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现代制造 2007年第16期 12-12页

作者： Sal spada David W.Humphrey

欧洲经济的发展，让自动化设备供货商们迎来了光辉的一年。在汉诺威博览会上显示出，自动化设备供货商们为今后10年的新一代自动化丰收播下了新的种子。自动化设备供货商们将继续努力，在这一新的业务浪潮中保持平衡，

关键词：自动化设备汉诺威博览会供货商经济欧洲显示平衡

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注射吸毒者中暴发高病死率的HAV感染

世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 59-59页

作者： spada E Genovese D Tosti M.E. 孟欣颖 Istituto Superiore di Sanità National Center of Epidemiology Surveillance and Health Promotion Clinical Epidemiology Unit Viale Regina Elena 299 00161 Rome Italy

Background/Aims: In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. Methods: We conducted an epidemiological investigation, including a case-control study, to identify the source and themodes of HAV transmission. Hepatitis B and C (HCV) viruses and human immunodeficiency vir us (HIV) coinfections were clinically analysed. Sequence analysis of the VP1/2A junction of the HAV isolates was also performed. Results: Of the 47 symptomatic cases, 35 were IDUs. The only associated risk factor was contact (not related to injecting practices) with a jaundiced person (odds ratio: 5.8; 95%confidence i nterval: 1.3-29.9). Of the cases, 58%were anti-HCV positive and 4.7%anti-HI V positive. Three individuals died of acute liver failure: 2 were HCV-coinfecte d alcohol abusers, with underlying liver cirrhosis; 1 was HCV/HIV-coinfected. H AV-RNA was found in 15 of the 24 tested patients: genotype IB (8 cases) and III A (7 cases) were detected. Conclusions: HAV was probably transmitted through the fecal-oral route, although parenteral transmission cannot be excluded. The hig h fatality ratewas probably due to severe underlying liver damage. The occurrenc e of this outbreak highlights the need for routine HAV vaccination for IDUs.

关键词：注射吸毒者 HAV 静脉吸毒者流行病学调查急性肝衰竭传播模式酗酒者肝脏损害序列分析病例

急性感染期HCV特异性T细胞早期增殖受损可致病毒清除失败

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 37-37页

作者： Folgori A. spada E. Pezzanera M. A. Vitelli 周智勇 Istituto di Ricerche di Biologia Molecolare P Angeletti Via Pontina km 30.600 00040 Pomezia Rome Italy Dr.

Background and aims: Cellular mediated immunity (CMI) is thought to play a key role in resolution of primary hepatitis C virus (HCV) infection. However, CD4+and CD8+T cell responses are also generated during acute infection in individuals who become chronic, suggesting that they developed a defective CMI. The aim of this study was to verify if and when such immune dysfunction is established by measuring the breadth, magnitude, function, and duration of CMI in a large cohort of subjects during the natural course of acute HCV infection. Methods: CMI was comprehensively studied by prospective sampling of 31 HCV acutely infected subjects enrolled at the onset of infection and followed for a median period of one year. Results: Our results indicated that while at the onset of acute HCV infection a measurable CMI with effector function was detected in the majority of subjects, after approximately six months less than 10%of chronically infected individuals displayed significant CMI compared with 70%of subjects who cleared the virus. We showed that progressive disappearance of HCV specific T cells from the peripheral blood of chronic patients was due to an impaired ability to proliferate that could be rescued in vitro by concomitant exposure to interleukin 2 and the antigen. Conclusion: Our data provide evidence of strong and multispecific T cell responses with a sustained ability to proliferate in response to antigen stimulation as reliable pharmacodynamic measures of a protective CMI during acute infection, and suggest that early impairment of proliferation may contribute to loss of T cell response and chronic HCV persistence.

关键词：急性感染期 HCV 特异性免疫功能障碍抗原刺激受试人群慢性感染者效应子慢性患者综合研究

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晚期胆道闭锁患儿的肝多层螺旋CT表现

国际医学放射学杂志 2010年第4期 406-406页

作者： S.Caruso R.Miraglia M.Milazzo L.Maruzzelli A.Pasta M.spada 李宁 Department of Radiology Istituto Mediterraneo Trapiantie Terapiead Alta Specializzazione (IsMeTT)Via Tricomi 190127 PalermoItaly

目的阐述晚期胆道闭锁(BA)的多层螺旋CT(MDCT)表现。方法研究对象包括2005年2月-2008年2月间的45例BA患儿,所有患儿在肝脏移植前均行MDCT检查。平均年龄36个月,其

关键词：胆道闭锁 CT 患儿多层螺旋

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欧洲货币政策和货币市场基金

金融市场研究 2024年第6期 103-105页

作者：马尔科·西普里亚尼丹尼尔·弗里克斯特凡·格雷普迈尔加布里埃尔·拉斯帕达凯罗尔·帕卢德凯维奇徐恒革(编译) 纽约联邦储备银行研究与统计小组德意志联邦银行德意志联邦银行金融市场研究部不详

根据纽约联储自由街经济学博客之前发表的文章(1),美国货币市场基金(MMF)份额的收益率对货币政策利率变化的反应远远大于银行存款利率。换句话说,货币市场基金的贝塔比存款贝塔高得多。与此相一致的是,美国货币市场基金行业规模随着利... 详细信息

根据纽约联储自由街经济学博客之前发表的文章(1),美国货币市场基金(MMF)份额的收益率对货币政策利率变化的反应远远大于银行存款利率。换句话说,货币市场基金的贝塔比存款贝塔高得多。与此相一致的是,美国货币市场基金行业规模随着利率周期波动,在货币政策收紧期间扩大。

关键词：银行存款利率货币市场基金周期波动货币政策贝塔经济学收益率