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Journal of Data Analysis and Information Processing 2024年第2期12卷 248-266页

作者： Masoud Asadi-Zeydabadi Marina Mizukoshi massimo Buscema Giulia Massini Weldon Lodwick Department of Physics University of Colorado Denver Colorado USA Institute of Mathematics and Statistics Federal University of Goi&#225s Goiania Goi&#225s Brazil Semeion Research Center Rome Italy Department of Mathematical and Statistical Sciences University of Colorado Denver Colorado USA

This study used Topological Weighted Centroid (TWC) to analyze the Coronavirus outbreak in Brazil. This analysis only uses latitude and longitude in formation of the capitals with the confirmed cases on May 24, 2020 to illustrate the usefulness of TWC though any date could have been used. There are three types of TWC analyses, each type having five associated algorithms that produce fifteen maps, TWC-Original, TWC-Frequency and TWC-Windowing. We focus on TWC-Original to illustrate our approach. The TWC method without using the transportation information predicts the network for COVID-19 outbreak that matches very well with the main radial transportation routes network in Brazil.

关键词： COVID-19 Topological Weighted Centroid (TWC) Algorithms TWC-Original TWC-Frequency and TWC-Windowing

Vulvar Swelling in a 12-Year-Old Girl: An Early Manifestation of Crohn’s Disease

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Case Reports in Clinical Medicine 2024年第7期13卷 219-226页

作者： Stefania Rendina Dolores Ferrara Rosanna Mamone Sara Isoldi massimo Zeccolini Francesco Esposito Department of Radiology Universit degli studi di Napoli Luigi Vanvitelli Naples Italy Department of Radiology A.O.R.N. Santobono-Pausilipon Children Hospital Naples Italy Pediatric Gastroenterology and Hepatology Unit Santobono-Pausilipon Childrens Hospital Naples Italy

Vulvar Crohn’s disease (VCD) is a rare complication of Crohn’s disease, especially in pediatric population. An early diagnosis can result difficult if the complication does not present in conjunction with the classic gastrointestinal symptoms that characterize this disease. In this study we present the case of a 12-year-old girl whose initial symptom of Crohn’s disease was a symptomatic vulvar swelling promoted by a rectovaginal fistula. We also provide an overview of Crohn’s disease and the vulvar changes found in the course of this disease.

关键词： Recto-Vaginal Fistula Vulvar Swelling Metastatic Crohn’s Disease

Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

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Journal of Intensive Medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere massimo Antonelli Kostoula Arvaniti Koen Blot Ben CreaghBrown Dylan Wde Lange Jan De Waele Mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann Guy Francois massimo Girardis Despoina Koulenti Sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam Mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers Stijn Blot the Abdominal Sepsis Study(AbSeS)group on behalf of the Trials Group of the European Society of Intensive Care Medicine Department of Internal Medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(SPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental Medicine University of SurreyGuildfordUK Department of Intensive Care Medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care Medicine Ghent University HospitalGhentBelgium Data Science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of Scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson Trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina Surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The AbSeS-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the AbSeS-classification and ***:This was a secondary analysis of an international observational study(“AbSeS”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,P<0.001)or after the implementation of additional source control interventions within the first week(OR=4.0,95%CI:1.3 to 12.2,P=0.013).Gramnegative bacteria were most frequently isolated(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limited series,essentials of the AbSeS-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection Sepsis

围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuchs-Buder Carolina S.Romero Heidrun Lewald massimo Lamperti Arash Afshari Ana-Marjia Hristovska Denis Schmartz Jochen Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Society of Anaesthesiology and Intensive Care,ESAIC)首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PICO原则(患者、干预、对照、结局;patient,intervention,comparator,outcome;PICO)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1C)。R3推荐在快速顺序诱导插管(rapid sequence induction intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2C)。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1C)。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

Mesenchymal stem cells,secretome and biomaterials in in-vivo animal models:Regenerative medicine application in cutaneous wound healing

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BIOCELL 2022年第8期46卷 1815-1826页

作者： massimo CONESE AURELIO PORTINCASA Department of Medical and Surgical Sciences University of FoggiaFoggia71122Italy Department of Clinical and Experimental Medicine University of FoggiaFoggia71122Italy

The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be *** mesenchymal stem cells(MSCs),obtained from different sources,and their secretome derived thereof(especially exosomes)can activate signaling pathways related to promotion of cell migration,vascularization,collagen deposition,and inflammatory response demonstrating prohealing,angiogenetic and anti-scarring *** the other hand,biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix *** this Review,we revise the complex composites made by biomimetic scaffolds,mainly hydrogels,and MSC-derived exosomes constructed for cutaneous wound *** demonstrate that there exists a synergistic action of scaffolds with encapsulated exosomes,displaying a sustained release profiles to facilitate longlasting healing *** can be envisioned that dressings made by biomimetic hydrogels and MSC-derived exosomes will be clinically applied in the near future for the effective treatment of nonhealing and chronic wounds.

关键词： Biomimetic scaffolds Cutaneous wound healing Exosomes Hydrogels Mesenchymal stem cells Secretome

The main tasks of a semiotics of artificial intelligence

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Language and Semiotic Studies 2023年第1期9卷 1-13页

作者： massimo Leone University of Turin TurinItaly Shanghai University ShanghaiChina University of Cambridge CambridgeEngland and Bruno Kessler Foundation TrentoItaly

The article indicates the essential tasks of a semiotics of artificial intelligence:studying the way it simulates the expression of intelligence;the way it produces content that is creatively endowed;the ideological assumptions of artificial intelligence within the culture that produces *** intelligence is,from a semiotic point of view,the predominant technology of fakery in the current *** the strength of its studies on the false,semiotics can therefore also be applied to the analysis of the fake that,in increasingly sophisticated forms,is produced through artificial intelligence and through the deep learning of neural *** article focuses on the adversarial ones,trying to highlight their ideological assumptions and cultural developments,which seem to indicate the entry of human societies and cultures into the‘realm of the absolute fake'.

关键词： fake generative adversarial networks simulation undecidability of the digital fake

Improved Parameterization of Snow Albedo in WRF+Noah:Methodology Based on a Severe Snow Event on the Tibetan Plateau

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Advances in Atmospheric Sciences 2022年第7期39卷 1079-1102页

作者： Lian LIU massimo MENENTI Yaoming MA Weiqiang MA Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemResources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China Delft University of Technology Delft 2600AANetherlands College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan

Snowfall and the subsequent evolution of the snowpack have a large effect on the surface energy balance and water cycle of the Tibetan Plateau(TP).The effects of snow cover can be represented by the WRF coupled with a land surface *** widely used Noah scheme is computationally efficient,but its poor representation of albedo needs considerable *** this study,an improved albedo scheme is developed using a satellite-retrieved albedo that takes snow depth and age into *** experiments were then conducted to simulate a severe snow event in March *** performance of the coupled WRF/Noah model,which implemented the improved albedo scheme,is compared against the model’s performance using the default Noah albedo scheme and against the coupled WRF/CLM that applied CLM albedo *** the improved albedo scheme is implemented,the albedo overestimation in the southeastern TP is reduced,reducing the RMSE of the air temperature by 0.7°*** improved albedo scheme also attains the highest correlation between the satellite-derived and the model-estimated albedo,which provides for a realistic representation of both the snow water equivalent(SWE)spatial distribution in the heavy snowbelt(SWE>6 mm)and the maximum SWE in the eastern *** underestimated albedo in the coupled WRF/CLM leads to underestimating the regional maximum SWE and a consequent failure to estimate SWE in the heavy snowbelt *** study demonstrates the feasibility of improving the Noah albedo scheme and provides a theoretical reference for researchers aiming to improve albedo schemes further.

关键词： WRF MODIS severe snowfall albedo scheme SWE Tibetan Plateau

Understanding spatial patterns in the drivers of greenness trends in the Sahel-Sudano-Guinean region

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Big Earth Data 2023年第2期7卷 298-317页

作者： Min Jiang Li Jia massimo Menenti Yelong Zeng State Key Laboratory of Remote Sensing Sciences Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina Department of Geoscience and Remote Sensing Delft University of TechnologyDelftThe Netherlands University of Chinese Academy of Sciences BeijingChina

The region-wide spatial pattern of the drivers of vegetation trends in the African Sahel-Sudano-Guinean region, one of the main drylands of the world, has not been fully investigated. Time-series satellite earth observation datasets were used to investigate spatiotemporal patterns of the vegetation greenness changes in the region and then a principal component regression method was applied to identify the region-wide spatial pattern of driving factors. Results find that vegetation greening is widespread in the region, while vegetation browning is more clustered in central West Africa. The dominant drivers of vegetation greenness have a distinct spatial pattern. Climatic factors are the primary drivers, but the impacts of precipitation decrease from north to south, while the impacts of temperature are contrariwise. Coupled with climatic drivers, land cover changes lead to greening trends in the arid zone, especially in the western Sahelian belt. However, the cluster of browning trends in central West Africa can primarily be attributed to the human-induced land cover changes, including an increasing fractional abundance of agriculture. The results highlight the spatial pattern of climatic and anthropic factors driving vegetation greenness changes, which helps natural resources sustainable use and mitigation of climate change and human activities in global dryland ecosystems.

关键词： Vegetation greenness driving factors Sahel-Sudano-Guinean principal component regression

The Bulk-Surface Virtual Element Method for Reaction-Diffusion PDEs:Analysis and Applications

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Communications in Computational Physics 2023年第3期33卷 733-763页

作者： massimo Frittelli Anotida Madzvamuse Ivonne Sgura Department of Mathematics and Physics“E.De Giorgi” University of SalentoVia per Arnesano73100 LecceItaly Department of Mathematics University of British Columbia1984 Mathematics RoadVancouverBC V6T 1Z2Canada Department of Mathematics School of Mathematical and Physical SciencesUniversity of SussexBrightonBN19QHUK Department of Mathematics and Applied Mathematics University of PretoriaPrivate Bag x 20Hatfield0028South Africa.

Bulk-surface partial differential equations(BS-PDEs)are prevalent in manyapplications such as cellular,developmental and plant biology as well as in engineeringand material *** numerical methods for BS-PDEs in three space dimensions(3D)are *** this work,we present a bulk-surface virtual elementmethod(BS-VEM)for bulk-surface reaction-diffusion systems,a form of semilinearparabolic BS-PDEs in *** previous studies in two space dimensions(2D),the3D bulk is approximated with general polyhedra,whose outer faces constitute a flatpolygonal approximation of the *** this reason,the method is restricted tothe lowest order case where the geometric error is not *** BS-VEM guaranteesall the advantages of polyhedral methods such as easy mesh generation andfast matrix assembly on general *** advantages are much more relevantthan in *** allowing for general polyhedra,general nonlinear reaction kineticsand general surface curvature,the method only relies on nodal values without needingadditional evaluations usually associated with the quadrature of general *** latter is particularly costly in *** BS-VEM as implemented in thisstudy retains optimal convergence of second order in space.

关键词： Bulk-surface PDEs bulk-surface reaction-diffusion systems polyhedral meshes bulksurface virtual element method convergence.

Vibro-acoustic characteristics of multifunctional carbon fiber reinforced panel

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Defence Technology（防务技术） 2023年第6期24卷 129-139页

作者： Liberata Guadagno Marialuigia Raimondo Luigi Vertuccio Giuseppina Barra Maurizio Arena massimo Viscardi Department of Industrial Engineering University of SalernoVia Giovanni Paolo II13284084FiscianoSAItaly Department of Engineering University of Campania“Luigi Vanvitelli”Via Roma 29I-81031AversaItaly Department of Industrial Engineering Aerospace SectionUniversity of Naples“Federico Ⅱ”Via Claudio 2180125NaplesItaly

This paper deals with the assessment of vibro-acoustic properties of a multifunctional carbon fiber reinfo rced panel manu factured by bulk infu sion,a modified resin film infusion *** components of the epoxy resin were chosen to contrast the electrical insulating property and poor flame resistance of the epoxy resins impregnating carbon woven *** confer electrical conductivity to the resin a percentage of 0.5 wt%of Multi-Wall Carbon Nanotubes(MWCNTs)was dispersed in the resin,whereas to increase flame resistance a percentage of 5 wt%of Glycidil Polyhedral Oligomeric Silsesquioxanes(GPOSS)was solubilized in the epoxy ***,as hardener agents,a mixture of 4,4’-DiaminoDiphenyl Sulfone(DDS)(53.4 wt%)and Bis(3-Aminophenyl)Methyl Phosphine Oxide(BAMPO)(46.7 wt%)was *** values of the electrical conductivity were found satisfactory enough,being4.02×10^(-2)S/m for the multifunctional resin and 1.39×10^(4)S/m for the in-plane conductivity of the panel,whereas the Limiting Oxygen Index(LOI)value of the multifunctional resin was found to increase from 27%to 36%.Considering these promising results,an experimental assessment of the vibro-acoustic properties of the manufactured multifunctional panel was also *** panel was tested mainly to evaluate its low-frequency vibration damping and sound insulation *** manufactured panel demonstrated an improved efficiency if compared to a baseline configuration,presenting almost the double modal damping and a gain of 10 dB on the global noise reduction.

关键词： Composite materials Electrical properties Damping Tunneling atomic force microscopy(TUNA) Vibro-acoustic properties