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Chinese Medical Journal 2004年第7期117卷 1017-1022页

作者：刘伟范吴强 Toshihiko Yanase masayuki Saitoh 吴茵 Department of Medicine and Endocrinology Department of Medicine and Bioregulatory Science Department of Geriatric Medicine

Background The aim of this study was to identify the subnuclear distribution pattern of human orphan nuclear receptor steroidogenic factor 1 (SF-1) in living cells with and without the activation of protein kinase A (PKA) signal pathway, and thus try to explain the unknown mechanism by which PKA potentiates SF-1 transactivation. Methods Full-length cDNAs of wild type and a naturally occurring mutant (G35E) human SF-1 were cloned and fused with green fluorescent protein (GFP). Subcellular distribution pattern of human SF-1 in living cells, whose PKA signaling was either activated or not, was studied by laser confocal microscopy after the validity of the gene sequence was *** The transactivation ability of the GFP-SF-1 chimeric protein was highly conserved. Wild type human SF-1 diffused homogeneously within the nuclei of cells when PKA was not active, and converged to clear foci when PKA was activated. Mutant SF-1 diffused within the nuclei even in the presence of PKA activation, surprisingly aggregating as fluorescent dots inside the nucleoli, a phenomenon not altered by *** Activation of PKA causes wild type, but not mutant SF-1 to alter its subnuclear distribution pattern to a transactivationally active form (foci formation). This finding may throw new light on the mechanism by which PKA activates the orphan nuclear receptor.

关键词： steroidogenic factor 1· protein kinase A· green fluorescent protein

Temporal adjustment of short calls according to a partner during vocal turn-taking in Japanese macaques

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Current Zoology 2019年第1期65卷 99-105页

作者： Noriko KATSu Kazunori Yamada Kazuo Okanoya masayuki Nakamichi Graduate School of Arts and Sciences The University of Tokyo Meguro Tokyo Japan Graduate School of Human Sciences Osaka University Suita Osaka Japan Japan Society for the Promotion of Science Tokyo Japan

Turn-taking is a common feature in human speech, and is also seen in the communication of other primate species. However, evidenee of turn-taking in vocal exchanges within a short time frame is still scarce in non human primates. This study in vestigated whether dynamic adjustme nt during turn-taking in short calls exists in Japanese macaques Macaca fuscata. We observed exchanges of short calls such as grunts, girneys, and short, low coos during social interactions in a free-ranging group of Japanese macaques. We found that the median gap between the turns of two callers was 250 ms. Call intervals varied among individuals, suggesting that call intervals were not fixed among individuals. Solo call intervals were shorter than call intervals interrupted by responses from partn ers (i.e., excha nges) and Ion ger than those between the partner's reply and the reply to that call, indicating that the monkeys did not just repeat calls at certain intervals irrespective of the social situation. The differences in call intervals during exchanged and solo call sequences were explained by the response interval of the partner, suggesting an adjustment of call timing according to the tempo of the part ner's call utterance. These findi ngs suggest that mon keys display dyn amic temporal adjustment in a short time window, which is comparable with turn-taking in human speech.

关键词： turn-taking rhythm vocalization primate

The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

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Neural Regeneration Research 2015年第9期10卷 1388-1389页

作者： Misako Okumura masayuki Miura Takahiro Chihara Department of Genetics Graduate School of Pharmaceutical Sciences The University of Tokyo Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E）（Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers.

关键词： The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure

p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy

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World Journal of Gastroenterology 2005年第36期11卷 5696-5700页

作者： Fumiko Sunada masayuki Itabashi Hisanao Ohkura Toshiyuki Okumura Departments of Internal Medicine Pathology Radiology Ibaraki Prefectural Central Hospital and Cancer Center Koibuchi 6528 Tomobe-machi Nishiibaraki-gun Ibaraki-ken Japan

AIM： Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy （CRT）, but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT. METHODS： The intensities of expression of p53, Ki67, Bci-2, Bax, olclin D1, VEGF, CDC25B, and metallothionein （MT） were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT. RESULTS： The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT. CONCLUSION： Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity, if with CDC25B positivity, CRT can be expected. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： p83 CDC25B Metallothionein Chemoradiotherapy Esophageal squamous cell carcinomas

Challenges for a reduced inertia power system due to the large-scale integration of renewable energy

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Global Energy Interconnection 2022年第3期5卷 266-273页

作者： Hiromu Hamada Yoshitaka Kusayanagi Masamoto Tatematsu masayuki Watanabe Hiroshi Kikusato Tokyo Electric Power Company Holdings Inc.4-1Egasaki-choTsurumi-kuYokohama230-8510KanagawaJapan Kansai Electric Power Company Inc.3-11-20NakojiAmagasaki661-0974 HyogoJapan Kyushu Institute of Technology 1-1 Sensui-choTobata-kuKitakyushuFukuoka 804-8550Japan Fukushima Renewable Energy Institute AIST(FREA)2-2-9 MachiikedaiKoriyama963-0298 FukushimaJapan

This paper reports on the status of technology development under a national project launched in 2019 to address the problem of decreased system inertia associated with the large-scale integration of renewable *** project comprises two parts:the development of a system inertia observation technology using a continuous monitoring system to observe inertia and development of an inverter equipped with a function to provide virtual inertia as a countermeasure *** both these efforts,the project aims to facilitate the introduction of renewable energy in the future with minimum *** was confirmed that the trend of inertia observed with the developed method was generally the same as that of the total inertia of synchronous machines observed by an electric *** effectiveness of the countermeasure device in reducing the frequency swing during a disturbance was confirmed through evaluation tests.

关键词： Renewable energy System inertia Fast Fourier Transform(FFT) Inverter

Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells

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Cellular & Molecular Immunology 2010年第6期7卷 440-446页

作者： Tomoyuki Suzuki Myint Oo Chang masayuki Kitajima Hiroshi Takaku Department of Life and Environmental Sciences Chiba Institute of TechnologyChibaJapan High Technology Research Center Chiba Institute of TechnologyChibaJapan Immunology Program Benaroya Research InstituteSeattleWAUSA

A dendritic cell(DC)vaccine strategy has been developed as a new cancer immunotherapy,but the goal of complete tumor eradication has not yet been *** have previously shown that baculoviruses potently infect DCs and induce antitumor immunity against hepatomas in a mouse ***-infected,bone marrow-derived DCs(BMDCs)display increased surface expression of costimulatory molecules,such as CD80,CD86 and major histocompatibility complex(MHC)classes I and II,and secrete interferons and other proinflammatory *** this study,we evaluated the induction of antitumor immunity in mice by baculovirus-infected BMDCs against lung cancer and *** treatment with baculovirus-infected BMDCs,murine lung tumors caused by Lewis lung carcinoma(LLC)cells were significantly reduced in size,and the survival of the mice was *** addition,experiments using a melanoma mouse model showed that baculovirus-infected BMDCs inhibited tumor growth and improved survival compared with *** alanine aminotransferase(ALT),aspartate aminotransferase(AST)and creatinine levels remained normal in baculovirus-infected BMDC-treated *** findings show that baculovirus-infected DCs induce antitumor immunity and pave the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.

关键词： dendritic cells natural killer cells T cells tumor Immunity

Strangulated hernia through a defect of the broad ligament and mobile cecum: A case report

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World Journal of Gastroenterology 2006年第9期12卷 1479-1480页

作者： Kunihiko Hiraiwa Kyoei Morozumi Hiroshi Miyazaki Keiichi Sotome Akio furukawa Makoto Nakamaru Department of Surgery Hamamatsu Red Cross Hospital HamamatsuShizuokaJapan Department of Surgery Fussa Hospital FussaTokyoJapan

We report a case of 28-year-old woman presenting with small bowel obstruction. She had neither prior surgery nor delivery. An upright abdominal radiograph revealed several air-fluid levels in the small bowel in the midabdomen and the pelvic cavity. Computed tomography demonstrated a dilated small bowel loop in the Douglas＇s fossa, but no definite diagnosis could be made. Supportive therapy with draining the intestinal fluid by a long intestinal tube did not result in improvement, which suggested the possibility of a strangulated hernia. Exploratory laparotomy revealed mobile cecum and a 20-cm length of the ileum herniated into a defect of the right broad ligament. As a gangrenous change was recognized in the incarcerated bowel, its resection was carried out, followed by endto-end anastomosis and closure of the defects of the broad ligament. The postoperative course was uneventful. Intestinal obstruction is a very common cause for presentation to an emergency department, while internal hernia is a rare cause of obstruction. Among internal hernias, those through defects of the broad ligament are extremely rare. Defects of the broad ligament can be either congenital or secondary to surgery, pelvic inflammatory disease, and delivery trauma. In conclusion, we emphasize that hernia of the broad ligament should be added to the list of differential diagnosis for female patients presenting with an intestinal obstruction. Early diagnosis and surgical repair reduce morbidity and mortality from strangulation.

关键词： Internal hernia Broad ligament Intestinal obstruction Mobile cecum

Lymphangiogenesis:A new player in cancer progression

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World Journal of Gastroenterology 2010年第32期16卷 4003-4012页

作者： masayuki Nagahashi Subramaniam Ramachandran Omar M Rashid Kazuaki Takabe Division of Surgical Oncology Department of SurgeryVirginia Commonwealth University School of Medicine and Massey Cancer CenterRichmondVA 23298-0011United States

Lymph node metastasis is the hallmark of colon cancer progression,and is considered one of the most important prognostic ***,there has been growing evidence that tumor lymphangiogenesis(formation of new lymphatic vessels) plays an important role in this ***,we review the latest f indings of the role of lymphangiogenesis in colorectal cancer progression,and discuss its clinical application as a biomarker and target for new *** the molecular pathways that regulate lymphangiogenesis is mandatory to pave the way for the development of new therapies for *** the future,tailored treatments consisting of combinations of chemotherapy,other targeted therapies,and anti-lymphangiogenesis agents will hopefully improve patient *** progression to the clinic must be guided by new avenues of research,such as the identif ication of biomarkers that predict response to treatment.

关键词： Colorectal neoplasms Angiogenesis Lymphangiogenesis Lymphatic vessels Lymphatic metastasis Vascular endothelial growth factor Monoclonal antibody D2-40 Therapy-related neoplasms Biomarkers

Indirect photocatalytic reduction of arsenate to arsenite in aqueous solution with TiO_2 in the presence of hole scavengers

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Chinese Journal of Chemical Engineering 2018年第3期26卷 529-533页

作者： Abdus Samad Shamim Ahsan Ikki Tateishi Mai furukawa Hideyuki Katsumata Tohru Suzuki Satoshi Kaneco Department of Chemistry Jagannath University Department of Earth and Atmospheric Sciences Metropolitan State University of Denver Department of Chemistry for Materials Graduate School of Engineering Mie University Mie Global Environment Center for Education & Research Mie University

The indirect photocatalytic reduction of arsenate to arsenite in aqueous solution with titanium dioxide(TiO_2)was investigated with various hole scavengers such as methanol, ethanol, 2-propanol, formaldehyde, acetone,formic acid and acetic acid. Although the direct photocatalytic reduction of arsenate to arsenite with TiO_2 was impossible, an indirect reduction of As(V) was possible in the presence of sacrificial electron donors to form strongly reductive radicals. The addition of ethanol was very effective for indirect photocatalytic reduction of As(V) in aqueous solution with TiO_2 photocatalyst. The indirect photocatalytic reduction rate of As(V) may be related with both the reaction rate constants of reaction of hydroxyl radicals with hole scavenger and the reactivities for the radicals M· which are produced by the reaction of ·OH with hole scavenger.

关键词： Indirect photocatalytic reduction Arsenate Arsenite Titanium dioxide Hole scavenger

Optimum Position of Polarizer-Based Compensator for Enhanced Tolerance to Polarization Mode Dispersion

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光学学报 2003年第S1期23卷 583-584页

作者： Daniele Alzetta masayuki Matsumoto Department of Communications Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 JapanDepartment of Communications Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan

We show through numerical simulation that the performance of two types of polarization-mode dispersion polarizer-based compensation techniques may be improved by optimizing the position of the compensator along the tr... 详细信息

关键词： for as it PMDC of line that