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World Journal of Gastroenterology 2006年第24期12卷 3866-3873页

作者： Hirotaka Arai Takehiko Abe Hitoshi Takagi masatomo Mori Department of Gastroenterology Maebashi Red Cross Hospital 3-20-14 Asahi-choMaebashi 371-0014Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine (previously known as the First Department of Internal Medicine Gunma University School of Medicine)MaebashiGunma 371-8511Japan

AIM： To evaluate the effect of three interventional treatments involving transvenous obliteration for the treatment of gastric varices, and to compare the efficacy and adverse effects of these methods, METHODS： From 1995 to 2004, 93 patients with gastric fundal varices underwent interventional radiologic embolotherapy at our hospital. Of the 93 patients, 75 were treated with the balloon-occluded retrograde transvenous obliteration （BRTO） procedure; 8 were with the percutaneous transhepatic obliteration （PTO） procedure; and 10 were with the combined BRTO and PTO therapy. A follow-up evaluation examined the rates of survival, recurrence and rebleeding of the gastric varices, worsening of esophageal varices and complications in each group. RESULTS： The BRTO, PTO, and combined therapy were technically successful in 81% （75/93）, 44% （8/18）, and 100% （10/10） patients, respectively. Recurrence of gastric varices was found in 3 patients in the BRTO group and in 3 patients in the PTO group. Rebleeding was observed in 1 patient in the BRTO group and in 1 patient in the PTO group. The 1- and 3-year survival rates were 98% and 87% in the patients without hepatocellular carcinoma （HCC） in the BRTO group, 100% and 100% in the PTO group, and 90% and 75% in the combined therapy group, respectively. CONCLUSION： Combined BRTO and PTO therapy may rescue cases with uncontrollable gastric fundal varices that remained even after treatment with BRTO and/or PTO, though there were limitations of our study, including retrospective nature and discrepancy in sample size between the BRTO, PTO and combined therapy groups.

关键词： Gastric varices Balloon-occluded retrogradetransvenous obliteration Percutaneous transhepaticobliteration Combined therapy

Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C

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World Journal of Gastroenterology 2006年第8期12卷 1205-1210页

作者： Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiJapan School of Health Sciences Gunma University Graduate School of MedicineMaebashiJapan

AIM： To estimate the contribution of autoimmune thrombocytopenia to hepatitis C virus-related liver cirrhosis （type C cirrhosis）, we evaluated the influence of splenectomy upon platelet-associated immunoglobulin G （PAIgG） levels and platelet numbers. METHODS： PAIgG titers and immune markers were determined in 24 type C cirrhotic patients with an intact spleen, 17 type C cirrhotic patients submitted to splenectomy, and 21 non-C cirrhosis with an intact spleen. RESULTS： Thrombocytopenia （PLT〈15×10^4/μL） in type C cirrhosis was diagnosed in all patients with an intact spleen, 8 patients submitted to splenectomy, and in 19 non-C cirrhosis with intact spleen. Elevated titers of PAIgG at more than 25.0 ng/107cells were detected in all cirrhotic patients except for one splenectomized patient. PAIgG titers （ng/10^7cells） were significantly higher in the type C cirrhosis with an intact spleen （247.9 ± 197.0） compared with the splenectomized patients （125.6±87.8） or non-C cirrhosis （152.4± 127.4）. PAIgG titers were negatively correlated with platelet counts in type C cirrhotic patients with an intact spleen. In comparison with the type C cirrhosis with an intact spleen, the splenectomized patients had a reduced CD4/CD8 ratio and serum neopterin levels. The spleen index （cm^2） was negatively correlated with platelet counts in the non-C cirrhosis, but not in the type C cirrhosis. CONCLUSION： Our data indicate that the autoimmune mechanism plays an important role in thrombocytosis complicated by HCV-positive cirrhosis. In addition, splenectomy may impair T cells function through, at least in part, a reduction of CD4/CD8 ratio, consequently suppressing PAIgG production.

关键词： Platelet-associated immunoglobulin G Autoimmune thromboo/topenia Liver cirrhosis Hepatitis C virus Splenectomy CD4/CD8 ratio

Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection

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World Journal of Gastroenterology 2006年第13期12卷 2089-2094页

作者： Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiJapan School of Health Sciences Gunma University Graduate School of Medicine MaebashiJapan

AIM： To examine the hepatitis C virus （HCV） levels and immunological markers in cirrhotic patients after splenectomy. METHODS： HCV RNA titers as well as cellular and humoral immune markers were determined in 20 cirrhotic patients after splenectomy and in 32 cirrhotic controls with an intact spleen. RESULTS： Serum HCV RNA titers were lower in the splenectomized patients than in the controls （186 ± 225 × 10^3 copies/mL vs 541 ± 417×10^3 copies/mL, P〈0.01）. HCV RNA was judged to have been spontaneously eradicated in 4 splenectomized patients, but in none of the controls. Natural killer cell activity was higher in the splenectomized patients than in the controls （41.2 ± 19.3% vs 24.7 ± 15.3%, P〈 0.01）, and natural killer cell activity was negatively correlated to HCV RNA titers in the splenectomized patients except in those with serotype 2-related infection. The CEH/CD8 ratio was significantly lower in the splenectomized patients than in the controls. CONCLUSION： The findings suggest that splenectomy may diminish virus burden in cirrhotic patients with HCV infection at least in part, through augmentation of natural killer cell activity.

关键词： Hepatitis C virus Liver cirrhosis Natural killer cell Splenectomy

Fulminant hepatic failure resulting from small-cell lung cancer and dramatic response of chemotherapy

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World Journal of Gastroenterology 2006年第15期12卷 2466-2468页

作者： Kyoichi Kaira Atsushi Takise Rieko Watanabe masatomo Mori Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineShowa-machiMaebashiGunma 371-8511Japan Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Showa-machiMaebashiGunma 371-8511Japan

Prompt treatment in tumor-associated encephalopathy may prolong survival. We describe a 69-year-old male patient who was presented with fulminant hepatic failure, secondary to small-cell lung carcinoma with rapidly progressing encephalopathy. Both symptoms remitted following chemotherapy, suggesting swift diagnosis and administration of chemotherapy to be effective in treatment of fulminant hepatic failure and encephalopathy.

关键词： Small-cell lung carcinoma Fulminant hepatic failure Chemotherapy

Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats

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World Journal of Gastroenterology 2011年第17期17卷 2223-2228页

作者： Tomohiro Kudo Shinichi Okamura Yajing Zhang Takashige Masuo masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Gunma 371-8511 Japan Department of Medical Informatics and Decision Sciences Gunma University School of Medicine Gunma 371-8511 Japan

AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium *** with colitis were intrarectally administered GL-p or *** extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage *** expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array *** effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was ***:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with *** antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed ***,GL-p inhibited the oxidative activity of mucosal and purified ***:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC.

关键词： Glycyrrhizin Colitis Dextran sodium sulfate Ulcerative colitis Cytokine Chemokine Protein array Myeloperoxidase Enema Carboxymethylcellulose

Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

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World Journal of Gastroenterology 2005年第38期11卷 5966-5972页

作者： Yuichi Yamazaki Satoru Kakizaki Norio Horiguchi Hitoshi Takagi masatomo Mori Masahiko Negishi Department of Medicine and Molecular Science Pharmacogenetics Section

AIM： To investigate the precise roles of CAR in CCI4- induced acute hepatotoxicity. METHODS： To prepare an acute liver injury model, CCI4 was intraperitoneally injected in CAR＋/＋ and CAR-/- mice. RESULTS： Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR＋/＋ mice without PB. Administration of a CAR inducer, PB, revealed that CCl4-induced liver toxicity was partially inhibited in CAR-/- mice compared with CAR＋/＋ mice. On the other hand, androstanol, an inverse agonist ligand, inhibited hepatotoxicity in CAR＋/＋ but not in CAR./. mice. Thus, CAR activation caused CCl4 hepatotoxicity while CAR inhibition resulted in partial protection against CCl4-induced *** were no differences in the expression of CYP2E1, the main metabolizing enzyme for CCl4, between CAR＋/＋ and CAR./. mice. However, the expression of other CCI4-metabolizing enzymes, such as CYP2B10 and 3All, was induced by PB in CAR＋/＋ but not in CAR-/- mice. Although the main pathway of CCl4-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3All in the presence of activator or inhibitor. CONCLUSION： The nuclear receptor CAR modulates CCl4- induced liver injury via induction of CCl4-metabolizing enzymes in the presence of an activator. Our results suggest that drugs interacting with nuclear receptors such as PB might play critical roles in drug-induced liver injury or drug- drug interaction even though such drugs themselves are not hepatotoxic.

关键词： CAR Phenobarbital Cytochrome P450 CCl4 Drug-induced liver injury

Analysis of ABC (D) stratification for screening patients with gastric cancer

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World Journal of Gastroenterology 2011年第43期17卷 4793-4798页

作者： Tomohiro Kudo Satoru Kakizaki Naondo Sohara Yasuhiro Onozato Shinichi Okamura Yoshikatsu Inui masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi Department of Endoscopy and Endoscopic Surgery Shirakawa Clinic Inui Clinic of Internal Medicine

AIM:To evaluate the value of ABC(D) stratification [combination of serum pepsinogen and Helicobacter pylori(***) antibody]of patients with gastric ***:Ninety-five consecutive patients with gastric cancer were enrolled into the *** serum pepsinogenⅠ(PGⅠ) /pepsinogenⅡ(PGⅡ) and *** antibody levels were *** were classified into five groups of ABC(D) stratification according to their serological *** findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC(D) ***:The mean patient age was(67.9±8.9) *** patients(3.2%) were classified into group A,7 patients(7.4%) into group A',27 patients(28.4%) into group B,54 patients(56.8%) into group C,and 4patients(4.2%) into group D,*** were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for ***(group A') were *** three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC(D) ***,the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma(P<0.05) .There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated ***:ABC(D) stratification is a good method for screening patients with gastric *** is needed for grey zone cases to check the extent of mucosal atrophy.

关键词： Gastric cancer Helicobacter pylori Pepsinogen ABC (D) stratification Cancer screening

High-pressure MOCVD growth of InGaN thick films toward the photovoltaic applications

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Fundamental Research 2023年第3期3卷 403-408页

作者： Liwen Sang Meiyong Liao masatomo Sumiya Xuelin Yang Bo Shen International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki 305-0044Japan JST-PRESTO The Japan Science and Technology AgencyTokyo 102-0076Japan Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukubaIbaraki 305-0044Japan State Key Laboratory of Artificial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijingChina

The highly efficient photovoltaic cells require the In-rich InGaN film with a thickness more than 300 nm to achieve the effective photo-electricity energy ***,the InGaN thick films suffer from poor crystalline quality and phase separations by using the conventional low-pressure metal organic chemical vapor deposition(MOCVD).We report on the growth of 0.3-1μm-thick InGaN films with a specially designed vertical-type high-pressure MOCVD at the pressure up to 2.5 *** In incorporation is found to be greatly enhanced at the elevated pressures although the growth temperatures are the *** phase separations are inhibited when the growth pressure is higher than atmospheric pressure,leading to the improved crystalline quality and better surface morphologies especially for the In-rich *** In 0.4 Ga 0.6 N with the thickness of 300 nm is further demonstrated as the active region of solar cells,and the widest photoresponse range from ultraviolet to more than 750 nm is achieved.

关键词： InGaN Solar cell High-pressure MOCVD Photo-electricity energy conversion In-rich XRD

Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaiiana

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Molecular Plant 2017年第8期10卷 1082-1094页

作者： Ayan Sadhukhan Yuriko Kobayashi Yuki Nakano Satoshi luchi masatomo Kobayashi Lingaraj Sahoo Hiroyuki Koyama Faculty of Applied Biological Sciences Gifu University Gifu 501-1193 Japan Experimental Plant Division RIKEN BioResource Center Tsukuba Ibaraki 305-0074 Japan Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati India

Hydrogen peroxide （H202） is a reactive oxygen species that affects cell signaling in various plant defense responses and induces programmed cell death. To identify the new components associated with H202 signaling and tolerance, we conducted a genome-wide association study （GWAS） on the root growth of 133 Arabidopsis thaliana accessions grown in the presence of toxic H2O2 levels. The most significant SNPs were associated with a cluster of chromosome 4 genes encoding an aquaporin NODULIN 26-LIKE INTRINSIC PROTEIN 1; 1 （NIP1;1）, an NB-ARC domain-containing disease resistance protein （AT4G19050）, and a putative membrane lipoprotein （AT4G19070）. The expression level of NIP1;1 was relatively high in A. thaliana accessions sensitive to H2O2. Additionally, overexpression of NIP1;1 in a tolerant accession （e.g., Col-0） increased the sensitivity of transgenic plants to H2O2. An in planta β-glucuronidase reporter assay revealed that variations in the NIP1;1 promoter were responsible for the differences of its expression level in H2O2-tolerant and -sensitive accessions. Cell death was extensive and H2O2 levels were high in the roots of H2O2-sensitive and NIP1;1-overexpressing accessions. Together, our results indicate that the aquaporin NIP1;1 is a key determinant of the sensitivity ofA. thaliana to H2O2, and contributes to the phenotypic variations detected by our GWAS.

关键词： aquaporin GWAS hydrogen peroxide programmed cell death root length signaling