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Elicitation-Based Modulation of Shelf Life in Fruits: Physiological and Molecular Insights

Phyton-International Journal of Experimental Botany 2023年第8期92卷 2283-2300页

作者： Ankita Kundu Abir Das Sayan Pal Arijit Ghosh Malay Kumar Adak masayuki Fujita Mirza Hasanuzzaman Plant Physiology and Molecular Biology Research Unit Department of BotanyUniversity of KalyaniKalyani741235India Laboratory of Plant Stress Responses Faculty of AgricultureKagawa UniversityKagawa761-0795Japan Department of Agronomy Faculty of AgricultureSher-E-Bangla Agricultural UniversityDhaka1207Bangladesh

The process of ripening involves physiological and biochemical events that become a concern during postharvest *** have documented different approaches for the preservation and maintenance of fruit quality during the postharvest period that are biocompatible and fully safe for *** residues that sustain sensory characteristics,such as color,ﬂavor,aroma,and texture,are *** fruit ripening,both physical and chemical elicitors are described that regulate ethylene biosynthesis or its signaling for gene *** key regulatory enzymes,such as ACC synthase and ACC oxidase,for ethylene biosynthesis,are important for both climacteric and non-climacteric ***-oxidizing genes that retain sensory characteristics are concerns in this *** elicitors,including chitosan,polyamine,phenolics,lipopolysaccharide,silver derivatives,and nanocomposites,are *** pressure,light wavelengths,relative humidity,cooling,and other environmental factors are important for improved postharvest *** elicitors maintain redox status by inhibiting the generation of reactive oxygen species(ROS)or their *** regulators,including abscisic acid,auxin,brassinosteroids,jasmonic acid,and salicylic acid,are important for the regulation of *** injuries,ionic imbalances,temperature variations,and tissue dehydration can occur irrespective of ripening *** use of synthetic physiochemically active compounds is discussed in terms of physiological,metabolic,cellular,and molecular ***-induced autocatalytic processes,antioxidant cascades,epigenetic regulation,and homeodomain gene expression are ***–acid metabolism,dissolution of the cell wall,and direct or indirect production of secondary metabolites related to postharvest storage are mentioned regarding chilling *** and agrochemicals that trigger plant defense to increase secondary metabolite production are discussed fo

关键词： Epigenetics ethylene elicitors ripening polyphenolics postharvest storage

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Bile acids as global regulators of hepatic nutrient metabolism

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Liver Research 2017年第1期1卷 10-16页

作者： Phillip B.Hylemon Kazuaki Takabe Mikhail Dozmorov masayuki Nagahashi Huiping Zhou Department of Microbiology and Immunology Medical College of Virginia CampusVirginia Commonwealth UniversityRichmondVAUSA McGuire VA Medical Center RichmondVAUSA Department of Surgery Medical College of Virginia CampusVirginia Commonwealth UniversityRichmondVAUSA Department of Biostatistics Medical College of Virginia CampusVirginia Commonwealth UniversityRichmondVAUSA Department of Surgery Niigata UniversityJapan

Bile acids(BA)are synthesized from cholesterol in the *** are essential for promotion of the absorption of lipids,cholesterol,and lipid-soluble vitamins from the *** are hormones that regulate nutrient metabolism by activating nuclear receptors(farnesoid X receptor(FXR),pregnane X receptor,vitamin D)and G protein-coupled receptors(e.g.,TGR5,sphingosine-1-phosphate receptor 2(S1PR2))in the liver and *** the liver,S1PR2 activation by conjugated BAs activates the extracellular signal-regulated kinase 1/2 and AKT signaling pathways,and nuclear sphingosine kinase *** latter produces sphingosine-1-phosphate(S1P),an inhibitor of histone deacetylases 1/2,which allows for the differential up-regulation of expression of genes involved in the metabolism of sterols and *** discuss here the emerging concepts of the interactions of BAs,FXR,insulin,S1P signaling and nutrient metabolism.

关键词： Sphingosine-1-phosphate Sphingosine kinase 2 Sphingosine-1-phosphate receptor 2 Fatty liver Epigenetics

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Current status of laparoscopic repeat liver resection for recurrent hepatocellular carcinoma

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Hepatoma Research 2020年第11期6卷 85-91页

作者： Daisuke Hokuto Takeo Nomi Takahiro Yoshikawa Yasuko Matsuo Naoki Kamitani masayuki Sho Department of Surgery Nara Medical UniversityNara 634-8522Japan

Repeat liver resection(RLR)is an effective treatment approach for recurrent hepatocellular carcinoma(HCC)and can provide acceptable long-term outcomes in select *** randomized controlled trials comparing RLR with radiofrequency ablation revealed that the latter approach was associated with a higher rate of early recurrence compared with *** recent advances in laparoscopic liver resection(LLR),RLR has been increasingly performed using *** propensity score-matched studies reported that laparoscopic RLR achieved lower blood loss and shorter hospital stays compared to open ***,laparoscopic RLR requires more advanced techniques because of adhesions formed after the previous liver resection,changes in anatomical landmarks,and deformity of the remnant *** recently described difficulty classification of laparoscopic RLR is based on five factors including type of previous liver resection(open or laparoscopic),number of previous liver resections,surgical procedure used in previous liver resections,tumor location in previous liver resections,and difficulty score of LLR for recurrent *** reviewed the available literature to summarize available evidence suggesting that laparoscopic RLR might be considered a more minimally invasive surgical treatment approach for recurrent HCC as long as the indication for laparoscopic RLR is carefully determined.

关键词： Hepatocellular carcinoma repeat liver resection laparoscopic repeat liver resection

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Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第18期24卷 1989-1994页

作者： Kazuki Takakura Tsunekazu Oikawa Yoichi Tomita Yusuke Mizuno Masanori Nakano Chisato Saeki Yuichi Torisu masayuki Saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

As the incidence of hepatocellular carcinoma(HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis(NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Research into the pathological progression of NASH to HCC has advanced by use of several beneficial rodent models. In this review, we summarize the established mouse models for preclinical research of NASH-associated HCC and discuss the underlying hepatic mechanisms of NASH-related tumorigenesis identified to date that could lead to new targets for treatment and prevention.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease

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Key vacuum technology issues to be solved in evacuated tube transportation

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Journal of Modern Transportation 2011年第2期19卷 110-113页

作者： Yaoping ZHANG Daryl OSTER masayuki KUMADA Jianye YU Shengshan LI Institute of Evacuated Tube Transportation Xijing University Xi＇an 710123 China ET3. COM INC. Crystal River Florida 34423-1423 USA Feynman Co. Ltd. 4-5-11 Azuma Tsukuba 305-0031 Japan

Evacuated tube transportation （ETT） will be one of the ultra-large-scale vacuum application areas. This paper lists some key vacuum technology issues in ETT：（1） how to construct ultra-large-scale vacuum chamber with lower cost and high reliability, （2） how to evacuate gas out of the ETT tube in short time, （3） how to release heat or reduce temperature in the vacuum tube, （4） how to avoid vacuum discharge, （5） how to make vehicles with airproof shells and life support system, and （6） how to detect leaks and find leak positions efficiently. At the same time, some solutions are proposed.

关键词： vacuum technology evacuated tube transportation vacuum tube Maglev

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Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 307-313页

作者： Masahiro Okada Kazunari Ishii Kazushi Numata Tomoko Hyodo Seishi Kumano masayuki Kitano Masatoshi Kudo Takamichi Murakami Department of Radiology Kinki University Faculty of Medicine Gastroenterological Center Yokohama City University Medical Center Department of Radiology and Department of Gastroenterology and Hepatology Kinki University Faculty of Medicine

BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethyl- enetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1 weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin ≥1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffé’s post-hoc test after two-way repeated measures ANOVA and Pearson’s correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ***: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB- DTPA.

关键词： magnetic resonance imaging Gd-EOB-DTPA liver bile duct hepatobiliary phase

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Introduction to Volume 1 Issue 3 of Journal of Cancer Metastasis and Treatment

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 111-112页

作者： masayuki Watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan.

It is a great honor for me to introduce the third issue of the Journal of Cancer Metastasis and *** is a special issue focusing on recent advances in research and treatment for gastrointestinal(GI)*** arising from the GI tract,including esophagus,stomach,colorectum,liver,gallbladder and pancreas,are frequently observed all over the *** to the global cancer statistics 2012,there were approximately 407,000 newly diagnosed cases with GI cancers and 304,000 deaths among them.[1]They accounted for 29%and 37%of all cancers excluding non-melanoma skin cancer *** progress in molecular biological techniques facilitated the understanding of the mechanism of cancer development and *** issue contains nine review articles concerning the topics which attract a lot of attention in the field of GI malignancies.

关键词： Cancer Metastasis stomach

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Self Assembly of Honeycomb TiO<sub>2</sub>Coatings by Tea-Leaf Extracts as the Dispersoids

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World Journal of Condensed Matter Physics 2011年第3期1卷 59-62页

作者： masayuki Kamei 不详

Photo catalytic TiO2 coatings with well defined honeycomb structure were successfully self-assembled on glass substrates by a simple “dip and burn solgel method“. The crux of this new method is that the starting material for the sol-gel coating (the water solution of ammonium titanium citrate) was “doped” with “tea-leaf extracts”. Tea-leaf extracts were completely dissolved in the water solution of ammonium titanium citrate and nucleate uniformly during the drying procedure of the coating precursor formation. This uniformly dispersed nucleation of the “tea-leaf extracts (tannin, catechin…)” were extracted during calcinations and leaving honeycomb-cell like nano-structure in the TiO2 coatings. Self-assembled cells were uniformly distributed in the TiO2 coatings and the diameter of the cells was in the range of 200 - 1000 nm. Fine honeycomb structures were clearly observed with microscopic observations.

关键词： TiO2 Coatings Photo-Catalysis

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Introduction to the special issue on reviews of gastric cancer metastasis and treatment

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 567-570页

作者： masayuki Watanabe Department of Gastroenterological Surgery the Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan

It is a great honor for me to introduce the special issue entitled reviews of Gastric Cancer Metastasis and Treatment.I’ve been focusing on 6 topics including tumor microenvironment(TME),biomarker research,regional variation in gastric cancer treatment,diagnosis and treatment for peritoneal carcinomatosis(PC),surgical treatment for advanced or metastatic gastric cancer,and novel treatment *** special issue includes 18 review articles concerning these *** has been proven to be deeply implicated in tumor progression and metastasis in gastric cancer.

关键词： metastasis diagnosis treatment

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Sensitive and Reproducible Photocatalytic Activity Evaluation Instrument for Transparent Coatings

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World Journal of Condensed Matter Physics 2012年第1期2卷 47-49页

作者： masayuki Kamei National Institute for Materials Science Tsukuba Japan

A new photocatalytic activity (PC) measurement instrument based on the measurement of the photo-induced reduction of Ag ions was proposed. The feature of this system is to perform “ultraviolet irradiation for PC activation” and “Ag film thickness determination for PC evaluation” simultaneously and automatically. Realizing a PC measurement system with high sensitivity, wide dynamic range, easy operation and reproducibility, which is especially suited for the PC measurement of the coatings on transparent substrates.

关键词： TiO2 Coatings Photo-Catalysis

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