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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong Mi Park masoud rahmati Sang Chul Lee Jae Il Shin Yong Wook Kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgro

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

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Comparative analysis of unipolar and bipolar plasma electrolytic oxidation coatings on Al-Mg laminated macro composites

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Transactions of Nonferrous Metals Society of China 2024年

作者： Mohsen RASTEGARI masoud ATAPOUR Aboozar TAHERIZADEH Amin HAKIMIZAD Maryam rahmati Department of Materials Engineering Isfahan University of Technology Yekta Mobaddel Pars Co. Science and Technology Campus Yazd University Dental Materials Research Center Dental Research Institute School of Dentistry Isfahan University of Medical Sciences

Al-Mg laminated macro composites （LMC） have garnered attention due to their excellent mechanical properties and low density. However， their weak corrosion resistance has limited their industrial applications. Plasma electrolytic oxidation （PEO） has been explored as a potential solution to this issue by producing hard and thick oxide coatings on the surface of Al-Mg LMCs manufactured through hot extrusion bonding. In this study， PEO coatings were prepared on Al-Mg LMCs using both unipolar and bipolar waveforms in an appropriate electrolyte for both aluminum and magnesium alloys. The techniques of FESEM/EDX， GIXRD， and electrochemical methods of Potentiodynamic polarization and EIS were carried out. The results revealed that the coatings produced using the bipolar waveform exhibited lower porosity and higher thickness than those produced using the unipolar one. The corrosion performance of the specimens' cut edge was investigated using electrochemical impedance spectroscopy （EIS） after 1， 8， and 12 hours of immersion in a 3.5%wt. NaCl solution. It was observed that the coating produced using the bipolar waveform demonstrated the highest corrosion resistance after 12 hours of immersion， with an estimated corrosion resistance of 41.87 kΩ.cm2， which was approximately three times higher than that of the unipolar coating. Notably， no signs of galvanic corrosion were observed in the LMC， and only minor corrosion attacks were observed on the magnesium layer in some areas.

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Efficiency-based Pareto Optimization of Building Energy Consumption and Thermal Comfort:A Case Study of a Residential Building in Bushehr,Iran

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Journal of Thermal Science 2024年第3期33卷 1037-1054页

作者： masoud NASOURI Navid DELGARM Department of Environment University of TehranAras International CampusP.O.Box ***TehranIran Department of Mechanical and Aerospace Engineering Malek-Ashtar University of TechnologyP.O.Box 83145/115IsfahanIran

In Iran,the intensity of energy consumption in the building sector is almost 3 times the world average,and due to the consumption of fossil fuels as the main source of energy in this sector,as well as the lack of optimal design of buildings,it has led to excessive release of toxic gases into the environment.This research develops an efficient approach for the simulation-oriented Pareto optimization(SOPO)of building energy efficiency to assist engineers in optimal building design in early design phases.To this end,EnergyPlus,as one of the most powerful and well-known whole-building simulation programs,is combined with the Multi-objective Ant Colony Optimization(MOACO)algorithm through the JAVA programming language.As a result,the capabilities of JAVA programming are added to EnergyPlus without the use of other plugins and third parties.To evaluate the effectiveness of the developed method,it was performed on a residential building located in the hot and semi-arid region of Iran.To obtain the optimum configuration of the building under investigation,the building rotation,window-to-wall ratio,tilt angle of shading device,depth of shading device,color of the external walls,area of solar collector,tilt angle of solar collector,rotation of solar collector,cooling and heating setpoints of heating,ventilation,and air conditioning(HVAC)system are chosen as decision variables.Further,the building energy consumption(BEC),solar collector efficiency(SCE),and predicted percentage of dissatisfied(PPD)index as a measure of the occupants'thermal comfort level are chosen as the objective functions.The single-objective optimization(SO)and Pareto optimization(PO)are performed.The obtained results are compared to the initial values of the basic model.The optimization results depict that the PO provides optimal solutions more reliable than those obtained by the SOs,owing to the lower value of the deviation index.Moreover,the optimal solutions extracted through the PO are depicted in the form of Pareto fronts.Eventually,the Linear Prog

关键词： building energy consumption thermal comfort collector efficiency simulation-oriented pareto optimization

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Effects of physical rehabilitation interventions in COVID-19 patients following discharge from hospital:A systematic review

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Journal of Integrative Medicine 2023年第2期21卷 149-158页

作者： masoud rahmati Mahdieh Molanouri Shamsi Wongi Woo Ai Koyanagi Seung Won Lee Dong Keon Yon Jae Il Shin Lee Smith Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan University*** KhoramabadIran Department of Physical Education&Sport Sciences Faculty of HumanitiesTarbiat Modares University*** TehranIran Department of Thoracic and Cardiovascular Surgery Yonsei University College of MedicineGangnam Severance HospitalGangnam-guSeoul 06273Republic of Korea Research and Development Unit Parc Sanitari Sant Joan de DéuSant Boi de Llobregat08830 BarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) Barcelona 08010Spain Department of Precision Medicine Sungkyunkwan University School of MedicineSuwon 16419Republic of Korea Medical Science Research Institute Kyung Hee UniversitySeoul 02447Republic of Korea Department of Pediatrics Kyung Hee University Medical CenterKyung Hee UniversitySeoul 02447Republic of Korea Department of Pediatrics College of MedicineYonsei UniversitySeoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK

Background:Hospitalized patients recovering from coronavirus disease 2019(COVID-19)may experience disability and suffer from significant physical and mental impairment requiring physical rehabilitation following their discharge.However,to date,no attempt has been made to collate and synthesize literature in this area.Objective:This systematic review examines the outcomes of different physical rehabilitation interventions tested in COVID-19 patients who were discharged from hospital.Search strategy:A systematic search of MEDLINE/PubMed,CINAHL,Scopus and medRxiv was conducted to identify articles published up to March 2022.Inclusion criteria:This systematic review included studies of outpatient rehabilitation programs for people recovering from COVID-19 who received physical activity,exercise,or breathing training to enhance or restore functional capacity,pulmonary function,quality of life,and mental health or function.Data extraction and analysis:Selection of included articles,data extraction,and methodological quality assessments were conducted by two review authors respectively,and consensus was reached through discussion and consultation with a third reviewer.Finally,we review the outcomes of studies based on four categories including:(1)functional capacity,(2)pulmonary function,(3)quality of life,and(4)mental health status.Results:A total of 7534 titles and abstracts were screened;10 cohort studies,4 randomized controlled trials and 13 other prospective studies involving 1583 patients were included in our review.Early physical rehabilitation interventions applied in COVID-19 patients who were discharged from the hospital improved multiple parameters related to functional capacity,pulmonary function,quality of life and mental health status.Conclusion:Physical rehabilitation interventions may be safe,feasible and effective in COVID-19 patients discharged from the hospital,and can improve a variety of clinically relevant outcomes.Further studies are warranted to determine the underlying mechanisms.

关键词： COVID-19 Physical activity Exercise Rehabilitation Systematic review

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Seismic control of multi-degrees-of-freedom structures by vertical mass isolation method using MR dampers

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 503-510页

作者： Mohamad Shahrokh Abdi masoud Nekooei Mohammad-Ali Jafari Department of Civil Engineering Marivan BranchIslamic Azad UniversityMarivan ***Iran Department of Civil Engineering Science and Research BranchIslamic Azad UniversityTehran ***Iran Structural Department of Transmission and Distribution Research Center Niroo Research Institute(NRI)Tehran ***Iran

Vertical mass isolation(VMI)is one of the novel methods for the seismic control of structures.In this method,the entire structure is assumed to consist of two mass and stiffness subsystems,and an isolated layer is located among them.In this study,the magnetorheological damper in three modes:passive-off,passive-on,and semi-active mode with variable voltage between zero and 9 volts was used as an isolated layer between two subsystems.Multi-degrees-of-freedom structures with 5,10,and 15 floors in two dimensions were examined under 11 pairs of near field earthquakes.On each level,the displacement of MR dampers was taken into account.The responses of maximum displacement,maximum inter-story drift,and maximum base shear in controlled and uncontrolled buildings were compared to assess the suggested approach for seismic control of the structures.According to the results,the semi-active control method can reduce the response by more than 12%compared to the uncontrolled mode in terms of maximum displacement of the mass subsystem of the structures.This method can reduce more than 16%and 20%of the responses compared to the uncontrolled mode in terms of maximum inter-story drift and base shear of the structure,respectively.

关键词： seismic control vertical mass isolation base shear magnetorheological damper semi-active control

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Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期12卷 330-339页

作者： Zohreh Emami Bistgani Allen V.Barker masoud Hashemi Isfahan Agricultural and Natural Resources Research and Education Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of Agriculture University of MassachusettsAmherstMA 01002USA

Drought poses a significant challenge,restricting the productivity of medicinal and aromatic plants.The strain induced by drought can impede vital processes like respiration and photosynthesis,affecting various aspects of plants’growth and metabolism.In response to this adversity,medicinal plants employ mechanisms such as morphological and structural adjustments,modulation of drought-resistant genes,and augmented synthesis of secondary metabolites and osmotic regulatory substances to alleviate the stress.Extreme water scarcity can lead to leaf wilting and may ultimately result in plant death.The cultivation and management of medicinal plants under stress conditions often differ from those of other crops.This is because the main goal with medicinal plants is not only to increase the yield of the above-ground parts but also to enhance the production of active ingredients such as essential oils.To elucidate these mechanisms of drought resistance in medicinal and aromatic plants,the current review provides a summary of recent literature encompassing studies on the morphology,physiology,and biochemistry of medicinal and aromatic plants under drought conditions.

关键词： Drought stress Medicinal and aromatic plants Phytochemistry Physiology

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Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 185-206页

作者： masoud SHARIFI-YAZDI Amirhossein ENAYATI Jamal SALEHI AGHDAM Mohammad BAHREHVAR Seyed Mustafa REZAEI Department of Geology Faculty of Earth SciencesGeography and AstronomyUniversity of Vienna1090 Vienna.Austria Geology and Geophysics Department Tehran Energy Consultants(TEC Co.)TehranIran School of Geology College of ScienceUniversity of TehranTehranIran Department of Geology Tarbiat Modares UniversityTehranIran

The Qom Formation is the most important hydrocarbon reservoir target in Central Iran.The Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan Seaway.This formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study area.Six third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene succession.According to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma sequence.Then,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle profile.With respect to tectonic activity,this phase was a calm period during the deposition of the Qom Formation.Finally,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red Formation.Regarding all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

关键词： carbonate ramp depositional facies submarine fan eustasy basement faults back-arc basin

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Groundwater vulnerability assessment using a GIS-based DRASTIC method in the Erbil Dumpsite area (Kani Qirzhala), Central Erbil Basin, North Iraq

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Journal of Groundwater Science and Engineering 2024年第1期12卷 16-33页

作者： masoud H Hamed Rebwar N Dara Marios C Kirlas Department of Earth Sciences and Petroleum College of ScienceSalahaddin University-ErbilErbilIraq Department of Petroleum Engineering College of EngineeringKnowledge UniversityErbilIraq Department of Agriculture Faculty of AgricultureForestry and Natural EnvironmentAristotle University of Thessaloniki

Groundwater vulnerability assessment is a crucial step in the efficient management of groundwater resources,especially in areas with intensive anthropogenic activities and groundwater pollution.In the present study,the DRASTIC method was applied using Geographic Information System(GIS)to delineate groundwater vulnerability zones in the Erbil Dumpsite area,Central Erbil Basin,North Iraq.Results showed that the area was classified into four vulnerability classes:Very low(16.97%),low(27.67%),moderate(36.55%)and high(18.81%).The southern,south-eastern and northern parts of the study area exhibited the highest vulnerability potential,while the central-northern,northern and north-western regions displayed the lowest vulnerability potential.Moreover,results of the single-parameter sensitivity analysis indicated that amongst the seven DRASTIC parameters,the unsaturated zone and the aquifer media were the most influencing parameters.In conclustion,the correlation of 25 nitrate concentration values with the final vulnerability map,assessed using the Pearson correlation coefficient,yielded a satisfactory result of R=0.72.

关键词： DRASTIC Erbil Iraq Groundwater vulnerability assessment Nitrate Pollution Sensitivity analysis

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利用标准化降雨指数对伊朗法尔斯省干旱危害的GIS分析

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Journal of Resources and Ecology 2024年第2期15卷 439-447页

作者： masoudI masoud TAHERI Zahra 伊朗设拉子大学农业学院自然资源与环境工程系伊朗设拉子13131-71441 伊朗德黑兰大学自然资源学院环境科学系伊朗德黑兰31587-77871

干旱是广泛影响经济和环境的主要自然灾害之一。因此,有必要采用诸如标准化降雨指数(SPI)等指标来研究干旱的影响,以辨析决策和规划的现实条件。本研究的目的是利用SPI指数分析伊朗南部法尔斯省的干旱空间格局。本文根据法尔斯省42个站... 详细信息

干旱是广泛影响经济和环境的主要自然灾害之一。因此,有必要采用诸如标准化降雨指数(SPI)等指标来研究干旱的影响,以辨析决策和规划的现实条件。本研究的目的是利用SPI指数分析伊朗南部法尔斯省的干旱空间格局。本文根据法尔斯省42个站点的数据,对1990-2019年间的干旱灾害格局进行了评价。评价模型中使用的干旱危害标准包括:该时期的最严重干旱程度、干旱趋势和连续干旱年的最大数量,最终的干旱灾害图是通过计算干旱强度、连续性和趋势三个指标的算术平均值获得的。三个指标的灾害图和最终灾害脆弱图采用反距离加权法(IDW)插值制图,分为无、轻度、中度、重度和极重度5个危害等级。最终的干旱脆弱性图显示,在研究区南部观察到的中度灾害区域占研究区36%,比在北部和中部观察到的严重和非常严重灾害区(占研究区64%)分布范围更小。

关键词：干旱标准化降雨指数 GIS 灾害地图反距离加权法法尔斯省

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A Novel Layered Double Hydroxide and Dodecyl Alcohol Assisted PCM Composite with High Latent Heat Storage Capacity and Thermal Conductivity

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Journal of Thermal Science 2024年第2期33卷 537-547页

作者： AL-AHMED Amir SARI Ahmet KHAN Firoz AL-RASHEIDI masoud Hekimoğlu Gökhan AFZAAL Mohammad A.ALSULAMI Ahmed DAFALLA Hatim SALHI Billel A.ALSULAIMAN Fahad Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Metallurgical and Material Engineering Karadeniz Technical UniversityTrabzon61080Turkey Maths and Natural Sciences Division Higher Colleges of TechnologyP.O.Box 7947SharjahUnited Arab Emirates Department of Mechanical Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Core Research Facilities King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Membranes and Water Security King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia

Dodecyl alcohol(DDA) is a promising solid-liquid phase change material(PCM) due to its favorable latent heat storage(LHS) characteristics.However,the leakage issue of PCM in a melted state during the heating period and low thermal conductivity restricts its utilization potential in thermal energy storage(TES) practices.Within the same context,the present work aims to overcome the leakage issue and improve the thermal conductivity of the DDA.With this in mind,a novel leak-proof layered double hydroxide(LDH)/DDA composite PCM is proposed through a solution-based impregnation method.The leak-proof impregnation ratio of the DDA impregnated within the cavities of the synthesized Al/Fe-LDH was determined to be 60%.Detailed morphological,physicochemical,and thermal properties of the fabricated composite were studied by scanning electron microscopy(SEM),Fourier transforms infrared(FTIR) spectroscopy,X-ray diffraction(XRD)spectroscopy,differential scanning calorimetry(DSC),thermalgravimetric analysis(TGA),and thermal cycling study.The results show that the LDH/DDA composite has a suitable phase change temperature(about 20℃) for passive solar thermal management of building envelopes.This composite PCM showed high LHS enthalpy(about136 J/g),good thermal stability,and cycling LHS reliability.It also showed nearly 152% higher thermal conductivity compared to that of pure DDA,ultimately reducing the melting and solidification time of the pure DDA by 44.9% and 45.5%,respectively.

关键词： dodecyl alcohol layered double hydroxide composite PCM thermal conductivity thermal energy storage(TES)

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