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Disease-associated oligodendrocyte signatures in neurodegenerative disease:the known and unknown

Neural Regeneration Research 2023年第10期18卷 2192-2193页

作者： Kristen H.schuster Hayley S.McLoughlin Department of Neurology University of MichiganAnn ArborMIUSA

Oligodendrocytes are one of the most abundant cell types in the central nervous system(CNS)and act in close contact with neurons to assist with their cellular function and health(Kuhn et al.,2019).Oligodendrocytes play particular roles in rapid nerve impulse conduction through the wrapping of their myelinating projections a round a nerve axon,as well as by offering trophic and metabolic support for the high energy expenditure of ***。

关键词： cytes degenerative

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District Partisan Homogeneity, Communications, and the Electoral Motive: An Analysis of the Facebook Posts of Members of the u.S. House of Representatives

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Social Networking 2017年第2期6卷 148-163页

作者： Scot Schraufnagel Quan Li Adam schuster Department of Political Science Northern Illinois University DeKalb Illinois USA College of Political Science and Public Administration Wuhan University Wuhan China Northern Illinois university DeKalb Illinois USA

The research examines the way in which members of the u.S. House of Representative represent themselves on the social network site Facebook. Each member’s activity is observed on seven different occasions and the frequency and substantive character of posts made during the second half of 2013 are established. The focus is on position-taking posts versus posts which mention the district the member serves in. Our expectation is that members from electorally safe districts will be more likely to advertise their policy positions while members from marginal districts will be more inclined to advertise their district connections. We control for minority party status, gender, and ideological extremism among other concerns and learn electoral safety is a good predictor of both “position-taking” and “district mentions”. Consistent with an electoral motive, we also find members from the minority party less likely to take positions on the issues of the day and more likely to mention the district they serve in.

关键词： u.S. House of Representatives Facebook Posts Electoral Motives Credit Claiming

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Virus-host Interactions during Hepatitis C Virus Entry-Implications for Pathogenesis and Novel Treatment Approaches

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Virologica Sinica 2008年第2期23卷 124-131页

作者： Joachim Lupberger Mirjam B. Zeisel Anita Haberstroh Eva K. Schnober Sophie Krieger Eric Soulier Christine Thumann Cathy Royer Samira Fafi-Kremer Catherine schuster Franoise Stoll-Keller Hubert E. Blum Thomas F. Baumert Inserm U748 Hpitaux Universitaires de Strasbourg Université Louis Pasteur 3 Rue Koeberle Department of Medicine II University of Freiburg

Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies.

关键词： Hepatitis C virus Viral entry Entry inhibitor Neutralizing antibodies

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Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA university of Califomia BerkeleyCaliformnia 94720USA university of California DavisCalifornia 95616USA university of Califormnia Los AngelesCalifomia 90095USA universidade Estadual de Campinas Sao PauloBrazil university of Illinois at Chicago ChicagoIlinois 60607USA Creighton university OmahaNebraska 68178USA Czech Technical university in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic university of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana university BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia university of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State university KentOhio 44242USA university of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State university East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and utrecht university AmsterdamThe Netherlands Ohio State university ColumbusOhio 43210USA Old Dominion university NorfolkVA23529USA Panjab university Chandigarh 160014India PennsyIvania State university University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue university West LafayetteIndiana 47907USA Pusan National university PusanRepublic of Korea university of Rajasthan Jaipur 302004India Rice university HoustonTexas 77251USA universidade de Sao Paulo Sao PauloBrazil university of Science&Technology of China Hefei 230026.China Shandong university JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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