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一种新的G6PD基因突变型的鉴定

海南医学院学报 2003年第1期9卷 1-3,7页

作者：蔡望伟周代锋蔡兰洁邝宇周玉英 Filosa Stefania martini Giuseppe 海南医学院生物化学教研室海口571101 Istituto Internazionale di Genetica e Biofisica

目的:鉴定1例葡萄糖-6-磷酸脱氢酶缺乏症患者的基因突变。方法:用聚合酶链反应、限制性内切酶筛查葡萄糖-6-磷酸酶基因1388G→A、1376G→T、1360C→T、1024C→T、592C→T、517T→C、493A→G,487G→A、392G→T、95A→G突变,用单链构象多... 详细信息

目的:鉴定1例葡萄糖-6-磷酸脱氢酶缺乏症患者的基因突变。方法:用聚合酶链反应、限制性内切酶筛查葡萄糖-6-磷酸酶基因1388G→A、1376G→T、1360C→T、1024C→T、592C→T、517T→C、493A→G,487G→A、392G→T、95A→G突变,用单链构象多态性筛查葡萄糖-6-磷酸脱氢酶基因的所有外显子,用核苷酸序列测定确定基因突变。结果:该患者未存在1388G→A、1376G→T、1360C→T、1024C→T、592C→T、517T→C、493A→G、487G→A、392G→T、95A→G突变,但在外显子8发现了一种新的G6PD基因突变———835A→G突变,此突变导致第279位的苏氨酸被丙氨酸取代,将其命名为G6PD-海口,其酶活性约是正常的10%,比835A→T突变型的活性低,后者的酶活性约是正常的40%;分析人G6PD的三维结构模型表明,第279位苏氨酸残基的羟基对于维持G6PD亚基的相互作用具有非常重要的作用。结论:835A→G突变是一种新的G6PD基因突变型,G6PD的第279位苏氨酸残基的羟基是维持G6PD亚基相互作用及酶活性的必需基团。

关键词：葡萄糖-6-磷酸脱氢酶葡萄糖-6-磷酸脱氢酶缺乏症聚合酶链反应三雏结构模型

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探地雷达(GPR)在海岸环境勘测中的应用

海洋地质与第四纪地质 2001年第2期21卷 99-105页

作者：唐文武朱大奎葛晨东蒋松柳 IPeter martini 南京大学海岸与海岛开发国家试点实验室南京210093 University of Guelph OntarioCanadaN1E4E5

探地雷达 (Ground Penetrating Radar,简称 GPR)是目前很有潜力的一种探测浅地层内部结构的地球物理探测技术。 GPR依靠高频电磁脉冲的发射、传播、反射和接收过程可以快速高效地产生连续地层剖面的雷达图像。通过对雷达图像的处理和解... 详细信息

探地雷达 (Ground Penetrating Radar,简称 GPR)是目前很有潜力的一种探测浅地层内部结构的地球物理探测技术。 GPR依靠高频电磁脉冲的发射、传播、反射和接收过程可以快速高效地产生连续地层剖面的雷达图像。通过对雷达图像的处理和解译 ,可以重建测量地区地层的构造特征 ,满足工程勘测与环境演变研究的需要。在日益增长的地球科学研究和工程勘测方面。

关键词：探地雷达海岸环境中国海南岛工作原理工程勘测雷达图像处理

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亚临床甲状腺疾病临床应用

美国医学会杂志（中文版） 2005年第2期24卷 121-124页

作者： NanandaF.Col,MD,MPP,MPH martini.Surks,MD GilbertH.Daniels,MD 王东冷希圣不详 DivisionofWomen＇sHealthandDepartmentofMedicine HarvardMedicalSchoolBrighamandWomen＇sHospitalBostonMass DepartmentofMedicineandPathology MontefioreMedicalCenterandtheAlbertEinsteinCollegeofMedicineBronxNY ThyroidUnitandDepartmentofMedicine MassachusettsGeneralHospitalHarvardMedicalSchoolBoston

亚临床甲状腺功能低下和亚临床甲状腺功能亢进是根据实验室检查做出诊断的。此时患者尚未出现明显的临床症状或体征。亚临床甲状腺功能低下是指血清促甲状腺激素(thyroid-sthnulating hormone，TSH)水平超过正常值上限(O．45—4．5mIU... 详细信息

亚临床甲状腺功能低下和亚临床甲状腺功能亢进是根据实验室检查做出诊断的。此时患者尚未出现明显的临床症状或体征。亚临床甲状腺功能低下是指血清促甲状腺激素(thyroid-sthnulating hormone，TSH)水平超过正常值上限(O．45—4．5mIU／L)而血清游离T4(FT4)浓度正常；亚临床甲状腺功能亢进则是指血清TSH水平低于正常值。而血清。FT4和T4浓度正常。虽然这些状况见于甲状腺功能异常的最早期阶段。但是诊断并治疗亚临床甲状腺疾病的益处还无定论。大多数发现患有亚临床甲状腺疾病的患者其TSH水平介于0．1—0．45mIU／L或4．5—10mIU／L之间，对其进行治疗的价值还未确定；但是对血清TSH低于0．1mIU／L或高于10mIU／L的患者进行治疗可能是有益的。本文应用循证医学手段通过5个案例分析。说明了亚临床甲状腺功能低下或亢进的处理。由于对亚临床甲状腺功能低下及亢进不予治疗的后果以及给予治疗的好处均不明确。因此对此类亚临床疾病的治疗重点是充分征求患者的意见。

关键词：亚临床甲状腺疾病亚临床甲状腺功能低下亚临床甲状腺功能亢进临床应用甲状腺功能异常 TSH水平促甲状腺激素实验室检查正常值上限血清TSH 临床症状血清游离 T4浓度早期阶段案例分析循证医学临床疾病患者 FT4

疑似冠心病病人CT冠状动脉成像的预后价值:24个月随访研究

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国际医学放射学杂志 2009年第5期32卷 506-507页

作者： A.Aldrovandi E.Maffei A.Palumbo S.Seitun C.martini V.Brambilla 王鹤 Department of Radiology c/o Piastra Tecnica-Piano 0CT SectionAzienda Ospedaliero-Universitaria di Parmavia Gramsci1443100 ParmaItaly

本研究的目的是评价64层CT冠状动脉成像（CTCA）对疑似冠心病（CAD）病人主要心脏事件的预期价值。共有187例无心脏病史的临床疑似CAD病人[男性119例，年龄（62．5±10．5）岁1应用单源64层CT（Somatom Sensation 64，Siemens）行冠状... 详细信息

本研究的目的是评价64层CT冠状动脉成像（CTCA）对疑似冠心病（CAD）病人主要心脏事件的预期价值。共有187例无心脏病史的临床疑似CAD病人[男性119例，年龄（62．5±10．5）岁1应用单源64层CT（Somatom Sensation 64，Siemens）行冠状动脉成像检查，187例为连续病例。对上述病人的随访内容包括心源性死亡、非致死性心肌梗死、不稳定型心绞痛及心脏血管重构的发生情况。

关键词： CT冠状动脉成像预后可疑冠心病程序价值中期

Predicting Mortality and Functional Outcomes after Ischemic Stroke: External Validation of a Prognostic Model

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Journal of Behavioral and Brain Science 2018年第10期8卷 587-597页

作者： Achala Vagal Heidi Sucharewv Christopher Lindsell Dawn Kleindorfer Kathleen Alwell Charles J. Moomaw Daniel Woo Matthew Flaherty Pooja Khatri Opeolu Adeoye Simona Ferioli Jason Mackey Sharyl martini Felipe De Los Rios La Rosa F. Brett Kissela Departments of Radiology University of Cincinnati Medical Center Cincinnati OH USA Department of Biostatistics and Epidemiology Cincinnati Children’s Hospital Cincinnati OH USA Department of Emergency Medicine University of Cincinnati Medical Center Department of Neurology Cincinnati OH USA University of Cincinnati Medical Center Cincinnati OH USA Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA Baylor College of Medicine Baptist Health Neuroscience Center Miami Florida USA

Background: We previously developed predictive models for 3-month mortality and modified Rankin Score (mRS) after ischemic stroke. Aim: The aim was to test model validity for 3-month mortality and mRS after ischemic stroke in two independent data sets. Methods: Our derivation models used data from 451 subjects with ischemic stroke in 1999 enrolled in the Greater Cincinnati/Northern Kentucky Stroke Study (GCKNSS). We utilized two separate cohorts of ischemic strokes through GCKNSS (460 in 2005 and 504 in 2010) to assess external validity by utilizing measures of agreement between predicted and observed values, calibration, and discrimination using Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis. Results: The 3-month mortality model performed well in the validation datasets with an average prediction error (Brier score) of 0.045 for 2005 and 0.053 for 2010 and excellent discrimination with an area under the curve of 0.86 (95% CI: 0.79, 0.93) for 2005 and 0.84 (0.76, 0.92) for 2010. Predicted 3-month mRS also performed well in the validation datasets with R2 of 0.57 for 2005 and 0.50 for 2010 and a root mean square error of 0.85 for 2005 and 1.05 for 2010. Predicted mRS tended to be higher than actual in both validation datasets. Re-estimation of the model parameters for age and severe white matter hyperintensity in both 2005 and 2010, and for diabetes in 2005, improved predictive accuracy. Conclusions: Our previously developed stroke models performed well in two study periods, suggesting validity of the model predictions.

关键词： Ischaemic Stroke Epidemiology Stroke Leukoaraiosis African American Stroke Prevalence

冠状动脉CTA在钙化积分为0分的病人中的诊断精确性

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国际医学放射学杂志 2010年第2期 190-191页

作者： F.Cademartiri E.Maffei A.Palumbo C.martini S.Seitun C.Tedeschi 金涵弢 Department of Radiology Azienda Ospedaliero-Universitaria-Parmac/o Piastra Tecnica-Piano 0Via Gramsci1443100 ParmaItaly

本研究主要目的是评价64层CT冠状动脉成像(CTCA)在Agatston钙化评分(CACS)为0分的病人中检测出有明显冠状动脉狭窄的诊断正确性。我们收集了279个怀疑有冠状动脉

关键词：病人无症状 CAG 冠状动脉狭窄 CTCA CTA

Radiology科学论著摘要（2010年7月、8月杂志）

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国际医学放射学杂志 2010年第5期33卷 470-492页

作者： J.M.Van Werkhoven F.Cademartiri S.Seitun E.Maffei A.Palumbo C.martini 吴海军 Departments of Radiology and Cardiology Azienda Ospedaliero-Universitaria di Parma

扩散加权成像提高常规3．0TMRI诊断乳腺病变的准确性,1996年-2004年放射学家在基于社区乳腺癌监测联盟的乳腺X线摄影筛查中解释性能随时间变化趋势。

关键词：冠状动脉血管成像非糖尿病人群摘要论著科学杂志扩散加权成像乳腺X线摄影

Importance of Primary Health Care in Medicine: Simultaneous Analysis of Two Colleges, under the Vision of Teachers and Students

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Journal of Biosciences and Medicines 2017年第11期5卷 6-12页

作者： Sebastiao Celio Horta Coelho Filho Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Mateus de Oliveira Reis Bruna Sande Miguel Vinicius Sande Miguel Aline Gabriela Santos Costa Lilian Costa Brito Bruno Fonseca dos Santos Veronica Clemente Villar martini Daniel Almeida da Costa The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Introduction: The involvement of undergraduate student at the beginning of their training in activities based on Primary Health Care (PHC), provides preventive and health promoting actions, and ensures the evaluation of the vulnerability of communities and people. Objectives: To analyze the opinion of students and teachers of two medicine higher education institutions on the relevance of Primary Health Care in this course. METHODS: Students and teachers should be effectively enrolled in order for the study to be conducted, being chosen in a random manner and without interferences on the part of the researchers so that the work was as reliable as possible. A cross-sectional study was conducted with interviews structured in questionnaires about what they thought about PHC. To some students and teachers of the medical course of Valen?a and Grande Rio University (UNIGRANRIO). Before receiving the questionnaire, all interviewed signed a Free and Informed Consent Term, which included the objectives and methodology of the work. Results: 310 students and 51 teachers participated in the study, where 91.43% of the students and 100% of the teachers affirmed that primary care plays a fundamental role in medical education. 94.86% of students and 97.91% of teachers, claimed that the discipline allows a greater contact between undergraduates and community. When questioned about the encouragement that teachers give to students to pursue a career in PHC, 57.87% of the students and 70.83% of the professors said they lacked in such a stimulus. Conclusion: PHC is still very neglected by governmental policies, educational institutions and by the own teachers, that often, turn they attention only to tertiary medicine and, as a consequence, a discouragement of this area occur. Therefore, a higher PHC value is necessary, allowing a more humane look at the patient, valuing their feelings, anguishes and their pathological framework.

关键词： Primary Health Care Graduation Medicine

高危无症状人群冠状动脉钙化积分和CT冠状动脉血管成像评价非阻塞性冠状动脉疾病诊断准确性和患病率的对照研究

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国际医学放射学杂志 2010年第3期 300-301页

作者：刘静红 F. Cademartiri E. Maffei A. Palumbo S. Seitun C. martini C. Tedeschi Department of Radiology and Cardiology Azienda Ospedaliero-Universitaria

摘要目的对比研究冠状动脉钙化积分(CACS)和CT冠状动脉血管成像(CTCA)在评价高危无症状人群非阻塞性/阻塞性冠状动脉

关键词：冠状动脉血管成像 CT 冠状动脉疾病阻塞性冠状动脉钙化积分无症状患病率