检索结果-南通市图书馆

Improved Method for the Total Synthesis of Azaperone and Investigation of Its Electrochemical Behavior in Aqueous Solution

引用

Chemical Research in Chinese Universities 2022年第2期38卷 546-551页

作者： Mohammad Javad TAGHIZADEH Maryam Saleh MOHAMMADNIA masoumeh ghalkhani Esmail SOHOULI Department of Chemistry Faculty of ScienceUniversity of Imam HosseinTehranIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran Electrochemical Sensors Research Laboratory Department of ChemistryFaculty of ScienceShahid Rajaee Teacher Training UniversityLavizanP.O.Box ***TehranIran Young Researchers and Elites Club Science and Research BranchIslamic Azad UniversityTehranIran

Azaperone,with anti-anxiety and anti-aggressive activities used in veterinary medicine,is a member of the butyrophenone *** is ordinarily utilized for a wide range of indications,such as sedation,obstetrics,and *** this research,an improved synthetic route is presented for azaperone using a phase-transfer catalyst(PTC).In general,it was synthesized as a dopamine antagonist in four *** bis(2-chloroethyl)amine intermediate is easily obtained after the conversion of the alcohol groups into the chloride leaving group using thionyl chloride(95%yields).The alkylation of commercially available 2-amino pyridine in the presence of PTC was then carried out,giving 1-(pyridin-2-yl)piperazine with 75%yield.1-(Pyridin-2-yl)piperazine was finally alkylated using 4-chloro-1-(4-fluorophenyl)butan-1-one to achieve azaperone with 60%*** butyrophenone intermediate was obtained via the Friedel-Crafts reaction of fluorobenzene with 4-chlorobutyryl chloride in the presence of *** efficiency,gentle reaction conditions,and fast and simple procedure are the advantages of this ***,the electrochemical oxidation behaviour of azaperone was investigated using cyclic and differential pulse voltammetry *** voltammetric studies indicated an irreversible process for azaperone electro-oxidation with a peak potential of 0.78 V in a phosphate buffer solution(pH=7.0)***/AgCl(saturated KCl)*** value of the peak current *** azaperone concentration was enhanced linearly in the range of 10―70μmol/L,and the detection limit was found to be 3.33μmol/L.

关键词： Azaperone Anesthetic drug Chemical synthesis Butyrophenone class Electrochemical behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：