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Aqueous extract of lavender(Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease

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Neuroscience Bulletin 2011年第2期27卷 99-106页

作者： masoud soheili Kashani Mostafa Rezaei Tavirani Sayyed Alireza Talaei Mahmoud Salami Shaheed Beheshti医科大学蛋白质组研究中心卡珊医科大学生理学研究中心

Objective Alzheimer＇s disease（AD） is one of the most important neurodegenerative *** is characterized by dementia including def icits in learning and *** present study aimed to evaluate the effects of aqueous extract of lavender（Lavandula angustifolia） on spatial performance of AD *** Male Wistar rats were f irst divided into control and AD *** model of AD was established by intracerebroventricular injection of 10 ？g A？1-42 20 d prior to administration of the lavender *** in both groups were then introduced to 2 stages of task learning（with an interval of 20 d） in Morris water maze,each followed by one probe *** the f irst stage of spatial learning,control and AD animals received different doses（50,100 and 200 mg/kg） of the lavender *** In the first stage of experiment,the latency to locate the hidden platform in AD group was significantly higher than that in control ***,in the second stage of experiment,control and AD rats that received distilled water（vehicle） showed similar performance,indicating that the maze navigation itself could improve the spatial learning of AD ***,in the second stage of experiment,control and AD rats that received lavender extract administration at different doses（50,100,and 200 mg/kg） spent less time locating the platform（except for the AD rats with 50 mg/kg extract treatment）,as compared with their counterparts with vehicle treatment,*** addition,lavender extract significantly improved the performance of control and AD rats in the probe test,only at the dose of 200 mg/kg,as compared with their counterparts with vehicle *** The lavender extract can effectively reverse spatial learning def icits in AD rats.

关键词： Alzheimer's disease Lavandula angustifolia spatial learning rat water maze

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Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

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Neuroscience & Medicine 2012年第4期3卷 362-367页

作者： masoud soheili Mostafa Rezaei Tavirani Mahmoud Salami Physiology Research Center Kashan University of Medical Sciences Kashan Iran. Proteomics Research Center Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran Student Research Committee Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran

An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

关键词： Alzheimer Amyloid Beta Lavandula angustifolia

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