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Feasibility of cabazitaxel in octogenarian prostate cancer patients

Current Urology 2023年第3期17卷 153-158页

作者： Paolo Tralongo Sebastiano Bordonaro Giuseppe Di Lorenzo Ugo De Giorgi NicolòBorsellino Gaetano Facchini Sabrina Rossetti Giuseppe Fornarini Vito Longo Antonino Carmelo Tralongo Francesca Caspani massimiliano spada Nicola Calvani Paolo Carlini Medical Oncology Unit RAO-Umberto I HospitalSiracusa96100Italy Department of Medicine and Health Sciences‘Vincenzo Tiberio' University of MoliseCampobassoItaly Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(IRST)IRCCS Meldola(FC)Italy Medical Oncology Unit Ospedale Buccheri La FerlaFatebenefratelliPalermoItaly Medical Oncology Unit Santa Maria delle Grazie di PozzuoliNapoliItaly Departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale TumoriIRCCSFondazione G.PascaleNapoliItaly Medical Oncology 1 IRCCSOspedale Policlinico San MartinoGenovaItaly Istituto Tumori Giovanni PaoloⅡI.R.C.C.S. BaOspedale di CircoloVareseItaly Medical Oncology Unit ASSTSETTE LAGHIOspedale di CircoloVareseItaly Medical Oncology Unit Fondazione Istituto G.Giglio di CefalùPalermoItaly Medical Oncology Division&Breast Unit Sen.A.Perrino HospitalBrindisiItaly Medical Oncology 1 Istituto Nazionale Tumori Regina ElenaRomaItaly

Background:To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged>80 years,we performed a retrospective study on a sample of patients from 11 Italian cancer *** and methods:Fifty-seven patients aged>80 years were treated with cabazitaxel after previous failure with docetaxel;39 completed a comprehensive geriatric assessment questionnaire(34 fit and 5 vulnerable)and 8 patients(14%)had an Eastern Cooperative Oncology Group performance status(PS)>2,while most had a PS of 0-1(86%).Cabazitaxel was administered at a dose of 25 mg/m^(2)in 30(52%)patients and 20 mg/m^(2)or adapted schedules in 27(48%)*** schedules were adopted mainly in patients>85 years(75%),with a PS>2(87.5%),and those classified as vulnerable(100%).Results:The duration of treatment was 4.8 months and was comparable in all subgroups;disease control rate was reported in 36 patients(63%);prostate-specific antigen response was recorded in 18 patients(31.5%).Median overall survival was 13.1 months regardless of age(85 years),but overall survival was reduced in vulnerable(7.2 months)and PS>2 patients(6.8 months).The most frequently documented grade 3-4 toxicities were neutropenia(14%)and diarrhea(10.5%).Six patients(10.5%)dropped out due to severe ***:Octogenarian patients can be treated with cabazitaxel with reduced doses or alternative schedules that are associated with less toxicity and fewer treatment *** geriatric assessment could facilitate more appropriate patient selection.

关键词： Cabazitaxel Cancer Octogenarian Prostate

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Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta Gabriele Capurso Ivo Boskoski Cristiano spada Jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

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Capsule endoscopy in celiac disease

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World Journal of Gastroenterology 2008年第26期14卷 4146-4151页

作者： Cristiano spada Maria Elena Riccioni Riccardo Urgesi Guido Costamagna Digestive Endoscopy Unit Catholic UniversityRome 00168Italy

Video capsule endoscopy is an attractive and patient- friendly tool that provides high quality images of the small bowel. Obscure gastrointestinal bleeding is the primary and most evaluated indication to capsule endoscopy;however,indications are expanding and a small number of preliminary reports have been presented concerning the role of video capsule endoscopy in the diagnosis of celiac disease. The purpose of this review is to update the current knowledge and to hypothesize on future perspectives of the use of video capsule endoscopy in patients with celiac disease.

关键词： Capsule endoscopy Celiac disease Diagnosis of celiac disease Celiac disease complications

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Pediatric liver transplantation

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World Journal of Gastroenterology 2009年第6期15卷 648-674页

作者： Marco spada Silvia Riva Giuseppe Maggiore Davide Cintorino Bruno Gridelli Istituto Mediterraneo peri Trapiantie Terapie ad alta specializzazione-IsMeTT University of Pittsburgh Medical Center90127 PalermoItaly Department of Reproductive Medicine and Child Development University of Pisa56100 PisaItaly

In previous decades,pediatric liver transplantation has become a state-of-the-art operation with excellent success and limited *** and patient survival have continued to improve as a result of improvements in medical,surgical and anesthetic management,organ availability,immunosuppression,and identification and treatment of postoperative *** utilization of split-liver grafts and living-related donors has provided more organs for pediatric *** immunosuppression regimens,including induction therapy,have had a significant impact on graft and patient *** developments of pediatric liver transplantation will deal with long-term followup,with prevention of immunosuppression-related complications and promotion of as normal growth as *** review describes the state-of-the-art in pediatric liver transplantation.

关键词： Pediatric liver transplantation Indications Surgical techniques Complications

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A Mixed Radiative-Convective Technique for the Calibration of Heat Flux Sensors in Hypersonic Flow

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Fluid Dynamics & Materials Processing 2022年第2期18卷 189-203页

作者： Antonio Esposito Marcello Lappa Rocco Pagliara Gennaro spada Department of Industrial Engineering University of NaplesNaples80125Italy Department of Mechanical and Aerospace Engineering University of StrathclydeGlasgowG11XJUK Cheminox srl San Vito dei Normanni(BR)72019Italy

The ability to measure the very high heat fluxes that typically occur during the hypersonic re-entry phase of space vehicles is generally considered a subject of great importance in the aerospace *** of the sensors used for these measurements need to be checked periodically and re-calibrated *** bottleneck relates to the need to procure thermal sources that are able to generate reliable reference heat fluxes in the range between 100 and 1000 kW/m^(2)(as order of magnitude).In the present study,a method is presented by which,starting from a calibration system with a capacity of approximately 500 kW/m^(2) only,heat fluxes in the range of interest for hypersonic applications are *** related procedure takes advantage of established standards for the characterization of a radiative heat *** also builds on the hybrid radiative-convective nature of typical hypersonic heat fluxes and the yet poorly explored possibility to use convective sources of heat to produce high-intensity *** reliability of such a strategy has been tested using a high enthalpy supersonic flow facility relying on an electric arc-heater and pure Nitrogen as work ***-point heat fluxes have been successfully measured(with reasonable accuracy)in the range between 600 and 1500 kW/m^(2) for values of the centerline enthalpy spanning the interval from to 6 to 24 MJ/kg.

关键词： Photometry heat flux sensor calibration facility radiative source convective source

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Looking for the right TNM staging system for pancreatic neuroendocrine tumors

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 382-384页

作者： Nicola Fazio Francesca spada Emilio Bertani Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors European Institute of OncologyIEOIRCCSMilanItaly Division of Digestive Surgery European Institute of OncologyIEOIRCCSMilanItaly

Pancreatic neuroendocrine tumors(panNETs)represent a rare subgroup of neuroendocrine neoplasms(NENs)which showed an impressive increase of incidence over the last decade(1).As over the same period particularly low sta... 详细信息

关键词： neuroendocrine neoplasms tumors

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Newborn screening for galactosemia:a 30-year single center experience

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World Journal of Pediatrics 2015年第2期11卷 160-164页

作者： Francesco Porta Severo Pagliardini Veronica Pagliardini Alberto Ponzone Marco spada Department of Pediatrics University of TorinoTorinoItaly

Background:Galactosemia due to complete or near-complete galactose-l-phosphate uridyltransferase(GALT)deficiency was the first disorder added to the pioneering newborn screening panel besides *** the last 50 years,many criticisms have been focused on the opportunity of its ***,long-term single center experiences with this issue are generally ***:We reviewed the outcome of newborn screening for hypergalactosemia performed at our department since 1982 and the correspondent long-term clinical ***:Among 1123909 newborns screened for hypergalactosemia,33 showed abnormal results confirmed at second tier *** patients were affected with classic galactosemia,8 partial GALT deficiency,3 severe galactokinase deficiency,7 transient galactosemia,one congenital porto-systemic shunt,and one glucose transporter 2 *** neonatal liver failure in the late first week of life(5.8±1.1 days)unavoidably complicated the clinical course of classic galactosemia,unless in three second-born siblings treated on the basis of presumptive diagnosis immediately after newborn screening sample collection on day *** early treatment and longterm steadily normal peripheral blood galactose,77%of patients with severe GALT deficiency present mild to severe intellectual *** patients with partial GALT deficiency showed normal intellectual development on a regular diet,as well as patients with galactokinase deficiency under ***:Availability of screening results within the fifth day after birth would allow the prevention of acute decompensation in classic galactosemia.A systematic diagnostic work-up in all positive newborns is essential to unravel the etiology of hypergalactosemia.

关键词： galactose galactosemia liver failure mental retardation newborn screening

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Different modalities of arterial reconstruction in hepatic retransplantation using right partial graft

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World Journal of Gastroenterology 2009年第26期15卷 3322-3323页

作者： Salvatore Gruttadauria Fabrizio di Francesco Marco spada Mariapina Milazzo Bruno Gridelli Mediterranean Institute for Transplant and Advanced Specialized Therapies University of Pittsburgh Medical Center in Italy

Though split-liver and living-related transplantation are routinely performed,they are done almost exclusively for primary liver transplantation because of potential surgical *** difficulties are generally related to arterial revascularization,particularly if there is hepatic artery *** to UNOS data,of the hepatic retransplantations performed between 1996 and 2007,only 8.7% were done using right or extended right grafts from deceased donors,and 14.3% using right grafts from live *** we report our experience with 5 hepatic retransplantations in which right partial grafts resulting from conventional in situ splits,and one right lobe resulting from an adult-toadult living-related transplant,were successfully used with different modalities of graft arterialization.

关键词： Hepatic artery Liver transplantation Split liver Living related transplantation Hepatic retransplantation

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Influence of Blueberry and Jaboticaba Agroindustrial Residue Particle Size on Color Change of Corn Starch Based Films Submitted to Different pH Values Solutions

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Journal of Renewable Materials 2019年第3期7卷 235-243页

作者： Cláudia Leites Luchese Julia Menegotto Frick Pavoni Jordana Corralo spada Isabel Cristina Tessaro Laboratory of Packaging Technology and Membrane Development(LATEM) Department of Chemical Engineering-Federal University of Rio Grande do Sul(UFRGS)Street Ramiro Barcelos2777.Porto Alegre/RS-ZC:90035-007-Brazil

Corn starch,glycerol and agroindustrial residues were used to produce films by ***-products from juice processing,blueberry and jaboticaba in powder with different particle sizes were added in the filmogenic matrix to evaluate its potential as a colorimetric *** and jaboticaba peels are commonly discarded although contain high amount of important compounds as *** compounds have the ability to color change after immersion in different pH values,demonstrating its potential for the intelligent packaging *** were performed in a colorimeter after films immersion in different buffer *** color changes were perceived;reddish and bluish color in acidic and basic pH values,*** of the particle size,theΔE* values were greater than 5,showing visually perceptible change to the human *** results indicate the potential of use of these residues as a pH indicator for the development of renewable and biodegradable sensor of food deterioration.

关键词： Blueberry jaboticaba anthocyanin casting colorimetric analysis

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Gastric duplication associated with pancreas divisum diagnosed by a multidisciplinary approach before surgery

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World Journal of Gastroenterology 2010年第8期16卷 1031-1033页

作者： Marta Di Pisa Gabriele Curcio Gianluca Marrone Mariapina Milazzo Marco spada Mario Traina Mario Traina Gastroenterology Service Department of Radiology IsMeTT-UPMC Department of Surgery IsMeTT-UPMC

We report a unique case of communicating gastric duplication associated with pancreas divisum,diagnosed with a multidisciplinary approach,including X-rays,computed tomography,magnetic resonance imaging,esophagogastro duodenoscopy,ultrasound endoscopy and histology. We believe that this approach constitutes a fuller diagnostic evaluation,resulting in better and safer surgery.

关键词： Gastric duplication Pancreas divisum Computed tomography Magnetic resonance imaging Ultra-sonic endoscopy

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