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Timing of metamorphism and deformation in the Swat valley, northern Pakistan:Insight into garnet-monazite HREE partitioning

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Geoscience Frontiers 2019年第3期10卷 849-861页

作者： Kyle P.Larson Asghar Ali Sudip Shrestha mathieu Soret John M.Cottle Rafique Ahmad University of British Columbia Okanagan Earth Environmental and Geographic Sciences University of Peshawar Department of Geology University of Califomia Santa Barbara Department of Earth Sciences The Bacha Khan University Department of Geology

New metamorphic petrology and geochronology from the Loe Sar dome in the Swat region of northern Pakistan place refined constraints on the pressure, temperature and timing of metamorphism and deformation in that part of the Himalayan orogen. Thermodynamic modelling and monazite petrochronology indicate that metamorphism in the area followed a prograde evolution from ～525 ± 25 ℃and 6 士 0.5 kbar to ～610 ± 25 ℃ and 9 士 0.5 kbar, between ca. 39 Ma and 28 Ma. Partitioning of heavy rare earth elements between garnet rims and 30-28 Ma monazite are interpreted to indicate coeval crystallization at peak conditions. Microtextural relationships indicate that garnet rim growth post-dated the development of the main foliation in the area. The regional foliation is folded about large-scale N-S trending fold axes and overprinting E-W trending folds to form km-scale domal culminations. The textural relationships observed indicate that final dome development must be younger than the 30-28 Ma monazite that grew with garnet rims post-regional foliation development, but pre-doming-related deformation. This new timing constraint helps resolve discrepancy between previous interpretations,which have alternately suggested that N-S trending regional folds must be either pre-or post-early Oligocene. Finally, when combined with existing hornblende and white mica cooling ages, these new data indicate that the study area was exhumed rapidly following peak metamorphism.

关键词： Pakistan Himalaya Monazite petrochronology Metamorphism Phase equilibria modelling Deformation

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Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

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Cancer Drug Resistance 2019年第3期2卷 381-398页

作者： Clélia mathieu Samir Messaoudi Elias Fattal Juliette Vergnaud-Gauduchon Institut Galien Paris-Sud CNRSUMR 8612UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France BioCIS CNRSUMR 8076UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France.

Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local *** using HSP90 inhibitors,some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their *** review will present some advantages of HSP90 inhibitors to treat resistant tumors;especially those targeting the mitochondrial protein *** will also focus on the targeting of the primary tumors,cancer stem cells and metastatic cells.

关键词： Heat-shock proteins cancer resistance nanoparticles

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Influence of Electromagnetic Stirring on the Macrosegregation in Arc Remelted Ti and Zr Alloy Ingots

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Journal of Iron and Steel Research International 2012年第S1期19卷 199-202页

作者： Alain Jardy mathieu Revil-Baudard Hervé Combeau Universite de Lorraine Institut Jean Lamour-Dépt.SI2MUMR CNRS 7198Ecole des MinesParc de SauruptNancy F-54042France

A numerical model of the VAR process has been developed in close collaboration with titanium and zirconium *** model is based on the solution of the coupled heat,mass and momentum transport equations in the whole ingot(liquid pool,mushy zone and solidified part)using a finite volume *** accounts for electromagnetic stirring, buoyancy flows and turbulence *** mechanisms implemented in the model include a full coupling between energy and solute transport in the mushy *** numerical model has been applied to simulate the remelting of *** influence of the applied magnetic field on the fluid flow and segregation behaviour,for a number of different stirring practices,is presented and ***,the macrosegregation in Zy4 ingots is *** comparison between the predicted segregation and the experimental results shows the importance of accounting for both the stirring and thermosolutal convection to forecast properly the segregation in remelted ingots.

关键词： Vacuum Arc Remelting simulation zirconium titanium macrosegregation stirring

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Preemptive targeted muscle reinnervation:the single incision approach should be avoided in trans‑tibial traumatic amputation

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军事医学研究:英文版 2023年第4期10卷 569-571页

作者： Laurent mathieu Constance Diner Philippe Aries Marie Thomas Stéphanie Truffaut Nicolas de L’escalopier Department of Orthopedic Trauma and Reconstructive SurgeryPercy Military Hospital101 avenue Henri Barbusse92140 ClamartFrance French Military Hand Surgery Center Percy Military Hospital92140 ClamartFrance Department of Surgery Ecole du Val‑de‑GrâceFrench Military Health Service Academy75005 ParisFrance Department of Anesthesia and Intensive Care Clermont-Tonnerre Military Hospital29240 BrestFrance Department of Rehabilitation Medicine Percy Military Hospital92140 ClamartFrance Department of Rehabilitation Medicine National Institution of Invalids75007 ParisFrance.

Dear Editor,Chronic pain is a significant concern after major lower limb amputations that often preclude prosthetic fitting,decrease ambulation,and impact the quality of life[1,2].In the last decade,targeted muscle reinnervation(TMR)has been proposed as a surgical strategy for treating or preventing symptomatic neuromas and phantomlimb phenomena in major amputees[1].This technique involves the transfer of an amputated mixed-motor and sensory nerve to a nearby recipient motor nerve[1,2].Unlike most surgical strategies that aim to hide or protect the neuroma,TMR gives the amputated nerves“somewhere to go and something to do”[2].In a randomized clinical trial on neuroma and phantom pain,Dumanian et al.[1]demonstrated that TMR reduces amputationrelated chronic pain at 1-year post-intervention when compared with the excision and muscle-burying technique,which remains the current gold *** et al.[2]also proposed applying TMR at the time of major limb amputation for preventing chronic pain and found that TMR patients experienced less residual limb pain(RLP)and phantom limb pain(PLP)when compared with untreated amputee controls.

关键词： Heterotopic ossification Nerve transfer Targeted muscle reinnervation Trans-tibial amputation Trauma

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The ACE trial： a new perspective on the effect of acarbose on cardiovascular outcomes

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中华内分泌代谢杂志 2017年第12期33卷 1012-1014页

作者： Chantal mathieu 比利时鲁汶市鲁汶大学盖斯堡医学院临床与实验内分泌科

阿卡波糖心血管评估(ACE)研究旨在评价阿卡波糖能否降低中国冠心病合并糖耐量受损(IGT)患者的心血管事件。ACE研究在诸多方面与既往另一项阿卡波糖基于IGT人群的研究，STOP-NIDDM (Study to Prevent Non-Insulin-Dependent Diabetes Mel... 详细信息

阿卡波糖心血管评估(ACE)研究旨在评价阿卡波糖能否降低中国冠心病合并糖耐量受损(IGT)患者的心血管事件。ACE研究在诸多方面与既往另一项阿卡波糖基于IGT人群的研究，STOP-NIDDM (Study to Prevent Non-Insulin-Dependent Diabetes Mellitus)研究不同，如样本量、心血管事件数、平均年龄、阿卡波糖的剂量以及人群。ACE研究支持了STOP-NIDDM研究中阿卡波糖可以预防IGT人群进展为糖尿病这一结果，并把这一结果扩展至冠心病人群。但是未看到心血管事件的减少，其原因可能是阿卡波糖剂量过低(50 mg tid)。总之，ACE研究是一个可靠的、设计良好和有效力的研究，证实了阿卡波糖可以预防糖尿病前期进展为糖尿病，但未能减少心血管事件。鉴于中国目前迅速增长的糖尿病前期人群，阿卡波糖的使用有助于遏制糖尿病的爆发性增长。

关键词：《中华内分泌代谢杂志》期刊编辑工作发行工作

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Alternatives to norepinephrine in septic shock:Which agents and when?

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Journal of Intensive Medicine 2022年第4期2卷 223-232页

作者： mathieu Jozwiak Service de Médecine Intensive Réanimation Centre Hospitalier Universitaire l’Archet 1151 route Saint Antoine de Ginestière06200 NiceFrance Equipe 2 CARRES UR2CA–Unitéde Recherche Clinique Côte d’Azur UniversitéCôte d’Azur UCA06103 NiceFrance

Vasopressors are the cornerstone of hemodynamic management in patients with septic *** is currently recommended as the first-line vasopressor in these *** addition to norepinephrine,there are many other potent vasopressors with specific properties and/or advantages that act on vessels through different pathways after activation of specific receptors;these could be of interest in patients with septic *** is no longer recommended in patients with septic shock because its use is associated with a higher rate of cardiac arrhythmias without any benefit in terms of mortality or organ *** is currently considered as a second-line vasopressor therapy,because of the higher rate of associated metabolic and cardiac adverse effects compared with norepinephrine;however,it may be considered in settings where norepinephrine is un-available or in patients with refractory septic shock and myocardial *** to its potential effects on mortality and renal function and its norepinephrine-sparing effect,vasopressin is recommended as second-line vasopressor therapy instead of norepinephrine dose escalation in patients with septic shock and persistent arterial ***,two synthetic analogs of vasopressin,namely,terlipressin and selepressin,have not yet been employed in the management of patients with septic shock,as their use is associated with a higher rate of digital ***,angiotensin II also appears to be a promising vasopressor in patients with septic shock,especially in the most severe cases and/or in patients with acute kidney injury requiring renal replacement ***,due to limited evidence and concerns regarding safety(which remains unclear because of potential adverse effects related to its marked vasopressor activity),angiotensin II is currently not recommended in patients with septic *** studies are needed to better define the role of these vasopressors in the manage

关键词： Adverse effects Mortality Sepsis Vasopressors

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Malleostapedotomy for otosclerosis,our experience of nitinol piston on twelve patients

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Journal of Otology 2020年第4期15卷 129-132页

作者： Stephane Gargula Mary Daval Nicolas Arej mathieu Veyrat Alain Corre Denis Ayache Department of Otorhinolaryngology Rothschild Foundation HospitalParisFrance Clinical Research Department Rothschild Foundation HospitalParisFrance

Objective:Malleostapedotomy allows to completely by-pass the incus in otosclerosis *** its use has been rivaled by hydroxyapatite cement for cases of mild and moderate necrosis of the ***,it remains gold standard for cases of extensive necrosis,incus dislocation,or epitympanic *** heat-crimping pistons make surgery easier and *** study focuses on our experience with this ***:Retrospective analysis of patient’s files and pre-and post-operative audiograms,for cases of surgically treated otosclerosis with ***:Twelve patients underwent malleostapedotomy for otosclerosis between 2011 and *** them there were 10 revision surgeries and 2 primary cases.75%had incus long-process necrosis,17%had epitympanic fixation and one had a history of incus *** patients(75%)had closure of air-bone gap(ABG)of<10 dB(p<0.001)and 11(92%)had a threshold of 20 dB(p<0.001).Mean pre-operative ABG was 31 dB(15 dBe55 dB),and mean post-operative ABG was 7 dB(0 dBe21 dB;p<0.001).There was no sensorineural hearing loss nor any other post-operative ***:Malleostapedotomy is a safe and reliable technique,allowing an ABG closure comparable to conventional incus to vestibule *** remains the preferred technique whenever the incus cannot be used.

关键词： Malleus Stapes Otosclerosis Conductive hearing loss Chronic otitis media Hydroxyapatite

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End-to-end differentiability and tensor processing unit computing to accelerate materials’ inverse design

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npj Computational Materials 2023年第1期9卷 1072-1083页

作者： Han Liu Yuhan Liu Kevin Li Zhangji Zhao Samuel S.Schoenholz Ekin D.Cubuk Puneet Gupta mathieu Bauchy SOlids informaTics AI-Laboratory(SOFT-AI-Lab) College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China AIMSOLID Research Wuhan 430223China Physics of AmoRphous and Inorganic Solids Laboratory(PARISlab) Department of Civil and Environmental EngineeringUniversity of CaliforniaLos AngelesCA 90095USA Department of Computer Science University of CaliforniaLos AngelesCA 90095USA Google Research Brain TeamMountain ViewCAUSA Department of Electrical and Computer Engineering University of CaliforniaLos AngelesCA 90095USA

Numerical simulations have revolutionized material ***,although simulations excel at mapping an input material to its output property,their direct application to inverse design has traditionally been limited by their high computing cost and lack of ***,taking the example of the inverse design of a porous matrix featuring targeted sorption isotherm,we introduce a computational inverse design framework that addresses these challenges,by programming differentiable simulation on TensorFlow platform that leverages automated end-to-end *** to its differentiability,the simulation is used to directly train a deep generative model,which outputs an optimal porous matrix based on an arbitrary input sorption isotherm ***,this inverse design pipeline leverages the power of tensor processing units(TPU)—an emerging family of dedicated chips,which,although they are specialized in deep learning,are flexible enough for intensive scientific *** approach holds promise to accelerate inverse materials design.

关键词： enough inverse isotherm

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Efficient visual learning by bumble bees in virtual-reality conditions:Size does not matter

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Insect Science 2023年第6期30卷 1734-1748页

作者： Gregory Lafon Marco Paoli Benjamin HPaffhausen Gabriela de Brito Sanchez mathieu Lihoreau Aurore Avarguès-Weber Martin Giurfa Centre de Recherches sur la Cognition Animale Centre de Biologie Intégrative(CBI)University of ToulouseCNRSUPSToulouseFrance French Academy of Sciences for University Professors Institut Universitaire de France(IUF)ParisFrance

Recent developments allowed establishing virtual-reality (VR) setups to study multiple aspects of visual learning in honey bees under controlled experimental conditions. Here, we adopted a VR environment to investigate the visual learning in the buff-tailed bumble bee Bombus terrestris. Based on responses to appetitive and aversive reinforcements used for conditioning, we show that bumble bees had the proper appetitive motivation to engage in the VR experiments and that they learned efficiently elemental color discriminations. In doing so, they reduced the latency to make a choice, increased the proportion of direct paths toward the virtual stimuli and walked faster toward them. Performance in a short-term retention test showed that bumble bees chose and fixated longer on the correct stimulus in the absence of reinforcement. Body size and weight, although variable across individuals, did not affect cognitive performances and had a mild impact on motor performances. Overall, we show that bumble bees are suitable experimental subjects for experiments on visual learning under VR conditions, which opens important perspectives for invasive studies on the neural and molecular bases of such learning given the robustness of these insects and the accessibility of their brain.

关键词： Bombus terrestris bumble bees interindividual size/weight differences reinforcement responses visual learning virtual reality

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LES METAPHORES DU CORPS DANS LE DISCOURS POLITIQUE DE MONTAIGNE

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法国研究 1992年第1期 59-75页

作者： Gisele mathieu-CASTELLANI

此文论述蒙泰涅的《随笔集》(发表于1580—1592)如何开启了现代主义文学的先河。蒙泰涅在观察、描绘自己时也观察、描绘了社会,在自己的身体和他那个时代的社会机制之间建立起了类似网络,从中得出怀疑主义的结论,认为社会机体同人的身... 详细信息

此文论述蒙泰涅的《随笔集》(发表于1580—1592)如何开启了现代主义文学的先河。蒙泰涅在观察、描绘自己时也观察、描绘了社会,在自己的身体和他那个时代的社会机制之间建立起了类似网络,从中得出怀疑主义的结论,认为社会机体同人的身体一样也要经历生、老、病、死的阶段。此文作者运用精神分析学的概念和方法,探讨了这些有关身体的隐喻,指出蒙泰涅的哲学基础是一种自恋式的恐惧,他害怕在“公共事务”构成的陌生而危险的氛围中失去自我,因此宁愿进行自我分析,以“自知之明”阅读、书写社会。

关键词：现代主义文学精神分析学身体社会机制社会机体哲学基础怀疑主义公共事务自我分析观察

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