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Role of preoperative CT colonography in patients with colorectal cancer

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World Journal of Gastroenterology 2014年第14期20卷 3795-3803页

作者： Lapo Sali massimo Falchini Antonio Taddei Mario Mascalchi Department of Experimental and Clinical Biomedical Sciences University of Florence Department of Surgery and Translational Medicine University of Florence

In patients with colorectal cancer (CRC), accurate preoperative evaluation is essential for a correct therapeutic plan. Colonoscopy and intravenous contrast-enhanced computed tomography (CT) are currently recommended in the preoperative work-up for CRC. Preoperative colonoscopy has some limitations such as misdiagnosis of synchronous cancers in cases of incomplete exploration of the colon and inaccurate tumor localization. Intravenous contrast-enhanced CT successfully documents distant metastases although it sometimes enables unsatisfactory locoregional staging. Computed tomography colonography (CTC) is obtained after gas insufflation of the colon and offers a comprehensive preoperative evaluation in patients with CRC, including a definition of the segmental location of the tumor, presence of synchronous lesions or lack thereof, and fairly accurate locoregional staging. CTC has some limitations, including a lack of biopsy capability, suboptimal sensitivity for synchronous small polyps, and unsatisfactory nodal staging. Bearing in mind these limitations, CTC could be employed as a “one-stop-shop” examination for preoperative assessment in patients with CRC.

关键词： Colorectal cancer Colonoscopy Computed tomography colonography Synchronous cancer Cancer staging

Catalytic behavior in propane aromatization using GA-MFI catalyst

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1863-1870页

作者： Alfredo Aloise Enrico Catizzone massimo Migliori Janos B.Nagy Girolamo Giordano University of Calabria Department of Environmental and Chemical Engineering Via P. Bucci 1-87036 Rende CS Italy

Ga-Al-MFI samples were synthesized in hydrothermal conditions from gels of composition 1.08CH3NH2- 0.134TPABr-1SiO2-xAl2O3-yGa2O3-40H2O at 175 ℃ for 7 days, with x = 0.005 and 0.0025, y = 0.005, 0,010 and 0.020. The samples were characterized by XRD, BET measurements, thermal analysis （TGA-DTA） atomic absorption and high resolution solid state MAS 27Al and 71Ga NMR measurements. The aromatization of propane was studied as catalytic test. The activity and selectivity of the catalysts were determined for benzene, toluene and xylenes on the one hand and for methane and ethane on the other hand. The most active sample was obtained with the highest Ga/AI ratio. For this sample, the BTX selectivity obtained by aromatization was always higher than the hydrocracking selectivity leading to methane and ethane. The relative amount of toluene was higher than that of benzene and ofxylenes. The samples were deactivated by coke formation that was revealed more severe for the most active sample,

关键词： Propane aromatization Gallium ZSM-5 Coke formation Catalyst deactivation

Portal hypertension in patients with nonalcoholic fatty liver disease:Current knowledge and challenges

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World Journal of Gastroenterology 2024年第4期30卷 290-307页

作者： Anita Madir Ivica Grgurevic Emmanuel A Tsochatzis massimo Pinzani Department of Gastroenterology Hepatology and Clinical NutritionUniversity Hospital DubravaZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia UCL Institute for Liver and Digestive Health Royal Free Hospital and University College LondonLondon NW32PFUnited Kingdom

Portal hypertension(PH)has traditionally been observed as a consequence of significant fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease(NAFLD).However,recent studies have provided evidence that PH may develop in earlier stages of NAFLD,suggesting that there are additional pathogenetic mechanisms at work in addition to liver *** early development of PH in NAFLD is associated with hepatocellular lipid accumulation and ballooning,leading to the compression of liver *** compression and intraluminal obstacles cause mechanical forces such as strain,shear stress and elevated hydrostatic pressure that in turn activate mechanotransduction pathways,resulting in endothelial dysfunction and the development of *** spatial distribution of histological and functional changes in the periportal and perisinusoidal areas of the liver lobule are considered responsible for the pre-sinusoidal component of PH in patients with ***,current diagnostic methods such as hepatic venous pressure gradient(HVPG)measurement tend to underestimate portal pressure(PP)in NAFLD patients,who might decompensate below the HVPG threshold of 10 mmHg,which is traditionally considered the most relevant indicator of clinically significant portal hypertension(CSPH).This creates further challenges in finding a reliable diagnostic method to stratify the prognostic risk in this population of *** theory,the measurement of the portal pressure gradient guided by endoscopic ultrasound might overcome the limitations of HVPG measurement by avoiding the influence of the pre-sinusoidal component,but more investigations are needed to test its clinical utility for this *** and spleen stiffness measurement in combination with platelet count is currently the best-validated non-invasive approach for diagnosing CSPH and varices needing *** change remains the cornerstone of the treatment of PH in NAFLD,together with correcting the comp

关键词： Non-alcoholic fatty liver disease Portal hypertension Mechanotransduction Endothelial dysfunction Hepatic venous pressure gradient

Differential diagnosis between functional and organic intestinal disorders:Is there a role for non-invasive tests?

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World Journal of Gastroenterology 2007年第2期13卷 219-223页

作者： Francesco Costa Maria Gloria Mumolo Santino Marchi massimo Bellini Section of Gastroenterology Department of Internal MedicineUniversity of Pisa Pisa Italy

Abdominal pain and bowel habits alterations are common symptoms in the general population. The investigation to differentiate organic from functional bowel disorders represents a considerable burden both for patients and public health service. The selection of patients who should undergo endoscopic and/or radiological procedures is one of the key points of the diagnostic process, which should avoid the abuse of invasive and expensive tests as well as the underestimation of potentially harmful diseases. Over the cominci years,dinidans and researchers will be challenged to develop strategies to increase the patient＇s compliance and to reduce the economic and social costs of the intestinal diseases.

关键词： Intestinal diseases Intestinal inflammation Functional bowel disorders Faecal markers

Spouting behaviour of binary mixtures in square-based spouted beds

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Particuology 2019年第2期17卷 193-201页

作者： Cristina Moliner Filippo Marchelli massimo Curti Barbara Bosio Giorgio Rovero Elisabetta Arato Department of Civil Chemical and Environmental Engineering (DICCA) University of Genova (UNIGE) Genova Italy Faculty of Science and Technology Free University of Bolzano (UNIBZ) Bolzano Italy Department of Applied Science and Technology (DISAT) Polytechnic University of Turin (POLITO) Turin Italy

From experime nts, the influe nee of the physical characteristics of different bin ary mixtures of solids on the spouting regime of a pyramidal square-based spouted bed reactor is assessed. The applied methodology permits a more precise evaluation of the effects of the tested variables (diameter, density, sphericity) on the response variables (minimum air flows at which spouting begins and at which to maintain spouting con ditions). The associated pressure drops along the bed of particles a nd the height of the formed fountai n are analysed in each case. During the initial stages of fluidisation, binary mixtures containing different density ratios show dead zones. Segregation becomes more evident at large-size and high-density ratios. The lack of sphericity was found to be the main reason leading to blocking, channelling, and start-up problems when system failures occur. Nevertheless, the extent of segregation in all cases decreases with increasing the spouting velocity. In addition, a computational fluid dynamic model based on the discrete element method, previously validated for a single solid bed, is proposed as a tool to predict and evaluate potential segregation phenomena in binary mixtures. This model reproduced with high accuracy the encountered segregation phenomena. Its use may help define the technical limts inherent in the pyramidal spouted bed reactor.

关键词： Spouted bed reactor Segregation Computational fluid dynamics

Sediment provenance of a carbonate bioclastic pocket beach—Le Dune(Ionian Sea,South Italy)

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Journal of Palaeogeography 2022年第2期11卷 238-255页

作者： Isabella Lapietra Stefania Nunzia Lisco Salvatore Milli Beatrice Rossini massimo Moretti Dipartimento di Scienze Della Terra e Geoambientali Universit a Degli Studi di BariVia Orabona 470124 BariItaly Dipartimento di Scienze Della Terra SapienzaUniversit a di RomaPiazzale Aldo Moro 500185 RomaItaly

This study focuses on the analysis of a carbonate bioclastic pocket beach located along a coastal sector of the Apulia Ionian Sea,Le Dune beach,South *** beach develops for about 800 m and it is exposed to the south-westerly and southerly *** sediments range from very coarse to medium-fine sands and they are mainly composed of bioclasts(more than 90%)which include molluscs,foraminifers,echinoderms,algae branched,bryozoans,spicules of sponges and *** study area is one part of a marine protected reserve characterised by 15 different habitats of the typical Mediterranean submerged populations and the presence of Posidonia oceanica *** aim of our research is to highlight the correlation between physical and biological processes influencing Le Dune beach dynamics and its sediment provenance by analysing the textural and compositional characteristics of beach sands,which is fundamental for pocket beach *** beach sand analysis,deriving from textural,compositional and bioclast investigations,underlines that one of the main indicators of the beach dynamics is the bioclast component,which provides relevant information about sand provenance and sediment *** beach constitutes a semi-close system only nourished by the shells of organisms and by the erosion of headlands and dunes without important sediment interchange with adjacent littoral sectors.

关键词： Pocket beach Carbonate sediment supply Bioclast distribution Coastal dynamics

Chronic hepatitis B: Advances in treatment

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World Journal of Hepatology 2014年第5期6卷 284-292页

作者： Teresa Antonia Santantonio massimo Fasano Department of Clinical and Experimental Medicine University of Foggia 71100 Foggia Italy

Treatment of chronic hepatitis B(CHB) has markedly improved in the last 15 years due to the availability of direct antivirals which greatly increase therapeutic options. Currently, there are two classes of agents licensed for CHB treatment: standard or pegylated interferon alpha(IFN or Peg-IFN) and five nucleoside/nucleotide analogues(NAs). Long-term treatment with NAs is the treatment option most often used in the majority of CHB patients. Entecavir and tenofovir, the most potent NAs with high barrier to resistance, are recommended as first-line monotherapy by all major treatment guidelines and can lead to long-lasting viro-logical suppression, resulting in histological improve-ment or reversal of advanced fibrosis and reduction in disease progression and liver-related complications. In this review, we focus on current treatment strategies of chronic hepatitis B and discuss the most recent efficacy and safety data from clinical trials and real life clinical practice. Recent findings of response-guided approach-es are also discussed.

关键词： Chronic hepatitis Antiviral therapy Peginterferon Nucleos(t)ide analogues Antiviral resistance

High risk of thrombosis recurrence in people with idiopathic or only locally caused non-cirrhotic splanchnic vein thrombosis: it is time for guidelines’ revision

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 699-702页

作者： massimo Primignani Giulia Tosetti Andrea Artoni Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico–SC Gastroenterologia ed Epatologia MilanItaly Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanItaly

Portal hypertension caused by non-cirrhotic(and non neoplastic)splanchnic vein thrombosis(NC-SVT)is responsible for 5–10%of portal hypertension cases in the western world(1).Chronic myeloproliferative neoplasms(MPN)or systemic prothrombotic disorders are in cause in about 40%of subjects,while in about 30%a local condition,such as recent abdominal surgery or infection/inflammation triggers the *** local condition,however,can only be the precipitating cause,since a thorough screening allows identifying the co-occurrence of systemic thrombophilia in about 30%of such ***,screening is mandatory even in cases where the cause of NC-SVT seems ***,about 30%of cases of NC-SVT remains unexplained and defined idiopathic(1).

关键词： Non-cirrhotic splanchnic vein thrombosis factor VIII thrombosis recurrence

Screening for pancreatic cancer-a compelling challenge

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 264-266页

作者： Gabriele Capurso Salvatore Paiella massimo Falconi Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilanItaly General and Pancreatic Surgery Unit Pancreas InstituteUniversity of VeronaVeronaItaly Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSUniversitàVita-SaluteMilanItaly

Efficacy of pancreatic cancer surveillance programs The publication of the American Gastroenterology Association(AGA)Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals(HRIs)underlines the increasing attention for this topic(1).Secondary prevention(surveillance)for pancreatic ductal adenocarcinoma(PDAC),however,remains a challenge with many unsolved questions(Table 1).

关键词： prevention cancer Cancer