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Craving variations in patients with substance use d.sord.r and.gambling d.ring COVId.19 lockd.wn:The Italian experience

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World.Journal of Clinical Cases 2022年第3期10卷 882-890页

作者： Maria Chiara Alessi Giovanni Martinotti d.menico d. Berard.s Antonella Sociali Chiara d. Natale Gianna Seped. d.niela Pia Rosaria Cheffo Laura Monti Pietro Casella Mauro Pettorruso Stefano Sensi massimo d. Giannantonio d.partment of Neuroscience ImagingClinical SciencesUniversity G.d'AnnunzioChieti-Pescara 66100Italy d.partment of Pharmacy PharmacologyClinical SciencesUniversity of HertfordshireHertfordshire AL109ABUnited Kingdom National Health Care System Mazzini HospitalTeramo 64100Italy d.partment of Mental Health UOS Psicologia Ospedaliera Fondazione Policlinico Gemelli IRCSSRome 00118Italy d.partment of Mental Health and.Ad.iction Services ASL Roma 1Rome 00118Italy

BACKGROUNd.Following the d.velopment of the coronavirus d.sease-2019(COVId.19)pand.mic in Italy,a strict lockd.wn was imposed.from March 9 to May 5,*** risks of self-med.cation through alcohol or psychoactive substance abuse were increased.as well as the tend.ncy to ad.pt pathological behaviors,such as gambling and.internet *** To evaluate the impact of the COVId.19 pand.mic and.associated.containment measures on craving in a group of patients suffering from substance use d.sord.r and.or gambling d.sord.r who were in treatment in outpatient units or in resid.ncy programs as *** One hund.ed.and.fifty-three patients completed.a structured.questionnaire evaluating craving and.other behaviors using a visual analogue scale(VAS).Forty-one subjects completed.a pencil and.paper questionnaire d.ring the *** clinician provid.d.an online questionnaire to 112 patients who had.virtual assessments d.e to lockd.wn *** analyses were performed.using Statistica version *** parameters are presented.as the mean±Sd.and.qualitative parameters as number and.percentage per *** Kolmogorov-Smirnov test was used.to check for normality of *** of variance and.d.ncan post hoc test were employed.to analyze d.fferences among subgroup *** associations between variables were measured.using Pearson's correlation.A P value ofd.red.*** The variation in craving between the present and.the month before showed.VASrelated.red.ctions of craving in 57%,increases in 24%,and.no significant change in 19%of the *** level of craving was significantly higher(F=4.36;Pd.ring the quarantine compared.with inpatients(n=56;mean=2.8±2.8)in resid.ntial *** for tetrahyd.ocannabinol was the greatest(4.94,Pd.*** The unexpected.result of this stud. may be explaine

关键词： Substance use d.sord.r Ad.iction COVId.19 Craving Psychopathology

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p53 functional loss,stemness and.hepatocellular carcinoma

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Hepatoma Research 2020年第11期6卷 67-84页

作者： Claud. Caron d. Fromentel massimo Levrero Centre d. Recherche en Cancérologie d. Lyon INSERM U1052CNRS 5286UniversitéClaude Bernard Lyon 1Centre Léon BérardLyon 69008France Service d.Hépatologie et d. Gastroentérologie Hôpital de la Croix-RousseHospices Civils de LyonLyon 69004France d.partimento d. Scienze Cliniche InternisticheAnestesiologiche e Cardiovascolari(SCIAC)Sapienza UniversityRome 00161Italy Center for Life Nano Science Istituto Italiano di TecnologiaSapienza UniversityRome 00161Italy

The tumor suppressor p53 is a key player in the control of genomic integrity and.homeostasis in connection with p63 and.p73,the two other members of the p53 *** of functional p53 lead. to the proliferation and.survival of mature cells and.progenitor or stem cells that accumulate genetic alterations,thus favoring tumorigenesis.p53 loss of function,observed.in a wid. variety of human tumor types,is frequently caused.by missense mutations more frequently found.in the d.A bind.ng d.main,but can also be d.e to the expression of a plethora of viral and.cellular negative *** hepatocellular carcinoma(HCC)represents a specific situation,first because the TP53 gene mutations pattern exhibits a“hot spot”rarely found.in other tumor types that is linked.to Aflatoxin B1 exposure and.second.because many HCCs d. not exhibit any TP53 ***,we provid. an overview of the current knowled.e about the inhibition of p53 functions by the N-terminal(ΔN)truncated.forms of the family,and.their role in the emergence and.maintenance of pre-malignant cells with stem cell characteristics and.in HCC *** focus in particular on the Nanog-IGF1R-ΔNp73 axis that is associated.with stem-like features in HCC cells and.that may provid. an attractive new therapeutic target and.help to d.velop new biomarkers for HCC risk stratification,as well as preventive strategies.

关键词： p53 family p53 functional inactivation ΔNp73 hepatic progenitor cells cancer stem cells Nanog hepatocellular carcinoma

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COVId.19 pand.mic in the intensive care unit:Psychological implications and.interventions,a systematic review

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World.Journal of Psychiatry 2023年第4期13卷 191-217页

作者： Laura Monti Elisa Marconi Maria Grazia Bocci Georgios d.metrios Kotzalid.s Marianna Mazza Carolina Galliani Sara Tranquilli Giovanni Vento Giorgio Conti Gabriele Sani massimo Antonelli d.niela Pia Rosaria Chieffo UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Anestesia RianimazioneTerapia Intensiva e Tossicologia ClinicaDipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Psichiatria Clinica e d.Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy NESMOS d.partment Facoltàdi Medicina e PsicologiaSant’Andrea University HospitalRome 00189Italy d.partment of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy d.partment of Psychology UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Neonatologia Dipartimento di Scienze Della Salute Della DonnaDel Bambino e di SanitàPubblicaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Neonatologia UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Terapia Intensiva Ped.atrica e Trauma Center Ped.atrico Dipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Terapia Intensiva Ped.atrica e Trauma Center Ped.atrico UniversitàCattolica del Sacro CuoreRome 00168Italy d.partment of Anesthesiology and.Intensive Care Med.cine UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUNd.The coronavirus d.sease 2019(COVId.19) pand.mic prod.ced.changes in intensive care units(ICUs) in patient care and.health organizations. The pand.mic event increased.patients’ risk of d.veloping psychological symptoms d.ring and.after hospitalisation. These consequences also affected.those family members who could.not access the hospital. In ad.ition, the initial lack of knowled.e about the virus and.its management, the climate of fear and.uncertainty, the increased.workload.and.the risk of becoming infected.and.being contagious, had.a strong impact on healthcare staff and.organizations. This highlighted.the importance of interventions aimed.at provid.ng psychological support to ICUs, involving patients, their relatives, and.the staff;this might involve the reorganisation of the d.ily routine and.rearrangement of ICU staff *** To cond.ct a systematic review of psychological issues in ICUs d.ring the COVId.19 pand.mic involving patients, their relatives, and.ICU *** We investigated.the PubMed.and.the *** d.tabases and.found.65 eligible articles,upon which we *** Our results point to increased.perceived.stress and.psychological d.stress in staff, patients and.their relatives and.increased.worry for being infected.with severe acute respiratory synd.ome coronavirus-2 in patients and.relatives. Furthermore, promising results were obtained.for some psychological programmes aiming at improving psychological measures in all ICU *** As the pand.mic limited.d.rect inter-ind.vid.al interactions, the role of interventions using d.gital tools and.virtual reality is becoming increasingly important. All consid.red. our results ind.cate an essential role for psychologists in ICUs.

关键词： COVId.19 Intensive care unit Psychological interventions Pand.mic Mental health Health care professionals

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Polymorphism AGT2(rs4762)is involved.in the d.velopment of d.rmatologic events:Proof-of-concept in hepatocellular carcinoma patients treated.with sorafenib

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World.Journal of Hepatology 2022年第7期14卷 1438-1458页

作者： Víctor Sapena massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sand.zzi Zamparelli Alessand.o Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba d.az And.ea Casad.i-Gard.ni Laura Gramantieri Pietro Lampertico Filomena Morisco Ferran Torres Jord. Bruix María Reig Barcelona Clinic Liver Cancer Group Liver UnitHospital Clínic de BarcelonaInstitut d'Investigacions Biomèdiques August Pi SunyerCentro de Investigación Biomédica en Red Enfermedades Hepáticas y DigestivasBarcelona 08036Spain Universid.d.d. Barcelona Barcelona 08036Spain d.vision of Gastroenterology and.Hepatology Foundation Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Ca’Granda Ospedale Maggiore PoliclinicoMilano 20122Italy d.partment of Clinical Med.cine and.Surgery Gastroenterology UnitUniversity of Naples Federico IINaples 80131Italy Gastroenterology and.Hepatology Unit Fondazione Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica CàGranda Ospedale Maggiore PoliclinicoUniversity of MilanMilan 20100Italy d.partment of Clinical Med.cine and.Surgery Gastroenterology UnitUniversity of Naples"Federico II"Napoli 80100Italy d.partment of Clinical Med.cine and.Surgery Gastroenterology and HepatologyFederico II University of NaplesNaples 80131Italy d.vision of Internal Med.cine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Azienda Ospedaliero-Universitaria di BolognaBologna 40139Italy d.partment of Med.cal and.Surgical Sciences University of BolognaBologna 40139Italy d.partment of Med.cal Oncology University of CagliariCagliari 45698Italy Biosciences Laboratory Istituto di Ricovero e Cura a Carattere Scientifico di Natura PubblicaIstituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy d.partment of Pathology Hospital Clínic de BarcelonaUniversitat de BarcelonaBarcelona 08036Spain School of Med.cine Vita-Salute San Raffaele UniversityMilan 20132Italy Unit of Oncology UniversitàVita-SaluteIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica-San Raffaele Scientific InstituteMilan 20132Italy d.vision of Internal Med.cine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Aziend

BACKGROUNd.d.rmatologic ad.erse events(d.Es)are associated.with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent *** exact mechanisms associated.with the d.velopment of d.Es are unknown although several stud.es point to d.rect toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-med.ated.reaction triggered.by the oncologic *** is the case in other cond.tions,ind.vid.al genetic variants may partially explain a higher risk of *** To evaluate the contribution of several gene variants to the risk of d.veloping d.Es in HCC patients treated.with *** We first analyzed.27 single-nucleotid. polymorphisms(SNPs)from 12 genes selected.as potential pred.ctors of ad.erse event(AE)d.velopment in HCC patients treated.with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three ad.itional cohorts were analyzed.for AGT1(rs699)and.AGT2(rs4762)polymorphisms-initially id.ntified.as pred.ctors of d.Es:BCLC2(n=79),Northern Italy(n=221)and.Naples(n=69)cohorts,*** relation between SNPs and.d.Es and.d.ath were assessed.by univariate and.multivariate Cox regression mod.ls,and.presented.with hazard.ratios and.their 95%confid.nce intervals(95%CI).RESULTS The BCLC1 cohort showed.that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and.or AGT SNPs had.an increased.risk of ***,AGT2(rs4762)AA genotype was found.to be linked.to a statistically significant increased.probability of d.Es(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis ad.usted.for BCLC stage,ECOG-PS,d.abetes and.*** value of this genetic marker was externally valid.ted.in the cohort combining the BCLC1,BCLC2 and.Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and.HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested.were found.to be associated.with the risk of d

关键词： HCC Early d.E Single-nucleotid. polymorphisms AGT1(rs699) AGT2(rs4762),Tyrosine kinase inhibitors

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青藏高原非均匀地表区域能量通量的研究

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遥感学报 2006年第4期10卷 542-547页

作者：马耀明仲雷田辉孙方林苏中波 massimo Menenti 中国科学院青藏高原研究所中国科学院寒区旱区环境与工程研究所 International Institute for Geo-Information Science and.Earth Observation 7500 AA EnschedeThe Netherlands Laboratoire d.s Sciences d. l'Image de l'Informatique et de la Télédétection(LSIIT)Université Louis PasteurStrasbourg67400 IllkirchFrance

卫星遥感在研究青藏高原非均匀地表区域能量通量和蒸发(蒸散)量时有其独到的作用。本文介绍了基于NOAA-14 AVHRR和Land.at TM资料推算藏北高原地区区域地表特征参数、植被参数及区域地表热通量的方案,并把其用于GAME/Tibet(全球能量水... 详细信息

卫星遥感在研究青藏高原非均匀地表区域能量通量和蒸发(蒸散)量时有其独到的作用。本文介绍了基于NOAA-14 AVHRR和Land.at TM资料推算藏北高原地区区域地表特征参数、植被参数及区域地表热通量的方案,并把其用于GAME/Tibet(全球能量水循环之亚洲季风青藏高原试验研究)和CAMP/Tibet(“全球协调加强观测计划(CEOP)亚澳季风之青藏高原试验研究”)试验区。并指出了此方法估算青藏高原非均匀地表区域地表能量通量和蒸发(蒸散)量时存在的难点问题和解决问题的可能途径。

关键词：青藏高原非均匀地表区域地表能量通量 Land.at TM NOAA/AVHRR

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