检索结果-南通市图书馆

Neural Regeneration Research 2017年第1期12卷 43-46页

作者： Syoichi Tashiro masaya nakamura Hideyuki Okano Department of Rehabilitation Medicine Keio University School of MedicineTokyoJapan Department of Orthopaedic Surgery Keio University School of MedicineTokyoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury（SCI）.By contrast,there are still only a few studies have focused on the treatment of the chronically injured spinal cord,in which cell-based regenerative medicine seems less *** the majority of SCI patients are in the chronic phase,representing a major challenge for the clinical application of cellbased regenerative *** combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized,there had been very few studies involving rehabilitative treatments to *** a recent study,we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI,not only in additive but also in synergistic *** though we have succeeded to outline the profiles of recovery secondary to the combination therapy,the mechanism underlying the effects remain *** this review article,we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models.

关键词： transplantation spinal cord injury regenerative medicine chronic phase rehabilitation treadmill training

Regenerative medicine strategies for chronic complete spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 818-824页

作者： Shogo Hashimoto Narihito Nagoshi masaya nakamura Hideyuki Okano Department of Orthopedic Surgery Keio University School of Medicine Department of Physiology Keio University School of Medicine

Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various *** rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable,most research in this field has focused on the early phase of incomplete ***,the majority of patients have chronic severe injuries;therefore,treatments for these situations are of fundamental *** reason why the treatment of complete spinal cord injury has not been studied is that,unlike in the early stage of incomplete spinal cord injury,there are various inhibitors of neural ***,we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe ***,we established a combination therapy of cell transplantation and drug-releasing scaffolds,which contributes to functional recovery after chronic complete transection spinal cord injury,but we found that functional recovery was limited and still needs further ***,for the further development of the treatment of chronic complete spinal cord injury,we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss,with reference to the literature,which combination of treatments is most effective in achieving functional recovery.

关键词： cell transplantation chronic phase complete transection regenerative medicine spinal cord injury

Neurorehabilitation using a voluntary driven exoskeletal robot improves trunk function in patients with chronic spinal cord injury: a single-arm study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 427-432页

作者： Hiroki Okawara Syoichi Tashiro Tomonori Sawada Keiko Sugai Kohei Matsubayashi Michiyuki Kawakami Satoshi Nori Osahiko Tsuji Narihito Nagoshi Morio Matsumoto masaya nakamura Department of Orthopaedic Surgery Keio University School of MedicineTokyoJapan Department of Rehabilitation Medicine Keio University School of MedicineTokyoJapan Department of Orthopedic Surgery National Hospital OrganizationMurayama Medical CenterTokyoJapan

Body weight-supported treadmill training with the voluntary driven exoskeleton(VDE-BWSTT) has been shown to improve the gait function of patients with chronic spinal cord injury. However, little is known whether VDE-BWSTT can effectively improve the trunk function of patients with chronic spinal cord injury. In this open-label, single-arm study, nine patients with chronic spinal cord injury at the cervical or thoracic level(six males and three females, aged 37.8 ± 15.6 years, and time since injury 51.1 ± 31.8 months) who underwent outpatient VDE-BWSTT training program at Keio University Hospital, Japan from September 2017 to March 2019 were included. All patients underwent twenty 60-minute gait training sessions using VDE. Trunk muscular strength, i.e., the maximum force against which patient could maintain a sitting posture without any support, was evaluated in four directions: anterior, posterior, and lateral(right and left) after 10 and 20 training sessions. After intervention, lateral muscular strength significantly improved. In addition, a significant positive correlation was detected between the change in lateral trunk muscular strength after 20 training sessions relative to baseline and gait speed. The change in trunk muscular strength after 20 training sessions relative to baseline was greatly correlated with patient age. This suggests that older adult patients with chronic spinal cord injury achieved a greater improvement in trunk muscle strength following VDE-BWSTT. All these findings suggest that VDE-BWSTT can improve the trunk function of patients with chronic spinal cord injury and the effect might be greater in older adult patients. The study was approved by the Keio University of Medicine Ethics Committee(IRB No. 20150355-3) on September 26, 2017.

关键词： body weight-supported treadmill training gait disorders hybrid assistive limb neurologic neurophysiotherapy postural balance precision medicine robot-assisted gait training robotics spinal cord injury trunk

SYNTHESIS, CHARACTERIZATION AND SOME PROPERTIES OF POLY[PROPARGYL（3-METHOXY-4-PROPARGYL）CINNAMATE]

在线全文

学校读者我要写书评

暂无评论

SYNTHESIS, CHARACTERIZATION AND SOME PROPERTIES OF POLY[PROP...

iShim and Water Excitation Improves the Signal-to-Noise Ratio on q-Space Imaging: A Single-Center Clinical Study

5th East-Asian Polymer Conference

作者： Miriam F. Beristain masaya nakamura Kzukiyo Nagai Takeshi Ogawa Department of Applied Chemistry School of Science and technology Meiji University 1-1-1 Higashimita Tamaku Kawasaki 214-8571 Japan Instituto de Investigaciones en Materiales Universidad nacional Autonoma de Mexico Circuito Exterior Ciudad Universitaria Mexico DF 04510 Mexico

＜正＞3-Methoxy-4-hydroxycinnamic acid （ferulic acid） is a natural product obtained from rice bran, and it is a bifunctional compound. Therefore it is possible to obtain various polymers. Earlier, Elias and Palacios...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Radiology 2018年第4期8卷 244-259页

作者： Yoshifumi Sone Junichi Hata Yasushi Sera Katsuya Maruyama Thomas Benkert Zhouchen Lu Jun Kasahara Hideyuki Okano Morio Matsumoto masaya nakamura Daisuke Nakashima Takeo Nagura Medical Scanning Tokyo Tokyo Japan Central Institute for Experimental Animals Kanagawa Japan Department of Physiology Keio University School of Medicine Tokyo Japan Riken Brain Science Institute Saitama Japan Institute for Integrated Sports Medicine Keio University School of Medicine Tokyo Japan MR Research & Collaboration Department Diagnostic Imaging Business Area Siemens Healthcare K.K. Tokyo Japan Siemens Healthcare GmbH Erlangen Germany Department of Orthopaedic Surgery Keio University School of Medicine Tokyo Japan

Purpose: This study aimed to examine whether the signal-to-noise ratio (SNR) could be increased by combining integrated slice-by-slice shimming (iShim) with a fat suppression (FS) method other than short-tau inversion recovery (STIR) in diffusion-weighted imaging (DWI) and q-space imaging (qsi). Methods: We acquired DWI images (b-values: 0 and nine steps from 400 to 10,000 s/mm2 for six axes) using a prototypical single-shot echo planar imaging sequence by combining two types of shimming (3D Shim and iShim) and two types of FS (STIR and water excitation [WE]) in 10 volunteers. In the DWI study, the SNR for each b-value, FS effect in the b0 image, and distortion in the added image (b0 - b10,000) were evaluated for the above-mentioned four imaging methods. qsi involved original DWI images. In the qsi study, the SNR was evaluated. Results: With regard to both 3D Shim and iShim, the SNRs were significantly higher when using WE than when using STIR in b0 - b900 images (p Conclusion: The combination of iShim and WE has a high SNR on qsi.

关键词： iShim Fat Suppression Water Excitation Diffusion-Weighted Imaging q-Space Imaging (qsi)

Development of a roll-to-roll high-speed laser micro processing machine for preparing through-holed anodes and cathodes of lithium-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2023年第3期5卷 534-546页

作者： Mitsuru Yamada Naohiko Soma masaya Tsuta Susumu nakamura Nobuo Ando Futoshi Matsumoto Department of Materials and Life Chemistry Kanagawa University3-27-1RokkakubashiKanagawa-kuYokohamaKanagawa221-8686Japan Wired Co. Ltd2-4-15kitashinboSanjoNiigata955-0861Japan Department of Electrical and Electronic Systems Engineering National Institute of TechnologyNagaoka College888NishikatakaiNagaokaNiigata940-8532Japan Research Institute for Engineering Kanagawa University3-27-1RokkakubashiKanagawa-kuYokohamaKanagawa221-8686Japan

Aiming to improve the battery performance of lithium-ion batteries(LIBs),modification of the cathodes and anodes of LIBs using laser beams to prepare through-holes,non-through-holes or ditches arranged in grid and line patterns has been proposed by many researchers and *** this study,a laser processing system attached to rollers,which realizes this modification without large changes in the present mass-production system,was *** laser system apparatus comprises roll-to-roll equipment and laser *** roll-to-roll equipment mainly consists of a hollow cylinder with openings on its circumferential *** and anode electrodes for LIBs are wound around the cylinder in the longitudinal direction of the electrodes.A pulsed beam reflected from the central axis of the cylinder can continuously open a large number of through-holes in the thin ***-holes were formed at a rate of 100000 holes per second on lithium iron phosphate cathodes and graphite anodes with this *** through-holed cathodes and anodes prepared with this system exhibited higher C-rate performance than nontreated cathodes and anodes.

关键词： lithium-ionbatteries laser processingsystem roll-to-roll system through-holing structure high-rate performance

Non-robotic minimally invasive gastrectomy as an independent risk factor for postoperative intra-abdominal infectious complications: A single-center, retrospective and propensity score-matched analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第11期26卷 1172-1184页

作者： Susumu Shibasaki Koichi Suda masaya Nakauchi Kenichi nakamura Kenji Kikuchi Kazuki Inaba Ichiro Uyama Department of Surgery Fujita Health UniversityToyoake 470-1192AichiJapan Collaborative Laboratory for Research and Development in Advanced Surgical Technology Fujita Health University School of MedicineToyoake 470-1192AichiJapan

BACKGROUND Minimally invasive surgery for gastric cancer(GC) has gained widespread use as a safe curative procedure especially for early *** To determine risk factors for postoperative complications after minimally invasive gastrectomy for *** Between January 2009 and June 2019, 1716 consecutive patients were referred to our division for primary GC. Among them, 1401 patients who were diagnosed with both clinical and pathological Stage Ⅲ or lower GC and underwent robotic gastrectomy(RG) or laparoscopic gastrectomy(LG) were enrolled. Retrospective chart review and multivariate analysis were performed for identifying risk factors for postoperative *** Morbidity following minimally invasive gastrectomy was observed in 7.5% of the patients. Multivariate analyses demonstrated that non-robotic minimally invasive surgery, male gender, and an operative time of ≥ 360 min were significant independent risk factors for morbidity. Therefore, morbidity was compared between RG and LG. Accordingly, propensity-matched cohort analysis revealed that the RG group had significantly fewer intra-abdominal infectious complications than the LG group(2.5% vs 5.9%, respectively;P = 0.038), while no significant differences were noted for other local or systemic *** analyses of the propensity-matched cohort revealed that non-robotic minimally invasive surgery [odds ratio = 2.463(1.070–5.682);P = 0.034] was a significant independent risk factor for intra-abdominal infectious *** The findings showed that robotic surgery might improve short-term outcomes following minimally invasive radical gastrectomy by reducing intra-abdominal infectious complications.

关键词： Stomach neoplasms Gastrectomy Robotic surgical procedure Minimally invasive procedures Morbidity Pancreatic fistula

Prognostic factors of minimally invasive surgery for gastric cancer: Does robotic gastrectomy bring oncological benefit?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第39期27卷 6659-6672页

作者： masaya Nakauchi Koichi Suda Susumu Shibasaki Kenichi nakamura Shinichi Kadoya Kenji Kikuchi Kazuki Inaba Ichiro Uyama Department of Gastroenterological Surgery Fujita Health UniversityToyoake 470-1192AichiJapan Department of Gastroenterological Surgery Ishikawa Prefectural Central HospitalKanazawa 920-8535IshikawaJapan

BACKGROUND Gastric cancer is the third leading cause of cancer-related death worldwide and surgical resection remains the sole curative treatment for gastric *** invasive gastrectomy including laparoscopic and robotic approaches has been increasingly used in a few *** far,only a few reports have investigated the oncological outcomes following minimally invasive *** To determine the 5-year survival following minimally invasive gastrectomy for gastric cancer and identify prognostic *** This retrospective cohort study identified 939 patients who underwent gastrectomy for gastric cancer during the study *** excluding 125 patients with non-curative surgery(n=77),other synchronous cancer(n=2),remnant gastric cancer(n=25),insufficient physical function(n=13),and open gastrectomy(n=8),a total of 814 consecutive patients with primary gastric cancer who underwent minimally invasive R0 gastrectomy at our institution between 2009 and 2014 were retrospectively ***,5-year overall and recurrence-free survival were analyzed using the Kaplan–Meier method with the log-rank test and Cox regression analyses,while factors associated with survival were determined using multivariate *** Our analysis showed that age>65 years,American Society of Anesthesiologists(ASA)physical status 3,total or proximal gastrectomy,and pathological T4 and N positive status were independent predictors of both 5-year overall and recurrencefree ***,the included patients had a 5-year overall and recurrence-free survival of 80.3%and 78.2%,*** the 814 patients,157(19.3%)underwent robotic gastrectomy,while 308(37.2%)were diagnosed with pathological stage II or III ***,our findings showed that robotic gastrectomy was an independent positive predictor for recurrence-free survival in patients with pathological stage II/III[hazard ratio:0.56(0.33-0.96),P=0.035].Comparison of recurrence-fre

关键词： Laparoscopy Gastric cancer Minimally invasive surgery Prognostic factor Stomach neoplasms

Review of the structure and performance of through-holed anodes and cathodes prepared with a picosecond pulsed laser for lithium-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2023年第1期5卷 1-20页

作者： Futoshi Matsumoto Mitsuru Yamada masaya Tsuta Susumu nakamura Nobuo Ando Naohiko Soma Department of Material and Life Chemistry Faculty of EngineeringKanagawa University3-27-1 Rokkakubashikanagawa-kuYokohama 221-8686Japan Department of Electrical and Electronic Systems Engineering National Institute of TechnologyNagaoka College888 NishikatakaiNagaokaNiigata 940-8532Japan Research Institute for Engineering Kanagawa University3-27-1RokkakubashiKanagawa-kuYokohamaKanagawa 221-8686Japan Wired Co. Ltd1628 Hitotsuyashiki ShindenSanjoNiigata 959-1152Japan

To move the performance of lithium-ion batteries into the next stage,the modification of the structure of cells is the only choice except for the development of materials exhibiting higher *** this review paper,the employment of through-holing structures of anodes and cathodes prepared with a picosecond pulsed laser has been *** laser system and the structure for improving the battery performance were *** performance of laminated cells constructed with through-holed anodes and cathodes was reviewed from the viewpoints of the improvement of high-rate performance and energy density,removal of unbalanced capacities on both sides of the current collector,even greater high-rate performance by hybridizing cathode materials and removal of irreversible *** conclusion,the points that should be examined and the problem for the through-holed structure to be in practical use are summarized.

关键词： lithium-ionbattery picosecond pulsedlaser through-holed structure high-rate performance energydensity prelithiation

Practical applications and limitations of basalt discrimination diagrams

在线全文

学校读者我要写书评

暂无评论

Big Earth Data 2023年第4期7卷 1081-1093页

作者： Kentaro nakamura Frontier Research Center for Energy and Resources(FRCER) School of EngineeringThe University of TokyoTokyoJapan

Determining the tectonic setting of unknown volcanic rocks continues to be one of the key challenges in *** discrimination diagrams have been successfully employed due to their ease of use,recently,validation with big data has raised questions about their *** this study,the discrimination boundaries of Th/Yb versus(vs.)Nb/Yb and TiO2/Yb ***/Yb diagrams,which are the most used types of discrimination diagrams,were redefined based on a large amount of compiled data and support vector machine,a machine learning *** effectiveness of discrimination diagrams was verified,and the limitations and conditions when using them were *** results show that when using the Th/Yb ***/Yb diagram,only basalts with Th/Yb ratios higher than the discrimination boundary can be identified as volcanic arcs in *** contrast,a significant overlap occurs across boundaries in other cases when using these diagrams,particularly for enriched samples with Nb/Yb ratios higher than ***,when using these diagrams to determine the tectonic setting of unknown samples,their limitations must be considered when interpreting their results.

关键词： Discrimination diagram tectonic setting support vector machine big data large petrological databases