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Personalized clinical managements through exploring circulating neural cells and electroencephalography

World Journal of Experimental Medicine 2023年第4期13卷 75-94页

作者： Parvin Mehdipour Nima Fathi masoud nosratabadi Department of Medical Genetics Tehran University of Medical SciencesTehran 14176-1315Iran Neuro-Science Paarand Specialized Center for Human EnhancementTehran 157699304Iran Department of Research Paarand Specialized Center for Human EnhancementTehran 157699304Iran

BACKGROUND Since an initial diagnosis of Alzheimer disease(AD)in 1907,early detection,was unavailable through 116 ***-regulation of V-Ets erythroblastosis virus E26 oncogene homolog 2(Ets2)is capable to enhance neuronal susceptibility and *** expression(PE)of Ets2 has functional impact on AD and Down’s syndrome,with diverse *** of Ets2 has an influential pathogenic impact on *** aspects of neurological disorders directly interact with psychological ***,deterioration requires an early management including programmed based *** To include cell biology in neuro-genetics;personalized,prognostics,predictive,preventive,predisposing(5xP)platform,accompanied by stratifying brain channels behavior pre-and post-intervention by light music in the *** Include exploration of PE assay and electroencephalography of brain *** processes are applied according to:(1)Triangle style,by application of cellular network;and(2)PE assay of Ets2 in the peripheral blood of the patients with AD,by Manual single cell based analysis,and Flow-cytometry.(1)Applying the Genetic counselling and pedigree analysis;(2)considering the psychological status of the referral cases;(3)considering the macro-and/or micro-environmental factors;(4)performing the required Genetics’analysis;and(5)applying the required complementary test(s).RESULTS PE of Ets2 has pathogenic role in *** unmasked the nature of heterogeneity/diversity/course of evolution by exploring Ets2,D1853N polymorphism in Ataxia Telangiectasia mutated gene(ATM),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF)and course of evolution at the single cell level of the ***2 revealed different cellular behavior in the blood and suggested the strategy as‘Gene Product-Based Therapy’and the personalized managements for the *** reflected weak expression of ATM,mosaic pattern of Ets2;remarkable expression of VEGF and EGF by highlighting

关键词： Alzheimer Protein expression Brain channels Predictive/early detection

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