检索结果-南通市图书馆

Regulations and ethical codes for clinical cell therapy trials in Iran

Translational Neuroscience and Clinics 2015年第2期1卷 110-113页

作者： Hooshang Saberi Nazi Derakhshanrad Babak Arjmand Jafar Ai masoud soleymani Amir Ali Hamidieh Mohammad Taghi Joghataei Zahid Hussain Khan Seyed Hassan Emami Razavi Department of Neurosurgery Imam Khomeini HospitalTehran University of Medical Sciences Brain and Spinal cord Injuries Repair Research Center Tehran University of Medical Sciences cG MP‐Compliant Stem Cell Facility Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences Department of Hematology Tarbiat Modarres University Department of Hematology-Oncology Shariati Hospital Tehran University of Medical Sciences Department of Anatomy Cellular and Molecular Research Center Iran University of Medical Sciences Department of Neurosurgery Imam Khomeini HospitalTehran University of Medical Sciences

Objective: The local regulations for conducting experimental and clinical cell therapy studies are dependent on the national and cultural approach to the issue, and may have many common aspects as well as differences with the regulations in other *** study reflects the latest national aspects of cell therapy in Iran and relevant regulations. Methods: The following topics are discussed in the article including sources of cell harvest, regulations for cell disposal, stem cell manufacturing, and economic aspects of stem cell, based on current practice in Iran. Results: All cell therapy trials in Iran are required to strictly abide with the ethical codes, national and local regulations, and safety requirements, as well as considering human rights and respect. Adherence to these standards has facilitated the conduct of human cell therapy trials for research, academic advancement, and therapy. Conclusions: The cell therapy trials based on the aforementioned regulations may be assumed to be ethical and they are candidates for clinical translations based on safety and efficacy issues.

关键词： stem cell research ethical codes animal models cell therapy embryonic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative induction of controlled circulation by magnesium and remifentanil in spine surgery

引用

World Journal of Orthopedics 2014年第1期5卷 51-56页

作者： Mohammad R Ghodraty Mohammad M Homaee Kourosh Farazmehr Ali R Nikzad-Jamnani masoud soleymani-Dodaran Ali R Pournajafian Nader D Nader Department of Anesthesiology Tehran University of Medical Sciences Department of Public Health Tehran University of Medical Sciences Department of Anesthesiology University at Buffalo

AIM: To evaluate the efficacy of magnesium sulfate(MGS) in comparison with remifentanil for induction of relative hypotension in posterior fusion of spine(PSF).METHODS: In this randomized clinical trial, 40 patients with the American Society of Anesthesiologists Ⅰ and Ⅱ physical status undergoing lumbar PSF were randomized to receive remifentanil(REM) 0.15 μg/kg or MGS 50 mg/kg for controlled hypotension. The administering anesthesiologist was blinded to the medication. Continuous infusion was maintained at a fixed volume rate to deliver precalculated doses of either study drugs. All other aspects of anesthesia and surgery were similar in the two groups. The target mean arterial pressure(MAP) range used in this study was 60-70 mm Hg. In the course of surgery, the hemodynamic variables, volumeof blood loss, urine output, fluid intake and surgeon's satisfaction were recorded. Data was analyzed with SPSS version 13.0 and P values less than 0.05 were considered ***: Twenty patients in the MGS group and 19 patients in the REM group were studied. There was no difference between the two groups in the hemodynamic variables, blood loss, urine output, fluid requirement and surgeon's satisfaction for exposure. The target MAP was achieved in 75% of Mg and 58% of remifentanil groups. Although a higher number of patients in the REM group required nitroglycerin(42.1%) to reach the target MAP than those in the MGS group(25%), this difference was not statistically significant(P = 0.32).CONCLUSION: Our findings showed that in patients undergoing lumbar PSF surgery, remifentanil and MGS have a similar hypotensive effect and comparable amount of blood loss without any significant adverse effects.

关键词： Controlled hypotension Magnesium sulfate Remifentanil Spine surgery Blood loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：