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Anti-Sickle Cell Anemia and Bacterial Inhibitory Effects of <i>Uvariodendron molundense</i>(Diels) ***. (Annonaceae) from Ubangi River Basin, DR Congo

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Journal of Biosciences and Medicines 2017年第3期5卷 71-84页

作者： Koto-Te-Nyiwa Ngbolua Dorotheé D. Tshilanda Djolu R. Djoza Clarisse M. Falanga masengo C. ashande Damien S. T. Tshibangu Jeff B. Iteku Virima Mudogo Pius T. Mpiana Dé partement de Biologie Facult&eacute des Sciences Universit&eacute de Kinshasa Kinshasa R&eacute publique Dé mocratique du Congo Institut Supé rieur Pé dagogique d’Abumombazi Abumombazi R&eacute publique Dé mocratique du Congo Dé partement des Sciences de l’Environnement Facult&eacute des Sciences Universit&eacute de Gbadolite Gbadolite R&eacute publique Dé mocratique du Congo Dé partement de Chimie Facult&eacute des Sciences Universit&eacute de Kinshasa Kinshasa R&eacute publique Dé mocratique du Congo

The present study was carried out with the aim of evaluating the chemical composition and bioactivity of Uvariodendron molundense against Sickle cell disease and associated pathogenic bacteria agents. The antisickling and antibacterial activities were assessed using Emmel and micro-dilution methods respectively. The results revealed that the leaves and stem bark of U. molundense contains various secondary metabolites such as total phenols, flavonoids, anthocyanins, tannins, quinones, saponins, alkaloids, steroids, terpenoids and leuco-anthocyanins. The n-hexane (non-polar solvent) extract displayed poor yield (0.66) than the extracts obtained in the polar solvents which have a high yield (Methanol: 1.68, Ethanol: 1.46 and Ethyl acetate: 1.40). These results indicate that the abundant secondary metabolites/compounds in this plant species are those which pass easily through the polar solvents (methanol, ethanol and ethyl acetate). This is the case of phytomarkers like flavonoids and tannins (which are most concentrated in methanol) and anthocyanins which are concentrated in ethyl acetate. The extraction yield of organic/triterpenoic acids (betulinic acid rich extract) was 1.70%. All tested extracts displayed antisickling activity. At 100 μg/mL, the rates of normalization were 89% for organic extract (ED50 = 0.391 μg/ml) and 82% for anthocyanins extract (ED50 = 0.659 μg/mL). The antibacterial activity of tested extracts was very good toward Staphyloccocus areus (CMI ≤ 31.25 μg/mL) while, for Escherichia coli, only the organic extract exhibit interesting activity (CMI = 31.25 μg/mL). This study validates for the first time the in vitro antisickling activity of U. molundense. The bioactivity profiles of organic acids extract from the studied plant material indicate that they constitute promising fraction to be further investigated phytochemically for the discovery of new lead compounds for pharmaceutical application.

关键词： Sickle Cell Disease Traditional Foods Nutraceuticals Anthocyanins Triterpenic Acids

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Ethno-medical Profiling of Myrianthus arboreus ***:A Phyto-resource Food of Chimpanzees(Pan troglodytes Blumenbach,1799)in the Ubangi Eco-region of Democratic Republic of the Congo

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Journal of Botanical Research 2023年第2期5卷 12-28页

作者： Pascal Bobuya Koto-Te-Nyiwa Ngbolua Antoine Mumba masengo ashande Lemmy Lassa Willy Lusasi Monizi Mawunu Damien Tshibangu Pius Mpiana Virima Mudogo High School of Agricultural studies of Bokonzi P.O.Box 67GemenaDemocratic Republic of the Congo Department of Biology Faculty of ScienceUniversity of KinshasaP.O.Box 190Kinshasa XIDemocratic Republic of the Congo Department of Phytotechny Faculty of Agricultural SciencesNational Pedagogical UniversityP.O.Box 8815Kinshasa-NgaliemeDemocratic Republic of the Congo Department of Environment Faculty of ScienceUniversity of Gbado-LiteP.O.Box 111Gbado-LiteDemocratic Republic of the Congo Department of Agronomy&Botanical Garden University of Kimpa VitaP.O.Box 77 UigeRepublic of Angola Department of Chemistry Faculty of ScienceUniversity of KinshasaP.O.Box 190Kinshasa XIDemocratic Republic of the Congo

The aim of this study was to evaluate the ethnomedical knowledge of the population of South Ubangi on Myrianthus arboreus,a plant consumed by chimpanzees,with the assumption that this bio-resource is also used by the population in African Traditional Medicine to treat common *** results revealed that *** treats 23 diseases in the province of South Ubangi in Democratic Republic of the *** these diseases,six(anaemia,bronchitis,tooth decay,gastritis,hypertension,and spleen)are the most *** and spleen are treated by all socio-cultural *** leaf is the most used organ(48%)followed by sap,roots,stems,bark,flowers,and ***(61.5%)is the most used method of preparation followed by decoction,maceration,and ***(94.5%)is the most used method of administration followed by body bath,massage,anal and auricular *** is a vulnerable species(Iv≥2.5)in the study *** diseases treated are influenced by the level of education and the profession of the respondents(p<0.05).While the mode of preparation of recipes is influenced by the family situation,also the composition of recipes is influenced by gender,age and occupation(p<0.05).The search for new sources of bio-inspired drugs through zoopharmacognosy may thus allow the development of effective phytomedicines for the health care of humans or non-human primates ex *** the need for advanced phytochemical and pharmacological studies and the domestication of *** for its multiple food and pharmacological uses is necessary.

关键词： Great apes Zoopharmacognosy Traditional medicine Myrianthus arboreus Domestication

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Ethnobotanical Study and Vulnerability of Uvariodendron molundense(Annonaceae)in Gbado-Lite City(Ubangi Eco-region),Democratic Republic of the Congo

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Journal of Botanical Research 2021年第3期3卷 41-48页

作者： Ruphin Djolu Djoza Colette masengo ashande Koto-te-Nyiwa Ngbolua Mawunu Monizi Jeff Iteku Bekomo Damien Sha-T.Tshibangu Dorothée Dinangayi Tshilanda Pius T.Mpiana Mudogo Virima Département de l’Environnement Facultédes SciencesUniversitéde Gbado-LiteGbado-LiteRépublique Démocratique du Congo Département de Biologie Facultédes SciencesUniversitéde KinshasaKinshasaRépublique Démocratique du Congo Department of Agronomy Polytechnical Higher Institute of UígeKimpa Vita UniversityRepublic of Angola Département de Chimie Facultédes SciencesUniversitéde KinshasaKinshasaRépublique Démocratique du Congo

Democratic Republic of the Congo is a real reservoir of medicinal *** plants play a major role in the treatment of certain common pathologies in tropical *** aim of this study was to list the ethno-medical uses of Uvariodendron molundense,a medicinal and aromatic plant from the Ubangi *** ethnobotanical survey was carried out in Gbado-Lite with 200 people using stratified probability *** respondents were interviewed individually on the basis of free *** study revealed that the majority of respondents were men(72%)and had a secondary education(37%),followed respectively by illiterates(34%)and those with a primary education(28%),and finally,university graduates represented only 1%of the respondents.83%of the respondents were farmers,while 79%of the respondents were *** leaf is the most used organ(81%)followed by stem and root *** is used both as food and *** plant treats eight diseases(pain,malaria,cold,hypertension,gastritis,infection,headache and rheumatism).The calculated value of the informant consensus factor is 0.96 and indicates that there is a high degree of consensus among informants regarding the use of *** against these diseases in *** is the most commonly used method of preparation(89%)and 50%of the respondents stated that the species is currently not very abundant,while 31%of the respondents felt that the plant was *** calculated value of the vulnerability index shows that *** is very vulnerable in its natural environment(Iv˃2.5).

关键词： Traditional medicine Endigenous knowledge Mecicinal and aromatic plant Domestication Nord-Ubangi

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