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Risk factors and molecular mechanisms of esophageal cancer: differences between the histologic subtypes

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 1-7页

作者： masayuki watanabe Department of Gastroenterological Surgery Esophageal Cancer DivisionCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 1358550Japan.

The two major histologic subtypes of esophageal cancer have different risk factors as well as different molecular *** this review,the differences in risk factors and genetic/epigenetic alterations between esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC)will be *** smoking and alcohol consumption are risk factors for ESCC,while gastroesophageal refl ux,cigarette smoking,and obesity are the main EAC risk *** mutated genes of both subtypes are TP53 and *** genome-wide analysis revealed that the activation of the RAC1 pathway may contribute to EAC *** abnormality in copy number was observed in several genes in ESCC,whereas a few genes were specifically altered at high frequency in *** changes,such as DNA methylation,histone modifications,and altered expression of microRNAs,have been revealed to influence carcinogenesis and progression of both ESCC and EAC.

关键词： Epigenetic alterations esophageal cancer genetic alterations risk factors

Introduction to the special issue on reviews of gastric cancer metastasis and treatment

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 567-570页

作者： masayuki watanabe Department of Gastroenterological Surgery the Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan

It is a great honor for me to introduce the special issue entitled reviews of Gastric Cancer Metastasis and Treatment.I’ve been focusing on 6 topics including tumor microenvironment(TME),biomarker research,regional variation in gastric cancer treatment,diagnosis and treatment for peritoneal carcinomatosis(PC),surgical treatment for advanced or metastatic gastric cancer,and novel treatment *** special issue includes 18 review articles concerning these *** has been proven to be deeply implicated in tumor progression and metastasis in gastric cancer.

关键词： metastasis diagnosis treatment

Introduction to Volume 1 Issue 3 of Journal of Cancer Metastasis and Treatment

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 111-112页

作者： masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan.

It is a great honor for me to introduce the third issue of the Journal of Cancer Metastasis and *** is a special issue focusing on recent advances in research and treatment for gastrointestinal(GI)*** arising from the GI tract,including esophagus,stomach,colorectum,liver,gallbladder and pancreas,are frequently observed all over the *** to the global cancer statistics 2012,there were approximately 407,000 newly diagnosed cases with GI cancers and 304,000 deaths among them.[1]They accounted for 29%and 37%of all cancers excluding non-melanoma skin cancer *** progress in molecular biological techniques facilitated the understanding of the mechanism of cancer development and *** issue contains nine review articles concerning the topics which attract a lot of attention in the field of GI malignancies.

关键词： Cancer Metastasis stomach

Conversion surgery for stage Ⅳ gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 272-280页

作者： Satoshi Ida masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan

Gastric cancer with distant metastases,such as para-aortic lymph node metastases,hepatic metastases,and peritoneal dissemination,is classified as stage *** this situation,cancer cells have formed micrometastases throughout the body;therefore,according to the algorithm of the Japanese guidelines,stage IV cancer is outside the indication for curative *** advances in some chemical agents have been remarkable,and some patients have survived for long periods even with stage IV gastric ***,even in patients with stage IV gastric cancer,there is a possibility that gastrectomy as conversion surgery could play an important role in the treatment *** as conversion therapy can be safely conducted without perioperative mortality and is considered a sufficiently acceptable treatment ***,the significance of conversion surgery for stage IV gastric cancer remains *** this review,we summarize the treatment strategies and outcomes of conversion surgery for stage IV gastric cancer.

关键词： Gastric cancer stageⅣ gastrectomy conversion surgery outcome

Trends in clinical use of targeted therapy for gastrointestinal cancers

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 163-171页

作者： Kojiro Eto masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital3-8-31 AriakeKoto-kuTokyo 135-8550Japan

Targeted drugs therapies that block the molecular pathways involved in the development and progression of gastro-intestinal(GI)cancers have recently gained considerable *** addition to agents targeting vascular endothelial growth factor(VEGF),epidermal growth factor receptor,the multi-kinase inhibitor,and regorafenib have also become available for the treatment of metastatic colorectal cancer ***,trastuzumab,an antibody targeting human epidermal growth factor receptor-2(HER-2),in combination with cytotoxic drugs is considered as the standard treatment for patients with HER-2 positive gastric cancer(GC).The efficacy of ramucirumab,a human monoclonal antibody that inhibits VEGF from binding to its receptor in GC,has also been recently *** present,a great number of novel targeted drugs are in pre-clinical or clinical *** this review,we summarize trends in the use of molecularly targeted drugs that have proven to be effective for treating GI cancers,with a focus on emerging strategies for personalized treatment.

关键词： Gastro-intestinal tumors molecular pathways molecular targeted drug

MicroRNAs in gastrointestinal cancer: a novel biomarker and its clinical application

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 144-155页

作者： Yukiharu Hiyoshi masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan.

Gastrointestinal(GI)cancers remain one of the most common malignancies and are the major cause of cancer deaths *** cant advancements have improved our understanding of the pathogenesis and pathology of GI cancers,but high mortality rates,an unfavorable prognosis,and lack of clinical predictive biomarkers provide an impetus to investigate novel diagnostic/prognostic markers and therapeutic targets for GI ***(miRNAs)are short(19-24 nucleotides),non-coding RNA molecules that regulate gene expression at the post-transcriptional level,thus playing an important role in modulating various biological *** includes developmental processes,proliferation,apoptosis,metabolism and differentiation,all involved in initiation and progression of various human *** miRNA expression profi les have been observed in various cancer types at different stages,suggesting their potential as diagnostic and prognostic *** to their tumor-and tissue-specific expression profiles,stability,and the availability of robust clinical assays for their detection in serum as well as in formalin-fi xed tissue samples,miRNAs have emerged as attractive candidates for diagnostic and prognostic *** review summarizes recent research supporting the utility of miRNAs as novel diagnostic/prognostic tools and therapeutic targets,thus potentially illuminating future treatment strategies for GI cancers.

关键词： Biomarker gastrointestinal cancer microRNA therapeutic target

Challenges for a reduced inertia power system due to the large-scale integration of renewable energy

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Global Energy Interconnection 2022年第3期5卷 266-273页

作者： Hiromu Hamada Yoshitaka Kusayanagi Masamoto Tatematsu masayuki watanabe Hiroshi Kikusato Tokyo Electric Power Company Holdings Inc.4-1Egasaki-choTsurumi-kuYokohama230-8510KanagawaJapan Kansai Electric Power Company Inc.3-11-20NakojiAmagasaki661-0974 HyogoJapan Kyushu Institute of Technology 1-1 Sensui-choTobata-kuKitakyushuFukuoka 804-8550Japan Fukushima Renewable Energy Institute AIST(FREA)2-2-9 MachiikedaiKoriyama963-0298 FukushimaJapan

This paper reports on the status of technology development under a national project launched in 2019 to address the problem of decreased system inertia associated with the large-scale integration of renewable *** project comprises two parts:the development of a system inertia observation technology using a continuous monitoring system to observe inertia and development of an inverter equipped with a function to provide virtual inertia as a countermeasure *** both these efforts,the project aims to facilitate the introduction of renewable energy in the future with minimum *** was confirmed that the trend of inertia observed with the developed method was generally the same as that of the total inertia of synchronous machines observed by an electric *** effectiveness of the countermeasure device in reducing the frequency swing during a disturbance was confirmed through evaluation tests.

关键词： Renewable energy System inertia Fast Fourier Transform(FFT) Inverter

Recent updates of therapeutic strategy of esophagogastric junction adenocarcinoma

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 727-736页

作者： Suguru Maruyama Yu Imamura Yasukazu Kanie Kei Sakamoto Daisuke Fujiwara Akihiko Okamura JunKanamori masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation of Cancer ResearchTokyo 135-8550Japan.

The incidence of esophagogastric junction(EGJ)adenocarcinoma has been increasing in Asian *** the recent advances in multidisciplinary treatments,EGJ adenocarcinoma remains aggressive with unfavorable *** surgical strategy,EGJ adenocarcinoma arises between the esophagus and the stomach,and thus tumor cells spread through the lymphatic system both upward to the mediastinum and downward to the ***,an optimal extent of lymphadenectomy remains *** drug therapy,the latest topic in gastric and EGJ adenocarcinoma is trastuzumab deruxtecan,which is an antibody-drug conjugate consisting of an anti-HER2 *** addition,many clinical trials have recently demonstrated the efficacy of immune checkpoint ***,recent advances in sequencing technology have revealed that gastroesophageal adenocarcinoma could be categorized into four molecular subtypes:epstein-Barr virus-associated,high-level microsatellite instability,genomically stable,and chromosomal instability ***,these subtypes show distinct clinical phenotypes and molecular *** review the current surgical strategy and drug treatment such as molecular-targeted agents,immune checkpoint inhibitors,and molecular-subtype-based therapeutic strategies in EGJ *** and molecular characteristics and response to immune checkpoint inhibitors differ among molecular *** strategies based on molecular subtypes may be clinically beneficial for patients with EGJ adenocarcinoma.

关键词： Esophagogastric junction adenocarcinoma Barrett’s esophagus microsatellite instability molecular subtype

Chronic infl ammation and gastrointestinal cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 138-143页

作者： Satoshi Ida masayuki watanabe Hideo Baba Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityKumamoto 860-8556Japan.

Chronic inflammation has been identified as an important risk factor in the development of the gastrointestinal(GI)tract cancers,and the underlying molecular mechanisms have been studied *** infl ammation is able to trigger cellular events to promote malignant transformation of normal epithelial cells in the GI tract to *** inflammation responses in carcinogenesis are through multiple mechanisms such as reactive oxygen and nitration species from mononuclear phagocytes and leukocytes,immune response and pro-inflammatory *** factor-κB(NF-κB)has been considered as the central mediator of the immune *** of NF-κB by phosphorylation leads to translocation of NF-κB protein to the nucleus,and in turn regulates the transcription of several pro-infl ammatory cytokines and ***,chronic inflammation creates an environment for genomic and epigenetic *** this review,we summarize the important molecular mechanisms that link chronic infl ammation and GI tract cancer,including esophageal,gastric and colonic cancers,focusing on infective and noninfective agents such as gastroesophageal reflux disease,Helicobacter pylori gastritis and infl ammatory bowel disease.

关键词： Cancer gastrointestinal tract immune response infl ammation