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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

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Emerging properties of non-crystalline phases of graphene and boron nitride based materials

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Nano Materials Science 2022年第1期4卷 10-17页

作者： Aleandro Antidormi Luigi Colombo Stephan roche Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and BISTCampus UABBellaterra08193BarcelonaSpain Department of Materials Science and Engineering The University of Texas at DallasRichardsonTX75080United States ICREA-InstitucióCatalana de Recerca i Estudis Avancats 08010BarcelonaSpain

We review recent developments on the synthesis and properties of two-dimensional materials which, although being mainly of an sp^(2) bonding character, exhibit highly disordered, non-uniform and structurally random morphologies. The emergence of such class of amorphous materials, including amorphous graphene and boron nitride, have shown superior properties compared to their crystalline counterparts when used as interfacial films. In this paper we discuss their structural,vibrational and electronic properties and present a perspective of their use for electronic applications.

关键词： boron amorphous properties

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Fusion of spatiotemporal and thematic features of textual data for animal disease surveillance

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Information Processing in Agriculture 2023年第3期10卷 347-360页

作者： Sarah Valentin Renaud Lancelot mathie. roche CIRAD F-34398 MontpellierFrance ASTRE Univ MontpellierCIRADINRAEMontpellierFrance TETIS Univ MontpellierAgroParisTechCIRADCNRSINRAEMontpellierFrance Departement de Biologie Universite de SherbrookeSherbrookeQuebecCanada

Several internet-based surveillance systems have been created to monitor the web for animal health *** systems collect a large amount of news dealing with outbreaks related to animal *** identifying news articles that describe the same outbreak event is a key step to quickly detect relevant epidemiological information while alleviating manual curation of news *** paper addresses the task of retrieving news articles that are related in epidemiological *** tackle this issue using text mining and feature fusion *** main objective of this paper is to identify a textual representation in which two articles that share the same epidemiological content are *** compared two types of representations(i.e.,features)to represent the documents:(i)morphosyntactic features(i.e.,selection and transformation of all terms from the news,based on classical textual processing steps)and(ii)lexicosemantic features(i.e.,selection,transformation and fusion of epidemiological terms including diseases,hosts,locations and dates).We compared two types of term weighing(i.e.,Boolean and TF-IDF)for both *** combine and transform lexicosemantic features,we compared two data fusion techniques(i.e.,early fusion and late fusion)and the effect of features generalisation,while evaluating the relative importance of each type of *** conducted our analysis using a corpus composed of a subset of news articles in English related to animal disease *** results showed that the combination of relevant lexicosemantic(epidemiological)features using fusion methods improves classical morphosyntactic representation in the context of disease-related news *** lexicosemantic representation based on TF-IDF and feature generalisation(F-measure=0.92,r-precision=0.58)outperformed the morphosyntactic representation(F-measure=0.89,r-precision=0.45),while reducing the features *** the features into lower granular

关键词： Animal disease surveillance Text mining Ranking Fusion

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Solitary Bodies and Emotions:Contemporary Plastic Art in the Context of Individualization Society

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Fudan Journal of the Humanities and Social Sciences 2022年第3期15卷 367-388页

作者： Juan Antonio roche Cárcel Department of Sociology I University of AlicanteAlicanteSpain

This article follows the trail of Weber’s comprehensive sociology and uses the hermeneutical method as well as the iconological applied to 11 contemporary works of plastic art which can be described as significant and representative of contemporary *** pursues two specific objectives:(a)analyzing the construction of loneliness both in contemporary plastic art and within the society of individuality and separateness,through human bodies and emotions;and(b)attesting how this theme has evolved in artistic practices from simple to reflexive *** have indeed placed solitary men and women in the geographical and symbolic center of their compositions,additionally providing a contrast with a spatial and temporal environment which marginalizes *** conclude that,for contemporary art,subjects are neither fully fledged individuals nor citizens in their own right and that they do not voluntarily live in an individualized society,but rather in one defined by separateness.

关键词： Sociology of art Sociology of bodies and emotions Individualization society Liquid society Separateness society Loneliness

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Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [Med Nov Technol Dev, 13, 2022, 100112]

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Medicine in Novel Technology and Devices 2024年第1期21卷 120-120页

作者： Michael A.Kokko Ryan M.Chapman Martin W.roche Douglas W.Van Citters Thayer School of Engineering at Dartmouth College 14 Engineering DriveHanoverNH03755USA Department of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and informed consent statement for this *** study did not involve human subjects or animal research,and was therefore not subject to institutional ethics approval and did not require informed *** single cadaveric specimen used in ex vivo evaluation was obtained from Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statement alignment

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‘All Solid Things Vanish Into Thin Air.’The Space in Modern andLate Modern Plastic Art

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Fudan Journal of the Humanities and Social Sciences 2022年第1期15卷 117-142页

作者： Juan Antonio.roche Carcel Angel Enrique Carretero Pasin Departamento de Sociologia I Universidad deAlicanteCarreterade San Vicentes/n03690 San Vicente del Raspeig-AlicanteSpain Departamento de Sociologia University of Santiago de Compostela(Spain) Santiago de CompostelaSpain

The article follows Max Weber's Comprehensive Sociology and uses the hermeneutic and iconological analysis sociological methods applied to plastic works(painting and sculpture),significant and representative of modern and late modern *** from these theoretical and methodological bases,it pursues three specific objectives:to analyze the construction of space in plastic art,to verify how this theme has evolved in artistic practices from the first modernity to the second and to verify the way in which the complementary visual language the conceptual of contemporary sociological *** this regard,the analysis and interpretation of the eleven selected works reveals three important consequences of the modern influence on space,gradually emptied of meaning and replaced by non-places:its conversion into merchandise,its loss of solidity and stability and the confusion that occurs in it between reality and its ***,the implicit content converges with the essential postulates of the sociologists who have approached the subject of space,although it goes further because the foray into the iconographic hermeneutics of these works puts an image to the conceptual theoretical discourses of the sociologists,inaway that visual language complements and enriches,with more emotional and sensitive nuances Therefore our discipline begins to overcome a traditional deficit,in that it moves from the essential rationality that structures its origin and turns towards a greater coupling of the emotional and sensitive social plane.

关键词： Sociology of culture Evanescent space Plastic art Iconological analysis Social hermeneutic

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Quantum Transport Properties of Chemically Functionalized Long Semiconducting Carbon Nanotubes

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Nano Research 2010年第4期3卷 288-295页

作者： Alejandro Lopez-Bezanilla Xavier Blase Stephan roche Commissariat a l’Energie Atomique 38054 Grenoble CedexFrance Institut Néel CNRS and UniversitéJoseph FourierB.P.16638042 Grenoble Cedex 09France CIN2(CSIC-ICN)Barcelona Campus UABE-08193 BellaterraSpain

We present a first-principles study of the electronic transport properties of micrometer long semiconducting carbon nanotubes randomly covered with carbene functional groups. Whereas prior studies suggested that metallic tubes are hardly affected by such addends, we show here that the conductance of semiconducting tubes with standard diameter is, on the contrary, severely damaged. The configurational-averaged conductance as a function of tube diameter, with a coverage of up to one hundred molecules, is extracted. Our results indicate that the search for a conductance-preserving covalent functionalization route remains a challenging issue.

关键词： Nanotubes functionalization carbene electronic transport

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Hot corrosion mechanism of yttria-stabilized zirconia powder in the presence of molten Na_(2)SO_(4)+V_(2)O_(5) salts

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Rare Metals 2021年第5期40卷 1307-1316页

作者： Jhonattan De la roche Juan Manuel Alvarado-Orozco Alejandro Toro Tribology and Surfaces Group Universidad Nacional de ColombiaMedellin 050041Colombia Centro de Ingeniena y Desarrollo Industrial-CIDESI Queretaro 76125Mexico Consorcio de Manufactura Aditiva-CONMAD Queretaro 76125Mexico

The hot corrosion behavior of yttria-stabilized zirconia(YSZ)powder specimens exposed to Na_(2)SO_(4)/V_(2)O_(5) salts mixtures at high temperature was *** tests were carried out at 1000℃ for 10 h,the salt concentrations varied from 0.1 wt%to 1.00 wt%,and the Na_(2)SO_(4)/V_(2)O_(5) mass ratios were between 0.20 and 0.44 following a factorial design 22.X-ray diffraction(XRD)analyses of the tested samples showed with a confidence of95%that the mixture composed of 32 wt%Na_(2)SO_(4)+68 wt%V_(2)O_(5),and 1.00 wt% salt concentration led to high destabilization of the t’-YSZ phase and formation of YVO_(4) products.A second set of experiments were conducted to assess the influence of temperature on the hot corrosion response of the YSZ in the range between 490 and 1100℃.Thermogravimetric analysis(TGA)experiments and Rietveld adjustments of XRD patterns showed that the mass loss of the samples varied with testing temperature and also that the major destabilization of tetragonal phase occurred at 900℃.

关键词： Hot corrosion Molten salts Yttria-stabilized zirconia Thermal barrier coatings

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Identifying associations between epidemiological entities in news data for animal disease surveillance

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Artificial Intelligence in Agriculture 2021年第1期5卷 163-174页

作者： Sarah Valentin Renaud Lancelot mathie. roche CIRAD UMR ASTREUMR TETISF-34398 MontpellierFrance ASTRE Univ MontpellierCIRADINRAEMontpellierFrance TETIS Univ MontpellierAgroParisTechCIRADCNRSINRAEMontpellierFrance

Event-based surveillance systems are at the crossroads of human and animal(and plant and ecosystem)health,epidemiology,statistics,and ***,their deployment faces many challenges specific to each domain and their intersections,such as relations among automation,artificial intelligence,and *** this context,ourwork pertins to the extraction of epidemiological events in textual data(***)by unsupervised *** define the event extraction task as detecting pairs of epidemiological entities(e.g.a disease name and location).The quality of the ranked lists of pairs was evaluated using specific ranking evaluation *** used a publicly available annotated corpus of 438 documents(*** articles)related to animal disease *** statistical approach was able to detect event-related pairs of epidemiological features with a good trade-off between precision and *** results showed that using a window of words outperformed document-based and sentence-based approaches,while reducing the probability of detecting false *** results indicated that Mutual Information was less adapted than the Dice coefficient for ranking pairs of features in the event extraction *** believe that Mutual Information would be more relevant for rare pair detection(*** signals),but requires higher manual curation to avoid false positive extraction ***,generalising the country-level spatial features enabled better discrimination(***)of relevant disease-location pairs for event extraction.

关键词： Animal disease surveillance Text mining Event extraction

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Contributors’enrollment in collaborative online communities:the case of OpenStreetMap

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Geo-Spatial Information Science 2017年第3期20卷 282-295页

作者： Daniel Bégin Rodolphe Devillers Stéphane roche Department of Geography Memorial University of NewfoundlandSt.John’sCanada Centre de Recherche en Géomatique UniversitéLavalQuébecCanada

The number of people registering in an online community depends on two main factors:interest in,and awareness of,the *** to a project does not,however,imply contributing to it,as lacking the knowledge and skills can be a barrier to *** order to identify the nature of events that might have facilitated or hindered enrollments in the OpenStreetMap(OSM)project over time,we analyzed the correlations between the number of new participants and the events that dotted its *** different metrics were defined to characterize participants’behaviors:the daily number of registrations,the daily number of participants that made a first contribution,the delays between contributors’registration and their first edits,and a daily contribution ratio built from the number of new contributors and the number of new registered *** series analyses were used to identify trends,and outstanding variations of the number of *** inventory of events that took place along the OSM project’s history was created and appreciable variations of the metrics have been linked to events that seemed to be *** a correlation does not imply causality,many of the explanations these correlations suggest are supported by the results of other studies,either directly or *** instance,when considering the time participants spend as“lurker”,as well as on the nature of the contribution of early *** other cases,they suggest new explanations for the origin of the spam accounts that affect registration statistics,or the decline in the proportion of registered members who actually become contributors.

关键词： OpenStreetMap(OSM) contributors lurkers participation knowledge motivation

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