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Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

骨研究:英文版 2023年第3期11卷 607-616页

作者： Minglu Yan masayuki Tsukasaki Ryunosuke Muro Yutaro Ando Kazutaka Nakamura Noriko Komatsu Takeshi Nitta Tadashi Okamura Kazuo Okamoto Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).However,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

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ANALYTICAL SOLUTIONS FOR THE SLOSHING LOADING ON CIRCULAR CYLINDRICAL LIQUID TANKS WITH INTERIOR SEMI-POROUS BARRIERS

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Journal of Hydrodynamics 2001年第2期13卷 32-39页

作者： Miao, G.P. Ishida, H. Saitoh, T. kurosaki, K. Sch. of Naval Arch. and Ocean Eng. Shanghai Jiaotong Univ. Shanghai 200030 China

The estimation of sloshing loading on liquid tanks is of fundamental importance due to the wide and important applications of liquid tanks in various engineering aspects. Analytical solutions for the sloshing loading on circular cylindrical liquid tanks with an interior concentric vertical thin semi-porous barrier under external excitations are presented. And the extensions of the solutions to the elastic vibrations and to the high frequency limit to count for the earthquake response are also included. A clear view on the influence of semi-porous barriers to the sloshing response of oscillating tanks is obtained by the analyses of systematic computational results. The present results may offer guidance to the corresponding design for liquid tanks of various applications and also a basis of comparison for the development of more sophisticated numerical methods for hydrodynamic and hydro-elastic analyses.

关键词： Boundary conditions Mathematical models Tanks (containers) Vibration measurement

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Numerical Study on Low-Reynolds Compressible Flows around Mars Helicopter Rotor Blade Airfoil

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Journal of Flow Control, Measurement & Visualization 2023年第2期11卷 30-48页

作者： Takuma Yamaguchi masayuki Anyoji Interdisciplinary Graduate School of Engineering Sciences Kyushu University Fukuoka Japan

High-speed rotor rotation under the low-density condition creates a special low-Reynolds compressible flow around the rotor blade airfoil where the compressibility effect on the laminar separated shear layer occurs. However, the compressibility effect and shock wave generation associated with the increase in the Mach number (M) and the trend change due to their interference have not been clarified. The purpose is to clear the compressibility effect and its impact of shock wave generation on the flow field and aerodynamics. Therefore, we perform a two-dimensional unsteady calculation by Computational fluid dynamics (CFD) analysis using the CLF5605 airfoil used in the Mars helicopter Ingenuity, which succeeded in its first flight on Mars. The calculation conditions are set to the Reynolds number (Re) at 75% rotor span in hovering (Re = 15,400), and the Mach number was varied from incompressible (M = 0.2) to transonic (M = 1.2). The compressible fluid dynamics solver FaSTAR developed by the Japan aerospace exploration agency (JAXA) is used, and calculations are performed under multiple conditions in which the Mach number and angle of attack (α) are swept. The results show that a flow field is similar to that in the Earth’s atmosphere above M = 1.0, such as bow shock at the leading edge, whereas multiple λ-type shock waves are observed over the separated shear layer above α = 3° at M = 0.80. However, no significant difference is found in the Cp distribution around the airfoil between M = 0.6 and M = 0.8. From the results, it is found that multiple λ-type shock waves have no significant effect on the airfoil surface pressure distribution, the separated shear layer effect is dominant in the surface pressure change and aerodynamic characteristics.

关键词： CFD CLF5605 Rotor Blade Airfoil Compressibility Effect Low-Reynolds Number Mars Helicopter Separation Bubble Shock Wave

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HYDRODYNAMIC LOADS ON OIL STORAGE TANKS WITH INTERIOR SEMI-POROUS BARRIERS UNDER EARTHQUAKES

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Journal of Hydrodynamics 2001年第1期13卷 1-7页

作者： Miao, G.P. Ishida, H. Saitoh, T. kurosaki, K. Sch. of Naval Archit. and Ocean Eng. Shanghai Jiaotong Univ. Shanghai 200030 China

The estimation of the hydrodynamic loading on cylindrical oil storage tank during earthquakes is of fundamental importance in the anti-seismic design. Interior semi-porous barriers are considered being effective to reduce the hydrodynamic response of the inner fluid and the loading on the tank wall. A reduced two-dimensional source distribution method and sub-region matching technique are developed for the prediction of three-dimensional hydrodynamic forces on oil storage tanks of arbitrary sections with interior semi-porous barriers of different configurations under earthquake excitations. Excellent agreement is observed between the present results and the corresponding analytical results for a circular cylindrical oil tank with a concentric interior semi-porous barrier, which shows the validity and effectiveness of the present method. A clear view of the influence of semi-porous barriers on the hydrodynamic response of tanks during earthquakes is obtained by the analyses of computational results, which may offer some guidance to the corresponding anti-seismic design for oil storage tanks and similar structures. The method is also extended to include the effects of the elastic vibrations of the tank.

关键词： Earthquake resistance Hydrodynamics

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DEM simulation of polydisperse systems of particles in a fluidized bed

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Particuology 2009年第1期7卷 9-18页

作者： Nobuyuki Tagami Ajit Mujumdar masayuki Horio Bio Applications and Systems Engineering Tokyo University of Agriculture & TechnologyNaka-choKoganei-shiTokyo 184-8588Japan

Numerical simulations based on three-dimensional discrete element model （DEM） are conducted for mono-disperse, binary and ternary systems of particles in a fluidized bed. Fluid drag force acting on each particle depending on its size and relative velocity is assigned. The drag coefficient corresponding to Ergun＇s correlation is applied to the system of fluidized bed with particle size ratios of 1：1 for the mono-disperse system, 1：1.2, 1：1.4 and 1：2 for the binary system and 1：1.33：2 for the ternary system by keeping total volume and surface area of the particles constant. Results indicated that a reasonable estimation of drag force based on individual particle diameters as compared to that of the mean diameter of the particles is achieved in the fluid cells. The total translational kinetic energy of the particles is found to increase as the particle size ratio increases, suggesting an enhanced momentum transfer in polydisperse particle systems. Systems with wide particle size distribution exhibited higher particle velocities around bubbles, resulting in faster bubble growth and its subsequent rise through the fluidized bed.

关键词： Discrete element method Fluid drag force Fluidized bed Particle size distribution

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Efficacy and Safety of the Atrial Septal Defect Closure for Patients with Absent or Malaligned Aortic Rim Using a Figulla Flex II Device Flared and Straddling Behind the Aorta

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Congenital Heart Disease 2021年第3期16卷 269-283页

作者： Masataka Kitano Kazuto Fujimoto Atsuko Kato Ken-ichi kurosaki Isao Shiraishi Department of Pediatric Cardiology National Cerebral and Cardiovascular CenterOsakaJapan Department of Pediatric Cardiology Okinawa Prefectural Nanbu Medical Center&Children’s Medical CenterOkinawa PrefectureJapan

Background:Although transcatheter closure of atrial septal defect(ASD)is safe and effective for patients with sufficient rim,ASD patients with absent and/or malaligned aortic and/or superior rim have higher risks of device embolization and cardiac *** have treated such high-risk patients using a Figulla Flex II(FFII)device shaped flared and straddling behind the aorta because this method would avoid such serious ***,its long-term efficacy and safety remain ***,the midterm efficacy and safety of this method were ***:We retrospectively evaluated the outcome of 47 consecutive patients with such rim(age 6–73 years,weight 17–75 kg,31 females)treated with this method at our hospital between February 2016 and September *** make the flared and straddling shape,we selected a FFII 4–6 mm larger than the balloon sizing diameter by stop-flow *** also studied the device shape,the disc pressure to the Valsalva wall and their changes over 6 months by transesophageal ***:All procedures were successful,and leakage disappeared within 1 *** a mean follow up of 37±12 months,complications included a transient sinus node dysfunction and one I°atrioventricular block within 3 *** device shape changed from bulky to thin:the device waist and thickness significantly decreased by around 1.5 mm and 3.5 mm,respectively(p<0.05),but the two discs remained flared and straddling behind the aorta over 6 months;therefore,the disc edges seldom pressed the Valsalva wall perpendicularly,even though the inner plane of either disc often slightly pressed the ***:ASD closure using a FFII shaped flared and straddling behind the aorta is probably effective and safe for patients with absent and/or malaligned aortic and/or superior rim although requiring care for conduction disorders.

关键词： Atrial septal defect catheter intervention device embolization cardiac erosion conduction disorder

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A study of optimal switching problem in limited-cycle with multiple periods

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 933-937页

作者： Jing SUN Hisashi YAMAMOTO masayuki MATSUI Graduate School of Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya Aichi 466-8555 Japan Department of System Design Management Systems Engineering Tokyo Metropolitan University 6-6 Asahigaoka Hino Tokyo 191-0065 Japan Department of lnformatics Graduate School of lnformatics and Engineering The University of Electro-Communications 1-5-1 Chofugaoka Chofu-shi Tokyo 182-8585 Japan

In a social system or production line,the restrictions of the cost and the due-time exist in each ***,whether these restrictions are satisfied is dependent not only on the risks of this period,but also on the risks generated *** consider controlling the production process by switching the processing rate to a faster one at a given *** paper deals with the optimal switching period to minimize the total expected cost of the production *** first propose the optimal switching period model,and then the mathematic formulation of the total expectation is ***,the policy of optimal switching period is investigated in detail by numerical experiments.

关键词： Limited-cycle problem Multi-period Optimal switching period Production seat system Manufacturing line

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Enzyme replacement therapy in two patients with classic Fabry disease from the same family tree:Two case reports

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World Journal of Clinical Cases 2023年第15期11卷 3542-3551页

作者： Yuki Harigane Issei Morimoto O Suzuki Jumpei Temmoku Takayuki Sakamoto Kohichiro Nakamura Kazuo Machii masayuki Miyata Department of Urology Fukushima Medical UniversityFukushima 960-1295Japan Otsuki Sleep Clinic Fukushima 960-8044Japan Department of Diagnostic Pathology Fukushima Medical UniversityFukushima 960-1295Japan Center of Internal Medicine for Rheumatology and Collagen Disease Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Cardiology Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Neurology Fukushima Red Cross HospitalFukushima 960-8530Japan Machii Cardiology and Internal Medicine Clinic Fukushima 960-8530Japan

BACKGROUND The pathophysiology of Fabry disease(FD)-induced progressive vital organ damage is *** progression can be delayed using enzyme replacement therapy(ERT).In patients with classic FD,sporadic accumulation of globotriaosylceramide(GL-3)in the heart and kidney begins in utero;however,until childhood,GL-3 accumulation is mild and reversible and can be restored by *** current consensus is that ERT initiation during early childhood is ***,complete recovery of organs in patients with advanced FD is *** SUMMARY Two related male patients,an uncle(patient 1)and nephew(patient 2),presented with classic *** patients were treated by *** 1 was in his 50s,and ERT was initiated following end-organ damage;this was subsequently *** developed cerebral infarction and died of sudden cardiac *** 2 was in his mid-30s,and ERT was initiated when the patient was diagnosed with FD,during which the damage to vital organs was not overtly *** he had left ventricular hypertrophy at the beginning of this treatment,the degree of hypertrophy progression was limited to a minimal range after>18 years of *** We obtained discouraging ERT outcomes for older patients but encouraging outcomes for younger adults with classic FD.

关键词： Enzyme replacement therapy Fabry disease Pedigree Left ventricular hypertrophy α-galactosidase Case report

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Molecular design and application of luminescent materials composed of group 13 elements with an aggregation-induced emission property

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National Science Review 2021年第6期8卷 80-93页

作者： Shunichiro Ito masayuki Gon Kazuo Tanaka Yoshiki Chujo Department of Polymer Chemistry Graduate School of EngineeringKyoto University

Complexation of π-conjugated ligands by metal or semimetal ions leads to the enhancement of the planarity and rigidity of π-conjugated systems. Boron, especially, has played a central role in the design of luminescent main-group complexes. However, these complexes still suffer the disadvantage of aggregation-caused quenching as well as typical organic fluorophores. It has recently been reported that some types of boron complexes exhibit the aggregation-induced emission(AIE) property. Moreover, AIE behavior from complexes and organometallic compounds composed of the other group 13 elements, such as aluminum and gallium, has emerged in this decade. These observations greatly encourage us to develop advanced functional materials based on the group 13 elements. Indeed, recent research has demonstrated that these classes of materials are potentially versatile scaffolds for constructing chromic luminophores,efficiently emissive π-conjugated polymers and so on. This review mainly describes AIE-active group 13 complexes with four-coordinate structures and their application as photo-functional materials. Proposed mechanisms of the origins of AIE behavior are briefly discussed.

关键词： aggregation-induced emission crystallization-induced emission chromism conjugated polymer group 13

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Modulation of valosin-containing protein by Kyoto University Substances(KUS) as a novel therapeutic strategy for ischemic neuronal diseases

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Neural Regeneration Research 2017年第8期12卷 1252-1255页

作者： masayuki Hata Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Neuroprotective Treatment Project for Ocular Diseases Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate（ATP） depletion and subsequent induced endoplasmic reticulum（ER） stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity. Based on the chemical structure, we developed novel valosin-containing protein modulators, Kyoto University Substances（KUSs）, that not only inhibit intracellular ATP depletion, but also ameliorate ER stress. Suppressing ER stress by KUSs is associated with neural cell survival in animal models of several neurodegenerative diseases, such as glaucoma and retinal degeneration. Given that a major pathology of ischemic retinal diseases, other than intracellular ATP depletion, is ER stress-induced cell death, KUSs may provide a novel strategy for cell protection in ischemic conditions. Hence, we investigated the efficacy of KUS121 in a rat model of retinal ischemic injury. Intravitreal injections of KUS121, which is clinically preferable route of drug administration in retinal diseases, significantly suppressed inner retinal thinning and retinal cell death, and maintained visual functions. Valosin-containing protein modulation by KUS is a promising novel therapeutic strategy for ischemic retinal diseases.

关键词： adenosine triphosphatase C/EBP homologous protein central retinal artery occlusion endoplasmicreticulum stress neuroprotective therapy retinal ganglion cell

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