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Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,087 Clinical Isolates

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Genomics, Proteomics & Bioinformatics 2019年第2期17卷 169-182页

作者： Valentina Galata Cédric C. Laczny Christina Backes Georg Hemmrich-Stanisak Susanne Schmolke Andre Franke Eckart Meese mathias herrmann Lutz von Müller Achim Plum Rolf Mü ller Cord Stahler Andreas E. Posch Andreas Keller Chair for Clinical Bioinformatics Saarland University 66123 Saarbrücken Germany Helmholtz Center for Infection Research and Pharmaceutical Biotechnology (HZI) Saarland University 66123 Saarbrücken Germany Institute of Clinical Molecular Biology Christian-Albrechts University of Kiel 24105 Kiel Germany Siemens Healthcare GmbH Strategy and Innovation 91052 Erlangen Germany Department of Human Genetics Saarland University 66421 Homburg Germany Institute of Medical Microbiology and Hygiene Saarland University 66421 Homburg Germany Ares Genetics GmbH 1030 Vienna Austria Curetis GmbH 71088 Holzgerlingen Germany Department of Pharmacy Pharmaceutical Biotechnology Saarland University 66123 Saarbrücken Germany Department of Microbial Natural Products Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) Saarland University 66123 Saarbrücken Germany

Emerging antibiotic resistance is a major global health threat. The analysis of nucleic acid sequences linked to susceptibility phenotypes facilitates the study of genetic antibiotic resistance determinants to inform molecular diagnostics and drug development. We collected genetic data (11,087 newly-sequenced whole genomes) and culture-based resistance profiles (10,991 out of the 11,087 isolates comprehensively tested against 22 antibiotics in total) of clinical isolates including 18 main species spanning a time period of 30 years. Species and drug specific resistance patterns were observed including increased resistance rates for Acinetobacter baumannii to carbapenems and for Escherichia coli to fluoroquinolones. Species-level pan-genomes were constructed to reflect the genetic repertoire of the respective species,including conserved essential genes and known resis-tance factors. Integrating phenotypes and genotypes through species-level pan-genomes allowed to infer gene–drug resistance associations using statistical testing. The isolate collection and the analysis results have been integrated into GEAR-base,a resource available for academic research use free of charge at https://***.

关键词： Antibiotic resistance Whole-genome sequencing Bacteria Pan-genome

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Identifying suitable areas for plenter forest management

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FOREST ECOSYSTEMS 2025年第1期12卷 83-92页

作者： Leiter, mathias Pucher, Christoph Kessler, Michael Hoeuronigsberger, Ferdinand Lexer, Manfred J. Vacik, Harald Hasenauer, Hubert Univ Nat Resources & Life Sci BOKU Inst Silviculture Peter Jordan Str 82 A-1190 Vienna Austria Univ Nat Resources & Life Sci BOKU Inst Forest Engn Peter Jordan Str 82 A-1190 Vienna Austria

Plenter forests, also known as uneven-aged or continuous cover forests enhance forest resilience and resistance against disturbances compared to even-aged forests. They are considered as an adaptation option to mitigate climate change effects. In this study, we present a conceptual approach to determine the potentially suitable area for plenter forest management within central European mixed species forests and apply our approach to the case study area in Styria, the south-eastern Province of Austria. The concept is based on ecological and technical-economic constraints and considers expected future climate conditions and its impact on plenter forest management. For each 1 ha forest pixel, we assess the ecological conditions for plenter forest management according to the autecological growth conditions of silver fir, and at least one additional shade tolerant tree species. The technical-economic constraints are defined by slope (<= 30%) and distance to the next forest road (<= 100 m) to ensure cost-efficient harvesting. The results show that under current climate conditions 28.1% or 305,349 ha of the forests in Styria are potentially suitable for plenter forest management. For the years 2071-2100 and under the climate change scenario RCP 4.5, the potential area decreases to 286,098 ha (26.3% of the total forest area) and for the scenario RCP 8.5 to 208,421 ha (19.1% of the total forest area). The main reason for these changes is the unfavourable growing conditions for silver fir in the lowlands, while in the higher elevations silver fir is likely to expand. Our results may serve forest managers to identify areas suitable for plenter forests and assist in the transformation of even-aged pure forests to uneven-aged forests to increase resistance, resilience, and biodiversity under climate change.

关键词： Plenter forest Uneven-aged forest management Tree species suitability Tree harvesting Transformation

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Identifying suitable areas for plenter forest management

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Forest Ecosystems 2025年第01期 83-92页

作者： mathias Leiter Christoph Pucher Michael Kessler Ferdinand H?nigsberger Manfred J.Lexer Harald Vacik Hubert Hasenauer Institute of Silviculture University of Natural Resources and Life Sciences (BOKU) Institute of Forest Engineering University of Natural Resources and Life Sciences (BOKU)

Plenter forests, also known as uneven-aged or continuous cover forests enhance forest resilience and resistance against disturbances compared to even-aged forests. They are considered as an adaptation option to mitigate climate change effects. In this study, we present a conceptual approach to determine the potentially suitable area for plenter forest management within central European mixed species forests and apply our approach to the case study area in Styria, the south-eastern Province of Austria. The concept is based on ecological and technicaleconomic constraints and considers expected future climate conditions and its impact on plenter forest management. For each 1 ha forest pixel, we assess the ecological conditions for plenter forest management according to the autecological growth conditions of silver fir, and at least one additional shade tolerant tree species. The technical-economic constraints are defined by slope(≤30%) and distance to the next forest road(≤100 m) to ensure cost-efficient harvesting. The results show that under current climate conditions 28.1% or 305,349 ha of the forests in Styria are potentially suitable for plenter forest management. For the years 2071–2100 and under the climate change scenario RCP 4.5, the potential area decreases to 286,098 ha(26.3% of the total forest area)and for the scenario RCP 8.5 to 208,421 ha(19.1% of the total forest area). The main reason for these changes is the unfavourable growing conditions for silver fir in the lowlands, while in the higher elevations silver fir is likely to expand. Our results may serve forest managers to identify areas suitable for plenter forests and assist in the transformation of even-aged pure forests to uneven-aged forests to increase resistance, resilience, and biodiversity under climate change.

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Pods Filling in Natural Pollination of 10 Spontaneous Cocoa Trees from French Guiana

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Agricultural Sciences 2025年第1期16卷 193-205页

作者： Inago Caudou Trebissou Gnion mathias Tahi Kacou Antoine Alban M’bo Cacao Breeding Laboratory National Center for Agronomic Research (CNRA) Research Station of Divo Divo Cte dIvoire African Center of Excellence on Climate Change Biodiversity and Sustainable Agriculture (CEA-CCBAD/WASCAL) Flix Houphout-Boigny University (UFHB) Abidjan Cte dIvoire

The study focuses on the filling of pods from ten cacao clones originating from French Guiana in Côte d’Ivoire. Two reference clones (IFC5 and NA32) were used as controls. The parameters studied include the number of ovules per ovary, the average number of beans per pod, the fresh bean weight, and the pod index. The aim was to evaluate the genetic variability and agronomic performance of these clones under natural pollination conditions. The results show significant genetic variability between the clones for all traits studied. The IFC5 clone, known for its excellent pod filling, exhibited the highest apparent fertility (0.91), while the GU183/A clone had the lowest filling (0.47). Three types of distributions of the number of beans per pod were identified: a right-skewed unimodal distribution, characteristic of well-filled clones;a left-skewed unimodal distribution, associated with poorly filled clones;and an intermediate bimodal distribution. These differences could be related to pollination compatibility and the availability of compatible pollen. Regarding the fresh bean weight and pod index, the GU183/A clone stood out with the heaviest beans (3.27 g) but had a high pod index (49.58), indicating relatively low productivity. None of the Guyanese clones achieved the filling level of the IFC5 clone, although some surpassed the NA32 control. This study highlights the importance of apparent fertility and the number of beans per pod as essential criteria for cacao genetic improvement programs. The authors recommend extending research to a larger number of Guyanese clones and exploring complementary traits, such as the influence of pollination type and intergroup compatibility.

关键词： Theobroma cacao Phytophthora Pod Index Apparent Fertility

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Modeling a Relativistic Star in Multi-layered Settings

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Research in Astronomy and Astrophysics 2025年第1期25卷 309-322页

作者： Avirt S.Lighuda Alberto K.mathias Department of Physics Mathematics and InformaticsDar es Salaam University College of Education Department of Mathematics and Statistics The University of Dodoma

This paper yields a new exact solution for dense stellar objects by employing the Einstein–Maxwell system of differential *** established model comprises three interior layers with distinguishable equations of state(EoSs):the polytropic EoS at the core layer,the quadratic EoS at the intermediate layer and the modified Van der Waals EoS at the envelope *** physical features indicate that the matter variables,metric functions and other physical conditions are viable with dense astrophysical ***,this model is an extension solution of the two-layered model generated by Sunzu and *** layers are matched gently across the junctions with the care of the Reissner–Nordstr?m exterior *** our model,star masses and radii compatible with observations and satisfactorily known objects are *** findings from this paper may be useful to describes purported strange stars such as SAX J1808.4-3658 and binary stars such as Vela X-1.

关键词： stars: general stars: interiors stars: massive stars: neutron

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SURFACE MODIFICATION OF POLYPROPYLENE MICROPOROUS MEMBRANE BY TETHERING POLYPEPTIDES

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Chinese Journal of Polymer Science 2006年第5期24卷 529-538页

作者：徐志康 mathias Ulbricht Institute of Polymer Science Department of Polymer Science & Engineering Zhejiang University Hangzhou 310027 China Institut für Technische Chemie Universit t Duisburg-Essen45117 EssenGermany

Two kinds of polypeptides were tethered onto the surface of polypropylene microporous membrane （PPMM） through a ring opening polymerization of L-glutamate N-carboxyanhydride initiated by amino groups which were introduced by ammonia plasma and y-aminopropyl triethanoxysilane treatments. X-ray photoelectron spectroscopy （XPS）, attenuated total reflectance Fourier transform infrared spectroscopy （FT-IR/ATR）, scanning electron microscopy （SEM）, together with water contact angle measurements were used to characterize the modified membranes. XPS analyses and FT-IR/ATR spectra demonstrated that polypeptides are actually grafted onto the membrane surface. The wettability of the membrane surface increases at first and then decreases with the increase in grafting degrees of polypeptide. Platelet adhesion and murine macrophage attachment experiments reveal an enhanced hemocompatibility for the polypeptide modified PPMMs. All these results give evidence that polypeptide grafting can simultaneously improve the hemocompatibility as well as reserve the hydrophobicity for the membrane, which will provide a potential approach to improve the performance of polypropylene hollow fiber microporous membrane used in artificial oxygenator.

关键词： Polypropylene microporous membrane Graft polymerization Polypeptide Surface modification Biocompatibility.

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Fine-Tuning by the Touch of Big Dudes: SUMOs Role in Light Signaling

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Molecular Plant 2020年第7期13卷 943-945页

作者： mathias Zeidler Institute of Plant Physiology Justus-Liebig-University GiessenSenckenbergstrasse 335390 GiessenGermany

Protein posttranslational modifications(PTM)are recognized to be important regulators for protein function,activity,localization,and/or stability and are a substantial component in the cell’s proteome *** the possible PTMs,the small ubiquitin-related modifiers(SUMO)have long had inferior standing to phosphorylation and ubiquitination.

关键词： SUMO phosphorylation stability

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Functional hyperconnectivity related to brain disease:maladaptive process or element of resilience?

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Neural Regeneration Research 2023年第7期18卷 1489-1490页

作者： Markus Aswendt mathias Hoehn Department of Neurology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Cognitive Neuroscience Institute of Neuroscience and Medicine(INM-3)Research Center JuelichJuelichGermany

Neuroimaging techniques such as magnetic resonance imaging(MRI)and positron emission tomography provide unique in vivo data to analyze structural and functional connectivity of the whole *** advances in small animal neuroimaging have opened new opportunities for the study of structure-function interactions in healthy and diseased brain networks,which are essential to develop therapies targeting network reorganization associated with functional improvement.

关键词： network connectivity element

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APPROXIMATING THE STATIONARY BELLMAN EQUATION BY HIERARCHICAL TENSOR PRODUCTS

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Journal of Computational Mathematics 2024年第3期42卷 638-661页

作者： mathias Oster Leon Sallandt Reinhold Schneider Technische Universität Berlin Strasse des 17.Juni 13510623 BerlinGermany

We treat infinite horizon optimal control problems by solving the associated stationary Bellman equation numerically to compute the value function and an optimal feedback *** dynamical systems under consideration are spatial discretizations of non linear parabolic partial differential equations(PDE),which means that the Bellman equation suffers from the curse of *** non linearity is handled by the Policy Iteration algorithm,where the problem is reduced to a sequence of linear equations,which remain the computational bottleneck due to their high *** reformulate the linearized Bellman equations via the Koopman operator into an operator equation,that is solved using a minimal residual *** the Koopman operator we identify a preconditioner for operator equation,which deems essential in our numerical *** overcome computational infeasability we use low rank hierarchical tensor product approximation/tree-based tensor formats,in particular tensor trains(TT tensors)and multi-polynomials,together with high-dimensional quadrature,*** controlling a destabilized version of viscous Burgers and a diffusion equation with unstable reaction term numerical evidence is given.

关键词： Feedback control Dynamic programming Hamilton-Jacobi-Bellman Tensor product approximation Variational Monte-Carlo

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Recruitment in species-rich grasslands: the effects of functional traits and propagule pressure

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Journal of Plant Ecology 2012年第3期5卷 260-269页

作者： mathiasÖster Ove Eriksson Department of Botany Stockholm UniversitySE-10691 StockholmSweden

Aims The assembly of plant communities is a complex process which combines impacts from the species pool,dispersal and propagule pressure,niche requirements of colonizing species and the niche structure of the *** theory development has incorporated all these aspects,***‘stochastic niche theory’.We investigated recruitment into a species-rich grassland community,using an experimental approach where we manipulated the trait composition of the community and examined the success of colonizing species entering with various propagule ***,we examined two predictions:(i)colonization success increases with increasing difference between traits of the colonizing species and the trait profile of the community and(ii)colonization success increases with increasing propagule *** The examined communities were species-rich semi-natural grasslands located in southern *** a careful documentation of the composition of the plant communities at the experimental sites,we manipulated the trait profile of species-rich grassland plots based on the plant functional trait specific leaf area(SLA),which is correlated with several key life history *** addition to SLA,seed mass was also used to describe the trait profile of grassland *** of 12 plant species from the regional species pool,varying in SLA and seed mass,were sown into plots using four different levels of propagule *** was examined after 1 *** also planted juvenile‘plug plants’of the same species which allowed us to examine survivorship and growth beyond the seedling *** Findings Overall we found very limited evidence for relationships between the traits of the colonizing species and the trait profile of the community and for recruitment after sowing these relationships were contrary to the *** of plug plants after two seasons of growth was high irrespective of the trait profile of the community,but growth of plug

关键词： assembly rules recruitment limitation seed size semi-natural grassland SLA

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