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Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

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Advances in Alzheimer's Disease 2013年第1期2卷 1-6页

作者： Jolanta Dorszewska Jolanta Florczak-Wyspianska Anna Oczkowska mateusz dezor Michal Prendecki Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical SciencesPoznanPoland

Alzheimer’s disease (AD) is accompanied by elevated levels of homocysteine (Hcy). Homocysteine may induce elevated concentration of asymmetric dimethylarginine (ADMA). Both Hcy and ADMA are the amino acids thought to represent risk factors of vascular diseases. Studies were conducted on the plasma levels of Hcy and methionine (Met), estimated by HPLC with electrochemical detection, as well as on levels of ADMA and arginine (Arg), estimated by HPLC with fluorescent detection, in the AD patients with benign through to severe dementia estimated by MMSE scale and in a control group. The studies disclosed elevated levels of Hcy and ADMA in AD (Hcy, p < 0.001) as compared to controls, as well as in subjects older than 60 years of age (Hcy, p < 0.01). The AD patients with severe dementia have shown elevated levels of Hcy (p < 0.05) as compared to the patients with moderate dementia. The concentration of Metand Arg showed a downward trend in AD patientswith severe dementia. The highest levels of ADMA have been demonstrated in AD patients in the early stages of the disease. In parallel, in AD with varying degrees of dementia and subjects older than 60 years of age a disturbed turnover was observed of Hcy to Met and of Arg to ADMA. Similarly to Hcy, ADMA seems to be a potential risk factor of AD and important factor for progress of dementia.

关键词： Homocysteine ADMA Dementia Alzheimer’s Disease

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Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease 2014年第1期3卷 24-32页

作者： Jolanta Dorszewska Agata Rozycka Anna Oczkowska Jolanta Florczak-Wyspianska Michal Prendecki mateusz dezor Izabela Postrach Pawel P.Jagodzinski Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Department of Biochemistry and Molecular Biology Poznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical Sciences10Fredry Str.61-701 PoznanPoland

Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.

关键词： TP53 8-oxo2dG p53 OGG1 AD

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Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

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Advances in Alzheimer's Disease（阿尔茨海默氏病研究进展） 2013年第1期

作者： Jolanta Dorszewska Jolanta Florczak-Wyspiańska Anna Oczkowska mateusz dezor Michał Prendecki Wojciech Kozubski Laboratory of Neurobiology Department of Neurology Poznan University of Medical Sciences Chair and Department of Neurology Poznan University of Medical Sciences

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Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease（阿尔茨海默氏病研究进展） 2014年第1期

作者： Jolanta Dorszewska Agata Ró？ycka Anna Oczkowska Jolanta Florczak-Wyspiańska Micha？ Prendecki mateusz dezor Izabela Postrach Pawe？ P. Jagodzinski Wojciech Kozubski

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