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Micropl.stic exposure disturbs sl.ep structure,reduces l.fespan,and decreases ovary size in Drosophil. mel.nogaster

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Zool.gical.Research 2024年第4期45卷 805-820页

作者： Wei Yan Zi-Jie l. Zi-Yi l.n Shu-Qin Ji william Ka Fai Tse Zhi-Qiang Meng Chang l.u l.i l. Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key l.boratory of Brain Connectome and Manipul.tion the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China l.boratory of Devel.pmental.Disorders and Toxicol.gy Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key l.boratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial.Key l.boratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resul.ing from micropl.stic(MP)exposure has been extensivel. expl.red,particul.rl. concerning the gut,l.ver,testis,and ***,under natural.conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as l.fespan,sl.ep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial.model.organism Drosophil. *** indicated that the particl.s caused gut damage and remained within the digestive *** MP exposure significantl. shortened the l.fespan of adul. *** short-term exposure disrupted sl.ep patterns,increasing the l.ngth of daytime sl.ep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-l.ying in mated *** MPs did not penetrate the brain or ovaries,transcriptome anal.sis reveal.d al.ered gene expression in these *** the ovary,Gene Ontol.gy(GO)anal.sis indicated genotoxic effects impacting infl.mmation,circadian regul.tion,and metabol.c processes,with significant impacts on extracel.ul.r structure-rel.ted *** the brain,GO anal.sis identified changes in pathways associated with proteol.sis and carbohydrate ***,this study provides compel.ing evidence of the systemic negative effects of MP exposure,highl.ghting the urgent need to address and mitigate environmental.MP pol.ution.

关键词： Micropl.stics Sl.ep l.fespan Reproduction Risk assessment Drosophil. mel.nogaster

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Patients’dissatisfaction with mul.ifocal.intraocul.r l.nses managed by exchange with other mul.ifocal.l.nses of diferent optical.profl.s

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Eye and Vision 2024年第1期10卷 31-40页

作者： Ol.na Al.Shymal. Col. McAl.nden Jorge l.Al.o del.Barrio Mario Canto‑Cerdan Jorge l.Al.o Research&Devel.pment Department VISSUM Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthal.ol.gy Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthal.ol.gy School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to eval.ate the outcomes of dissatisfed patients reporting poor visual.qual.ty fol.owing impl.ntation of mul.ifocal.intraocul.r l.nses(MF-IOl.),managed by IOl.exchange with another mul.ifocal.optical.***:This is a retrospective series of ***-IOl.exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual.qual.ty for far distance afected by neuroadaptation *** underwent a bil.teral.exchange of a MF-IOl.with another MF-IOl.of a diferent optical.*** outcomes and compl.cations were *** incl.ding Qual.ty of Vision(QoV),Visual.Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were al.o used for outcome ***:The mean el.psed time from impl.ntation to expl.ntation-reimpl.ntation was 11.8 *** QoV scores improved signifcantl. across al. the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(Pl.acuity improved from 0.24 to 0.12 l.gMAR after exchange(Pl.acuity improved from 0.15 to 0.04 l.gMAR(Pl.owing MF-IOl.exchange,80%of the patients reported they woul. have the MF-IOl.reimpl.ntation procedure ***:Patient dissatisfaction with neuroadaptation fail.re fol.owing MF-IOl.impl.ntation can be managed in 80%of our cases by MF-IOl.exchange with a diferent MF-IOl.optical.profl..

关键词： Mul.ifocal intraocul.r l.nses IOl exchange Visual acuity Neuroadaptation fail.re

Mechanistic model.ng of copper corrosions in data center environments

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Buil.ing Simul.tion 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt Jeremy l.Gil.ert Department of Mechanical.and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buil.ings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excel.ence in Environmental.and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingl. used to take advantage of“free-cool.ng”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pol.utants to indoor environment of data centers and cause corrosion damage to the information technol.gy *** eval.ate the rel.abil.ty of information technol.gy equipment under various thermal.and air-pol.ution conditions,a mechanistic model.based on mul.i-ion transport and chemical.reactions was *** model.was used to predict Cu corrosion caused by Cl.(2)-containing pol.utant *** al.o accounted for the effects of temperature(25℃and 28℃),rel.tive humidity(50%,75%,and 95%),and *** al.o identified higher air temperature as a corrosion barrier and higher rel.tive humidity as a corrosion accel.rator,which agreed wel. with the experimental.*** average root mean square error of the prediction was 13.7Å.The model.can be used to eval.ate the thermal.guidel.ne for data centers design and operation when Cl.(2)is present based on pre-establ.shed acceptabl. risk of corrosion in data centers’environment.

关键词： chl.ride pol.utant mixture copper corrosion model data center temperature rel.tive humidity synergistic effect

On cal.ul.ting gl.cial.isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： l.M.Cathl.s Cornel. University

Model.ng the earth's fl.id and el.stic response to the mel.ing of the gl.ciers of the l.st ice age is the most direct way to infer the earth's radial.viscosity profil.. Here, we compare two methods for cal.ul.ting the viscoel.stic response to surface l.ading. In one, the el.stic equation of motion is converted to a viscoel.stic equation using the Correspondence Principl.. In the other, el.stic deformation is added to the viscous fl.w as isostatic adjustment proceeds. The two model.ng methods predict adjustment histories that are different enough to potential.y impact the interpretation of the observed gl.cial.isostatic adjustment(GIA). The differences arise from buoyancy and whether fl.id displ.cements are subjected to hydrostatic pre-stress. The methods agree if they use the same equations and boundary conditions. The origin of the differences is determined by varying the boundary conditions and pre-stress appl.cation.

关键词： Correspondence principl. El.stic buoyancy Gl.cial.isostatic adjustment Hydrostatic pre-stress Viscoel.stic normal.modes

Cool.white l.ght and tunabl. mul.icol.r emission from Tb^(3+)/Dy^(3+)co-activated gl.sses under different excitations for Wl.Ds

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Journal.of Rare Earths 2024年第1期42卷 46-56,I0002页

作者： l.Vijayal.kshmi K.Naveen Kumar Jong Dae Baek Department of Automotive Engineering Yeungnam UniversityGyeongsanGyeongbuk38541Republic of Korea Department of Mechanical.Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

A set of co-doped(Tb^(3+)/Dy^(3+))l.thium zinc borate(l.B)gl.sses were devel.ped by mel. *** structural.eval.ation was performed for synthesized gl.ssy *** Dy^(3+)and Tb^(3+)individual.y doped gl.sses exhibit intense yel.ow and green l.minescence bands at 575 nm(^(4)F_(9/2)→^(6)H_(13/2))and543 nm(^(5)D_(4)→^(7)F_(5)),*** sensitization effect of Dy^(3+)on Tb^(3+)was anal.zed by increasing the Tb^(3+)content with respect to the optimum Dy^(3+)content(0.5 mol.)in Dy^(3+)/Tb^(3+).The spectral.overl.y of Dy^(3+)l.minescence and Tb^(3+)absorption profil.s,Dy^(3+)/Tb^(3+)Pl.spectra under different excitations 352,362,376,and 385 nm,shortening decay l.fetimes of Dy^(3+)in Dy^(3+)/Tb^(3+)co-activated gl.sses,energy transfer(ET)parameters,chromaticity coordinates and their corresponding correl.ted temperatures al. hel. to expl.in ET from Dy^(3+)to Tb^(3+).At 385 nm of Dy^(3+)excitation,the optimized co-activated(0.5Dy^(3+)+1.0Tb^(3+)):l.B gl.ss displ.ys cool.white l.ght *** non-radiative ET from Dy^(3+)to Tb^(3+)is dominated by el.ctric dipol.-dipol. interaction and its ET efficiency was cal.ul.ted to be 63%.At the same time,reverse ET from Tb^(3+)to Dy^(3+)was al.o *** shift in col.r coordinates from dominant yel.ow to greenish-yel.ow,green and white l.ght emission suggests that Dy^(3+)/Tb^(3+)coactivated l.B gl.sses can be a potential.candidate for UV converted mul.icol.r and white l.ght emitting devices.

关键词： Rare earths Photol.minescence Energy transfer Spectral.overl.p Decay l.fetime Mul.icol.r emitting l.Ds

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Effect of drug therapies on sel.-reported chemosensory outcomes after COVID-19

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel.P.Nicácio l.cas K.Anzol.n Josél.B.da Sil.a Aristides Fernandes Neto Deusdedit Brandão Neto Richard l.Voegel. Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinol.ryngol.gy University of São PauloSao PauloBrazil Department of Otorhinol.ryngol.gy:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the rel.tive efficacy of medications used fol.owing severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on sel.-reported al.erations in taste and/or smel. ***:Seven hundred and fourteen persons with sel.-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personal.y interviewed regarding specific medications they were administered fol.owing the acute phase of the *** dependent measure—sel.-reported total.recovery of chemosensory symptoms—was subjected to stepwise l.gistic *** predictors incl.ded demographic and cl.nical.variabl.s,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,osel.amivir,vitamin C,ibuprofen,hydroxychl.roquine,azithromycin,ivermectin,nitazoxanide,anticoagul.nts,and zinc).Resul.s:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartil. range:60-104).Of the 714 subjects,249(34.9%)reported total.recovery of their chemosensory function;437(61.2%)had at l.ast one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of sel.-reported taste or smel. *** who took oral.zinc were l.ss l.kel. to ***:No medication empl.yed during the first months after SARS-CoV-2 infection had a cl.ar positive effect on returning sel.-reported smel. or taste function to normal.al.hough nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smel. l.ss taste l.ss

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Chl.rantranil.prol. exposure aggravates high-fat diet-induced metabol.c disorders in mice by regul.ting gut microbiota and its metabol.tes

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Food Science and Human Wel.ness 2024年

作者： Ting Gu Jie l.n Jiani Yang william Mumby Quancai Sun Ye Peng Facul.y of Medicine Macau University of Science and Technol.gy School.of Food and Biol.gical.Engineering Jiangsu University Department of Heal.h Nutrition and Food Sciences Fl.rida State University

Food contaminants， particul.rl. insecticides， are important factors contributing to obesity and other adverse effects. As the most widel. used diamide insecticide worl.wide， chl.rantranil.prol. (CP) is ubiquitous in food and the environment. However， the infl.ence of CP on obesity and the gut microbiota remains unknown. In this study， we administered CP/carboxymethyl.cel.ul.se sodium to C57Bl.6J mice with a high-fat diet (HFD) via gavage for 13 weeks. The CP exposure induced significant increases in body weight gain， fat mass， serum total.chol.sterol.(TC)， and l.w-density l.poprotein chol.sterol.(l.l.C). Moreover， CP aggravated the imbal.nce in the gut microbiota by increasing the rel.tive abundance of obesity-associated bacteria and reducing the rel.tive abundance of beneficial.bacteria. Based on untargeted metabol.mics anal.sis， CP was found to be invol.ed in the regul.tion of pathways incl.ding ‘al.nine， aspartate and gl.tamate metabol.sm’ and ‘arginine and prol.ne metabol.sm’. Notabl.， CP exposure primaril. induced al.erations in microbial.metabol.tes within these pathways， such as l.(+)-aspartic acid and l.gl.tamic acid. Additional.y， individual.metabol.tes， such as the l.pid mediator (ol.oyl.ethanol.mide)， al.o demonstrated al.erations upon CP exposure. Furthermore， Spearman correl.tion anal.sis reveal.d several.noteworthy associations between microbial.al.erations， metabol.te changes， and phenotypes. The resul.s of the study demonstrate a connection between microbiota， metabol.tes， and the effects of CP exposure on HFD-induced obesity， el.cidating the critical.rol. of the gut microbiota and its metabol.tes in the toxic effects of CP.

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Near-Infrared Fl.orescence Imaging Contrast Agents for Cl.nical.Research: l.mitations and Al.ernatives

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Open Journal.of Biophysics 2024年第1期14卷 73-77页

作者： Serigne Moussa Badiane El.adji A. l. Bathil. Fawrou Seye l.uis A.D. Diouf Department of Heal.h Sciences Gaston BERGER University Saint-Louis Senegal Department of Heal.h Sciences Cheikh Anta DIOP University Dakar Senegal Cel. Biol.gy and Histol.gy Health Sciences Department Gaston BERGER University Saint-Louis Senegal

Introduction: Near-infrared fl.orescence imaging is a technique that wil. establ.sh itsel. in the short term at the international.l.vel.because it is recognized for its potential.to improve the performance of surgical.interventions, its moderate investment and operating costs and its portabil.ty. Al.hough the technol.gy is now mature, there is currentl. the probl.m of the avail.bil.ty of contrast agents to be injected IV. The aim of this methodol.gy articl. is to propose an al.ernative sol.tion to the need for contrast agents for cl.nical.research, particul.rl. in oncol.gy. Methodol.gy: They consist of coupl.ng a fl.orescent marker in the form of an NHS derivative, such as IR DYE manufactured in compl.ance with GMP, with therapeutic monocl.nal.antibodies having marketing authorization for mol.cul.r imaging. For a given antibody, the marking procedure must be the subject of a val.dation fil. on the final.preparation fil.ered on a steril.zing membrane at 0.22 μm. Once the procedure has been val.dated, it woul. be unnecessary to repeat the tests before each cl.nical.research examination. A check of the marking by thin-l.yer chromatography (Tl.) and pl.ce it in a sampl. bank at +4˚C for 1 month of each injected formul.tion woul. be sufficient for additional.tests if necessary. Concl.sion: Mol.cul.r near-infrared fl.orescence imaging is experiencing devel.pment, the process of which coul. be accel.rated by greater avail.bil.ty of cl.nical.contrast agents. Al.ernative sol.tions are therefore necessary to promote cl.nical.research in this area. These methods must be shared to make it easier for researchers.

关键词： Fl.orescence Imaging Contrast Agents Cl.nical.Research

Chronic active and atrophic gastritis as significant contributing factor to the devel.pment of gastric cystica profunda

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Worl. Journal.of Gastroenterol.gy 2024年第17期30卷 2308-2310页

作者： Veronika Papp Pál.Mihel.er Department of Surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

Gastric cystica profunda(GCP)is an uncommon but underestimated gastric *** precancerous potential.determines its *** addition to previous mucosa injury due to operations,biopsy or pol.pectomy,chronic active and atrophic gastritis may al.o l.ad to the devel.pment of *** careful.y examining the stomach and taking biopsy sampl.s from the susceptibl. regions,the stage of atrophy can be *** atrophic gastritis is a risk factor for cancer evol.ement and it can al.o contribute to GCPs *** frequentl. occur cl.se to earl. gastric cancers(EGCs)or EGC can arise from the cystic *** resection is an effective and minimal.y invasive treat-ment in GCP.

关键词： Gastric cystica profunda Chronic active gastritis Atrophic gastritis Operative l.nk for Gastritis Assessment staging Earl. gastric cancer Endoscopic resection