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幽门螺杆菌感染与小儿胃十二指肠疾病的关系

上海医学 1999年第8期22卷 466-468页

作者：许春娣苏林陈舜年徐家裕上海第二医科大学附属瑞金医院 200025

目的　研究幽门螺杆菌（Ｈｐ）感染与小儿慢性胃炎、消化性溃疡病之间的关系，探讨Ｈｐ的致病性。方法　我们对经胃镜检查证实的２４５例非溃疡性消化不良与６３例消化性溃疡患儿胃镜取材做Ｈｐ培养、快速尿素酶试验、病理学检... 详细信息

目的　研究幽门螺杆菌（Ｈｐ）感染与小儿慢性胃炎、消化性溃疡病之间的关系，探讨Ｈｐ的致病性。方法　我们对经胃镜检查证实的２４５例非溃疡性消化不良与６３例消化性溃疡患儿胃镜取材做Ｈｐ培养、快速尿素酶试验、病理学检查及血清Ｈｐ ＩｇＧ抗体测定。结果　在５６例十二指肠溃疡中Ｈｐ感染率为８３．９３％，７例胃溃疡为２８．５７％，２２４例慢性浅表性胃炎为４９．１１％，１１例慢性萎缩性胃炎为９０．０１％，其中３３例慢性活动性胃炎为９６．９７％，轻度胃炎为３２．７０％，中度胃炎为８３．７８％，而１０例正常胃粘膜者无１例发现Ｈｐ。结论　Ｈｐ感染与小儿胃十二指肠疾病密切相关，尤其是活动性胃炎和十二指肠溃疡。

关键词：幽门螺杆菌慢性胃炎消化性溃疡儿童

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食管闭锁和失弛缓样食管运动障碍

世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 27-27页

作者： Poon K.h. Lui V.C.h. P.K.h. Tam 郭战宏 Division of Paediatric Surgery Department of Surgery Univ. Hong Kong Med. Ctr. Qu. M. Hong Kong Hong Kong Prof.

A 14-year-old boy presented with regurgitation, malnutrition, and chronic lung insufficiency with a history of successful repair of esophageal atresia and tracheoesophageal fistula in the newborn period. Barium swallow and manometry results showed achalasia. hellar operation with antireflux procedure resulted in complete symptomatic relief. histology and immunohistochemistry including PGP9.5, MAP5, cKit, and nNOS of myotomy specimen showed intact innervation. Although esophageal dysmotility after esophageal atresia repair usually is caused by gastroesophageal reflux and incoordination of peristalsis, the possibility of achalasia should also be considered, because a casual relationship between esophageal atresia and achalasia may exist.

关键词：食管闭锁运动障碍胃食管反流气管食管瘘新生儿期肌切开术肺功能不全免疫组织化学神经支配

FAS promoter polymorphisms and cancer risk： a meta-analysis based on 34 casecontrol studies

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南京医科大学学报（自然科学版） 2009年第4期29卷 444-444页

作者： Zhang, Z. Z. Xue, h. C. Gong, W. D. Wang, M. L. Yuan, L. han, S. P. Zhang, Z. D. Nanjing med Univ Sch Publ Hlth Dept Mol &Genet Toxicol Ctr Canc Nanjing 210029 Peoples R China. Nanjing med Univ Key Lab Reprod Med Nanjing 210029 Peoples R China. Yangzhong Peoples hosp Dept Thorac Surg Inst Canc Res Yangzhong 212200 Peoples R China. Yixing Peoples hosp Dept Surg Yixing 214200 Peoples R Chino. Nanjing med Univ Affiliated Hosp 1 Dept Obstet & Gynecol Nanjing 210029 Peoples R China.

FAS is a cell surface receptor involved in apoptotic signal transmission and plays important roles in the etiology of cancer. The-1377G > A and-670A > G polymorphisms of the FAS gene influence the FAS transcription and have been implicated in cancer risk. however, the results from the published studies on the association between these two FAS polymorphisms and cancer risk are conflicting. To derive a more precise estimation of association between the FAS polymorphisms and risk of cancer, we performed a meta-analysis of 11 461 cancer cases and 12 708 controls from 34 published case-control studies for these two polymorphisms. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.

关键词：病因学医学肿瘤治疗临床

JWA as a functional molecule to regulate via MAPK cascades and F-actin cancer cells migration cytoskeleton

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南京医科大学学报（自然科学版） 2007年第10期27卷 1114-1114页

作者： Chen, h. R. Bai, J. Ye, J. Liu, Z. L. Chen, R. Mao, W. G. Li, A. P. Zhou, J. W. Nanjing med Univ Sch Publ Hlth Dept Mol Cell Biol ＆ Toxicol Nanjing 210029 Peoples R China.

Mitogen activated protein kinase (MAPK) cascades are thought to mediate diverse biological functions such as cell growth, differentiation and *** MAPK may affect microtubule (MT) which is essential for cellular polarity, differentiation and *** in this study show that JWA, a newly identified novel microtubule-associated protein (MAP) was essential for the rearrangement of F-actin cytoskeleton and activation of MAPK cascades induced by arsenic trioxide (As2O3) and phorbol ester (PMA).Over-expression of JWA alone in heLa, B16 and hCCLM3 cancer cells effectively inhibited cellular migration, whereas, cellular migration was significantly accelerated when cells were deficient in JWA *** mechanism underlying these phenomena might be due to JWA affected F-actin ***, JWA deficiency blocked anti-migratory effect produced by As2O3 but enhanced the migratory effect initiated by PMA in heLa cells.

关键词： JWA基因白血病分裂素相关蛋白激酶细胞骨架肿瘤转移

Proteomic-based identification of maternal proteins in mature mouse oocytes

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南京医科大学学报（自然科学版） 2009年第11期29卷 1513-1513页

作者： Zhang, P. Ni, X.J. Guo, Y. Guo, X. J. Wang, Y. F. Zhou, Z. M. huo, R. Sha, J. h. Nanjing med Univ Lab Reprod Med Dept Histol & Embryol Nanjing Peoples R China

颈动脉内膜中层厚度和斑块特性是日本老年男性中风的危险因素

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 59-59页

作者： Kitamura A. Iso h. Imano h. 邓剑平 Osaka med. Ctr. hlth. Sci. and Prom. 1- 3- 2 Nakamichi Higashinari- ku Osaka 537- 0025 Japan Dr

Background and Purpose - Few cohort studies have examined the association of carotid intima- media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence of stroke among Japanese men. Methods - Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated. Results - During the 4.5- year follow- up, 34 strokes occurred. The multivariate- adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; ≥ 1.07 versus ≤ 0.77 mm) was 3.0 (1.1 to 8.3) for *** combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of ≥ 1.5 mm, in the ICA had a 3- fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque. Conclusions - Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men.

关键词：内膜中层厚度颈内动脉队列研究超声成像颈总动脉患者群体钙化程度多变量

钆对比剂的速发型过敏反应:系统性综述和Meta分析

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国际医学放射学杂志 2018年第2期 225-225页

作者： A.h.Behzadi Y.Zhao Z.Farooq M.R.Prince 卜玮艺 Department of Radiology Weill Cornell Medical Center

摘要目的通过系统性综述和Meta分析,判定不同种类钆对比剂(GBCA)引起速发型过敏反应的概率有无差异。材料与方法于Pub med和Google学术数据库检索报道GB-

关键词：系统性综述对比剂速发型过敏反应

日本乙型脑炎病毒单克隆抗体介导ADCC效应的研究

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细胞与分子免疫学杂志 1986年第Z1期 40-46页

作者：张明杰汪美先姜绍谆马文煜第四军医大学微生物学教研室

以日本乙型脑炎病毒（JEV）感染的BhK2,细胞为靶细胞,小鼠脾细胞为效应细胞,测定了6株日本乙型脑炎病毒单克隆抗体（JEV-McAb）介导ADCC效应的活性。结果表明,2h4、2F2、nG2、mG9等种特异性及属特异性McAb无介导51Cr释放的活性,而mC3及... 详细信息

以日本乙型脑炎病毒（JEV）感染的BhK2,细胞为靶细胞,小鼠脾细胞为效应细胞,测定了6株日本乙型脑炎病毒单克隆抗体（JEV-McAb）介导ADCC效应的活性。结果表明,2h4、2F2、nG2、mG9等种特异性及属特异性McAb无介导51Cr释放的活性,而mC3及2D2两株亚组特异性McAb可介导ADCC效应;但mC3和2D2介导ADCC效应的活性也不相同。JEV-McAb的ADCC活性与血凝抑制（hI）、中和（NT）等功能之间无明显的关系,它是JEV-McAb的又一免疫学特征。小鼠感染JEV后,其脾细胞的ADCC活性下降,这可能与JEV的致病性有关。在JEV感染中,ADCC效应具有一定的保护功能。

关键词：日本乙型脑炎病毒单克隆抗体 ADCC效应

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定量脑电图双频指数在全麻中的临床应用

宁夏医学院学报 2002年第6期24卷 400-402页

作者：陈学新杨汝涂继善施伟忠宁夏医学院附属医院麻醉科银川750004

目的 :探讨监测定量脑电图双频指数 (BIS)在全麻深度判断中的临床应用。方法 :选择ASAI -Ⅱ级 ,全麻行上腹部手术 10 0例 ,全麻诱导用芬太尼 4μg/kg、氟哌定 0 0 8mg/kg、维库溴胺 0 1mg/kg、异丙酚 2mg/kg。吸入 1 5 %氨氟醚 ,静脉... 详细信息

目的 :探讨监测定量脑电图双频指数 (BIS)在全麻深度判断中的临床应用。方法 :选择ASAI -Ⅱ级 ,全麻行上腹部手术 10 0例 ,全麻诱导用芬太尼 4μg/kg、氟哌定 0 0 8mg/kg、维库溴胺 0 1mg/kg、异丙酚 2mg/kg。吸入 1 5 %氨氟醚 ,静脉持续泵注异丙酚 3～ 4mg·kg-1·h-1来维持。用hXD -Ⅰ型多功能监测仪进行连续监测 ,并记录时间点基础值 (T1)至清醒时 (T8)的生命体征和BIS ,均由计算机存储分析。全麻深度用SBP控制。清醒标准判定 :睁眼、正确回答年龄、床号、住址、工作单位。结果 :SBP、DBP分别在插管前 (T2 )、切皮前 (T4)低于基础值 (T1) ,差异有非常显著性意义 ,且超过 2 0 % ,插管后 (T3 )与插管前 (T2 )相比、切皮后 (T5)与切皮前 (T4)相比升高差异有非常显著性意义。BIS在T2 至拔管前 (T7)降低与基础值 (T1)相比差异有非常显著性意义 ,清醒时 (T8)接近基础值 (T1)。SBP和hR在体动时升高与体动前、给肌肉松弛药后比较有非常显著性意义 ,而BIS在体动前后及给肌肉松弛药后未见明显变化。结论

关键词：定量脑电图双频指数全麻临床应用