O_(12)(Ce:LuAG)transparent ceramics are considered as promising color converters for solid-state lighting because of their excellent luminous efficiency,high thermal quenching temperature,and good thermal ***,Ce:LuAG ceramics mainly emit green *** shortage of red light as well as the expensive price of Lu compounds are hindering their application for white *** this work,transparent(Lu,Gd)_(3)Al_(5)O_(12)–Al_(2)O_(3)(LuGAG–Al_(2)O_(3))nanoceramics with different replacing contents of Gd^(3+)(10%–50%)were successfully elaborated via a glass-crystallization *** obtained ceramics with full nanoscale grains are composed of the main LuGAG crystalline phase and secondary Al_(2)O_(3) phase,exhibiting eminent transparency of 81.0%@780 *** doping by Ce^(3+),the Ce:LuGAG–Al_(2)O_(3) nanoceramics show a significant red shift(510 nm→550 nm)and make up for the deficiency of red light component in the emission *** Ce:LuAG–Al_(2)O_(3) nanoceramics with 20%Gd^(3+)show high internal quantum efficiency(81.5%in internal quantum efficiency(IQE),96.7%of Ce:LuAG–Al_(2)O_(3) nanoceramics)and good thermal stability(only 9%loss in IQE at 150℃).When combined with blue LED chips(10 W),0.3%Ce:LuGAG–Al_(2)O_(3) nanoceramics with 20%Gd^(3+)successfully realize the high-quality warm white LED lighting with a color coordinate of(0.3566,0.435),a color temperature of 4347 K,CRI of 67.7,and a luminous efficiency of 175.8 lm·W^(−1).When the transparent 0.3%Ce:LuGAG–Al_(2)O_(3) nanoceramics are excited by blue laser(5 W·mm^(−2)),the emission peak position redshifts from 517 to 570 nm,the emitted light exhibits a continuous change from green light to yellow light,and then to orange-yellow light,and the maximum luminous efficiency is up to 234.49 lm·W^(−1)(20%Gd^(3+)).Taking into account the high quantum efficiency,good thermal stability,and excellent and adjustable luminous properties,the transparent Ce:LuGAG–Al_(2)O_(3) nanoceramics w

关键词： glass crystallization (Lu,Gd)_(3)Al_(5)O_(12)(LuGAG)-Al_(2)O_(3)nanoceramics high-power WLEDs/LDs white lighting

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The P-T-t-D evolution of the mahabharat,east-central Nepal:The out-of-sequence development of the Himalaya

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Geoscience Frontiers 2022年第2期13卷 372-382页

作者： Kyle P.Larson Sudip Shrestha mathieu Soret matthijs Smit Department of Earth Environmental and Geographic SciencesUniversity of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada Department of Earth Ocean and Atmospheric SciencesUniversity of British Columbia Vancouver2020-2207 Main MallVancouverBC V6T 1Z4Canada

A garnet-bearing schist from the southernmost such exposure along the Himalaya in east central Nepal records prograde metamorphism at 32.4±0.3 *** equilibria modelling,combined with Ti-in-biotite and quartz caxis thermometry,outline a tight-to-hairpin pressure-temperature(P-T)path extending from~515℃ and 5.5 kbar to peak conditions at~575℃ and 7 kbar followed by deformation during the retrograde phase at 480-515℃ and 6-7 *** new geochronology data place an upper bound on the evolution of metamorphism and deformation in the frontal-most part of the Himalaya,which lasted until 17.5 ma,as indicated by previously published ^(40)Ar/^(39)Ar *** P-T-time data from this part of the Himalaya,as well as that from more hinterlandward portions of the orogen,outline a progressive,stepwise,commonly out-of-sequence *** data from along the orogen indicates that this evolution is not a local phenomenon,but instead characterizes the tectonics of this system as a whole.

关键词： Himalaya Metamorphism Kinematics Lu-Hf Geochronology Nepal

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Pioneer of prostate cancer: past, present and the future of FOXA1

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Protein & Cell 2021年第1期12卷 29-38页

作者： Mona Teng Stanley Zhou Changmeng Cai mathieu Lupien Housheng Hansen He Princess margaret Cancer Centre University Health NetworkTorontoCanada Department of Medical Biophysics University of TorontoTorontoCanada Center for Personalized Cancer Therapy University of Massachusetts BostonBostonMA 02125USA Ontario Institute for Cancer Research TorontoONCanada

Prostate cancer is the most commonly diagnosed noncutaneous cancers in North American *** androgen deprivation has remained as the cornerstone of prostate cancer treatment,resistance ensues leading to lethal *** box A1(FOXA1)encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription *** direct interactions with the Androgen Receptor(AR),FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer ***1 also possesses an AR-independent role of regulating epithelial-to-mesenchymal transition(EMT).In prostate cancer,mutations converge onto the coding sequence and c/s-regulatory elements(CREs)of FOXA1,leading to functional *** addition,FOXA1 activity in prostate cancer can be modulated post-translationally through various mechanisms such as LSD1-mediated protein *** this review,we describe the latest discoveries related to the function and regulation of FOXA1 in prostate cancer,pointing to their relevance to guide future clinical interventions.

关键词： FOXA1 cancer alterations

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