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Antiglutamatergic agents for obsessive-compulsive disorder:Where are we now and what are possible future prospects?

World Journal of Psychiatry 2021年第9期11卷 568-580页

作者： Annalisa Maraone Lorenzo Tarsitani Irene Pinucci massimo pasquini Department of Human Neurosciences Sapienza University of RomeRome 00185LazioItaly

Recent data suggest that obsessive-compulsive disorder(OCD)is driven by an imbalance among the habit learning system and the goal-directed *** frontostriatal loop termed cortico-striatal-thalamo-cortical(CSTC)circuitry loop is involved in habits and their dysfunction plays an important role in *** neurotransmission is the principal neurotransmitter implicated in the CSTC model of *** in the CSTC loop implies a high level of glutamate in the cortical-striatal pathways as well as a dysregulation of GABA ergic transmission,and could represent the pathophysiology of ***,the dysregulation of glutamate levels can lead to neurotoxicity,acting as a neuronal *** hypothesis of a role of neurotoxicity in the pathophysiology of OCD clinically correlates to the importance of an early intervention for ***,some studies have shown that a reduction of duration of untreated illness is related to an earlier onset of *** robust data supporting a progression of such brain changes are not available so far,an early intervention could help interrupt damage from ***,agents targeting glutamate neurotransmission may represent promising therapeutical option in OCD patients.

关键词： Obsessive-compulsive disorder Antiglutamatergic agents Glutammate Early intervention Neurophysiopathology Duration of untreated illness

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Psychic euosmia and obsessive compulsive personality disorder

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World Journal of Psychiatry 2018年第3期8卷 105-107页

作者： massimo pasquini Annalisa Maraone Valentina Roselli Lorenzo Tarsitani Department of Human Neurosciences Sapienza University Department of Neuro- sciences and Mental Health Umberto I General Hospital

Patients with obsessive compulsive personality disorder(OCPD) often refer to a prompt mood improvement upon encountering good scents in general, or fresh laundry borax on their clothes, pillows or home settings. The Authors propose the new term psychic euosmia in the mean of an overstated psychological predisposition for a real pleasant smell that elicits an immediate sense of pleasure, order and calm. The prompt reactions to a pleasant odor might be explained by the involvement of rhinencephalon and its proximity to mood-related limbic circuits, which bypass the cognitive awareness. Cleanliness may not preclude a subject to enjoy a good smell, even if we are representing smells that resemble freshness, in other words order. A potentially even more important argument is given by the continuum of personality disorders and their variability. Not all personality characteristics led to disturbed behaviors. In evolutionary perspectives having the ability to differentiate between unpleasant and pleasant odors should have made the difference in surviving. On the other hand, psychic euosmia could be considered a normal reaction, but in our clinical experience it is over-represented among OCPD subjects with marked orderliness and disgust. Therefore, detecting psychic euosmia might vicariously confirm the relevance of disgust as a cognitive driver of OCPD. Hereby we support research to characterize psychic euosmia as a feature of orderliness and cleanliness for OCPD.

关键词： Psychic euosmia Obsessive compulsive personality disorder Orderliness Pleasure Positive emotion Pesonality

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Psychic euosmia among obsessive-compulsive personality disorder patients:A case control study

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World Journal of Psychiatry 2021年第2期11卷 50-57页

作者： Annalisa Maraone Lorenzo Tarsitani Marianna Frascarelli Federica Petrini Valentina Roselli MassimilianoTinè Gabriele Cavaggioni Vlasios Brakoulias massimo Biondi massimo pasquini Department of Human Neurosciences Sapienza UniversityRome 00185Italy Department of Neurosciences and Mental Health Umberto I PoliclinicRome 00185Italy School of Medicine Western Sydney University and Western Sydney Local Health DistrictBlacktown 2145SNWAustralia Department of Psychiatry Nepean HospitalSydney Medical SchoolThe University of SydneyPenrith 2751SNWAustralia

BACKGROUND Psychic euosmia(PE)has been described as a supposed psychological predisposition for which pleasant smells elicit an immediate sense of pleasure,order and calmness in obsessive-compulsive personality disorder(OCPD).In this study we tried to verify the interpretation that PE is the counterpart of disgust that has been associated to contamination and moral *** and morality are significantly associated in people with obsessive-compulsive personality *** expected that OCPD patients would experience higher levels of *** To investigate the PE frequency in OCPD patients and healthy controls(HC)and to evaluate the relationship between PE and *** A single-center,case-control study was conducted in an outpatient service for obsessive-compulsive and related *** sample consisted of 129 subjects:45 OCPD patients and 84 *** both groups we submitted the Disgust Scale Revised(DS-R)and the self-report Structured Clinical Interview for DSM-5 Screening Personality Questionnaire to which we added an additional yes or no question to investigate the presence of *** order to verify differences between groups,t-test was employed for continuous variables and 2 test for categorical variable;odds ratio was employed to analyze group differences in the PE *** was explored with Pearson r *** No differences were observed between groups in gender composition or education.A slight significant difference was found in mean age(t=1.988;P=0.049).The present study revealed significantly higher proportions of PE among OCPD patients when compared to HC(OR:5.3,2.28-12.46).Patients with OCPD were more likely to report PE(n=36;80%)whereas a much lower proportion endorsed PE in the HC group(n=36;42.9%).Interestingly,no differences were observed between groups in mean score for the Disgust *** was also no difference between the two groups in any of the Disgust Scale Revised ***,no significant correla

关键词： Psychic euosmia Obsessive-compulsive personality disorder Disgust Orderliness Olfactory Personality

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