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Evaluation of Important Factors Affecting Quench Distortion of Carburized Hypoid Gear with Shaft by Using Computer Simulation Methods

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材料热处理学报 2004年第5期25卷 480-485页

作者： Tsuyoshi sugimoto Youichi Watanabe Nissan Motor Co. Ltd. 6-1 Daikoku-cho Tsurumi Yokohama JapanNissan Motor Co. Ltd. 6-1 Daikoku-cho Tsurumi Yokohama Japan

To minimize quenching distortion and dispersion, carburizing and quenching process conditions must be optimized; this includes the parts racking design used for quenching. We investigated some factors affecting carburized quenching distortion with an experiment using a hypoid gear having a shaft and with numerical simulation methods. The experimental results and those obtained from simulation were generally in agreement. Focusing on the surface temperature distribution in the gear, we studied quenching distortion characteristics in terms of changes in tooth profile and helix deviation. In our experiments, distortions occur during quenching in 373 K oil after austenitized temperature treatments conducted with various attitudes. We calculated the distortions by simulating the carburized oil-quenching process for the hypoid gear. Our results show large differences between the cooling rates of the tooth toe, middle section, and heel edges, and these greatly influence the change in tooth profile and helix deviation. We found that reducing the differences in temperatures on the gear surfaces during quenching is most important for minimizing the quench distortion of the hypoid gear.

关键词：淬火变形螺旋偏差外形偏差冷却曲线传热系数准双曲面齿轮

A Simple Method for Synthesizing Ultra-high-molecular-weight Polystyrene through Emulsion Polymerization Using Alkyl-9-BBN as an Initiator

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Chinese Journal of Polymer Science 2018年第5期36卷 592-597页

作者： Chao Zhao Ryuichi sugimoto Yusuke Naruoka School of Environmental Science and Engineering Kochi University of Technology

Styrene emulsion polymerization using an alkyl-9-BBN, synthesized by reacting 9-BBN（9-borabicyclo-[3.3.1]-nonane） and styrene, in an aqueous sodium dodecyl sulfate（SDS） solution was studied. Ultra-high-molecular-weight（〉 1.0 × 10~7） polystyrene was synthesized using a radical initiator formed through the aerobic oxidation of this alkyl-9-BBN in a high yield（〉 80%）. The kinetics of this emulsion polymerization of styrene with the alkyl-9-BBN was investigated. We confirmed that in the initial stage of the polymerization, the initial reaction rate followed first-order kinetics. The activation energy for this emulsion polymerization of styrene was approximately 56.2 kJ/mol.

关键词： Emulsion polymerization 9-BBN Ultra-high molecular weight polystyrene

Updated results from the European Randomized Study of Prostate-Specific Antigen （PSA） Screening for Prostate Cancer： are Asian countries encouraged to promote PSA screening？

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Asian Journal of Andrology 2012年第4期14卷 522-524页

作者： Mikio sugimoto Yoshiyuki Kakehi Department of Urology Kagawa University Faculty of Medicine Kita-gun Kagawa 761-0793 Japan

An updated result of European Randomized Screening Trial for Prostate Cancer encourages Asian countries to proceed prostate-specific antigen （PSA） screening for early detection. On the other hand, the issue of overtreatment is emerging as a serious problem. Active surveillance （AS） should be more prevalent than now to avoid overtreatment for patients with favourablerisk prostate cancer （PCa） detected by PSA test.

关键词： Disease genetics Dyslipidaemias Endocrine system and metabolic diseases Therapeutics

Efficacy of tailored Helicobacter pylori eradication therapy based on antibiotic susceptibility and CYP2C19 genotype

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World Journal of Gastroenterology 2014年第21期20卷 6400-6411页

作者： Mitsushige sugimoto Takahisa Furuta First Department of Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan

The cure rates of Helicobacter pylori (H. pylori) eradication therapy using a proton pump inhibitor (PPI) and antimicrobial agents such as amoxicillin, clarithromycin, and metronidazole are mainly influenced by bacterial susceptibility to antimicrobial agents and the magnitude of the inhibition of acid secretion. Annual cure rates have gradually decreased because of the increased prevalence of H. pylori strains resistant to antimicrobial agents, especially to clarithromycin. Alternative regimens have therefore been developed incorporating different antimicrobial agents. Further, standard PPI therapy (twice-daily dosing) often fails to induce a long-term increase in intragastric pH > 4.0. Increasing the eradication rate requires more frequent and higher doses of PPIs. Therapeutic efficacy related to acid secretion is influenced by genetic factors such as variants of the genes encoding drug-metabolizing enzymes (e.g., cytochrome P450 2C19, CYP2C19), drug transporters (e.g., multidrug resistance protein-1; ABCB1), and inflammatory cytokines (e.g., interleukin-1β). For example, quadruple daily administration of PPI therapy potently inhibits acid secretion within 24 h, irrespective of CYP2C19 genotype. Therefore, tailored H. pylori eradication regimens that address acid secretion and employ optimal antimicrobial agents based on results of antimicrobial agent-susceptibility testing may prove effective in attaining higher eradication rates.

关键词： Helicobacter pylori Tailored eradication therapy Proton pomp inhibitor Cytochrome P450 2C19 Clarithromycin

A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： Nobuo sugimoto Atsushi Shimizu Ichiro Matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio

Provenance Description of Metadata Vocabularies for the Long-term Maintenance of Metadata

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Journal of Data and Information Science 2017年第2期2卷 41-55页

作者： Chunqiu Li Shigeo sugimoto Graduate School of Library Information and Media StudiesUniversity of TsukubaJapan Faculty of Library Information and Media ScienceUniversity of TsukubaJapan

Purpose： The purpose of this paper is to discuss provenance description of metadata terms and metadata vocabularies as a set of metadata terms. Provenance is crucial information to keep track of changes of metadata terms and metadata vocabularies for their consistent maintenance. Design/methodology/approach： The W3C PROV standard for general provenance description and Resource Description Framework（RDF） are adopted as the base models to formally define provenance description for metadata ***： This paper defines a few primitive change types of metadata terms, and a provenance description model of the metadata terms based on the primitive change types. We also provide examples of provenance description in RDF graphs to show the proposed *** limitations： The model proposed in this paper is defined based on a few primitive relationships（e.g. addition, deletion, and replacement） between pre-version and post-version of a metadata term. The model is simplified and the practical changes of metadata terms can be more complicated than the primitive relationships discussed in the model. Practical implications： Formal provenance description of metadata vocabularies can improve maintainability of metadata vocabularies over time. Conventional maintenance of metadata terms is the maintenance of documents of terms. The proposed model enables effective and automated tracking of change history of metadata vocabularies using simple formal description scheme defined based on widely-used ***/value： Changes in metadata vocabularies may cause inconsistencies in the longterm use of metadata. This paper proposes a simple and formal scheme of provenance description of metadata vocabularies. The proposed model works as the basis of automated maintenance of metadata terms and their vocabularies and is applicable to various types of changes.

关键词： Metadata maintenance Metadata vocabulary Metadata term Metadata provenance Metadata longevity

Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第37期21卷 10584-10597页

作者： Mitsuro Kanda Hiroyuki sugimoto Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery Ⅱ) Nagoya University Graduate School of Medicine

Hepatocellular carcinoma(HCC) is a primary cancer of the liver that is predominant in developing countries and is responsible for nearly 600000 deaths each year worldwide. Similar to many other tumors, the development of HCC must be understood as a multistep process involving the accumulation of genetic and epigenetic alterations in regulatory genes, leading to the activation of oncogenes and the inactivation or loss of tumor suppressor genes. Extensive research over the past decade has identified a number of molecular biomarkers, including aberrant expression of HCCrelated genes and microRNAs. The challenge facing HCC research and clinical care at this time is to address the heterogeneity and complexity of these genetic and epigenetic alterations and to use this information to direct rational diagnosis and treatment strategies. The multikinase inhibitor sorafenib was the first molecularly targeted drug for HCC to show some extent of survival benefits in patients with advanced tumors. Although the results obtained using sorafenib support the importance of molecular therapies in the treatment of HCC, there is still room for improvement. In addition,no molecular markers for drug sensitivity, recurrence and prognosis are currently clinically available. In this review, we provide an overview of recently published articles addressing HCC-related genes and microRNAs to update what is currently known regarding genetic and epigenetic aspects of the pathogenesis of HCC and propose novel promising candidates for use as diagnostic and therapeutic targets in HCC.

关键词： Hepatocellular carcinoma Oncogene Tumor suppressor

Risk factors for de novo hepatitis B during solid cancer treatment

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World Journal of Clinical Cases 2020年第24期8卷 6264-6273页

作者： Rie sugimoto masayuki Furukawa Takeshi Senju Yoshihusa Aratake Yuki Tanaka Hiroki Inada Tatsuya Noguchi Lingaku Lee Masami Miki Yuji Maruyama Risa Hashimoto Terumasa Hisano Mototsugu Shimokawa Department of Hepato-Biliary-Pancreatology National Hospital Organization Kyushu Cancer CenterFukuoka City 811-1395Fukuoka PrefectureJapan National Hospital Organization Kyushu Cancer Center Clinical Research InstituteFukuoka City 811-1395Fukuoka PrefectureJapan Department of Biostatistics Yamaguchi University Graduate School of MedicineUbe City 755-8505Yamaguchi PrefectureJapan

BACKGROUND Reactivation of hepatitis B virus(HBV)during anticancer treatment is a critical *** treating patients with solid tumors,it is unclear whether specific cancer types or treatments affect HBV reactivation in hepatitis B surface antigen(HBsAg)-negative and hepatitis B core antibody(HBcAb)-positive patients,socalled de novo hepatitis B *** risk of de novo hepatitis B may vary based on different background *** To determine the frequency and risk factors for de novo hepatitis B during solid tumor *** This retrospective cohort study comprised 1040 patients without HBsAgs and with HBcAbs and/or hepatitis B surface antibodies(HBsAbs).The patients were treated for solid cancer from 2008 to 2018 at the National Kyushu Cancer Center and underwent HBV DNA *** characteristics and disease and treatment information were *** DNA measurements were performed using TaqMan polymerase chain reaction(PCR).To identify the risk factors associated with HBV DNA expression,the age,sex,original disease,pathology,treatment method,presence or absence of hepatitis C virus(HCV),and HBsAb and/or HBcAb titers of all subjects were *** patients with HBV DNA,the time of appearance,presence of HBsAgs and HBsAbs at the time of appearance,and course of the subsequent fluctuations in virus levels were also *** Among the 1040 patients,938 were HBcAb positive,and 102 were HBcAb negative and HBsAb *** DNA expression was observed before the onset of treatment in nine patients(0.9%)and after treatment in 35 patients(3.7%),all of whom were HBcAb *** HBV reactivation group showed significantly higher median HBcAb values[9.00(8.12-9.89)vs 7.22(7.02-7.43),P=0.0001]and significantly lower HBsAb values(14 vs 46,P=0.0342)than the group without ***,the reactivated group showed a significantly higher proportion of cancers in organs related to digestion and absorption(79.0%vs 58.7%,

关键词： Hepatitis B Reactivation Solid cancer treatment Digestion and absorption organ Hepatitis B surface antibody Hepatitis B core antibody titer

Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population:Meta-analysis

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World Journal of Gastroenterology 2020年第15期26卷 1820-1840页

作者： Mitsushige sugimoto Masaki Murata Yoshio Yamaoka Department of Gastroenterological Endoscopy Tokyo Medical University HospitalSinjukuTokyo 1600023Japan Department of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555Japan Department of Gastroenterology Department of Environmental and Preventive MedicineOita University Faculty of MedicineYufuOita 8795593Japan

BACKGROUND Helicobacter pylori(***)infection is a risk factor for gastric cancer(GC),especially in East Asian *** East Asian populations infected with *** are at higher risk for GC than ***-positive European and United States *** eradication therapy reduces gastric cancer risk in patients after endoscopic and operative resection for GC,as well as in non-GC patients with atrophic *** To clarify the chemopreventive effects of *** eradication therapy in an East Asian population with a high incidence of *** PubMed and the Cochrane library were searched for randomized control trials(RCTs)and cohort studies published in English up to March *** analyses were conducted with regard to study designs(i.e.,RCTs or cohort studies),country where the study was conducted(i.e.,Japan,China,and South Korea),and observation periods(i.e.,≤5 years and>5 years).The heterogeneity and publication bias were also *** For non-GC patients with atrophic gastritis and patients after resection for GC,4 and 4 RCTs and 12 and 18 cohort studies were included,*** RCTs,the median incidence of GC for the untreated control groups and the treatment groups was 272.7(180.4–322.4)and 162.3(72.5–588.2)per 100000 person-years in non-GC cases with atrophic gastritis and 1790.7(406.5–2941.2)and 1126.2(678.7–1223.1)per 100000 person-years in cases of after resection for *** with non-treated ***-positive controls,the eradication groups had a significantly reduced risk of GC,with a relative risk of 0.67[95%confidence interval(CI):0.47–0.96]for non-GC patients with atrophic gastritis and 0.51(0.36–0.73)for patients after resection for GC in the RCTs,and 0.39(0.30–0.51)for patients with gastritis and 0.54(0.44–0.67)for patients after resection in cohort *** In the East Asian population with a high risk of GC,*** eradication effectively reduced the risk of GC,irrespective of past histo

关键词： Helicobacter pylori Eradication therapy Gastric cancer Metachronous cancer East Asia Prevention