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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodule<3,and 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

Cold acclimation increases Asian citrus psyllid Diaphorina citri (Hemiptera: Liviidae) survival during exposure to freezing temperatures

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Insect Science 2022年第2期29卷 531-538页

作者： Xavier martini Kathi Malfa Dara Stockton Monique JRivera Department of Entomology and Nematology North Florida Research and Education CenterQuincyFloridaUSA USDA-ARS U.S.Pacific Basin Agricultural Research CenterHiloHawaiiUSA Department of Entomology University of CaliforniaRiversideCaliforniaUSA

The Asian citrus psyllid,Diaphorina citri,is the vector of the pathogenic bacteria that causes Huanglongbing,the most devasting disease affecting citrus *** cultivation of citrus tends to expand northward,the tolerance of psyllids to freezing temperatures needs to be *** mortality of *** to cold temperature has been previously studied,much less is known regarding the acclimation potential of psyllids to cold *** first evaluated cold resistance of *** depending on color morph and ***,we compared mortality of *** at−4°C for 10 hours between unacclimated psyllids,psyllids that were gradually acclimated to cold over 1 or 2 weeks,and psyllids intermittently acclimated also for 1 or 2 *** did not find major differences in cold resistance between color morphs and *** found that after 1 week of gradual acclimation,the survival of psyllids at−4°C increased to 86%,compared to 20%in the control *** did not increase after the second week of gradual *** intermittent acclimation improved survival compared to the control group,it was less effective than gradual acclimation with a survival at 30%and 70%after 1 and 2 weeks of acclimation,respectively,although this difference with gradual acclimation was not significant at week *** data show that gradual cold acclimation allows *** to survive brief periods below *** may serve as a mechanism responsible for increasing northern establishment of this pest.

关键词： cold acclimation cold hardy citrus cold resistance citrus greening Diaphorina citri overwintering

Clinical challenges of glycemic control in the intensive care unit:A narrative review

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World Journal of Clinical Cases 2022年第31期10卷 11260-11272页

作者： Roshni Sreedharan Adriana martini Gyan Das Nida Aftab Sandeep Khanna Kurt Ruetzler Anesthesiology Institute Cleveland ClinicClevelandOH 44195United States

Glucose control in patient admitted to the intensive care unit has been a topic of much debate over the past 20 *** harmful effects of uncontrolled hyperglycemia and hypoglycemia in critically ill patients is well *** a large clinical trial in 2001 demonstrated significant mortality and morbidity benefits with tight glucose control in this patient population,the results could not be replicated by other ***“Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation”trial in 2009 established that tight glucose control was not only of no benefit,but in fact harmful due to the significant risk of *** current guidelines suggest a moderate approach with the initiation of intravenous insulin therapy in critically ill patients when the blood glucose level is above 180 mg/*** most important factor that underpins glycemic management in intensive care unit patients is the consequent prevention of *** glucose monitoring strategies and insulin protocols need to be implemented in order to achieve this goal.

关键词： Diabetes management Intensive care unit Anesthesiology

Slow degrading Mg-based materials induce tumor cell dormancy on an osteosarcoma-fibroblast coculture model

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Bioactive Materials 2022年第10期7卷 320-333页

作者： Philipp Globig Regine Willumeit-Römer Fernanda martini Elisa Mazzoni Berengere J.CLuthringer-Feyerabend Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon21502GeesthachtGermany Department of Medical Sciences University of Ferrara44121FerraraItaly

Osteosarcoma is one of the most common cancers in young adults and is commonly treated using surgery and *** the past years,these therapy approaches improved but failed to ameliorate the ***,novel,targeted therapeutic approaches should be established to enhance treatment success while preserving patient’s quality of *** studies suggest the application of degradable magnesium(Mg)alloys as orthopedic implants bearing a potential antitumor ***,we examined the influence of Mg-based materials on an osteosarcoma-fibroblast ***,Mg and Mg-6Ag did not lead to tumor cell apoptosis at low degradation ***,the Mg-based materials induced cellular dormancy in the cancer cells indicated by a lower number of Ki-67 positive cancer cells and a higher p38 *** dormancy-like state could be reversed by reseeding on non-degrading glass slides but could not be provoked by inhibition of the protein kinase R-like endoplasmic reticulum *** investigating the influence of the disjunct surface-near effects of the Mg degradation on cell proliferation,an increased pH was found to be a main initiator of Mg degradation-dependent tumor cell proliferation inhibition.

关键词： Cancer Magnesium degradation Ki-67 Proliferation inhibition pH Alkalization

Role of platelet-rich plasma in the treatment of rotator cuff tendinopathy

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World Journal of Orthopedics 2023年第7期14卷 505-515页

作者： Ausberto Velasquez Garcia Liborio Ingala martini Andres Franco Abache Glen Abdo Department of Orthopedic Surgery Clínica Universidad de los AndesSantiago 7620157Chile Department of Orthopedic Surgery Hospital IVSS Dr.Luis OrtegaPorlamar 6301Venezuela Department of Orthopedic Surgery Hospital Clinicas del EsteLos Robles 6301Venezuela Department of Orthopedic Surgery Hospital de Especialidades Guayaquil MSPGuayaquil 090101Ecuador Department of Graduate Medical Education Internal Medicine Residence ProgramNew York Medical College at St.Mary’s and St.Clare’sPassaicNJ 07055United States

Shoulder pain is a common musculoskeletal complaint,and rotator cuff(RC)pathologies are one of the main *** RC undergoes various tendinopathic and avascular changes during the aging *** degenerative changes affecting its healing potential make it an appealing target for biological ***-rich plasma(PRP)has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators,and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle,ligaments,and tendinous *** review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical *** to the different characteristics and conflicting outcomes,clinicians should use PRP with moderate expectations until more consistent evidence is ***,it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate *** autologous origin makes it a safe treatment,and its characteristics make it a promising option for treating RC tendinopathy,but the efficacy has yet to be established.

关键词： Rotator cuff Tendinopathy Platelet-rich plasma Shoulder pain Nonoperative treatment Injectables

Wunderlich syndrome,an unexpected urological complication in a patient with coronavirus disease 2019(COVID-19):A case report

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Current Urology 2022年第2期16卷 74-76页

作者： Fabrizio Presicce Marco martini Francesco Minisola Cristina Falavolti Alessio Filianoti Department of Urology San Filippo Neri HospitalRome00135Italy

We describe the first case of Wunderlich syndrome as a hemorrhagic complication in a patient with severe acute respiratory syndrome coronavirus 2 infection and acute respiratory distress *** possible underlying pathophysiological mechanisms have been extensively *** management included selective angioembolization of the upper polar arterial branches of the left kidney and discontinuation of *** patient was discharged after 18 *** other localizations or local recurrence of bleeding occurred during the *** report suggests a broad spectrum of clinical manifestations in patients with coronavirus disease *** observed in our clinical case,in addition to thrombotic complications,bleeding is a significant cause of morbidity in coronavirus disease 2019 *** studies should determine whether these urological bleeding sequelae are a direct manifestation of the infection or an indirect effect of thromboprophylaxis.

关键词： Bleeding Coagulopathy Coronavirus disease 2019 Interventional radiology Wunderlich syndrome

Mg-based materials diminish tumor spreading and cancer metastases

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Bioactive Materials 2023年第1期19卷 594-610页

作者： Philipp Globig Roshani Madurawala Regine Willumeit-Römer Fernanda martini Elisa Mazzoni Bérengère J.C.Luthringer-Feyerabend Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon GmbH21502GeesthachtGermany Department of Medical Sciences University of Ferrara44121FerraraItaly

Cancer metastases are the most common causes of cancer-related *** formation of secondary tumors at different sites in the human body can impair multiple organ function and dramatically decrease the survival of the *** this stage,it is difficulty to treat tumor growth and spreading due to arising therapy ***,it is important to prevent cancer metastases and to increase subsequent cancer therapy *** metastases are conventionally treated with radiation or ***,these treatments elicit lots of side effects,wherefore novel local treatment approaches are currently *** studies already showed anticancer activity of specially designed degradable magnesium(Mg)alloys by reducing the cancer cell *** this work,we investigated the impact of these Mg-based materials on different steps of the metastatic cascade including cancer cell migration,invasion,and cancer-induced ***,Mg and Mg-6Ag reduced cell migration and invasion of osteosarcoma cells in coculture with ***,the Mg-based materials used in this study diminished the cancer-induced *** cells incubated with conditioned media obtained from these Mg and Mg-6Ag showed a reduced cell layer permeability,a reduced proliferation and inhibited cell *** tube formation as a last step of angiogenesis was stimulated with the presence of Mg under normoxia and diminished under hypoxia.

关键词： Cancer Osteosarcoma Magnesium degradation Cell migration Cell invasion Angiogenesis

Year-round multi-scale habitat selection by Crested Tit(Lophophanes cristatus)in lowland mixed forests(northern Italy)

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Avian Research 2022年第4期13卷 461-467页

作者： Alessandro Berlusconi Alessio Martinoli Lucas AWauters Giulia Tesoro Stefania martini Erminio Clerici Gualtiero Guenzani Gabriele Pozzi Diego Rubolini Michelangelo Morganti Adriano Martinoli Environment Analysis and Management Unit-Guido Tosi Research Group-Department of Theoretical and Applied Sciences Universita degli Studi dell’InsubriaVia J.H.Dunant 321100VareseItaly CNR-IRSA National Research Council–Water Research Institute Via del Mulino 1920861BrugherioMBItaly Gruppo Insubrico di Ornitologia c/o Civico Museo Insubrico di Storia Naturale di Clivio e Induno OlonaVia Manzoni21050ClivioVAItaly Parco Pineta di Appiano Gentile e Tradate Via Alessandro Manzoni1122070Castelnuovo BozzenteCOItaly e Dipartimento di Scienze della Vita Biologia dei Sistemi Universita degli Studi di TorinoVia Accademia Albertina 1310123TurinItaly Conservation Department LIPU-Birdlife Italia Via Udine 3/a43122ParmaItaly Department of Environmental Science and Policy Universita degli Studi di MilanoVia Celoria 2620122MilanItaly

Determining how animals respond to resource availability across spatial and temporal extents is crucial to understand ecological processes underpinning habitat ***,we used a multi-scale approach to study the year-round habitat selection of the Crested Tit(Lophophanes cristatus)in a semi-natural lowland woodland of northern Italy,analysing different habitat features at each *** performed Crested Tit censuses at three different spatial *** the macrohabitat scale,we used geolocalized observations of individuals to compute Manly's habitat selection index,based on a detailed land-use map of the study *** the microhabitat scale,the trees features were compared between presence and absence *** the foraging habitat scale,individual foraging birds and their specific position on trees were recorded using focal animal *** were performed during both the breeding(March to May)and wintering(December to January)*** the macrohabitat scale,the Crested Tits significantly selected pure and mixed pine forests and avoided woods of alien plant species,farmlands and urban *** the microhabitat scale,old pine woods with dense cover were selected,with no significant difference in the features of tree selection between the two phenological *** the foraging habitat scale,the species was observed spending more time foraging in the canopies than in the understorey,using mostly the portion of Scots Pine(Pinus sylvestris)canopies closer to the trunk in winter,while during the breeding period,the whole canopy was ***,breeding and wintering habitats largely overlapped in the Crested *** on our findings,lowland Crested Tits can be well defined as true habitat specialists:they are strictly related to some specific coniferous woodland ***,compared to other tit species,which normally show generalist habits during winter,the Crested Tit behaves as a habitat specialist also out of the breeding ***

关键词： Crested tit Functional response Habitat selection Multi-scale approach Scots pine

Essentials of anatomy & physiology / Frederic H. martini, Edwin F. Bartholomew .

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