检索结果-南通市图书馆

疑似阿尔茨海默病患者不自觉认知功能缺陷(认知功能病感失认)的对照研究

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 50-50页

作者： Barrett A.M. Eslinger P.J. Ballentine N.h. heilman K.M. 邓剑平 Kess ler med. Rehab. Res./Educ. Corp. 1199 Pleasant Valley Way West Orange NJ 07052 United States Dr.

Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive ***: Control (n =32) and prob able Alzheimer disease(pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood,and uncorrec ted vision, both before and after these abilities were assessed. Based on this e stimate and their performance the authors calculated an anosognosia ratio (AR) b y dividing the difference between estimated and actual performance by an estimat ed and actual performance sum. With perfect awareness,AR = 0. Overestimating abi lities would yield a positive AR (≤1); underestimation would yield a negative A R (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; p ost-testing (on-line), pAD subjects overestimated their memory. Control subjec ts also made selfrating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions:This anosognos ia assessment method may allow more detailed examination of distorted self-awar eness. These results suggest that screening for anosognosia in probable Alzheime r disease (pAD) should include self-estimates of visuospatial function, and tha t, in pAD, it may be useful to assess anosognosia for amnesia both before and af ter memory testing.

关键词：认知功能阿尔茨海默病失认病感记忆测试视觉空间过高估计矫正视力不自觉自我评价

脊髓灰质炎患者肘屈肌随意运动、肌力和耐力预测

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 25-25页

作者： Allen G.M. Middleton J. Katrak P.h. S.C. Gandevia 王英鹏 Prnc. of Wales med. Res. Institute High Street Sydney NSW2031 Australia

To examine the long term effects of polio, maximal vo luntary strength and voluntary activation of elbow flexor muscles of 177 patients from a postpolio clinic were investigated using twitch interpolation. Muscle endurance was studied in 142 patients during 45 min of submaximal exercise, and predictors of impaired muscle performance were investigated. Twentynine of 177 patients (16.4% ) had impaired voluntary drive to their elbowflexor muscles, but only 16 (9.0% ) had markedly reduced elbow flexor strength, despite 74 (41.8% ) reporting they were initially affected in their tested limb and 172 (97.2% ) patients reporting new generalized symptoms. Seven patients had impaired muscle endurance in the tests of strength and voluntary drive. During the submaximal exercise, 16 patients (11.3% ) had impaired peripheral muscle endurancewith normal voluntary activation. These results confirm a low incidence of impaired upper limb muscle performance in postpolio patients, despite many patients having subjective symptoms consistent with postpolio syndrome. There was an increased relative risk for impaired muscle function in those patients with a subjective decrease in strength in the tested limb, a recent decline in activities of daily living in their tested limb, and who used orthotic devices in their tested limb. Monitoring of function in prior polio patients with impaired muscle performance may be useful, particularly when combined with investigation of other potential contributory factors to the functional impairment.

关键词：屈肌肌肉功能运动试验患者主观症状自主活动运动减少远期影响上肢肌肉影响因子矫形器

Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population

在线全文

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2007年第5期27卷 456-456页

作者： Jin, G. F. Wang, L. N. Chen, W. S. hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, h. B. Nanjing med Univ Sch Publ Hlth Dept Epidemiol ＆ Biostat Canc Res Ctr Nanjing 210029 Peoples R China Nanjing med Univ Sch Publ Hlth Toxicol Lab Nanjing Peoples R China Yixing Peoples hosp Yixing Jiangsu Peoples R China Yangzhong Canc Inst Yangzhong Jiangsu Peoples R China Univ Calif Los Angeles Sch Publ Hlth Dept Epidemiol Los Angeles CA 90024 USA

Growing evidence suggests that the transforming growth factor 0 (TGF-beta) signaling pathway occupies a central position in the signaling networks that control cell growth and differentiation。TGF-beta 1 and its receptor TGF-beta RII have been correlated with the development of certain forms of cancer, including gastric cancer。We hypothesized that functional genetic variants in TGFBI and TGFBR2 are associated with gastric cancer risk。

关键词：胃癌 TGFB1 TGFBR2 等位基因分子流行病学多态性细胞因子

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

骨髓移植过程止凝血状态的改变

Oncology and Translational medicine 1994年第4期11卷 226-226页

作者： G.Salat E.holler B.Reinhardt h.J.Kolb E.hiller 谭细友 med Klinik Ⅱ Klinikum Grosshadern der Ludwig-Maximilians-Universitt Münehen Germany 同济医科大学附属同济医院

放疗、化疗后血小板减少,在骨髓移植(BMT)后的早期阶段是最重要的出血原因。且在早期预处理方案的自限性效应之后,止凝血系统还与移植有关的并发症,如移植物抗宿主病(GvhD)、败血症、静脉闭塞疾病(VOD)相关。在 GvhD 中,内皮细胞损伤在... 详细信息

放疗、化疗后血小板减少,在骨髓移植(BMT)后的早期阶段是最重要的出血原因。且在早期预处理方案的自限性效应之后,止凝血系统还与移植有关的并发症,如移植物抗宿主病(GvhD)、败血症、静脉闭塞疾病(VOD)相关。在 GvhD 中,内皮细胞损伤在发病过程中具有决定性,可导致胃肠道出血或肝功能受损伴连续出现的低凝状态。败血症能导致弥散性血管内凝血,使出血增多。VOD 的肝内微小静脉闭塞,代表着重要

关键词：骨髓移植 VOD 静脉闭塞内皮细胞

Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2007年第10期27卷 1149-1149页

作者： Jin, G. F. Miao, R. F. Deng, Y. M. hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, h. B. Nanjing med Univ Canc Res Ctr Dept Epidemiol ＆ Biostat Nanjing 210029 Peoples R China. Nanjing med Univ Sch Publ Hlth Toxicol Lab Nanjing 210029 Peoples R China. Yixing Peoples hosp Yixing 214200 Jiangsu Peoples R China. Yangzhong Canc Inst Yangzhong City 212200 Jiangsu Peoples R China.

Epidermal growth factor (EGF), a ligand of the EGF receptor, plays a critical role in the development of gastric cancer. Genetic variants in its promoter region may influence transcription activity and contribute to gastric cancer predisposition. To test this hypothesis, we genotyped three EGF promoter polymorphisms(G61A, G-1380A, and A-1744G) in a case-control study of 675 gastric cancer cases and 704 cancer-free controls. We found that the variant genotypes of EGF 61GA/AA were associated with a significantly decreased risk of gastric cancer(OR = 0.77, 95% CI = 0.61-0.95 ), when compared with wild-type homozygote 61GG. In the combined analysis with all three loci of EGF, subjects carrying one or more variant loci had a significantly decreased risk of gastric cancer in a dose-response manner (adjusted OR = 0.58, 95% CI = 0.42-0.80 for subjects carrying one variant locus and OR =0.46,

关键词：基因变异表皮生长因子启动子胃癌高危人群中国

疑诊和转诊偏倚不会影响妊娠期和产褥期妇女静脉血栓发病风险的评估

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 15-15页

作者： Melis F. Vandenbrouke J.P. Büller h.R. K.W.M.Bloemenkamp 龚雯洁 Department of Obstet-rics Department of Clinical Epidem iolog yLeidenUniv.Med.Ctr.LeidenC.AmsterdamNetherlands Dr.

Objectives The purpose of this study was to determine the relative risk of deep vein thrombosis(DVT)during preg-nancy and puerperium in a setting that was not influenced by diagnostic suspicion and referra l *** design Three hundred ninetythree consecut ive females with suspi-cion of a first episode of venous thro mbosis were referred in the same way to diagnostic *** history was obtained before objective testing f or deep vein *** Seventy -six of the 393females were diagnosed as having deep vein thrombosis;the oth ers were used as control *** odds ratios fo r pregnancy,cesarean section,and puerperium after adjustment for age,center,family history,and calendar timewe re,respectively,5.7(95%CI 2.5-12.9),4.0(95%CI 1.3-12.6),and2.9(95%CI 1.2-6.9).Conclusion In this case -con-trol study,in which patients and con trol patients were subject to the same referral and diag nostic procedures,we found similar risk estimates for pre gnancy and puerperium as in previous *** findings show that previous studies were less affected by diagnostic suspicion and re-ferral bias than presumed.

关键词：转诊偏倚静脉血栓产褥期妇女发病风险客观检查诊断中心诊断程序病史资料病例对照研究

MRS区分高、低级别胶质瘤效能的系统回顾与meta分析

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2016年第5期 594-594页

作者： Q.Wang h.Zhang J.S.Zhang C.Wu W.J.Zhu F.Y.Li 华蓓 Department of Neurosurgery Chinese PLA General Hospital

摘要目的 MRS分析技术是胶质瘤术前分级的重要方法。本研究应用meta分析评估MRS区分高级别(hGG)与低级别(LGG)胶质瘤的效能。方法在Pub med及Embase数据库中系统检索2015年3月27日之前胶质瘤MRS分级的相关文献。通过符合纳入标准的研究... 详细信息

摘要目的 MRS分析技术是胶质瘤术前分级的重要方法。本研究应用meta分析评估MRS区分高级别(hGG)与低级别(LGG)胶质瘤的效能。方法在Pub med及Embase数据库中系统检索2015年3月27日之前胶质瘤MRS分级的相关文献。通过符合纳入标准的研究数据获得不同化合物比值

关键词： MRS meta 特异度胶质瘤敏感度