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Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

International Journal of Ophthalmology(English edition) 2015年第1期8卷 1-10页

作者： Junmi Tanaka Hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura masayuki yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa Department of Ophthalmology and Visual Science Graduate School of MedicineYokohama City University Department of Ophthalmology Graduate School of MedicineUniversity of Tokyo Department of Obstetrics and Gynecology School of MedicineKeio University Department of Environmental Immuno-Dermatology Graduate School of MedicineYokohama City University Hatano Eye Clinic 438-1 FujisawaFujisawa Kanagawaken 251-0052Japan Tokushima Eye Clinic 1-2-14 Fujimi-choHigashimurayamaTokyo 189-0024Japan

AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic ***: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC ***: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future.

关键词： Semaphorin 3A experimental allergic conjunctivitis eosinophil infiltration serum total Ig E cytokines instillation subconjunctival administration

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含TiO_2的MgO-Al_2O_3-SiO_2系统玻璃分相的研究

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无机材料学报 1991年第3期6卷 269-277页

作者：邹学禄李家治王承遇山根正之大连轻工业学院中国科学院上海硅酸盐研究所东京工业大学

本文采用X射线小角散射技术(SAXS)、X 射线光电子能谱(XPS)、拉曼光谱(Raman)和电镜(TEM、SEM)等测试方法详细地研究了含 TiO_2的 MgO-Al_2O_3-SiO_2系统玻璃在靠近 T_g(=750℃)点的温度范围(700～820℃)内热处理时玻璃的分相过程。发... 详细信息

本文采用X射线小角散射技术(SAXS)、X 射线光电子能谱(XPS)、拉曼光谱(Raman)和电镜(TEM、SEM)等测试方法详细地研究了含 TiO_2的 MgO-Al_2O_3-SiO_2系统玻璃在靠近 T_g(=750℃)点的温度范围(700～820℃)内热处理时玻璃的分相过程。发现在低于 T_g 点的温度下,玻璃的分相获得了显著的发展;玻璃的转变温度、颜色以及玻璃分相的结构形貌均随热处理温度的不同而出现明显的差异。

关键词：氧化镁氧化铝二氧化硅玻璃分相

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Asymptotic behavior of solutions of defocusing integrable discrete nonlinear Schrodinger equation

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Frontiers of Mathematics in China 2013年第5期8卷 1077-1083页

作者： Hideshi yamane Department of Mathematical Sciences Kwansei Gakuin University Sanda 669-1337 Japan

We report our recent result about the long-time asymptotics for the defocusing integrable discrete nonlinear Schrodinger equation of Ablowitz- Ladik. The leading term is a sum of two terms that oscillate with decay of... 详细信息

关键词： Discrete nonlinear Schrodinger equation Ablowitz-Ladik model,asymptotics inverse scattering transform nonlinear steepest descent

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Response of understory vegetation over 10 years after thinning in an old-growth cedar and cypress plantation overgrazed by sika deer in eastern Japan

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Forest Ecosystems 2017年第2期4卷 93-102页

作者： Atsushi Tamura Masanobu yamane Division of Forest Research and Nature Restoration Planning Kanagawa Prefecture Natural Environment Conservation Center 657 Nanasawa AtsugiKanagawa 243-072 Japan

Background： Forest management strategies such as thinning have long been used to enhance ecosystem functions, especially in *** in plantations with high deer density, however, may not yield a desired increase in understory vegetation because deer graze on germinating plants after ***, we examine the changes in understory vegetation after thinning in plantations that have been overgrazed by sika deer to provide insight into the effects of thinning on ecosystem functions such as soil conservation and biological ***： We conducted our survey in the Tanzawa Mountains of eastern *** surveyed the change in understory vegetation within and outside of three deer exclosures on a single slope with three levels of understory vegetation cover： sparse（1%, exclosure ＂US＂）, moderate（30%, exclosure ＂MM＂）, and dense（80%, exclosure ＂LD＂） over10 years after a 30% thinning of an old-growth cedar and cypress plantation which was overgrazed by sika ***： Understory vegetation cover, biomass and species richness increased within and outside the ＂US＂ and＂MM＂ exclosures after thinning, and biomass was greater within than outside the exclosures at 10 years after *** species dominated both ＂US＂ and ＂MM＂ exclosures before thinning, and trees and shrubs dominated within the exclosures over time after *** contrast, unpalatable, grazing-tolerant, perennial,and annual species increased outside the ＂US＂ and ＂MM＂ *** noticeable changes were observed within and outside the ＂LD＂ exclosure when compared with the ＂US＂ and ＂MM＂ ***： Our results suggest that thinning a stand by 30% based on volume resulted in an increase in understory vegetation cover mainly composed of both unpalatable and grazing-tolerant species in a plantation forest where understory vegetation is sparse or moderate and sika deer density is *** emphasize that establishing deer exclosures or controlling deer is essential to ma

关键词： Biomass Deer exclosure Grazing-tolerant species Understory cover Unpalatable species

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Preharvest long-term exposure to UV-B radiation promotes fruit ripening and modifies stage-specific anthocyanin metabolism in highbush blueberry

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Horticulture Research 2021年第1期8卷 1082-1093页

作者： Taishan Li Hisayo yamane Ryutaro Tao Graduate School of Agriculture Kyoto UniversityKyoto 606-8502Japan

Ultraviolet-B(UV-B)light(280–315 nm)is an important environmental signal that regulates plant development and photomorphogenesis,while also affecting the flavonoid pathway,including anthocyanin *** the effects of UV-B radiation on fruits,the effects of a short-term or postharvest irradiation on fruit quality have been well-documented,but the effects of a long-term preharvest UV-B irradiation on fruit growth and coloration remain ***,in this study,we investigated the effects of a long-term treatment involving an environmentally relevant UV-B dose on highbush blueberry(Vaccinium corymbosum)*** preharvest UV-B treatment quickly promoted fruit growth and sugar accumulation,which is not commonly observed in other fruit tree *** UV-B exposure also accelerated fruit ripening and *** dual-luciferase assay proved that in blueberries,expression of VcUFGT encoding anthocyanin biosynthesis key enzyme,is positively and negatively regulated by VcMYBA1 and VcMYBC2,*** the fruit development stage,the UV-B treatment up-regulated VcMYBPA1 expression,which increased VcUFGT expression via *** the green fruit stage,the UV-B treatment increased HY5 encoding UV receptor,which up-regulates VcMYBPA1 and down-regulates VcMYBC2,thereby promotes the accumulation of *** the other hand,excessive anthocyanin synthesis was inhibited by increased VcMYBC2 levels in mature fruits when exposed to UV-B light through HY5-independent *** conclusion,anthocyanin-related MYB activators and repressor may coordinately balance the accumulation of anthocyanins in blueberry fruits,with UV-B treatments possibly influencing their effects in a stage-specific *** potential utility of preharvest UV-B treatments for improving blueberry fruit quality is discussed herein.

关键词： treatment metabolism specific

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Root pruning is effective in alleviating the inhibition of soybean growth caused by anaerobic stress for a short period

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Journal of Integrative Agriculture 2023年第4期22卷 1035-1044页

作者： Koji yamane Miki MARIYAMA Yoshihiro HIROOKA Morio IIJIMA Graduate School of Agriculture Kindai UniversityNara 631-8505Japan

Soybean is an important upland crop,but its productivity is often limited by anaerobic stress caused by *** ability to adjust root growth under environmental constraints is an important physiological trait for adapting to an everchanging environment,and root pruning is an artificial technique for regenerating the root *** the present study,we investigated whether root pruning in soybean can effectively alleviate the inhibitory effects of anaerobic *** plants were affected by anaerobic stress at the germination,vegetative stage 1(V1),and reproductive stage 1(R1)stages,and then the plants were treated with root pruning just after the stress *** plants at the germination stage were treated with root cap and tip removals after hypoxia(N_(2)treatment).Root cap removal was more effective in suppressing the inhibitory effects of hypoxia than root tip removal(5 mm from the tip).The shoot dry weights of the soybean plants with and without root cap removal after hypoxia were 51.2 and 73.8%of the control,respectively,while the root dry weights of plants with and without root cap removal after hypoxia were 43.2 and 62.8%of the control,*** root cap removal effectively enhanced soybean growth after anaerobic stress,the root cap may be the candidate tissue for the stress memory *** soybean plants at the V1 stage of growth were affected by anaerobic stress,the branch number,pod weight in the main stem,root length,and root surface area of the soybean plants treated with anaerobic stress at the R1 stage significantly decreased compared with those of the *** contrast,root pruning(2 mm from the tip)immediately after the stress treatment enhanced root growth,branch number,and pod *** branch number,pod weight,root length,and root surface area of the plants treated with root pruning were 1.13,1.14,1.12,and 1.13 times higher than those of plants treated with anaerobic *** was observed in the roo

关键词： crack fertilization nodulation control root cap removal stress memory waterlogging

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Hydrogen Adsorption by Woodceramics Produced from Biomass

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 330-333页

作者： TAKASAKI Akito IIJIMA Suguru yamane Tomoka OKABE Toshio Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Aomori Prefectural Industrial Technology Research Center Aomori 030-0142Japan

Hydrogen adsorption characteristics of woodceramics,made from radiata pine wood fiber boards carbonized at 1 473 K after impregnation with phenolic resin,with and without chemical treatment in an alkaline(KOH) or an acid(H 2 SO 4) solution were investigated The hydrogen adsorption capacity is improved by chemical *** chemical treatment by KOH improves the adsorption capacity more than by H 2 SO *** improvement of the capacity level,in any solution,is dependent on the type of chemical in the solution and its *** maximum hydrogen capacity measured at 93 K is mass fraction about w(H) = 2% for the woodceramics after chemical treatment in a volume fraction = 50% KOH solution,although that is about w(H) = 0.7% for one without chemical *** microscopic condition of pores in the woodceramics is thought to vary after chemical treatment.

关键词： woodceramics biomass hydrogen adsorption chemical treatment isotherm

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Influence of chirality on the cyclohexene-fused C_(60) fullerene derivatives as an accepter partner in a photovoltaic cell

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Green Energy & Environment 2016年第2期1卷 149-155页

作者： Kiyotaka Sugawara Naoshi Nakamura Yu yamane Shuichi Hayase Toshiki Nokami Toshiyuki Itoh Department of Chemistry and Biotechnology Graduate School of Engineering Tottori University Center for Research on Green Sustainable Chemistry Tottori University

Organic photovoltaic devices(OPVs) using chiral cyclohexene-fused [C_(60)]-fullerene derivatives that have(l)-menthyl ester moiety have been prepared and their properties evaluated as acceptor molecules with P3 HT polymer: racemic cyclohexene-fused [C_(60)] fullenene,(RS)-(1 R,2 S,5 R)-2 a showed higher PCE(2.81%) than that of standard [C_(60)]-PCBM(2.64%) under the same analysis conditions. On the contrary, devices using chiral(R)-(1 R,2 S,5 R)-2 a and(S)-(1 R,2 S,5 R)-2 a, showed PCE as 1.08% and 1.10%, respectively. The main origin of the differences in PCE was found to be their poor Jsc values. The results indicate that the aggregation state might influence the interaction state with P3 HT and impact the results of the OPV properties, Jsc values in particular.

关键词： Solar cell Accepter molecule Cyclohexene-fused[C60]-fullerene Chirality

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Dynamic skin deformation simulation using musculoskeletal model and soft tissue dynamics

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Computational Visual Media 2017年第1期3卷 49-60页

作者： Akihiko Murai Q.Youn Hong Katsu yamane Jessica K.Hodgins National Institute of Advanced Industrial Science and Technology Tokyo135-0064Japan Carnegie Mellon University USA Disney Research USA

Deformation of skin and muscle is essential for bringing an animated character to life. This deformation is difficult to animate in a realistic fashion using traditional techniques because of the subtlety of the skin deformations that must move appropriately for the character design. In this paper, we present an algorithm that generates natural, dynamic, and detailed skin deformation(movement and jiggle) from joint angle data sequences. The algorithm has two steps: identification of parameters for a quasi-static muscle deformation model, and simulation of skin deformation. In the identification step, we identify the model parameters using a musculoskeletal model and a short sequence of skin deformation data captured via a dense marker set. The simulation step first uses the quasi-static muscle deformation model to obtain the quasi-static muscle shape at each frame of the given motion sequence(slow jump). Dynamic skin deformation is then computed by simulating the passive muscle and soft tissue dynamics modeled as a mass–spring–damper system. Having obtained the model parameters, we can simulate dynamic skin deformations for subjects with similar body types from new motion data. We demonstrate our method by creating skin deformations for muscle co-contraction and external impacts from four different behaviors captured as skeletal motion capture data. Experimental results show that the simulated skin deformations are quantitatively and qualitatively similar to measured actual skin deformations.

关键词： three-dimensional graphics and realism musculoskeletal model quasi-static muscle model dynamic skin deformation

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The utility of point-of-care ultrasound in the assessment of volume status in acute and critically ill patients

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World Journal of Emergency Medicine 2019年第4期10卷 232-238页

作者： Ali Pourmand Matthew Pyle David yamane Kazi Sumon Sarah E.Frasure Department of Emergency Medicine George Washington University School of Medicine and Health Sciences

BACKGROUND:Volume resuscitation has only been demonstrated to be effective in approximately fifty percent of *** remaining patients do not respond to volume resuscitation and may even develop adverse outcomes(such as acute pulmonary edema necessitating endotracheal intubation).We believe that point-of-care ultrasound is an excellent modality by which to adequately predict which patients may benefi t from volume *** RESOURCES:We performed a search using PubMed,Scopus,and *** following search terms were used:fluid responsiveness,ultrasound,non-invasive,hemodynamic,fluid challenge,and passive leg *** was given to clinical trials and review articles that were most relevant to the topic of assessing a patient’s cardiovascular ability to respond to intravenous fl uid administration using ***:Point-of-care ultrasound can be easily employed to measure the diameter and collapsibility of various large vessels including the inferior vena cava,common carotid artery,subclavian vein,internal jugular vein,and femoral *** parameters are closely related to dynamic measures of fluid responsiveness and can be used by providers to help guide fluid resuscitation in critically ill ***:Ultrasound in combination with passive leg raise is a non-invasive,costand time-effective modality that can be employed to assess volume status and response to fluid *** sonographic studies have focused on the evaluation of large veins such as the inferior vena cava,and internal jugular vein.A number of recently published studies also demonstrate the usefulness of evaluating large arteries to predict volume status.

关键词： Stroke volume Fluid responsiveness Ultrasound Non-invasive Hemodynamic

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