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噻嗪类利尿剂与β受体阻滞剂联合治疗高血压有致糖尿病的风险

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中国处方药 2006年第1期5卷 22-22页

作者： mason jm Dickinson HO Nicolson DJ 任美峰

背景:最近发表的关于高血压药物治疗的研究中,将某种旧的治疗方案与新的治疗方案相比较时,发现新发糖尿病增加。噻嗪类利尿剂和β受体阻滞剂各自都有这种倾向,但是这些药物通常都是联用的,但是这两种药物联用的风险却尚无研究。[第一段]

关键词： β受体阻滞剂噻嗪类利尿剂糖尿病高血压联合治疗风险药物治疗治疗方案药物联用

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Association of cancer with comorbid inflammatory conditions and treatment in patients with Lynch syndrome

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World Journal of Clinical Oncology 2022年第1期13卷 49-61页

作者： Muhammad S Faisal Carol A Burke David Liska Amy L Lightner Brandie Leach Margaret O’Malley Lisa LaGuardia Benjamin Click JP Achkar Matthew Kalady jm Church Gautam Mankaney Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOH 44195United States Department of Colorectal Surgery Cleveland ClinicClevelandOH 44195United States Center for Personalized Genetic Healthcare Genomic Medicine InstituteClevelandOH 44195United States Department of Gastroenterology Hepatology&NutritionCleveland ClinicClevelandOH 44195United States Center for Inflammatory Bowel Disease Department of GastroenterologyHepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Colorectal Surgery Ohio State UniversityColumbusOH 43210United States Department of Gastroenterology and Hepatology Virginia Mason Franciscan HealthSeattleWA 98101United States

BACKGROUND Individuals with Lynch syndrome(LS)and hereditary non-polyposis colorectal cancer(HNPCC)are at increased risk of both colorectal cancer and other *** interplay between immunosuppression,a comorbid inflammatory condition(CID),and HNPCC on cancer risk is *** To evaluate the impact of CIDs,and exposure to monoclonal antibodies and immunomodulators,on cancer risk in individuals with *** Individuals prospectively followed in a hereditary cancer registry with LS/HNPCC with the diagnosis of inflammatory bowel disease or rheumatic disease were *** compared the proportion of patients with cancer in LS/HNPCC group with and without a *** also compared the proportion of patients who developed cancer following a CID diagnosis based upon exposure to immunosuppressive *** A total of 21 patients with LS/HNPCC and a CID were compared to 43 patients with LS/HNPCC but no *** occurred in 84.2% with a CID compared to 76.7% without a CID(P=0.74)with no difference in age at first cancer diagnosis 45.5±14.6 vs 43.8±7.1 years(P=0.67).LS specific cancers were diagnosed in 52.4% with a CID vs 44.2% without a CID(P=0.54).Nine of 21(42.9%)patients were exposed to biologics or immunomodulators for the treatment of their *** after diagnosis of CID was seen in 7(77.8%)of exposed individuals vs 5(41.7%)individuals unexposed to biologics/immunomodulators(P=0.18).All 7 exposed compared to 3/5 unexposed developed a LS specific *** exposed and unexposed groups were followed for a median 10 years and 8.5 years,*** hazard ratio for cancer with medication exposure was 1.59(P=0.43,95%CI:0.5-5.1).CONCLUSION In patients with LS/HNPCC,the presence of a concurrent inflammatory condition,or use of immunosuppressive medication to treat the inflammatory condition,might not increase the rate of cancer occurrence in this limited study.

关键词： Lynch syndrome Hereditary non-polyposis colorectal cancer Inflammatory bowel disease Immunosuppression Biologics

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