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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染患者时安全有效

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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染...

第十届全国疑难及重症肝病大会

作者： Kathleen B.Schwarz Philip Rosenthal Karen F.Murray Jonathan Robert Honegger Winita Hardikar Rosemary Hague Naveen Mittal benedetta massetto Diana Brainard Rebecca Begley Bandita Parhy Jiang Shao Michael R.Narkewicz Girish S.Rao Suzanne Whitworth Sanjay Bansal William F.Balistreri Johns Hopkins Hospital University of California San Francisco University of Washington School of Medicine and Seattle Children's Hospital The Ohio State University Medical Center The Royal Children's Hospital

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC...

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC)用于6至<12岁的患者中时的数据,其SVR12率分别为99%-100%。本研究评估了全口服LDV/SOF FDC疗法用于3至<6岁

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亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变异的流行率

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亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变...

12周或24周的索磷布韦+利巴韦林用于3至<12岁的基因2型或基因3型慢性丙型肝炎的儿童感染患者时安全有效

第九届全国疑难及重症肝病大会

作者： Wei Lai Masao Omata Young-Suk Lim Wan-Long Chuang Dao Long Xie Qing Hou Jin Lin Jia Jidong Evguenia Svarovskaia Ross Martin Brian Doehle Jenny Yang Shampa De-Oertel benedetta massetto Kathryn Kersey Diana M.Brainard Hongmei Mo Nguyen Kinh Jia-Horng Kao Kwang-Hyub Han Masashi Mizokami Duan Zhongping YamanashiPrefecturalHospitalOrganization KaohsiungMedicalUniversityHospital KaohsiungMedicalUniversity YonseiUniversityCollegeofMedicineSeoul ShanghaiJiaotonhUniversityRuijinHospital NationalHospitalOrganizationNagasakiMedicalCenter AsanMedicalCenter UniversityofUlsanCollegeofMedicine PekingUniversityPeople’sHospital NationalTaiwanUniversityCollegeofMedicineandHospital NationalHospitalofTropicalDiseases GileadScience Inc BeijingFriendshipHospitalAffiliatedtoCapitalMedicalUniversity BeijingYouanHospitalAffiliatedtoCapitalMedicalUniversity BachMaiHospital HanoiMedicalUniversityHospital NanfangHospitalofSouthernMedicalUniversity

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A...

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A和NS5B核苷类抑制剂(NI)RAS在中国大陆、中国台湾、日本、韩国和越南的基因1b、2、3和6型HCV感染患者中的流行率。

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12周或24周的索磷布韦+利巴韦林用于3至<12岁的基因2型或基因3型...

第十届全国疑难及重症肝病大会

作者： Philip Rosenthal Kathleen B.Schwarz Regino P Gonzalez-Peralta Chuan-Hao Lin Deirdre A.Kelly Scott Nightingale William F.Balistreri Sanjay Bansal Maureen M.Jonas benedetta massetto Diana Brainard Rebecca Begley Jiang Shao Bandita Parhy Suzanne Davison Cornelia Feiterna-Sperling Lynette A.Gillis Giuseppe Indolfi Etienne M.Sokal Karen F.Murray Stefan Wirth University of California San Francisco Johns Hopkins Hospital Pediatric Hepatology and Liver Transplantation University of Florida Children's Hospital Los Angeles

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。本研究评估了索磷布韦(SOF)+利巴韦林(RBV)全口服疗法用于3至<12岁的儿童患者...

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。本研究评估了索磷布韦(SOF)+利巴韦林(RBV)全口服疗法用于3至<12岁的儿童患者时的安全性和疗效。方法 3至<12岁的慢性HCVGT2或GT3儿童患者入组本项正在进行的开放标签研究,接受

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在基因1、2、3或6型的HCV感染患者中使用索磷布韦+利巴韦林±聚乙二醇干扰素:来源于中国的一项3期研究结果

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在基因1、2、3或6型的HCV感染患者中使用索磷布韦+利巴韦林±聚乙...

第九届全国疑难及重症肝病大会

作者： Wei Lai Xie Qing Hou Jin Lin Jia Jidong Li Wu Xu Min Li Jun Wu Shaming Cheng Jun Jiang Jianning Wang Guiqiang Yang Yongfeng Mu Zhuangbo Gao Zhi Liang Gong Guozhong Niu JunQi Hu Peng Tang Hong Lin Feng Dou Xiaguang Li Lanjuan Zhang LunLi Nan Yuemin Knox Steve Kersey Kathryn Brainard Diana massetto benedetta Jiang Deyuan Jiang Jiaji Ning Qin Duan Zhong-Ping Peking University People's Hospital Shanghai Jiaotonh University Ruijin Hospital Nanfang Hospital of Southern Medical University Beijing Friendship Hospital affiliated to Capital Medical University 1st Affiliated Hospital of Kunming Medical university Guangzhou Eighth People's Hospital Jiangsu Province People's Hospital Clinical Center of Shanghai Public Health Beijing Ditan Hospital affiliated to Capital Medical University The 1st Affiliated Hospital of GuangXi Medical University Peking University First Hospital The second hospital of Nanjing Jinan Infections Disease Hospital 3rd Affiliated Hospital of Sun Yat-Sen University The Second Xiangya Hospital of Central South University Jilin University First Hospital 2nd Affiliated Hospital of Chongqing Medical University West China Hospital Sichuan University Hainan General Hospital Shengjing hospital of China Medical University 1st Affiliated Hospital Zhejiang University Medical College The First Affiliated Hospital of Nanchang University 3rd Hospital Of Hebei Medical University

背景和目的索磷布韦(SOF)联合利巴韦林(RBV),联合/不联合聚乙二醇干扰素(Peg-IFN),在基因型(GT)为1-6的HCV感染患者中表现出较高的疗效。在中国,HCV感染的患病率估计为3.2%,其中以基因1,2,6型为主。因此在中国,全基因型治疗方案较为理...

背景和目的索磷布韦(SOF)联合利巴韦林(RBV),联合/不联合聚乙二醇干扰素(Peg-IFN),在基因型(GT)为1-6的HCV感染患者中表现出较高的疗效。在中国,HCV感染的患病率估计为3.2%,其中以基因1,2,6型为主。因此在中国,全基因型治疗方案较为理想。这项3期研究评估了SOF+RBV±PegIFN治疗方案用于初治(TN)和经治(TE)的感染GT1、2、3或6的HCV中国患者(伴或不伴肝硬化)时的疗效。

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Federated learning framework for mobile edge computing networks

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CAAI Transactions on Intelligence Technology 2020年第1期5卷 15-21页

作者： Romano Fantacci benedetta Picano Department of Information Engineering University of FlorenceFlorenceItaly

The continuous growth of smart devices needing processing has led to moving storage and computation from cloud to the network edges,giving rise to the edge computing *** to the limited capacity of edge computing nodes,the presence of popular applications in the edge nodes results in significant improvements in users’satisfaction and service ***,the high variability in the content requests makes prediction demand not trivial and,typically,the majority of the classical prediction approaches require the gathering of personal users’information at a central unit,giving rise to many users’privacy *** this context,federated learning gained attention as a solution to perform learning procedures from data disseminated across multiple users,keeping the sensitive data *** study applies federated learning to the demand prediction problem,to accurately forecast the more popular application types in the *** proposed framework reaches high accuracy levels on the predicted applications demand,aggregating in a global and weighted model the feedback received by users,after their local *** validity of the proposed approach is verified by performing a virtual machine replica copies and comparison with the alternative forecasting approach based on chaos theory and deep learning.

关键词： prediction forecasting framework

Multi-User Semantic Communications System with Spectrum Scarcity

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Journal of Communications and Information Networks 2022年第4期7卷 375-382页

作者： Romano Fantacci benedetta Picano Via di Santa Marta 3 Florence 50139Italy

Nowadays,the emerging paradigm of semantic communications seems to offer an attractive opportunity to improve the transmission reliability and efficiency in new generation communication *** particular,focusing on spectrum scarcity,expected to afflict the upcoming sixth generation(6G)networks,this paper analyses the semantic communications behavior in the context of a cell-dense scenario,in which users belonging to different small base station areas may be allocated on a same channel giving rise to a non-negligible interference that severely affects the communications *** such a context,artificial intelligence methodologies are of paramount importance in order to speed up the switch from traditional communication to the novel semantic communication *** a consequence,a deep-convolution neural networks based encoder-decoder architecture has been exploited here in the definition of the proposed semantic communications ***,extensive numerical simulations have been performed to test the advantages of the proposed framework in different interfering scenarios and in comparison with different traditional or semantic alternatives.

关键词： semantic communication terahertz communications machine learning

Spinal tuberculosis simulating metastatic malignancy:An unusual condition

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 83-84页

作者： Jacopo Giuliani benedetta Urbini Department of Oncology Mater Salutis HospitalASL 21della Regione VenetoLegnago(VR)Italy Clinical Oncology Unit-St.Anna University-Hospital-Ferrara Italy

Vertebral lesions can refer to many conditions with different clinical and radiological features suggestive but inconclusive for a *** differential diagnosis of vertebral lesions includes malignant primary tumors of the spine,metastatic tumors(carcinoma of the lung,kidney,prostate,thyroid,gastro-intestinal tract and breast,although less frequent in males,and occult cancer),haematological malignancies(plasmocytoma,Hodgkin and

关键词： PPD bone

Single-incision laparoscopic colorectal surgery for cancer: State of art

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World Journal of Gastroenterology 2014年第20期20卷 6073-6080页

作者： Fabio Cianchi Fabio Staderini benedetta Badii Department of Surgery and Translational Medicine Center of Oncological Minimally Invasive Surgery University of Florence 50134 Florence Italy

A number of clinical trials have demonstrated that the laparoscopic approach for colorectal cancer resection provides the same oncologic results as open surgery along with all clinical benefits of minimally invasive surgery. During the last years, a great effort has been made to research for minimizing parietal trauma, yet for cosmetic reasons and in order to further reduce surgery-related pain and morbidity. New techniques, such as natural orifice transluminal endoscopic surgery (NOTES) and single-incision laparoscopy (SIL) have been developed in order to reach the goal of “scarless” surgery. Although NOTES may seem not fully suitable or safe for advanced procedures, such as colectomies, SIL is currently regarded as the next major advance in the progress of minimally invasive surgical approaches to colorectal disease that is more feasible in generalized use. The small incision through the umbilicus allows surgeons to use familiar standard laparoscopic instruments and thus, perform even complex procedures which require extraction of large surgical specimens or intestinal anastomosis. The cosmetic result from SIL is also better because the only incision is made through the umbilicus which can hide the wound effectively after operation. However, SIL raises a number of specific new challenges compared with the laparoscopic conventional approach. A reduced capacity for triangulation, the repeated conflicts between the shafts of the instruments and the difficulties to achieve a correct exposure of the operative field are the most claimed issues. The use therefore of this new approach for complex colorectal procedures might understandingly be viewed as difficult to implement, especially for oncologic cases.

关键词： Colorectal cancer Laparoscopic surgery Single-incision surgery Single-access surgery Scarless surgery Technical challenges

Autoimmmune hepatitis

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Cellular & Molecular Immunology 2022年第2期19卷 158-176页

作者： benedetta Terziroli Beretta-Piccoli Giorgina Mieli-Vergani Diego Vergani Epatocentro Ticino&Facoltàdi Scienze Biomediche Universitàdella Svizzera ItalianaLuganoSwitzerland Institute for Research in Biomedicine BellinzonaSwitzerland. King’s College London Faculty of Life Sciences&Medicine at King’s College Hospital LondonUK. Paediatric Liver GI and Nutrition CentreMowatLabsKing’s College HospitalLondonUK. Institute of Liver Studies MowatLabsKing’s College HospitalLondonUK.

Autoimmune hepatitis(AIH)is a T-cell mediated,inflammatory liver disease affecting all ages and characterized by female preponderance,elevated serum transaminase and immunoglobulin G levels,positive circulating autoantibodies,and presence of interface hepatitis at liver *** type 1,affecting both adults and children,is defined by positive anti-nuclear and/or antismooth muscle antibodies,while type 2 AIH,affecting mostly children,is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 *** the autoantigens of type 2 AIH are well defined,being the cytochrome P4502D6(CYP2D6)and the formiminotransferase cyclodeaminase(FTCD),in type 1 AIH they remain to be ***-1 predisposition is conferred by possession of the MHC class II HLA DRB1*03 at all ages,while DRB1*04 predisposes to late onset disease;AIH-2 is associated with possession of DRB1*07 and DRB1**** majority of patients responds well to standard immunosuppressive treatment,based on steroid and azathioprine;second-and third-line drugs should be considered in case of intolerance or insufficient *** review offers a comprehensive overview of pathophysiological and clinical aspects of AIH.

关键词： Autoimmune Hepatitis Immunopathophysiology Treatment Genetic Predisposition