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Pyr.oloquinoline quinone:a potential neur.pr.tective compound for.neur.degener.tive diseases tar.eting metabolism

Neur.l r.gener.tion r.sear.h 2025年第1期20卷 41-53页

作者： Alessio Canovai Pete A.williams Depar.ment of Biology University of PisaPisaItaly Depar.ment of Clinical Neur.science Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyr.oloquinoline quinone is a quinone descr.bed as a cofactor.for.many bacter.al dehydr.genases and is r.por.ed to exer. an effect on metabolism in mammalian cells/*** quinone is pr.sent in the diet being available in foodstuffs,confer.ing the potential of this compound to be supplemented by dietar. *** quinone’s nutr.tional r.le in mammalian health is suppor.ed by the extensive deficits in r.pr.duction,gr.wth,and immunity r.sulting fr.m the dietar. absence of pyr.oloquinoline quinone,and as such,pyr.oloquinoline quinone has been consider.d as a“new vitamin.”Although the classification of pyr.oloquinoline quinone as a vitamin needs to be pr.per.y established,the wide r.nge of benefits for.health pr.vided has been r.por.ed in many *** this r.spect,pyr.oloquinoline quinone seems to be par.icular.y involved in r.gulating cell signaling pathways that pr.mote metabolic and mitochondr.al pr.cesses in many exper.mental contexts,thus dictating the r.tionale to consider.pyr.oloquinoline quinone as a vital compound for.mammalian *** the r.gulation of differ.nt metabolic mechanisms,pyr.oloquinoline quinone may impr.ve clinical deficits wher. dysfunctional metabolism and mitochondr.al activity contr.bute to induce cell damage and *** quinone has been demonstr.ted to have neur.pr.tective pr.per.ies in differ.nt exper.mental models of neur.degener.tion,although the link between pyr.oloquinoline quinone-pr.moted metabolism and impr.ved neur.nal viability in some of such contexts is still to be fully ***,we r.view the gener.l pr.per.ies of pyr.oloquinoline quinone and its capacity to modulate metabolic and mitochondr.al mechanisms in physiological *** addition,we analyze the neur.pr.tective pr.per.ies of pyr.oloquinoline quinone in differ.nt neur.degener.tive conditions and consider.futur. per.pectives for.pyr.oloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondr.a neur.degener.tive disease neur.pr.tection pyr.oloquinoline quinone r.tinal diseases

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Br.in r.sear.h on Mental Disor.er.: A Cr.ticism

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Open Jour.al of Medical Psychology 2024年第3期13卷 71-85页

作者： John r. r.ssiter Faculty of Business and Law University of Wollongong Wollongong Australia School of Psychology Charles Sturt University Wagga Wagga Australia

Objective: To expose the pr.blems and inher.nt limitations of neur.science-based br.in r.sear.h on mental disor.er.. Method: Discussion of the theor. under.ying br.in r.sear.h on mental disor.er., followed by a systematic evaluation of typical studies. r.sults: The fundamental pr.blem is that br.in r.sear.her. fail to differ.ntiate between biological mental disor.er. in which br.in pr.cesses cause the disor.er.(notably schizophr.nia, bipolar.disor.er. and melancholic depr.ssion) and lear.ed mental disor.er. in which br.in pr.cesses mediate but do not cause the disor.er.(which is the case with r.active depr.ssion, r.active anxiety, OCD, and PTSD). r.sear.her. have been unsuccessful in identifying mechanisms in the br.in that cause biological mental disor.er., and will never.be able to locate the innumer.ble specific neur.l connections that mediate lear.ed mental disor.er.. Mor.over. the author.s r.view of typical studies in this field shows that they have ser.ous pr.blems with theor., measur.ment, and data analysis, and that their.findings cannot be tr.sted. Conclusions: Neur.science-based br.in r.sear.h on mental disor.er., unlike other.neur.logical r.sear.h, has been an expensive failur. and it is not wor.h continuing.

关键词： Neur.science-Based Br.in r.sear.h Biological Mental Disor.er. Lear.ed Mental Disor.er. r.sear.h Pr.blems

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The Quantum Micr.ver.e: A Pr.me Number.Fr.mewor. for.Under.tanding the Univer.e

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Amer.can Jour.al of Computational Mathematics 2024年第2期14卷 264-274页

作者： John r. Cr.r. Independent r.sear.her Lake Zurich IL USA

This study aims to demonstr.te a pr.of of concept for.a novel theor. of the univer.e based on the Fine Str.ctur. Constant (α), der.ved fr.m n-dimensional pr.me number.pr.per.y sets, specifically α = 137 and α = 139. The FSC Model intr.duces a new per.pective on the fundamental natur. of our.univer.e, showing that α = 137.036 can be calculated fr.m these pr.me pr.per.y sets. The Fine Str.ctur. Constant, a cor.er.tone in Quantum Electr.dynamics (QED) and Quantum Chr.modynamics (QCD), implies an under.ying str.ctur.. This study identifies this mathematical fr.mewor. and demonstr.tes how the FSC model theor. aligns with our.cur.ent under.tanding of physics and cosmology. The r.sults unveil a hier.r.hy of α values for.twin pr.me pair. U{3/2} thr.ugh U{199/197}. These values, r.pr.sented by their.fr.ction par.s α♊ (e.g., 0.036), define the r.lative electr.magnetic for.es dr.ving quantum ener.y systems. The lower.twin pr.me pair., such as U{3/2}, exhibit higher.EM for.es that decr.ase as the twin pair. incr.ase, tur.ing dar. when they dr.p below the α♊ for.light. The r.sults pr.vide classical definitions for.Bar.onic Matter.Ener.y, Dar. Matter. Dar. Ener.y, and Antimatter.but mostly illustr.te how the combined α♊ values for.thr.e adjacent twin pr.mes, U{7/5/3/2} mir.or. the str.ng nuclear.for.e of gluons holding quar.s together.

关键词： Fine Str.ctur. Constant Fr.ctional Coupling Constants Matter.Antimatter Dar. Matter.Ener.y Quantum Gr.vity Pr.me Number. Set Theor.

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Decadal For.casts of Lar.e Ear.hquakes along the Nor.her. San Andr.as Fault System, Califor.ia: Incr.ased Activity on r.gional Cr.eping Faults Pr.or.to Major.and Gr.at Events

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Inter.ational Jour.al of Geosciences 2024年第2期15卷 204-230页

作者： Lynn r. Sykes Lamont-Doher.y Ear.h Obser.ator. of Columbia Univer.ity Palisades New York USA

The thr.e lar.est ear.hquakes in nor.her. Califor.ia since 1849 wer. pr.ceded by incr.ased decadal activity for.moder.te-size shocks along sur.ounding near.y faults. Incr.ased seismicity, double-differ.nce pr.cise locations of ear.hquakes since 1968, geodetic data and fault offsets for.the 1906 gr.at shock ar. used to r.-examine the timing and locations of possible futur. lar.e ear.hquakes. The physical mechanisms of r.gional faults like the Calaver.s, Haywar. and Sar.ent, which exhibit cr.ep, differ.fr.m those of the nor.her. San Andr.as, which is cur.ently locked and is not cr.eping. Much decadal for.r.nning activity occur.ed on cr.eping faults. Moder.te-size ear.hquakes along those faults became mor. fr.quent as str.sses in the r.gion incr.ased in the latter.par. of the cycle of str.ss r.stor.tion for.major.and gr.at ear.hquakes along the San Andr.as. They may be useful for.decadal for.casts. Year.y to decadal for.casts, however. ar. based on only a few major.to gr.at events. Activity along closer.faults like that in the two year. pr.or.to the 1989 Loma Pr.eta shock needs to be examined for.possible year.y for.r.nning changes to lar.e plate boundar. ear.hquakes. Geodetic obser.ations ar. needed to focus on identifying cr.eping faults close to the San Andr.as. The distr.bution of moder.te-size ear.hquakes incr.ased significantly since 1990 along the Haywar. fault but not adjacent to the San Andr.as fault to the south of San Fr.ncisco compar.d to what took place in the decades pr.or.to the thr.e major.histor.c ear.hquakes in the r.gion. It is now clear.fr.m a r.-examination of the 1989 mainshock that the incr.ased level of moder.te-size shocks in the one to two pr.ceding decades occur.ed on near.y East Bay faults. Double-differ.nce locations of small ear.hquakes pr.vide str.ctur.l infor.ation about faults in the r.gion, especially their.depths. The nor.her. San Andr.as fault is divided into sever.l str.ngly coupled segments based on differ.nces in seismicity.

关键词： San Andr.as and Haywar. Faults Califor.ia Fault Cr.ep For.casts Double-Differ.nce r.locations

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Outcome of meniscal r.pair. in paediatr.c population:A ter.iar. centr. exper.ence

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Wor.d Jour.al of Or.hopedics 2024年第6期15卷 547-553页

作者： Ayman Gabr.Samson williams Sophie Dodd Nick Bar.on-Hanson Depar.ment of Tr.uma&Or.hopaedics West Suffolk HospitalSuffolk IP332QZUnited Kingdom Depar.ment of Tr.uma and Or.hopaedics Alder Hey Children's HospitalLiverpool L145ABUnited Kingdom

BACKGr.UND Meniscal spar.ng sur.er. is a widely utilised tr.atment option for.unstable meniscal tear. with the aim of minimising the r.sk of pr.gr.ssion towar.s ***,ther. is limited data in the liter.tur. on meniscal r.pair.outcomes in skeletally immatur. *** To evaluate the r.-oper.tion r.te and functional outcomes of meniscal r.pair. in childr.n and *** We per.or.ed a r.tr.spective r.view of all patients who under.ent ar.hr.scopic meniscal r.pair.sur.er. between Januar. 2007 and Januar. *** patients wer. under.the age of 18 at the time of *** wer. all per.or.ed by a single *** was gather.d fr.m our.hospital Electr.nic Patient r.cor.s *** pr.mar. outcome measur. was r.-oper.tion r.te(need for.fur.her.sur.er. on the same meniscus).Secondar. outcome measur.s wer. sur.ical complications and patient r.por.ed outcome measur.s that wer. Inter.ational Knee Documentation Committee(IKDC),Tegner.and Lysholm *** We identified 59 patients who under.ent 66 All-inside meniscal r.pair.(32 medial meniscus and 34 Later.l meniscus).Meniscal r.pair. wer. per.or.ed utilizing FasT-Fix(Smith and Nephew)*** wer. 37 males and 22 females with an aver.ge age of 14 year.(r.nge 6-16).The aver.ge follow-up time was 53 months(r.nge 26-140).Six patients had concomitant anter.or.cr.ciate ligament r.constr.ction sur.er. along with the meniscal *** wer. no r.quir.ng fur.her.meniscal r.pair. and 9 patients under.ent par.ial *** mean postoper.tive IKDC scor. was 88(44-100),Tegner.scor. was 7(2-10)and Lysholm scor. was 94(57-100).CONCLUSION Our.r.sults showed that ar.hr.scopic r.pair.of meniscal tear. in the paediatr.c population is an effective tr.atment option that has a low failur. r.te and good postoper.tive clinical with the advantage of pr.ser.ing meniscal tissues.

关键词： Meniscus Meniscal r.pair Outcome Meniscal pr.ser.ation

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Health behavior.outcomes in str.ke sur.ivor. pr.scr.bed wear.bles for.atr.al fibr.llation detection str.tified by age

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Jour.al of Ger.atr.c Car.iology 2024年第3期21卷 323-330页

作者： Joanne mathew Jor.y Mehawej Ziyue Wang Taylor.Or.ig Er.c Ding Andr.as Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamr.n Noor.shir.zi Ir.nar.du Jane Saczynski David D.McManus Khanh-Van Tr.n Division of Car.iovascular.Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Depar.ment of Inter.al Medicine Central Michigan UniversityMount PleasantUSA Depar.ment of Phar.acy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Depar.ment of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGr.UND Smar.watches have become r.adily accessible tools for.detecting atr.al fibr.llation(AF).Ther. r.mains limited data on how they affect psychosocial outcomes and engagement in older.*** examine the health behavior.outcomes of str.ke sur.ivor. pr.scr.bed smar.watches for.AF detection str.tified by *** We analyzed data fr.m the Pulsewatch study,a r.ndomized contr.lled tr.al that enr.lled patients(≥50 year.)with a histor. of str.ke or.tr.nsient ischemic attack and CHA2DS2-VASc≥*** par.icipants wer. equipped with a car.iac patch monitor.and a smar.watch-app dyad,while contr.l par.icipants wor. the car.iac patch monitor.for.up to 44 *** evaluated health behavior.par.meter. using standar.ized tools,including the Consumer.Health Activation Index,the Gener.lized Anxiety Disor.er.questionnair.,the 12-Item Shor. For. Health Sur.ey,and wear.time of par.icipants categor.zed into thr.e age gr.ups:Gr.up 1(ages 50-60),Gr.up 2(ages 61-69),and Gr.up 3(ages 70-87).We per.or.ed statistical analysis using a mixedeffects r.peated measur.s linear.r.gr.ssion model to examine differ.nces amongst age *** Compar.tive analysis between Gr.ups 1,2 and 3 r.vealed no significant differ.nces in anxiety,patient activation,per.eption of physical health and wear.*** use of smar.watch technology was associated with a decr.ase in per.eption of mental health for.Gr.up 2 compar.d to Gr.up 1(β=-3.29,P=0.046).CONCLUSION Str.ke sur.ivor. demonstr.ted a willingness to use smar.watches for.AF ***,among these study par.icipants,the major.ty did not exper.ence negative health behavior.outcomes or.decr.ased engagement as age incr.ased.

关键词： pr.scr.bed str.tified wear

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Standar. Model Fer.ion Masses and Char.es fr.m Hologr.phic Analysis

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Jour.al of Moder. Physics 2024年第6期15卷 796-803页

作者： T. r. Mongan Sausalito CA USA

The Standar. Model of par.icle physics involves twelve fundamental fer.ions, tr.ated as point par.icles, in four.char.e states. However. the Standar. Model does not explain why only thr.e fer.ions ar. in each char.e state or.account for.neutr.no mass. This hologr.phic analysis tr.ats char.ed Standar. Model fer.ions as spher.s with mass 0.187 g/cm2 times their.sur.ace ar.a, using the pr.por.ionality constant in the hologr.phic r.lation between mass of the obser.able univer.e and event hor.zon r.dius. The analysis r.quir.s thr.e Standar. Model fer.ions per.char.e state and r.lates up quar. and down quar. masses to electr.n mass. Hologr.phic analysis specifies electr.n mass, to six significant figur.s, in ter.s of fundamental constants α,ℏ,G,Λ and Ω Λ . Tr.ating neutr.nos as spher.s and equating electr.n neutr.no ener.y density with cosmic vacuum ener.y density pr.dicts neutr.no masses consistent with exper.ment.

关键词： Electr.n Mass Up Quar. Mass Down Quar. Mass Neutr.no Masses

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Nucleotide Contr.bution to the Functioning of SEr., Na/K ATPase and GPCr.Pr.teins

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Jour.al of Biosciences and Medicines 2024年第5期12卷 61-76页

作者： Wynfor. r.ber. williams Faculty of Life Sciences & Education University of South Wales Cardiff UK

Pur.ne nucleotides ar. cr.cial for.the effective oper.tion of cell membr.ne pr.teins maintaining the neur.tr.nsmitter.r.sponses of 5-HT. Major.pr.tein tar.ets in the tr.atment of depr.ssion include SEr., N/K ATPase and GPCr. Each pr.tein tar.et is r.sponsive to a specific complement of dr.gs: antidepr.ssants (SEr.), lithium and car.iogenic ster.ids (N/K ATPase), 5-HT r.ceptor.ligands (GPCr.. Computational softwar. is useful for.compar.ng molecular.similar.ty within ligand-ligand and ligand-nucleotide str.ctur.s. Pr.vious studies demonstr.te that GPCr.ligands of differ.nt phar.acologic classes display r.lative molecular.similar.ty to nucleotide str.ctur.s. The cur.ent study applies this methodology to compound str.ctur.s modulating SEr. and N/K ATPase r.ceptor.. Minimum ener.y confor.er. of SEr. antagonists demonstr.te r.lative molecular.similar.ty to the str.ctur.l template of GTP nucleotide. GTP template fits of 5-HT and psilocin ar. similar. wher.as a SEr.-like fit is one of sever.l for.the ketamine str.ctur.. Endogenous and phar.aceutical modulator. of Na/K ATPase r.late to adenine nucleotide. The fits of car.iogenic ster.ids to a cGMP template demonstr.te similar.ties and differ.nces between compounds. r.lative molecular.similar.ty within the str.ctur.s of hor.ones, dr.gs and nucleotides has implications for.neur.tr.nsmitter.tr.nspor. and cell signal tr.nsduction pr.cesses.

关键词： SEr. SSr. GPCr Sodium/Potassium ATPase Nucleotides Depr.ssion

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Quantifying the Impact of In-Cab Aler.s on Tr.ck Speed r.ductions in Ohio

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Jour.al of Tr.nspor.ation Technologies 2024年第3期14卷 273-288页

作者： Jair.j Desai Jijo K. mathew Dar.y M. Bullock Lyles School of Civil Engineer.ng Purdue University West Lafayette IN USA

In-cab aler.s war. commer.ial vehicle dr.ver. of upcoming r.adway incidents, slowdowns and wor. zone constr.ction activities. This paper.r.por.s on a study evaluating the dr.ver.r.sponse to in-cab aler.s in Ohio. Dr.ver.r.sponse was evaluated by measur.ng the statistical tr.nds of vehicle speeds after.the in-cab aler.s wer. r.ceived. Vehicle speeds pr. and post in-cab aler. wer. collected over.a 47 day per.od in the fall of 2023 for.tr.cks tr.veling on inter.tate r.adways in Ohio. r.sults show that appr.ximately 22% of dr.ver. r.ceiving Danger.us Slowdown aler.s had r.duced their.speeds by at least 5 mph 30 seconds after.r.ceiving such an aler.. Segmenting this analysis by speed found that of vehicles tr.veling at or.above 70 mph at the time of aler.ing, 26% r.duced speeds by at least 5 mph. These speed r.ductions suggest dr.ver. taking actional measur.s after.r.ceiving aler.s. Futur. studies will involve fur.her.analysis on the impact of the types of aler.s shown, r.adway char.cter.stics and over.ll tr.ffic conditions on tr.ck speeds passing thr.ugh wor. zones.

关键词： In-Cab Aler.s Connected Tr.ck Data Dr.ver.Aler.s Danger.us Slowdowns

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Sickle cell r.tinopathy and systemic disease

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Annals of Eye Science 2024年第2期9卷 53-61页

作者： Oladipupo O.Anibir. Daniel ABr.ll Basil K.williams Jr Mehar.y Medical College NashvilleTNUSA Depar.ment of Ophthalmology University of Cincinnati College of MedicineCincinnatiOHUSA Cincinnati Eye Institute CincinnatiOHUSA Bascom Palmer.Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Sickle cell disease(SCD)is a widespr.ad hemoglobinopathy that r.sults in significant patient mor.idity and *** occlusion can cause acute pain,acute chest syndr.me,and avascular.necr.sis,while hemolysis and endothelial disr.ption can cause ischemic str.ke,leg ulcer.,pulmonar. hyper.ension,and *** ocular.and or.ital str.ctur.s can be affected by SCD ischemic events,including or.ital bone infar.tion,ischemic optic neur.pathy,r.tinal ar.er. occlusion,hyphema,secondar. glaucoma,sickle cell maculopathy,and sickle cell *** sickle cell r.tinopathy(PSr.is the most common cause of vision *** PSr.can lead to macular.ischemia,vitr.ous hemor.hage,and tr.ctional r.tinal *** scr.ening exams and multimodal imaging can lead to ear.ier.detection of sickle cell r.tinopathy and impr.ved patient *** patients under.oing vitr.or.tinal sur.er. may r.quir. coor.ination of car. with hematologists to avoid ischemic *** hydr.xyur.a was the only United States Food and Dr.g Administr.tion appr.ved tr.atment for.sever.l decades,patients with SCD now have sever.l mor. tr.atment *** the United States scr.ening all infants for.SCD,ther. can be delays in diagnosis and *** r.view ar.icle aims to pr.vide an over.iew of sickle disease for.the ophthalmologist,and to discuss emer.ing tr.atment options and cur.ent management of SCD ocular.complications.

关键词： Sickle cell anemia sickle cell disease(SCD) sickle cell r.tinopathy r.tinal detachment vitr.ous hemor.hage(VH)

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