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Pro-fertility effect of Ficus carica fruit extract in streptozotocin-induced male rats

Asian pacific Journal of Reproduction 2024年第1期13卷 34-41页

作者： mat Noor Mahanem Subramaniam Puvaratnesh AbuBakar Umarqayum Shamsusah Nadia A Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Institute of Biological Sciences Faculty of ScienceUniversity Malaya50603 Kuala LumpurMalaysia Department of Earth Sciences and Environment Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

Objective:To explore the impact of Ficus carica fruit aqueous extract on fertility parameters in streptozotocin(STZ)-induced male ***:Twenty-four male Sprague-Dawley rats were divided into four different *** groups except a normal control group were induced with 50 mg/kg of streptozotocin(STZ)intravenously to induce diabetes.A positive control group was treated with an antidiabetic drug,metformin(500 mg/kg)whereas a negative control group remained untreated throughout the ***,another diabetic rat group received treatment with 400 mg/kg of aqueous Ficus carica fruit *** in the treatment group were administered Ficus carica fruit aqueous extract daily through forcefeeding via oral gavage for a 21-day *** included the sperm quality(count,motility and morphology),histology of the testes,serum testosterone and fasting blood glucose(FBG)***:The FBG level of the Ficus carica-treated rats exhibited a significant decrease compared to the negative control group(Py analysis also indicated that the aqueous Ficus carica extract had significant positive effects on sperm count and motility(Py of the testes in Ficus caricatreated rats revealed an improved cell arrangement in the germinal cell ***,serum testosterone level showed an increment in the Ficus carica treatment group in comparison to the negative control ***:Our findings provide compelling evidence for the profertility and anti-hyperglycemic properties of aqueous Ficus carica fruit extract in diabetic-induced male rats.

关键词： Ficus carica fruit Male fertility parameter Diabetes mellitus Anti-hyperglicemic

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Virtual Transmission Solution Based on Battery Energy Storage Systems to Boost Transmission Capacity

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 466-474页

作者： matías Agüero Jaime Peralta Eugenio Quintana Victor Velar Anton Stepanov Hossein Ashourian Jean Mahseredjian Roberto Cárdenas Coordinador Eléctrico Nacional SantiagoChile PGSTech Montreal Canada Ecole Polytechnique de Montréal Montréal Canada University of Chile Santiago Chile IEEE

The increasing penetration of variable renewable energy(VRE)generation along with the decommissioning of conventional power plants in Chile,has raised several operational challenges in the Chilean National Power Grid(NPG),including transmission congestion and VRE *** mitigate these limitations,an innovative virtual transmission solution based on battery energy storage systems(BESSs),known as grid booster(GB),has been proposed to increase the capacity of the main 500 kV corridor of the *** paper analyzes the dynamic performance of the GB using a wide-area electromagnetic transient(EMT)model of the *** GB project,composed of two 500 MVA BESS units at each extreme of the 500 kV corridor,allows increasing the transmission capacity for 15 min during N-1 contingencies,overcoming transmission limitations under normal operation conditions while maintaining system stability during *** dynamic behavior of the GB is also analyzed to control power flow as well as voltage *** results show that the GB is an effective solution to allow greater penetration of VRE generation while maintaining system stability in the NPG.

关键词： Battery energy storage system(BESS) grid booster transient stability voltage stability electromagnetic transient(EMT)

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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

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Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： yolanda Diz-Chaves Zainab Maastor Carlos Spuch José Antonio Lamas Lucas C.González-matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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Growth performance,fatty acid profile,gut,and muscle histo-morphology of Malaysian mahseer,Tor tambroides post larvae fed short-term host associated probiotics

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Aquaculture and Fisheries 2024年第1期9卷 35-45页

作者： Mohammod Kamruzzaman Hossain Sairatul Dahlianis Ishak Shumpei Iehata mat Noordin Noordiyana Md Abdul Kader Ambok Bolong Abol-Munafi Department of Fisheries(DoF) Matshya BhabonRamnaDhaka1000Bangladesh Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia TerengganuKuala Nerus21030Malaysia Faculty of Fisheries and Food Sciences Universiti Malaysia TerengganuKuala Nerus21030Malaysia Alternative Aquatech Victoria3029Australia

Host associated probiotics(HAPs)provide health benefits to the host when administered as dietary ***,a short-term probiotics application strategy has yet to be optimized.A 90-days study was conducted to evaluate the response of Malaysian mahseer,Tor tambroides post larvae fed with basal diet enriched HAPs for 30-days,and its response following another 60-days feeding with only basal *** experimental diets(Enterococcus faecalis strain 2674(T1),Aeromonas *** A8-29(T2)and *** strain FC11682(T3))were prepared by spray-coating each HAPs on a basal diet at 1×108 CFU/g *** in growth performances,whole-body proximate and fatty acid composition,muscle morphometry,and gut morphology were *** showed that after 30 days,T3 fish produced highest *** HAP treatment groups showed better muscle distribution profile,improved fatty acid composition,and higher villus length,width and area,than control *** 90 days,the growth of T3 fish was still the *** distribution profile and villus growth were higher in HAP treatments,although only total n-6 PUFA,total MUFA,linoleic acids,and linolenic acids in HAP treated fish remained high after probiotics *** difference in whole-body proximate composition was observed in both 30 and 90 *** findings demonstrated that short-term application of HAPs at an early stage could be used to boost *** growth,with *** strain FC11682 showing the best efficacy.

关键词： Enhance culture Enterococcus faecalis Aeromonas sp. Muscle hypertrophy Short-term feeding Tor tambroides

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The effects of mixed prebiotics in aquaculture:A review

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Aquaculture and Fisheries 2024年第1期9卷 28-34页

作者： Wendy Wee Noor Khalidah Abdul Hamid Khairiyah mat Raja Ili Airina Raja Khalif Nor Dini Rusli Mohammad Mijanur Rahman Muhammad Anamul Kabir Lee Seong Wei Centre for Foundation and Continuing Education Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia School of Biological Sciences Universiti Sains Malaysia11800MindenPulau PinangMalaysia Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia Faculty of Fisheries Sylhet Agricultural UniversitySylhet3100Bangladesh

Aquaculture industry contributes significant aquaculture species production to meet fish protein demand from the *** industry is gearing towards intensification to increase more production in the near *** technologies and efforts were introduced into aquaculture industry to bring it up to the next higher ***,the development of aquaculture industry is hindered by disease *** a result,excessive use of antibiotics and chemicals were applied to reduce or minimize risk of disease outbreak in aquaculture farming ***,aquacultures products and environment were highly exposed to these antibiotics and *** resolve this issue,fish farmers were encouraged to utilize alternative method in aquaculture species health *** has become a new approach in aquaculture industry to maintain aquaculture species health and a good environment at the same time produce chemical and antibiotic-free aquaculture *** this review paper,we summarize and discuss the effects of prebiotic mixtures administration on growth performance,immune response,disease resistance,and tolerance against abiotic stressors of aquatic animals.

关键词： Growth performance Immunosaccharide Disease resistance Stress relieve

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Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad Ibrahim Devinder Kaur Ajit Singh Arimi Fitri mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

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Quran memorisation and heart rate variability:How do they correlate?

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World Journal of Clinical Cases 2024年第29期12卷 6275-6284页

作者： Ahmad Rohi Ghazali Nor Malia Abd Warif Noor Anisah A yazit Norsham Juliana Ismarulyusda Ishak Farah Wahida Ibrahim Arimi Fitri mat Ludin Dzalani Harun Santibuana Abd Rahman Wan Nor Atikah Che Wan Mohd Rozali Biomedical Science Programme Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Center for Toxicology and Health Risk Studies Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaNilai 71800Malaysia Center for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Center for Rehabilitation and Special Needs Studies Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Occupational Therapy Programme Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Pharmacy and Health Sciences Universiti Kuala Lumpur Royal College of Medicine PerakIpoh Perak 30450Malaysia

BACKGROUND Heart rate variability(HRV)was shown to be affected by performing religious *** To examine the relationship between the level of Quran(the holy book of Muslims)memorisation and HRV among *** This experimental study included 16 Tahfiz students and 16 non-Tahfiz students(n=32).The HRV was measured in three tasks:Recalling familiar verses,memorising new verses,and recalling the newly memorised verses of the *** analysis was done using these parameters:Standard deviation of N-N(heartbeat peak)interval;low frequency(LF);high frequency(HF)and LF/HF *** There were significant differences between tasks for all parameters(Py the LF/HF ratio had significant differences,with F=5.04,Py could be developed as an effective sympathovagal modulation training activity.

关键词： Heart rate variability Autonomic nervous system Quran memorisation Tahfiz student Heartbeat

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Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 384-391页

作者： AbdulRahman Muthanna Mohd Nasir Mohd Desa Nurul Asyikin Abdul Rahman Nurul Diana Dzaraly Nurul Hana Zainal Baharin Nur Afiza Aziz Chua Hui Shan Zalina Ismail Lailatul Akmar mat Nor Marlindawati Mohd Ali Nur Hanani Ahmad Mohammad Noor Amal Azmai Syafinaz Amin-Nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARANegeri Sembilan72000 Kuala PilahMalaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA University42610 JenjaromSelangorMalaysia School of Bioscience Faculty of Pharmacy and Biomedical SciencesMAHSA University42610 JenjaromSelangorMalaysia Department of Pathology Sultanah Aminah Hospital80100 Johor BahruJohorMalaysia Department of Pathology Melaka General Hospital75400 MelakaMalaysia Department of Medical Microbiology and Immunology Faculty of MedicineUniversiti Kebangsaan Malaysia56000 CherasKuala LumpurMalaysia Department of Pathology Sultan Idris Shah Serdang Hospital43000 KajangSelangorMalaysia Department of Pathology Tuanku Ja'afar Hospital70300 SerembanNegeri SembilanMalaysia Department of Pathology Sungai Buloh Hospital47000 Sungai BulohSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia

Objective:To address the lack of research on invasive group B Streptococcus(GBS)infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from ***:Medical records from patients with GBS infection isolated from the sterile site,such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020,were reviewed from six major hospitals in Peninsular *** criteria were invasive GBS,sterile sites and non-repeated GBS isolated from the same patients in the same *** isolates were re-identified for GBS and ***:A total of 118 patients were eligible,with a majority of non-pregnant adults(76.3%).Over half of the patients(62.7%)had underlying medical conditions,with diabetes as the most common disease,followed by respiratory disease,renal disease,cardiovascular disease and skin and soft tissue *** most common manifestations were sepsis,followed by soft tissue abscess,diabetic foot ulcer,wet gangrene and *** overall mortality was 7.6%.The most common serotype was serotype桋.Conclusions:Invasive GBS infection among non-pregnant adults showed a rising trend,particularly among diabetic *** study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

关键词： Streptococcus agalactiae Group B Streptococcus Invasive GBS infections Malaysia

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Physiotherapy Management of Rheumatic Diseases

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第1期14卷 37-47页

作者： Aly Badra Kamissoko Abdoulaye Barry Mamadou Lamine Diallo Boutros Cosme Nato Abdel Amide Gbadamassi Marie Traore Abèni Faouzyath yaya Facely Traore Paul Eloundou Sory Diane matènè Komara Halimatou Barry Moriba Toure Moriba Toure Kaba Conde Owonayo Oniankitan Department of Rheumatology Ignace Deen University Hospital Conakry Guinea Department of Rheumatology Sylvanus Olympio University Hospital Lome Togo Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Introduction: Physiotherapy is an integral part of the non-drug treatment strategy for rheumatological conditions. The evidence for its effects is not formal. The objective was to evaluate the impact of physiotherapy in the management of rheumatological disorders. Methods: 6-month case-control study (December 15, 2021 to June 20, 2022) at Ignace Deen University Hospital (Conakry). Patients with rheumatological disease who received drug therapy and physiotherapy were included in the case group. Age- and sex-matched controls had rheumatological conditions, treated without physiotherapy. The evaluation questionnaires were used: WOMAC (osteoarthritis), EIFEL (low back pain), NDI (neck pain), SPADI (shoulder). Patients with heart failure, respiratory failure and/or skin infection were not included. Results: We collected 773 patients (389 cases and 384 controls) with a mean age of 53.8 years ± 12.2 with female predominance (56.8%). Patients were mainly followed for osteoarthritis (65.2%). Rheumatological conditions managed were knee-based (119;30.6%), lumbar spine (220;56.6%), shoulders (27;6.9%) and cervical spine (23;5.9%). For an average duration of 53.4 ± 12.2 minutes per session, patients had benefited from a median of 19 physiotherapy sessions. After 3 months, the baseline mean VAS of 6/10 improved to 2.2 ± 1.6 for cases and 5.7 ± 1.2 for controls. Functional capacity was improved (WOMAC: 41.8 ± 22.7 vs. 18.3 ± 7.3). The satisfaction of patients treated with physiotherapy was 20 times higher than in controls. Conclusion: Physiotherapy performed in the management of rheumatological conditions significantly reduced pain and improved functional capacity.

关键词： Rheumatological Disease Physiotherapy WOMAC Guinea

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CRISPR/Cas9: Development and Application in Rice Breeding

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Rice science 2019年第5期26卷 265-281页

作者： Fernando matías ROMERO Andrés GATICA-ARIAS Laboratory of Plant Biotechnology School of Biology/Research Center in Cellular and Molecular Biology University of Costa Rica

Rice(Oryza sativa L.)is an important staple food crop worldwide due to its adaptability to different environmental *** of its great economic and social importance,there is a constant requirement for new varieties with improved agronomic characteristics,such as tolerance to different biotic(such as bacterium,fungus,insect and virus)and abiotic stresses(such as salinity,drought and temperature),higher yield and better organoleptic and nutritional *** the new genome editing technologies,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)system allows precise and specific edition in a targeted genome *** is one of the most frequently used techniques for the study of the function of new genes and for the development of mutant lines with enhanced tolerance to biotic and abiotic stresses,herbicide resistance or improved *** wide varieties of applications for this technology include simple non-homologous end joining,homologous recombination,gene replacement,and base *** this review,we analyzed how some of these applications have been used in rice cultivars to obtain rice varieties better adapted to current environmental conditions and market requirements.

关键词： rice CRISPR Cas genome editing biotic stress abiotic stress yield off-target mutation

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