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The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

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Neural Regeneration Research 2015年第9期10卷 1388-1389页

作者： Misako Okumura masayuki Miura Takahiro Chihara Department of Genetics Graduate School of Pharmaceutical Sciences The University of Tokyo Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E）（Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers.

关键词： The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure

p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy

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World Journal of Gastroenterology 2005年第36期11卷 5696-5700页

作者： Fumiko Sunada masayuki Itabashi Hisanao Ohkura Toshiyuki Okumura Departments of Internal Medicine Pathology Radiology Ibaraki Prefectural Central Hospital and Cancer Center Koibuchi 6528 Tomobe-machi Nishiibaraki-gun Ibaraki-ken Japan

AIM： Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy （CRT）, but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT. METHODS： The intensities of expression of p53, Ki67, Bci-2, Bax, olclin D1, VEGF, CDC25B, and metallothionein （MT） were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT. RESULTS： The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT. CONCLUSION： Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity, if with CDC25B positivity, CRT can be expected. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： p83 CDC25B Metallothionein Chemoradiotherapy Esophageal squamous cell carcinomas

Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells

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Cellular & Molecular Immunology 2010年第6期7卷 440-446页

作者： Tomoyuki Suzuki Myint Oo Chang masayuki Kitajima Hiroshi Takaku Department of Life and Environmental Sciences Chiba Institute of TechnologyChibaJapan High Technology Research Center Chiba Institute of TechnologyChibaJapan Immunology Program Benaroya Research InstituteSeattleWAUSA

A dendritic cell(DC)vaccine strategy has been developed as a new cancer immunotherapy,but the goal of complete tumor eradication has not yet been *** have previously shown that baculoviruses potently infect DCs and induce antitumor immunity against hepatomas in a mouse ***-infected,bone marrow-derived DCs(BMDCs)display increased surface expression of costimulatory molecules,such as CD80,CD86 and major histocompatibility complex(MHC)classes I and II,and secrete interferons and other proinflammatory *** this study,we evaluated the induction of antitumor immunity in mice by baculovirus-infected BMDCs against lung cancer and *** treatment with baculovirus-infected BMDCs,murine lung tumors caused by Lewis lung carcinoma(LLC)cells were significantly reduced in size,and the survival of the mice was *** addition,experiments using a melanoma mouse model showed that baculovirus-infected BMDCs inhibited tumor growth and improved survival compared with *** alanine aminotransferase(ALT),aspartate aminotransferase(AST)and creatinine levels remained normal in baculovirus-infected BMDC-treated *** findings show that baculovirus-infected DCs induce antitumor immunity and pave the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.

关键词： dendritic cells natural killer cells T cells tumor Immunity

Lymphangiogenesis:A new player in cancer progression

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World Journal of Gastroenterology 2010年第32期16卷 4003-4012页

作者： masayuki Nagahashi Subramaniam Ramachandran Omar M Rashid Kazuaki Takabe Division of Surgical Oncology Department of SurgeryVirginia Commonwealth University School of Medicine and Massey Cancer CenterRichmondVA 23298-0011United States

Lymph node metastasis is the hallmark of colon cancer progression,and is considered one of the most important prognostic ***,there has been growing evidence that tumor lymphangiogenesis(formation of new lymphatic vessels) plays an important role in this ***,we review the latest f indings of the role of lymphangiogenesis in colorectal cancer progression,and discuss its clinical application as a biomarker and target for new *** the molecular pathways that regulate lymphangiogenesis is mandatory to pave the way for the development of new therapies for *** the future,tailored treatments consisting of combinations of chemotherapy,other targeted therapies,and anti-lymphangiogenesis agents will hopefully improve patient *** progression to the clinic must be guided by new avenues of research,such as the identif ication of biomarkers that predict response to treatment.

关键词： Colorectal neoplasms Angiogenesis Lymphangiogenesis Lymphatic vessels Lymphatic metastasis Vascular endothelial growth factor Monoclonal antibody D2-40 Therapy-related neoplasms Biomarkers

Optimum Position of Polarizer-Based Compensator for Enhanced Tolerance to Polarization Mode Dispersion

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光学学报 2003年第S1期23卷 583-584页

作者： Daniele Alzetta masayuki Matsumoto Department of Communications Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 JapanDepartment of Communications Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan

We show through numerical simulation that the performance of two types of polarization-mode dispersion polarizer-based compensation techniques may be improved by optimizing the position of the compensator along the tr... 详细信息

关键词： for as it PMDC of line that

Numerical Analysis of Electrically Tunable Delay-Line with an SSB Modulator

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光学学报 2003年第S1期23卷 619-620页

作者： Tetsuya Kawanishi masayuki Izutsu Communications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 JapanCommunications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 Japan

By using an optical system simulator, we investigated the tunable delay-line with an optical SSB modulator and an optical fiber loop, where the delay can be controlled by the electric signal fed to the modulator.

关键词： SSB be of Numerical Analysis of Electrically Tunable Delay-Line with an SSB Modulator were FBG line into with

Regenerative medicine of cornea by cell sheet engineering using temperature-responsive culture surfaces

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Chinese Science Bulletin 2013年第35期58卷 4349-4356页

作者： UMEMOTO Terumasa YAMATO masayuki NISHIDA Kohji OKANO Teruo Institute of Advanced Biomedical Engineering and Science Tokyo Women’s Medical University Tokyo 162-8666 Japan Department of Ophthalmology Osaka University Medical School Osaka 565-0871 Japan

Recently,regenerative medicine has been focused on as next-generation definitive therapies for several diseases or injuries for which there are currently no effective *** therapies have been rapidly developed through the effective fusion between different fields such as stem cell biology and *** far,we have proposed"cell sheet engineering"through our core technology that simply applies alterations of the temperature which allows regulation of the attachment or detachment of living cells on the culture surfaces grafted with the temperature-responsive polymer"poly(N-isoproplyacrylamide)".This technology enables us to construct bioengineered sheet-like tissues,termed"cell sheets",without the need of using biodegradable scaffolds and protease treatments that are traditionally ***,our carrier-free cell sheets not only are independent of the issues observed in conventional methods,but also showed further advantages in the reconstruction of the corneal epithelium or endothelium(*** of optical transparency and cell-cell interactions to host stroma in reconstructed tissues).Moreover,our approach does not have issues such as immune rejection or limited number of donors,due to the use of cell sheets derived from autologous limbal(in patients with unilateral disease)or oral mucosal epithelial cells(in patients with bilateral disorders).Indeed,we have successfully performed the clinical application for the reconstruction of ocular surfaces through the transplantation of our carrier-free corneal epithelial cell sheets,as evidenced by improved visual acuity as well as long-term maintenance of postoperative health conditions on ocular surfaces in all *** have also proposed a novel approach for the reconstruction of the corneal endothelium using corneal endothelial cell sheets by demonstrating its successful ***,our cell sheet engineering technique provides a breakthrough in the field of regenerative medicine appli

关键词：干细胞生物学角膜上皮表面重建再生医学调节温度工程化反应性角膜内皮细胞

Lattice Boltzmann Flow Simulation in a Combined Nanochannel

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Advances in Applied Mathematics and Mechanics 2010年第5期2卷 609-625页

作者： Kazuhiko Suga Susumu Takenaka Takahiko Ito masayuki Kaneda Department of Mechanical Engineering Osaka Prefecture UniversitySakai 599-8531Japan

The widely used micro-flow wall-boundary conditions for lattice Boltzmann method(LBM)are evaluated in a force driven combined nanochannel *** flow field consists of a two-dimensional nanochannel(mother channel)of an infinite length having flat plates of a finite length *** flat plate is set above the bottom wall of the nanochannel with a narrow *** flow,thus,develops through this narrow gap(narrower channel)and the other side of the plate(wide gap).The Knudsen number based on the mother channel height is Kn=0.14 whereas the characteristic Knudsen number in the narrower channel is *** obtain the reference data,the molecular dynamics(MD)simulation is performed with a fully diffusive wall *** LBMs are based on the lattice BGK model and with the bounce-back/specular reflection(BSBC)and the diffuse scattering(DSBC)wall boundary *** relaxation time is modified to include sensitivity to *** DSBC shows generally satisfactory results in the test flow cases including fully developed force driven Poiseuille flows,where the BSBC performs worse at Kn>0.5 with a fixed bridge coefficient of b=*** results in its overprediction of the flow rate in the narrower channel region since the characteristic Knudsen number there is *** MD simulation suggests that the flow develops gradually through the narrower channel region though all the LBM predictions show almost instant flow *** fact suggests that the relaxation time model needs to have more sensitivity to the locally defined *** discussions of the BSBC with a different set of models suggest that the regularization process is required for predicting complex nanoscale flows.

关键词： Lattice Boltzmann method Knudsen number molecular dynamics simulation nanochannel wall boundary condition slippage velocity

Electrochemical Characterization of a Porous Pt Nanoparticle ＂Nanocube-Mosaic＂ Prepared by a Modified Polyol Method with HCI Addition

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Nano Research 2011年第8期4卷 746-758页

作者： Randy Jalem Ryosuke Koike Yong Yang Masanobu Nakayama masayuki Nogami Department of Materials Science and Engineering Nagoya Institute of Technology Showa Nagoya 466-8555 Japan

Porous and single crystalline platinum （Pt） nanoparticles （NPs） have been successfully synthesized by reduction of H2PtC16.6H20 and then investigated by optical spectroscopy and transmission electron microscopy. H2PtCI6-6H20 was reduced using ethylene glycol in the presence of polyvinylpyrrolidone under highly acidic conditions （pH 〈 1） to form single crystalline Pt particles about 5 nm in size. These particles were then stacked via {100} facets, forming 50-nm length porous nanocubes with a mosaic structure. The porous Pt NPs exhibited excellent catalytic properties for methanol oxidation. In particular, the electrochemical surface area was -63 m2/g, five times higher than that for non-porous Pt NPs prepared using a conventional method. We suggest that the high catalytic activity of porous Pt NPs is due to a combination of the crystalline structure having exposed {100} facets and a porous morphology.

关键词： Platinum porous nanoparticles catalyst methanol oxidation cyclic voltammetry