检索结果-南通市图书馆

COVID-19 emergency: Changes in quality of life perception in patients with chronic liver disease-An Italian single-centre study

引用

World Journal of Hepatology 2022年第1期14卷 274-286页

作者： Alessandra Zannella Silvia Fanella massimo marignani Paola Begini Department of Gastroenterology Sant’Andrea HospitalRome 00189Italy

BACKGROUND In December 2019,the coronavirus disease-2019(COVID-19)emerged and rapidly spread worldwide,becoming a global health threat and having a tremendous impact on the quality of life(QOL)of *** To evaluate the awareness of patients with chronic liver disease(CLD)regarding the COVID-19 emergency and how it impacted on their *** Patients with an established diagnosis of CLD(cirrhosis,autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing cholangitis)who had been evaluated at our Outpatient Liver Disease Clinic during the 6-mo period preceding the start of Italian lockdown(March 8,2020)were *** were asked to complete a two-part questionnaire,administered by telephone according to governmental restrictions:The first section assessed patients’basic knowledge regarding COVID-19,and the second evaluated the impact of the COVID-19 emergency on their *** used the Italian version of the CLD questionnaire(CLDQ-I).With the aim of evaluating possible changes in the QOL items addressed,the questionnaire was administered to patients at the time of telephone contact with the specific request to recall their QOL perceptions during two different time *** detail,patients were asked to recall these perceptions first during time 0(t0),a period comprising the 2 wk preceding the date of ministerial lockdown decree(from February 23 to March 7,2020);then,in the course of the same phone call,they were asked to recall the same items as experienced throughout time 1(t1),the second predetermined time frame encompassing the 2 wk(from April 6 to April 19)preceding our telephone contact and questionnaire *** data are expressed as number(%),and continuous variables are reported as the median(interquartile range).The data were compared using the Wilcoxon paired non-parametric *** A total of 111 patients were enrolled,of whom 81 completed the ***-nine had liver cirrhosis,and all of them had c

关键词： COVID-19 Liver disease Quality of life Liver cirrhosis Chronic liver disease questionnaire

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nasogastric or nasointestinal feeding in severe acute pancreatitis

引用

World Journal of Gastroenterology 2010年第29期16卷 3690-3696页

作者： Matteo Piciucchi Elettra Merola massimo marignani Mari-anna Signoretti Roberto Valente Lucia Cocomello Flavia Baccini Francesco Panzuto Gabriele Capurso Gianfranco Delle Fave Digestive and Liver Disease Unit Ⅱ Medical SchoolUniversity "Sapienza"

AIM:To assess the rate of spontaneous tube migration and to compare the effects of naso-gastric and nasointestinal(NI)(beyond the ligament of Treitz) feeding in severe acute pancreatitis(SAP).METHODS:After bedside intragastric insertion,tube position was assessed,and enteral nutrition(EN) started at day 4,irrespective of tube *** were monitored daily and clinical and laboratory parameters evaluated to compare the outcome of patients with nasogastric(NG) or NI ***:Spontaneous tube migration to a NI site occurred in 10/25(40%) prospectively enrolled SAP patients,while in 15(60%) nutrition was started with a NG *** were similar for demographics and pancreatitis aetiology but computed tomography(CT) severity index was higher in NG tube patients than in NI(mean 6.2 vs 4.7,P=0.04).The CT index seemed a risk factor for failed obtainment of spontaneous distal *** trough NG or NI tube were similar in terms of tolerability,safety,clinical goals,complications and hospital ***:Spontaneous distal tube migration is successful in 40% of SAP patients,with higher CT severity index predicting intragastric retention;in such cases EN by NG tubes seems to provide a pragmatic alternative opportunity with similar outcomes.

关键词： Acute pancreatitis Enteral feeding Tube migration Nasogastric Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Patients with hematological malignancies and serological signs of prior resolved hepatitis B

引用

World Journal of Gastrointestinal Oncology 2012年第3期4卷 37-45页

作者： massimo marignani Elia Gigante Paola Begini Alfredo Marzano Michela di Fonzo Ilaria Deli Sara Gallina Maria Christina Cox Gianfranco Delle Fave Digestive and Liver Disease Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy SCDU of Gastroenterology and Hepatology AO San Giovanni Battista Corso Bramante 88 10125 Torino Italy Haematology Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies.

关键词： Occult hepatitis B Hematological malignancies Hepatitis B virus Chemotherapy Hepatitis B reactivation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HCV infection, B-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions

引用

World Journal of Gastrointestinal Oncology 2012年第3期4卷 46-53页

作者： Maria Christina Cox Maria Antonietta Aloe-Spiriti Elena Cavalieri Eleonora Alma Elia Gigante Paola Begini Caterina Rebecchini Gianfranco Delle Fave massimo marignani Department of Haematology Sant'Andrea Hospital La Sapienza University Department of Gastroenterology and Liver Disease Sant'Andrea Hospital La Sapienza University

There is plenty of data confirming that hepatitis C virus (HCV) infection is a predisposing factor for a B-cell non-Hodgkin's lymphoma (B-NHL) outbreak, while relatively few reports have addressed the role of HCV in affecting B-NHL patients' outcome. HCV infection may influence the short-term outcome of B-NHL because of the emergence of severe hepatic toxicity (HT) during immunochemotherapy. Furthermore, the long term outcome of HCV-related liver disease and patients' quality of life will possibly be affected by Rituximab maintenance, multiple-lines of toxicity during chemotherapy and hematopoietic stem cell transplantation. In this review, data dealing with aggressive and low-grade B-NHL were separately analyzed. The few retrospective papers reporting on aggressive B-NHL patients showed that HCV infection is a risk factor for the outbreak of severe HT during treatment. This adverse event not infrequently leads to the reduction of treatment density and intensity. Existing papers report that low-grade B-NHL patients with HCV infection may have a more widespread disease, more frequent relapses or a lower ORR compared to HCV-negative patients. Notwithstanding, there is no statistical evidence that the prognosis of HCV-positive patients is inferior to that of HCV-negative subjects. HCV-positive prospective studies and longer follow-up are necessary to ascertain if HCV-positive B-NHL patients have inferior outcomes and if there are long term sequels of immunochemotherapies on the progression of liver disease.

关键词： Marginal zone lymphoma Diffuse large B cell lymphoma Hepatitis C virus Non-Hodgkin’s lymphomas Hepatotoxicity Chemotherapy Immunochemotherapy Prognosis Rituximab

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis B in patients with hematological diseases: An update

引用

World Journal of Hepatology 2017年第25期9卷 1043-1053页

作者： Chiara Coluccio Paola Begini Alfredo Marzano Adriano Pellicelli Barbara Imperatrice Giulia Anania Gianfranco Delle Fave massimo marignani Dig-estive and Liver Diseases Department Sant’Andrea HospitalSchool of Medicine and PsychologySapienza University Division of Gastroenterology and Hepatology San Giovanni Battista Hospital Liver Unit San Camillo Forlanini Hospital

Hepatitis B virus(HBV) reactivation(HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles. Articles published only in abstract form and case reports not giving considerable news were excluded. Clinical manifestation of HBVr can be manifold, ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure. In clusters of patients adverse outcomes are potentially predictable. Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers, occult HBV carriers and inactive carriers, the most intriguing category), and classes of immunosuppressive drugs. We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening. In case of serological sign(s) of current or past infection with the virus, appropriate therapeutic or preventive strategies are suggested, according to both virological categories, risk of HBVr by immunosuppressive drugsand liver status. Either antiviral drug management and surveillance and pre-emptive approach are examined, commenting the current international recommendations about this debated issue.

关键词： Reactivation Lymphoma Hematology Immunosuppressive therapy Prophylaxis Hepatitis B virus Chemotherapy Occult/active/inactive carrier Entecavir Lamivudine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

引用

World Journal of Hepatology 2011年第11期3卷 278-284页

作者： Adriano M Pellicelli massimo marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini Liver Unit Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense 8700149 Rome Italy Department of Digestive and Liver Disease Azienda Ospedaliera Sant’AndreaVia Grottarossa 1035/1039000189 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Liver Unit Ospedale Sandro PertiniVia dei Monti Tiburtini 38500157 Rome Italy Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense87 00149 Rome Italy Medicine of Migration National Institute for Migrant Health and Poverty Via di S. Gallicano 25/a 00153Rome Italy Department of Medical Pathophysiology University of Rome "La Sapienza" Viale del Policlinico 15500161 Rome Italy Liver Unit Campus Biomedico UniversityVia álvaro del Portillo 21 00128Rome Italy Histopathology Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149Rome Italy Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Department of Infectious and Tropical Disease University of Rome"La Sapienza"Viale del Policlinico155 00161 Rome Italy Liver Unit Ospedale Villa BetaniaVia Niccolò Piccolomini 2700165 RomeItaly Liver Unit Policlinico CasilinoVia Casilina104900169 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Infectious and Parasitic Diseases Policlinico San Matteo P.zzale Golgi 2 2710 PaviaItaly

AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management ***:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and *** with DLBCL were managed with the standard of care of *** with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course *** outcomes of the different approaches were ***:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent *** of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL *** lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection.

关键词： Hepatitis C virus infection Diffuse large B cell lymphoma Indolent lymphoma Pegylated interferon Lymphomagenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

‘Les liaisons dangereuses’: Hepatitis C, Rituximab and B-cell non-Hodgkin’s lymphomas

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第2期3卷 21-28页

作者： massimo marignani Michela di Fonzo Paola Begini Elia Gigante Ilaria Deli Adriano M Pellicelli Sara Gallina Emanuela de Santis Gianfranco Delle Fave M Christina Cox Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy Liver Unit Azienda Ospedaliera San Camillo Forlanini 000149 Rome Italy Department of Haematology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Rituximab has provided a revolutionary contribution to the treatment of B-cell non-Hodgkin’s lymphomas (NHL). A high prevalence of hepatitis C virus (HCV) infection has been described in B-cell NHL patients. Cases of liver dysfunction in HCV-positive patients have been reported with Rituximab-containing regimens. In this paper we review the recent data regarding the effects of Rituximab in NHL patients with HCV infection. We also added a section devoted to improving communication between oncohaematologists and hepatologists. Furthermore, we propose a common methodological ground to study hepatic toxicity emerging during chemotherapy.

关键词： Rituximab B-cell non-Hodgkin’s lymphoma Hepatitis C virus Immunochemotherapy Methodology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver biopsy:analysis of results of two specialist teams

引用

World Journal of Gastrointestinal Pathophysiology 2014年第2期5卷 114-119页

作者： Giulia Anania Elia Gigante Matteo Piciucchi Emanuela Pilozzi Eugenio Pucci Adriano Maria Pellicelli Carlo Capotondi Michele Rossi Flavia Baccini Giulio Antonelli Paola Begini Gianfranco Delle Fave massimo marignani Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Department of Pathology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera Liver Unit Azienda Ospedaliera San Camillo Department of Radiology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera

AIM:To analyze the safety and the adequacy of a sample of liver biopsies(LB)obtained by gastroenterologist(G)and interventional radiologist(IR)***:Medical records of consecutive patients evaluated at our GI unit from 01/01/2004 to31/12/2010 for whom LB was considered necessary to diagnose and/or stage liver disease,both in the setting of day hospital and regular admission(RA) care,were retrieved and the data entered in a *** were divided into two groups:one undergoing an ultrasonography(US)-assisted procedure by the G team and one undergoing US-guided biopsy by the IR *** the first group,an intercostal approach(US-assisted) and a Menghini modified type needle 16 G(length 90 mm) were *** IR team used a subcostal approach(US-guided) and a semiautomatic modified Menghini type needle 18 G(length 150 mm).All the biopsies were evaluated for appropriateness according to the current *** number of portal tracts present in each biopsy was assessed by a revision performed by a single pathologist unaware of the previous pathology ***,laboratory and demographic patient characteristics,the adverse events rate and the diagnostic adequacy of LB were ***:During the study period,226 patients,126 males(56%) and 100 females(44%),underwent LB:167(74%) were carried out by the G team,whereas 59(26%) by the IR *** was mostly performed in a day hospital setting by the G team,while IR completed more procedures on inpatients(P < 0.0001).The groups did not differ in median age,body mass index(BMI),presence of comorbidities and coagulation *** occurred in 26 patients(16 G team vs 10 IR team,P = 0.15).Most gross samples obtained were considered suitable for basal histological evaluation,with no difference among the two teams(96.4% G team vs 91.5% IR,P = 0.16).However,the samples obtained by the G team had a higher mean number of portal tracts(G team 9.5 ± 4.8; range 1-29 vs IR team 7.8 ± 4.1; range 1-2

关键词： Liver biopsy Ultrasound-guided biopsy Ultrasound-assisted biopsy Menghini needle Sample adequacy Portal tracts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：