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Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

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journal of Molecular Cell Biology 2015年第4期7卷 351-365页

作者： Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.j.Quesniaux Bernhard Ryffel Dieudonnee Togbe Laboratory of Experimental and Molecular Immunology and Neurogenetics(INEM) UMR 7355 CNRS-University of OrleansF-45071 Orleans-Cedex2France Artimmune SAS 45100 Orle´ansFrance Faculte´de Me´decine University of BourgogneDijonFrance INSERM U866DijonFrance Centre Georges Franc¸ois Leclerc DijonFrance CIIL–Center for Infection and Immunity of Lille INSERM U1019Institut PasteurLilleFrance Division of Rheumatology Penn State Milton S.Hershey Medical CenterHersheyPA 17033USA Clinical Immunology Section Third Affiliated Hospital at Sun Yat-Sen UniversityGuangzhou 510630China

The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 *** we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway *** report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive ***,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced ***-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient ***,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung ***,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both ***,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)*** study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation.

关键词： house dust mite allergic asthma caspase-1 inﬂammasomes IL-33 spleen tyrosine kinase(Syk) uric acid

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Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

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Molecular Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang Lorenz Wiese Hao Fang Saleh Alseekh Leonardo Perez de Souza Federico Scossa john Molloy mathias Christmann Alisdair R.Fernie Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustraBe 314195 BerlinGermany Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany Research Center for Genomics and Bioinformatics(CREA-GB) Via Ardeatina 54600178 RomeItaly

The diterpenoid paclitaxel(Taxol)is a chemotherapy medication widely used as a first-line treatment against several types of solid *** supply of paclitaxel from natural sources is ***,missing knowledge about the genes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to engineer the full *** this study,we used a combination of transcriptomics,cell biology,metabolomics,and pathway reconstitution to identify the complete gene set required for the heterologous production of *** identified the missing steps from the current model of paclitaxel biosynthesis and confirmed the activity of most of the missing enzymes via heterologous expression in Nicotiana ***,we identified a new C4β-C20 epoxidase that could overcome the first bottleneck of metabolic *** used both previously characterized and newly identified oxomutases/epoxidases,taxane 1β-hydroxylase,taxane 9aα-hydroxylase,taxane 9α-dioxygenase,and phenylalanine-CoA ligase,to successfully biosynthesize the key intermediate baccatin Ill and to convert baccatin Ill into paclitaxel in *** combination,these approaches establisha metabolic route to taxoidbiosynthesis and provide insights into the unique chemistry that plants use to generate complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biology baccatin Ill biosynthesis Taxus

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Quantum Entanglement and Cryptography for Automation and Control of Dynamic Systems

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Instrumentation 2019年第4期6卷 109-127页

作者： Farbod KHOSHNOUD Ibrahim I.ESAT Shayan jAVAHERIAN Behnam bahr Department of Electromechanical Engineering Technology College of EngineeringCalifornia State Polytechnic UniversityPomonaCA 91768USA Center for Autonomous Systems and Technologies Department of Aerospace EngineeringCalifornia Institute of TechnologyPasadenaCA 91125USA Department of Mechanical and Aerospace Engineering Brunel University LondonUxbridge UB83PHUnited Kingdom Department of Mechanical Engineering College of EngineeringCalifornia State Polytechnic UniversityPomonaCA 91768USA

This paper addresses the application of quantum entanglement and cryptography for automation and control of dynamic systems.A dynamic system is a system where the rates of changes of its state variables are not *** entanglement is realized by the Spontaneous Parametric Down-conversion *** entangled autonomous systems exhibit correlated behavior without any classical communication in between them due to the quantum entanglement ***,the behavior of a system,Bob,at a distance,is correlated with a corresponding system,*** an automation scenario,the"Bob Robot"is entangled with the"Alice Robot"in performing autonomous tasks without any classical connection between *** cryptography is a capability that allows guaranteed *** capabilities can be implemented in control of autonomous mechanical systems where,for instance,an"Alice Autonomous System"can control a"Bob Autonomous System"for applications of automation and *** applications of quantum technologies to mechanical systems,at a scale larger than the atomistic scale,for control and automation,is a novel contribution of this ***,the feedback control transfer function of an integrated classical dynamic system and a quantum state is proposed.

关键词： Quantum Entanglement Quantum Multibody Dynamics Quantum Cooperative Robotics Quantum Cryptography Quantum Autonomy

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八十年代欧洲市场的Escort新型轿车

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世界汽车 1982年第1期 23-29页

作者： j.Aigner A.bahr 林荣

1.产品系列介绍至目前为止,新型Escort轿车(也称为“C”级轿车)在轿车市场上的占有率已经超过25％,是市场占有率最高的车型。由于石油进口的不稳定,该车在市场上的占有率还将进一步增大。如果为广大的欧洲市场研制出一种能适于各国市场... 详细信息

1.产品系列介绍至目前为止,新型Escort轿车(也称为“C”级轿车)在轿车市场上的占有率已经超过25％,是市场占有率最高的车型。由于石油进口的不稳定,该车在市场上的占有率还将进一步增大。如果为广大的欧洲市场研制出一种能适于各国市场要求的方案,这种车就可以以其费用上的优势实现大批量出口(图1)。

关键词：轿车客车发动机 Escort 箱式车座椅

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Establishing a child and adolescent mental health center in Herat,Afghanistan:a project description

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Global Health journal 2023年第4期7卷 194-199页

作者： Abdul Fattah Najm Aziz-ur-Rahman Niazi Mina Alekozay Emily B.Allan Kaaren mathias Technical Director International Assistance MissionHerat 3001Afghanistan Department of Public Health and Infectious Diseases Faculty of MedicineHerat 3001Afghanistan Independent Consultant RedcarNorth YorkshireTS103JAUK Faculty of Health University of CanterburyChristchurch 8140New Zealand

Objective:Afghanistan has witnessed a long-lasting 4-decade armed conflict,which together with high levels of poverty and interpersonal violence,resulted in high incidence and prevalence of mental disorders in general population,including children and *** mid-2018,there was neither mental health care facility nor a child psychiatrist in ***,we report the establishment of the first children and adolescents'mental health center(CAMHC)in Herat province of ***:In july 2018,CAMHC was initiated at Mental Health Training *** was initially planned by the International Assistance Mission(IAM)and Herat Public Health Directorate;and financially supported by the Tearfund UK,the United Methodist Committee on Relief and Tearfund *** target population of CAMHC was children and adolescents in Herat and neighboring provinces,healthcare professionals,staff of government and non-governmental organizations,school teachers and community ***:A group of eight mental health professionals were trained and made the interdisciplinary board for diagnosis and management of mental disorders in children and *** the initial three-year period,2448 patients,including 1264(51.6%)boys and 1184(48.4%)girls,presented with mental disorders to *** and management of mental disorders were performed according to standard international *** awareness-raising seminars were held;2000 leaflets,10000 posters,and 30000 brochures were prepared and distributed;and two short video clips were produced and broadcast via IAM website,social media and local TV channels.A database was developed to house for project data,assessment of outcomes and reporting to ***:Establishment of CAMHC resulted in significant achievements in diagnosis and management of mental disorders among children and adolescents,healthcare staff capacity building,and awareness-raising about mental *** o

关键词： Child and adolescent Mental health Herat Afghanistan

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Automated Behavioral Phenotyping Reveals Presymptomatic Alterations in a SCA3 Genetrap Mouse Model

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journal of Genetics and Genomics 2012年第6期39卷 287-299页

作者： jeannette Hübener Nicolas Casadei Peter Teismann mathias W. Seeliger Maria Bjrkqvist Stephan von Horsten Olaf Riess Huu Phuc Nguyen Department of Medical Genetics University of TubingenTubingen 72076Germany Institute of Medical Sciences University of AberdeenAB25 2ZDUK Division of Ocular Neurodegeneration Centre for OphthalmologyInstitute for Ophthalmic ResearchUniversity of TubingenTubingen 72076Germany Neuronal Survival Unit Department of Experimental Medical SciencesWallenberg Neuroscience CenterLund UniversityLund 221 84Sweden Experimental Therapy Franz-Penzoldt-CenterUniversity of Erlangen-NurnbergErlangen 91054Germany

Characterization of disease models of neurodegenerative disorders requires a systematic and comprehensive phenotyping in a highly standardized manner. Therefore, automated high-resolution behavior test systems such as the homecage based LabMaster system are of particular interest. We demonstrate the power of the automated LabMaster system by discovering previously unrecognized features of a recently characterized atxn3 mutant mouse model. This model provided neurological symptoms including gait ataxia, tremor, weight loss and premature death at the age of 12 months usually detectable just 2 weeks before the mice died. Moreover, using the LabMaster system we were able to detect hypoactivity in presymptomatic mutant mice in the dark as well as light phase. Additionally, we analyzed inflammation, immunological and hematological parameters, which indicated a reduced immune defense in phenotypic mice. Here we demonstrate that a detailed characterization even of organ systems that are usually not affected in SCA3 is important for further studies of pathogenesis and required for the preclinical therapeutic studies.

关键词： Automated homecage behavior Genetrap mouse model Spinocerebellar Ataxia Type 3

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交互性数字公共艺术设计实践与体验评估

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装饰 2015年第9期 96-97页

作者：王峰胡军 mathias Funk 江南大学设计学院埃因霍温科技大学工业设计部

公共艺术设计中新材料和新技术的运用,提升了参与者的互动体验。本文呈现了Blobulous和Strijp-T-ogether两个设计案例,提出交互性数字公共艺术的设计手法和用户体验及评估方法,表明其可在社会与文化计算领域进行新的研究。

关键词：公共艺术交互性体验评估

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深圳中信金融中心项目结构体系优化设计

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建筑结构学报 2016年第S1期37卷 158-164页

作者： BEGHINI Alessandro mathias Neville SARKISIAN Mark 潘斌李盛勇程华群 Skidmore Owings&MerrillLLP旧金山94111 广州容柏生建筑结构设计事务所广东广州510170 华阳国际设计集团深圳公司广东深圳518038

介绍了基于数值有限元分析、图形静力学和Maxwell荷载路径等经典理论的结构优化工具,及其在深圳中信金融中心项目中的应用。结合使用了商用结构优化软件和自开发程序,以期得到深圳中信金融中心项目结构最佳几何形式。在结构优化过程中... 详细信息

介绍了基于数值有限元分析、图形静力学和Maxwell荷载路径等经典理论的结构优化工具,及其在深圳中信金融中心项目中的应用。结合使用了商用结构优化软件和自开发程序,以期得到深圳中信金融中心项目结构最佳几何形式。在结构优化过程中考虑结构性能标准,如整体刚度最大化、给定点变形最小化、目标周期、屈曲因子最大化、应力分布均匀等。最佳几何形式在最小化结构材料的前提下实现结构刚度最大化,整个优化过程是基于材料线弹性假定,为保证结构体系在地震作用下的延性,塔楼角部设置延性框架梁耗能。优化后的斜交网格结构体系效率高,相比核心筒提供更大的抗侧力刚度,但也使得节点层楼板拉应力增大,并且优化使得体系冗余度下降,因此需要注重楼板拉应力控制和抗连续倒塌设计。

关键词：高层结构结构优化拓扑优化可持续性设计概念设计

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灌区水资源合理配置研究进展

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水科学进展 2015年第2期26卷 287-295页

作者：齐学斌黄仲冬乔冬梅张现超李平 mathias N Andersen 水利部中国农业科学院农田灌溉研究所河南新乡453002 中国农业科学院河南新乡农业水土环境野外科学观测试验站河南新乡453002 中国农业科学院研究生院北京100081 中国农业科学院农业水资源高效安全利用重点开放实验室河南新乡453002 Department of Agroecology and Environment Faculty of Agricultural SciencesAarhus UniversityBlichers Alle 20Postboks 50DK-8830 TjeleDenmark

灌区水资源合理配置是提高灌区水资源利用效率及保障粮食安全的重要途径,也是实现灌区水资源可持续利用的有效调控措施。从灌区水资源管理政策、水资源循环转化规律、水资源优化配置模型与方法和水文生态4个方面,对国内外该领域的研究... 详细信息

灌区水资源合理配置是提高灌区水资源利用效率及保障粮食安全的重要途径,也是实现灌区水资源可持续利用的有效调控措施。从灌区水资源管理政策、水资源循环转化规律、水资源优化配置模型与方法和水文生态4个方面,对国内外该领域的研究现状进行了对比分析。研究发现,国内灌区水资源配置主要存在4个方面的问题:水资源合理配置与保护政策落实不到位、水资源的统一管理机制不健全、水资源优化配置模型实用性不强和水资源优化配置基础条件较为薄弱。建议加强灌区水资源的统一管理政策与机制、变化环境下水资源循环转化规律、水资源承载力基础理论与评价新方法、水文生态调控技术、水资源实时风险调度与智能化管理技术以及水资源优化配置耦合技术研究。

关键词：灌区水循环优化模型水文生态水管理

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Leisure-time physical activity and all-cause mortality and cardiovascular disease in adults with type 2 diabetes:Cross-country comparison of cohort studies

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journal of Sport and Health Science 2024年第2期13卷 212-221页

作者： jakob Tarp Mengyun Luo Miguel Adriano Sanchez-Lastra Knut Eirik Dalene Borja del Pozo Cruz mathias Ried-Larsen Reimar Wernich Thomsen Ulf Ekelund Ding Ding Department of Clinical Epidemiology Aarhus University&Aarhus University HospitalAarhus 8200Denmark Prevention Research Collaboration Sydney School of Public HealthThe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre the University of SydneyCamperdownNSW 2050Australia Department of Sports Medicine Norwegian School of Sports SciencesOslo 0806Norway Department of Special Didactics Faculty of Education and Sports SciencesUniversity of VigoPontevedra 36005Spain Well-Move Research Group Galicia Sur Health Research Institute(IIS Galicia Sur)SERGAS-UVIGOVigo 36213Spain Department of Chronic Diseases Norwegian Institute of Public HealthOslo 0473Norway Centre for Active and Healthy Ageing Department of Sports Science and Clinical BiomechanicsUniversity of Southern DenmarkOdense 5230Denmark Faculty of Education University of CadizCadiz 11519Spain Biomedical Research and Innovation Institute of Cadiz(INiBICA)Research Unit Puerta del Mar University HospitalUniversity of CadizCadiz 11009Spain The Centre of Inflammation and Metabolism&the Centre for Physical Activity Research RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark

Purpose:This study aimed to quantify the dose-response association and the minimal effective dose of leisure-time physical activity(PA)to prevent mortality and cardiovascular disease in adults with type 2 ***:Cross-country comparison of 2 prospective cohort studies including 14,913 and 17,457 population-based adults with type 2 diabetes from the UK and *** leisure-time PA was self-reported and categorized by metabolic equivalent hours per week(MET-h/week)according to World Health Organization recommendations:none,below recommendation(>0-7.49 MET-h/week);at recommended level(7.5-14.9 MET-h/week);above recommendation(>15 MET-h/week).Mortality and cardiovascular disease data were obtained from national ***:During a median follow-up of 12.4 and 9.7 years,in the UK and China cohorts,repectively,higher levels of leisure-time PA were inversely associated with all-cause(1571 and 2351 events)and cardiovascular mortality(392 and 1060 events),mostly consistent with a linear dose-response *** below,at,and above recommendations,compared with no activity,yielded all-cause mortality hazard ratios of0.94(95%confidence interval(95%CI):0.79-1.12),0.90(95%CI:0.74-1.10),and 0.85(95%CI:0.70-1.02)in British adults and 0.87(95%CI:0.68-1.10),0.88(95%CI:0.74-1.03),and 0.77(95%CI:0.70-0.85)in Chinese *** with cardiovascular mortality were more pronounced in British adults(0.80(95%CI:0.58-1.11),0.75(95%CI:0.52-1.09),and 0.69(95%CI:0.48-0.97))but less pronounced in Chinese adults(1.06(95%CI:0.76-1.47),1.01(95%CI:0.80-1.28),and 0.79(95%CI:0.69-0.92)).PA at recommended levels was not associated with lower rates of major adverse cardiovascular events(2345 and 4458 events).Conclusion:Leisure-time PA at the recommended levels was not convincingly associated with lower mortality and had no association with risk of major adverse cardiovascular events in British or Chinese adults with type 2 ***-time PA above current recom

关键词： Complications Epidemiology Exercise Prevention

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