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Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model

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Journal of Integrative Medicine 2020年第2期18卷 181-188页

作者： masoud seddighfar Sayid Mahdi Mirghazanfari Masoumeh Dadpay Department of Physiology and Iranian Medicine School of MedicineAJA University of Medical SciencesTehran ***Iran Department of Animal Biology School of BiologyCollege of ScienceUniversity of TehranTehran ***Iran Department of Pathology School of MedicineAJA University of Medical SciencesTehran ***Iran

Objective: The aim of this study was to evaluate the analgesic and anti-inflammatory effects of the hydroalcoholic extracts of Malva sylvestris flowers or Carum carvi and Medicago sativa seeds, alone and in combination, which have been used in traditional Iranian ***: Male Wistar rats were divided into 6 treatment groups: distilled water, sodium salicylate(SS),M. sylvestris extract(600 mg/kg), C. carvi extract(600 mg/kg), M. sativa extract(300 mg/kg) and combined extract(including 300 mg/kg M. sylvestris and C. carvi extracts, and 150 mg/kg M. sativa extract). The formalin pain model was used to evaluate the antinociceptive effects of the treatments. For anti-inflammatory effect, acute(one hour after injection) and chronic(during a week after injection)paw inflammation was measured after subcutaneous injection of 2.5% formalin in the ***, tissue samples from all groups were prepared for histopathological ***: The combined extract significantly inhibited the nociception in the acute phase of the formalin test(P < 0.001). In the chronic phase, all the extracts and SS had significant analgesic effect(P < 0.001).Analgesic activity of the combined extract was significantly stronger than SS(P < 0.01). In the acute inflammation model, M. sylvestris, C. carvi and the combined drug had significant inhibitory effects against paw edema(P < 0.05). All extracts, individually and in combination, significantly alleviated chronic paw inflammation(P < 0.01). The combined extract had much more anti-inflammatory activity than SS(P < 0.05). Histopathological results indicated improvement and reduction of inflammatory factors in the treatment ***: M. sylvestris, C. carvi and M. sativa have analgesic and anti-inflammatory ***, each of these extracts or a mixture of them might be a valuable alternative drug to control pain and inflammation.

关键词： Analgesic Anti-inflammatory Formalin test Malva sylvestris Carum carvi Medicago sativa

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