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辐射研究与辐射工艺学报 2002年第2期20卷 137-145页

作者：周舟王小华 Igisu Hideki 林远楼淑芬 matsuoka masato 程天民余争平第三军医大学复合伤研究所重庆400038 日本产业医科大学环境毒理研究室日本北九州市80785555

研究检测了γ辐射对IEC 6肠上皮细胞丝裂原激活的蛋白激酶 (MAPKS)的激活效应。 6Gyγ辐射未引起ERK蛋白磷酸化的显著改变 ,而辐照射后 30minJNK与 p38MAPK蛋白磷酸化显著增强 ,ERK、JNK和p38MAPK的总蛋白表达水平未见明显的变化。受照... 详细信息

研究检测了γ辐射对IEC 6肠上皮细胞丝裂原激活的蛋白激酶 (MAPKS)的激活效应。 6Gyγ辐射未引起ERK蛋白磷酸化的显著改变 ,而辐照射后 30minJNK与 p38MAPK蛋白磷酸化显著增强 ,ERK、JNK和p38MAPK的总蛋白表达水平未见明显的变化。受照后 12h细胞存活率显著降低。螯合细胞内Ca2 +可几乎完全抑制γ辐照引起的JNK与 p38MAPK的蛋白磷酸化 ,而清除细胞外Ca2 +却无此作用。p38MAPK的激活与γ辐射诱导的细胞凋亡显著相关 ,而ERK则无明显的关联。实验结果表明 ,γ辐射是一种强的JNK与 p38MAPK激活因素 ,并且细胞内储存Ca2 +的释放在γ辐射诱导的IEC

关键词： γ辐射 ERK JNK p38MAPK IEC-6细胞蛋白激酶蛋白磷酸化激活效应辐射诱导信号转导途径

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Differential activation of mitogen-activated protein kinases by γ-irradi-ation in IEC-6 cells: Role of intracellular Ca^(2+)

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Journal of Medical Colleges of PLA(China) 2002年第3期17卷 181-187页

作者：周舟王小华 Igisu Hideki 林远楼淑芬 matsuoka masato 程天民余争平 Institute of Combined Injury Third Military Medical University Chongqing 400038 China Institute of Combined Injury Third Military Medical University Chongqing 400038 China Department of Environmental Toxicology University of Occupational and Environmental Health Kitakyushu 807-85555 Japan Institute of Combined Injury Third Military Medical University Chongqing 400038 China

Objective: To explore the effects of γ-irradiation on mitogen-activated protein kinases (MAPKs) and role of intracellular calcium in this event in intestinal epithelial cell line 6 (IEC-6 cells). Methods: After cultured rat IIEC-6 cells with or without the pretreatment of intracellular Ca2+ chelator were exposed to Y-ir-radiation of 6 Gy, the total and phosphorylated MAPKs in the cells were determined with Western blotting and apoptosis was examined with flow cytometry. Activities of Extracellular signal-regulated protein kinase (ERK) and p38 MAPK were determined by using immuoprecipitation followed by Western blotting. Results: In response to γ-irradiation, phosphorylation of ERK was not significantly observed, while the levels of phosphorylated c-Jun NH2-terminal kinase (JNK) and p38 MAPK were increased in 30 min and reached the peak 2 h after exposure to 6 Gy γ-irradiation, though the cell viability was significantly lowered 12 h. On the other hand, no obvious changes were seen in the total protein levels of ERK, JNK and p38 MAPK. Chelation of intracellular Ca2+ almost completely suppressed the JNK and p38 MAPK phosphorylation induced by γ-irradia-tion, but removal of external Ca2+ had no such effect. Activation of p38 MAPK, but not of ERK, was seen to have a correlation with γ-irradiation induced apoptosis. Conclusion: The results suggest that γ-irradiation is a potent activator for JNK and p38 MAPK, and Ca2+ mobilized from intracellular stores plays an important role in the activation of MAPKs and the induction of apoptosis in IEC-6 cells.

关键词： r-irradiation extracellular signal-regulated protein kinase c-Jun NH2-terminal kinase mitogen- activated protein kinases p38 MAPK intracellular Ca2+ intestinal epithelial cell line 6

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Visualization of root canal morphology in mandibular incisors using micro focus CT images and India ink staining of transparent teeth

Visualization of root canal morphology in mandibular incisor...

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The 9th Asian Congress of Oral and Maxillofacial Radiology

作者： Hiromasa Kamemoto Kanade Kita Ichirou Shimizu Yukihiro Iida masato matsuoka Takashi Wakisaka Katsumata Akitoshi Department of Oral Radiology Asahi University School of Dentistry

＜正＞Aims:The root canal morphology of mandibular incisors creates difficulties for the dental practitioner when performing endodontic *** canal morphology in transparent tooth specimens has long been visualized by staining with India ***,micro-focus CT systems are increasingly favored for observation of tooth *** studied accessory canals in the root apex region of mandibular incisors to compare these techniques.

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Modified docetaxel, cisplatin and capecitabine for stage Ⅳ gastric cancer in Japanese patients: A feasibility study

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World Journal of Gastroenterology 2017年第6期23卷 1090-1097页

作者： Osamu Maeda Ayumu matsuoka Ryoji Miyahara Kohei Funasaka Yoshiki Hirooka Masahide Fukaya masato Nagino Yasuhiro Kodera Hidemi Goto Yuichi Ando Department of Clinical Oncology and Chemotherapy Nagoya University Hospital Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Surgery Nagoya University Graduate School of Medicine Department of Gastroenterological Surgery(Surgery II)Nagoya University Graduate School of Medicine

AIM To evaluate the feasibility of chemotherapy including fluoropyrimidine, platinum and taxane with modified dosages for unresectable gastric cancer in Japanese *** We performed a feasibility study of a modified docetaxel, cisplatin and capecitabine (DCX) regimen for stage Ⅳ gastric cancer. In particular, 30 or 40 mg/m^2 of docetaxel on day 1, 60 mg/m^2 of cisplatin on day 1, and 2000 mg/m^2 of capecitabine for 2 wk were administered every three *** Three patients were treated with modified DCX(m DCX) with 30 mg/m^2 docetaxel, and five patients were treated with this regimen with 40 mg/m^2 docetaxel. Grade 3 or 4 neutropenia was observed in six of the eight patients; no patients exhibited febrile neutropenia. Partial response was achieved in four of the eight patients. Three patients underwent gastrectomy, which achieved R0 resection without residual tumors in dissected lymph nodes. In one of these three patients, resected specimens revealed pathological complete response in the primary lesion and in lymph *** m DCX was well tolerated by Japanese patients with stage Ⅳ gastric cancer. This regimen might be useful for allowing gastric cancer patients with distant lymph node metastasis to undergo conversion surgery.

关键词： Docetaxel Cisplatin Capecitabine Gastric cancer

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Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

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World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

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