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Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy,and tumor-targeting *** A1-R is superior to first-line chemotherapy

引用

Signal Transduction and Targeted Therapy 2018年第1期3卷 220-225页

作者： Kentaro miyake Tasuku Kiyuna masuyo miyake Kei Kawaguchi Sang Nam Yoon Zhiying Zhang Kentaro Igarashi Sahar Razmjooei Sintawat Wangsiricharoen Takashi Murakami Yunfeng Li Scott D.Nelson Tara A.Russell Arun S.Singh Yukihiko Hiroshima Masashi Momiyama Ryusei Matsuyama Takashi Chishima Shree Ram Singh Itaru Endo Fritz C.Eilber Robert M.Hoffman AntiCancer Inc.San DiegoCAUSA Department of Surgery University of CaliforniaSan DiegoCAUSA Department of Gastroenterological Surgery Yokohama City University Graduate School of MedicineYokohamaJapan Department of Pathology University of CaliforniaLos AngelesCAUSA Division of Surgical Oncology University of CaliforniaLos AngelesCAUSA Division of Hematology-Oncology University of CaliforniaLos AngelesCAUSA Basic Research Laboratory National Cancer InstituteFrederickMDUSA

Cancer of unknown primary(CUP)is a recalcitrant disease with poor prognosis because it lacks standard first-line *** consists of diverse malignancy groups,making personalized precision therapy *** present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft(PDOX)*** paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of *** A1-R with first-line chemotherapy using the CUP PDOX *** present study is the first to use a CUP PDOX model,which was able to precisely distinguish the chemotherapeutic *** found that a carboplatinum(CAR)-based regimen was effective for this CUP *** also demonstrated that *** A1-R was more effective against the CUP tumor than first-line *** results indicate that *** A1-R has clinical potential for CUP,a resistant disease that requires effective therapy.

关键词： chemotherapy precisely therapy

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