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国外计量 1985年第3期 1-4页

作者： Y.ohtsuka 王新菊

一、前言在过去的十年里,小位移的动态激光干涉测量法取得了很大的进展。ohtsuka 最近对此散了综述性的介绍。当灵敏度的下限到达亚埃级区时,使用双光干涉和光学拍频的动态干涉测量法可以进行极高灵敏度的测量。与传统的技术不同,Oht-

关键词：小位移拍频光干涉激光束电磁波干涉莱塞光束干涉测量法分量双频

Antibiotic Resistance of <i>Helicobacter pylori</i>and Eradication Rate in Japanese Pediatric Patients

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Advances in Microbiology 2017年第4期7卷 241-252页

作者： Tamaki Ikuse Yo Aoyagi Naho Obayashi Keisuke Jimbo Takahiro Kudo Yoshikazu ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Helicobacter pylori (H. pylori) eradication rates achieved with a proton pump inhibitor (PPI), amoxicillin and clarithromycin have recently decreased to about 75% because of the increase in clarithromycin resistance in Japan. In the present study, H. pylori resistance rates against clarithromycin, amoxicillin and metronidazole were investigated in pediatric patients and eradication rates were evaluated when tailored antibiotics regimens based on antibiotic sensitivity data were used. We isolated H. pylori endoscopically from 77 pediatric patients suffering from abdominal symptoms. The susceptibility tests of H. pylori strains to clarithromycin, amoxicillin and metronidazole were examined and eradication therapy was tailored using the appropriate antibiotics. Seventy-seven patients were treated with a mean age of 12.16 ± 3.34 years (range, 4.92-19.75) consisting of 40 males and 37 females. The average resistance rates between 1998 and 2016 to clarithromycin, amoxicillin and metronidazole were 54.5% (42 of 77), 6.5% (5 of 77) and 5.2% (4 of 77) respectively. The prevalence of clarithromycin resistance increased significantly over time to reach 88.9% by 2013-2016. Successful eradication rates using tailored antibiotic treatment was 93.8% (61 of 65). Clarithromycin-based eradication therapy rate reached 92.6% against clarithromycin-sensitive strains. Metronidazole-based initial eradication therapy also had a high successful rate (97.0%) to clarithromycin-resistant strains. Although high rates of clarithromycin resistant H. pylori reaching about 90% were observed in Japanese children, tailored eradication therapy using the appropriate antibiotic agents were highly successful. H. pylori sensitivity testing and eradication therapy with appropriate antibacterial agents may contribute to accomplishment of high initial eradication rates and consequently reducing the incidence of developing gastric cancer.

关键词： Resistance Eradication Rate Susceptibility Test Clarithromycin Metronidazole

Correlation of prefrontal activity measured by near-infrared spectroscopy (NIRS) with mood, BDNF genotype and serum BDNF level in healthy individuals

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Open Journal of Psychiatry 2012年第3期2卷 194-203页

作者： Daisuke Matsuzawa Kotaro Takeda Hiroyuki ohtsuka Jun Takasugi Takashi Watanabe Junko Maeda Saeka Nagakubo Chihiro Sutoh Ichiro Shimoyama Ken Nakazawa Eiji Shimizu Clinical Research Center National Hospital Organization Murayama Medical Center Tokyo Japan Department of Cognitive Behavior Physiology Graduate School of Medicine Chiba University Chiba Japan Section for Human Neurophysiology Frontier Medical Engineering Chiba University Chiba Japan

Depression has been known to reduce the prefrontal activity associated with the execution of certain cognitive tasks, although whether a temporarily depressed or anxious mood in healthy individuals affects the prefrontal blood oxygen level during cognitive tasks is unknown. Combining the measurement of prefrontal activity with near-infrared spectroscopy (NIRS) and the two cognitive tasks, namely the letter version of the verbal fluency test (VFT-l) and the Stroop test, we measured the effect of a depressed or anxious mood and gender on the changes in the prefrontal oxygenated hemoglobin (Oxy-Hb) levels during those cognitive tests in healthy individuals. Depressed mood or anxious mood was assessed by the Hospital Anxiety and Depression Scale (HADS). Thereby we aimed to explore the possibility of NIRS measurement for detecting the early subclinical manifestation of major depression. Moreover, we examined the possible relationships between prefrontal activation and the functional Val66Met polymorphisms of the brain derived neurotropic factor (BDNF) gene and serum BDNF level. As a result, the increased prefrontal Oxy-Hb levels during cognitive tasks were significantly correlated with the severity of depressed mood in males. The course of the prefrontal Oxy-Hb increase was different depending on the cognitive tasks, i.e., the VFT-l or the Stroop test, in both genders. Correlations of BDNF genotype and serum BDNF level with the prefrontal Oxy-Hb levels during those cognitive tasks were negative. Our results suggest that the early subclinical manifestation of depressed mood in males might be detected by the NIRS measurement, which is not correlated with the individual properties of BDNF.

关键词： Near-Infrared Spectroscopy (NIRS) Depression Anxiety Brain Derived Neurotropic Factor (BDNF)

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i>Infection in Children

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Advances in Microbiology 2017年第4期7卷 253-264页

作者： Tamaki Ikuse Takahiro Kudo Naho Obayashi Keisuke Jimbo Yo Aoyagi Yoshikazu ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric patients. A retrospective analysis was performed on 141 pediatric patients requiring endoscopic evaluation and diagnostic tests for H. pylori infection to define the cause of abdominal symptoms. Non-invasive tests included the 13C-urea breath test (UBT), a monoclonal stool antigen test using enzyme-linked immuno-sorbent assay (mSAT), and a serum immunoglobulin G antibody test using antigens derived from Japanese individuals (S-Ab). This study investigated sensitivity, specificity, likelihood ratios for a positive and a negative test (LR+ and LR-), and accuracy of non-invasive tests, in comparison with invasive tests. Eighty two of 141 patients (58%) were recognized as H. pylori positive by invasive methods. When UBT, mSAT or S-Ab were analyzed, all were found to be effective over 94% accurate. Specificity ranged between 86.7% and 95.8%, and sensitivity ranged between 93.8% and 97.1%. When subjects were stratified into three distinct age groups, the best performance was achieved for 1-6 years old with mSAT at 100% for sensitivity, specificity, and accuracy. S-Ab yielded the best results for children 7-12 years old and the UBT test performed best for 13-18 years old. These results demonstrate the utility of UBT, mSAT, and S-Ab non-invasive tests in diagnosing H. pylori but suggest that certain tests may be optimal for children of distinct ages. Three non-invasive tests, UBT, mSAT and S-Ab showed sufficient sensitivity, specificity and accuracy for the initial diagnosis of H. pylori infection among pediatric patients. Non-invasive tests may contribute to achieving minimum invasive diagnosis with combining with a histological test and a culture test in children.

关键词： Accuracy Non-Invasive Tests Urea Breath Test Stool Antigen Test Serum Antibody Test

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小位移量的动态双频干涉测量

应用光学 1989年第3期10卷 54-58页

作者： Y. ohtsuka M. Tsubokawa 吴明强

从实用观点检验了小位移量的双频率干涉测量。用声光布莱恪盒进行正弦强度调制的激光束,产生动态干涉的信号和参考光波。接收干涉的光电探测器的输出信号,由光零差和外差分量组成。外差分量携带振动性位移以探测其振幅。正弦振幅可测到0... 详细信息

从实用观点检验了小位移量的双频率干涉测量。用声光布莱恪盒进行正弦强度调制的激光束,产生动态干涉的信号和参考光波。接收干涉的光电探测器的输出信号,由光零差和外差分量组成。外差分量携带振动性位移以探测其振幅。正弦振幅可测到0.5nm。

关键词：位移测量干涉测量强度调制输出信号声光调制器激光束光电探测器参考光光探测器迈克尔逊干涉仪

Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 364-368页

作者： Masatsugu Hiraki Yoshihiko Kitajima Takao ohtsuka Keita Kai Shuusuke Miyake Yasuo Koga Daisuke Mori Hirokazu Noshiro Osamu Tokunaga Kohji Miyazaki Department of Surgery Saga University Faculty of Medicine Department of Pathology and Biodefense Saga University Faculty of Medicine

A 77-year-old Japanese male patient was admitted to our hospital complaining of general fatigue and melena. A gastroduodenal endoscopic examination revealed no def initive localized lesions. However, both a large amount of cruor and blood ? ow from the small intestine into the ascending colon was observed during the colonoscopic examination. At least three tumors, believed to originate from the small intestine, were detected by abdominal computed tomography. Based on these f indings, multiple and hemorrhagic small intestinal tumors were diagnosed and surgical treatment of the tumors planned. During the celiotomy, twelve tumors were found in the small intestine. Intestinal wedge or partial resection was applied. All excised specimens demonstrated morphology of a submucosal tumor and the largest tumor had a delle with coagulation on the mucosal face. In the histological f indings, hematoxylin and eosin staining showed spindlecell morphology. The immunohistochemical examination revealed that the tumor cells were diffusely positive for KIT and CD34. The myenteric plexus layer of the small intestine was focal-positive for KIT and showed no intestinal cells of Cajal hyperplasia. The tumor sequencing results revealed an identical missense mutation in codon 642 of c-kit exon 13 leading to the replacement of lysine by glutamic acid and a silent germ-line mutation in exon 12 of the PDGFRA gene concerning whole blood, normal mucosa and tumors. We concluded that the current subject was categorized as having multiple sporadic-type gastrointestinal stromal tumor with identical mutational types. Although the patient did not receive any adjuvant chemotherapy, there has been no sign of recurrence over the 3 years since the surgery.

关键词： Gastrointestinal stromal tumor Plateletderived growth factor receptor a K642E c-kit Missense mutation Germline mutation KIT Surgery

Imaging pitfalls of pancreatic serous cystic neoplasm and its potential mimickers

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World Journal of Radiology 2014年第3期6卷 36-47页

作者： Kousei Ishigami Akihiro Nishie Yoshiki Asayama Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Shunichi Takahata Takao ohtsuka Tetsuhide Ito Hisato Igarashi Shuji Ikari Catherine M Metz Hiroshi Honda Department of Radiology University of Iowa Hospitals and Clinics Department of Clinical Radiology Kyushu University Department of Surgery and Oncology Kyushu University Department of Medicine and Bioregulatory Science Kyushu University Department of Internal Medicine Hokkaido Gastroenterology Hospital

The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm(SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts(honeycomb pattern), which may not be always found in the center. Fibrosis in SCN may be mistaken for a mural nodule of intraductal papillary mucinous neoplasm(IPMN). The absence of cyst wall enhancement may be helpful to distinguish SCN from mucinous cystic neoplasm. However, oligocystic SCN and branch duct type IPMN may morphologically overlap. In addition, solid serous adenoma, an extremely rare variant of SCN, is difficult to distinguish from neuroendocrine tumor.

关键词： Serous cystic neoplasm Intraductal papil-lary mucinous neoplasm Mucinous cystic neoplasm Computed tomography Magnetic resonance imaging

Effects of adding minor elements to ODS steel with dispersed complex oxides

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Effects of adding minor elements to ODS steel with dispersed...

Motion reconstruction of the small carry-on impactor aboard Hayabusa2

Ninth China-Japan Symposium on Materials for Advanced Energy Systems and Fission & Fusion Engineering Jointed with CAS-JSPS Core-university Program Seminar on Fusion Materials, System and Design Integration

作者： S.Ohnuki Y.Uchida M.Watanabe N.Hashimoto T.Shibayama S.Yamashita S.ohtsuka Fac.Eng. Hokkaido Univ.N-13 W-8 Kita-ku Sapporo 060-8628 Japan Fac.Eng. Hokkaido Univ.N-13 W-8 Kita-ku Sapporo 060-8628 Japan Fac.Eng. Hokkaido Univ.N-13 W-8 Kita-ku Sapporo 060-8628 Japan Fac.Eng. Hokkaido Univ.N-13 W-8 Kita-ku Sapporo 060-8628 Japan Fac.Eng. Hokkaido Univ.N-13 W-8 Kita-ku Sapporo 060-8628 Japan Japan Atomic Energy Agency Oarai Eng Center JNC Oarai Ibaraki 311-1393 Japan Japan Atomic Energy Agency Oarai Eng Center JNC Oarai Ibaraki 311-1393 Japan

Oxide dispersion strengthened（ODS）ferritic steels are one of candidate materials for both future fusion reactors and present fission reactors because of their good creep strength at high temperatures and excellent resistance for irradiation-induced ***,in order to develop advanced ODS steels,the critical issue is the nano-sized distribution of the particle in *** to our recent study,the addition of elements in Ⅳa family is effective to achieve the *** purpose of this study is to clarify the optimum concentration of such effective elements of Ti,Hf and Ce in Fe-9Cr-0.25YO.

关键词： ODS Effects of adding minor elements to ODS steel with dispersed complex oxides

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Astrodynamics 2020年第4期4卷 289-308页

作者： Takanao Saiki Yuya Mimasu Yuto Takei Manabu Yamada Hirotaka Sawada K azunori Ogawa Naoko Ogawa Hiroshi Takeuchi Akira Miura Yuri Shimaki Koji Wada Rie Honda Yasuhiro Yokota Kei Shirai Naruhisa Sano Hirohito ohtsuka Go Ono Kent Yoshikawa Shota Kikuchi Chikako Hirose Yukio Yamamoto Takahiro Iwata Masahiko Arakawa Seiji Sugita Satoshi Tanaka Fuyuto Terui Makoto Yoshikawa Satoru Nakazawa Sei-ichiro Watanabe Yuichi Tsuda Japan Aerospace Exploration Agency Sagamihara 252-5210Japan Chiba Institute of Technology Narashino 275-0016Japan Kobe University K obe 657-8501Japan The Graduate University for Aduanced Studies Sagamihara 252-5210Japan Kochi University Kochi 780-8520Japan IHI Aerospace Co. LtdTomioka 370-2398Japan The University of Tokyo Tokyo 113-0033Japan Nagoya University Nagoya 464-8601Japan

Subsurface exploration is one of the most ambitious scientific objectives of the Hayabusa2 mission.A small device called small carry-on impactor(SCI)was developed to create an artificial crater on the surface of asteroid *** enables us to sample subsurface materials,which will provide a window to the *** physical properties of the resulting crater are also useful for understanding the internal structure of *** understanding of the crater and ejecta properties,including the depth of excavation of subsurface materials,requires accurate information on impact *** particular,the impact angle is a critical factor because it greatly influences the size and shape of the *** April 5,2019,the Hayabusa2 spacecraft deployed the SCI at 500 m of altitude above the asteroid *** SCI gradually reduced its altitude,and it shot a 2 kg copper projectile into the asteroid 40 min after *** the position of the released SCI is essential for determining the impact *** study describes the motion reconstruction of the SCI based on the actual operation *** results indicate that the SCI was released with high accuracy.

关键词： small body exploration Hayabusa2 kinetic impact artificial crater motion reconstruction

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日本在制冷技术方面的研究活动

低温与特气 1984年第3期2卷 1-6页

作者： T．Fujita T．ohtsuka Y．Ishizaki 顾荣而周志舰王荣荫不详光明所杭州制氧机研究所

日本在低温制冷领域(温度低于20K)开展的研究工作是东北大学从研究低温物理开始的。在早期研究工作阶段，除积累了一些基本物理数据外，还在制造氦液化器方面做了一番努力。可是，日本第一台氦液化器是一台进口的ADL柯林斯机器，该机于1... 详细信息

日本在低温制冷领域(温度低于20K)开展的研究工作是东北大学从研究低温物理开始的。在早期研究工作阶段，除积累了一些基本物理数据外，还在制造氦液化器方面做了一番努力。可是，日本第一台氦液化器是一台进口的ADL柯林斯机器，该机于1952年安装在东北大学。在随后的十年里，另外几所大学、

关键词：研究活动制冷技术日本东北大学氦液化器低温物理研究工作低温制冷工作阶段早期研究物理数据 ADL