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Isolated Tricuspid Valve Repair and Right Atrial Plication Performed Using a Beating-Heart Technique for Atrial Functional Tricuspid Valve Regurgitation

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Open Journal of Thoracic Surgery 2023年第2期13卷 7-16页

作者： Kayo Sugiyama Hirotaka Watanuki masato Tochii Daisuke Koiwa Katsuhiko Matsuyama Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan

Background: Isolated tricuspid valve disease remains a controversial indication for surgical intervention. Many patients referred for surgery already have a poor clinical condition and an advanced New York Heart Association functional class. There is no consensus on the optimal surgical technique for this condition, including on whether to perform the procedure on a beating or an arrested heart and whether to perform valve repair or replacement. Methods: We analyzed four case series between 2015 and 2022 in which patients with secondary tricuspid regurgitation (TR) underwent valve repair on a beating heart and right atrial plication for a dilated right atrium. The TRI-SCORE was calculated for each patient. Results: All patients experienced a favorable postoperative course with significant improvements in heart failure symptoms. TR was markedly reduced;however, in one patient with concomitant mitral regurgitation (MR) and a high TRI-SCORE, MR worsened postoperatively. This patient later died from unknown causes due to multiple comorbidities in the late phase. Conclusions: Tricuspid valve repair on a beating heart was effective for improving the cardiac function, and the TRI-SCORE proved useful as a preoperative risk assessment tool. The underlying mechanism by which TR exacerbates MR requires further investigation.

关键词： Isolated Tricuspid Valve Surgery Beating-Heart Surgery Right Atrial Plication Atrial Functional Tricuspid Valve Regurgitation TRI-SCORE

Designing and generating a mouse model:frequently asked questions

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The Journal of Biomedical Research 2021年第2期35卷 76-90页

作者： Channabasavaiah BGurumurthy Thomas LSaunders masato Ohtsuka Department of Pharmacology and Experimental Neuroscience Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Mouse Genome Engineering Core Facility Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Department of Internal Medicine Division of Genetic MedicineUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Transgenic Animal Model Core University of MichiganAnn ArborMI 48109USA Department of Molecular Life Science Division of Basic Medical Science and Molecular MedicineTokai University School of MedicineIseharaKanagawa 259-1193Japan The Institute of Medical Sciences Tokai UniversityIseharaKanagawa 259-1193Japan

Genetically engineered mouse(GEM)models are commonly used in biomedical *** GEMs involve complex set of experimental procedures requiring sophisticated equipment and highly skilled technical *** of these reasons,most research institutes set up centralized core facilities where custom GEMs are created for research ***,on the other hand,when they begin thinking about generating GEMs for their research,several questions arise in their *** example,what type of model(s)would be best useful for my research,how do I design them,what are the latest technologies and tools available for developing my model(s),and finally how to breed GEMs in my *** there are several considerations and options in mouse designs,and as it is an expensive and time-consuming endeavor,careful planning upfront can ensure the highest chance of *** this article,we provide brief answers to several frequently asked questions that arise when researchers begin thinking about generating mouse model(s)for their work.

关键词： CRISPR transgenic mouse genetic engineering knockout mouse conditional knockout mouse knock-in mouse

Will the magnetic resonance imaging proton density fat fraction replace liver biopsy as the gold standard for detecting steatosis?

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 292-293页

作者： masato Yoneda Kento Imajo Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Yokohama Japan

Accompanied with the ongoing epidemics of obesity and metabolic syndrome arising from the westernization of lifestyles, the incidence of nonalcoholic fatty liver disease (NAFLD) has been getting higher worldwide in th... 详细信息

关键词： liver NAFLD biopsy

Effects of cloud,atmospheric water vapor,and dust on photosynthetically active radiation and total solar radiation in a Mongolian grassland

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Journal of Arid Land 2012年第4期4卷 349-356页

作者： Tserenpurev BAT-OYUN masato SHINODA Mitsuru TSUBOn Meiji University Tokyo168-8555Japa Arid Land Research Center Tottori UniversityTottori 680-0001Japan

Photosynthetically active radiation （PAR） is an important input parameter for estimating plant produc- tivity due to its key role in the growth and development of plants. However, a worldwide routine network for sys- tematic PAR measurements is not yet established, and PAR is often calculated as a constant fraction of total solar radiation （SR）. Although the ratio of PAR to SR （PAR/SR） has been reported from many places, few studies have been performed for dry regions. The present study was therefore carried out in an arid region of Mongolia to obtain PAP-JSR and examine its dependency on sky clearness （the clearness index）, water vapor in the atmosphere and aeolian dust. Continuous measurements of PAR and SR were taken every one second using quantum and pyranometer sensors, respectively, and the readings were averaged and recorded at intervals of 30 minutes for a period of 12 months. The lowest monthly mean daily PAR/SR occurred in April （0.420）, while the highest ratio was observed in July （0.459）. Mean daily PAR/SR during plant growing season （May-August） was estimated to be 0.442, which could be useful for modeling plant productivity in the study area. The annual mean daily PAR/SR （0.435） was lower than the values reported in many previous studies. This difference could be explained with the regional variation in climate： i.e. drier climatic condition in the study area. PAR/SR was negatively correlated with the clearness index （r= -0.36, P〈0.001）, but positively with atmospheric water vapor pressure （r=0.47, P〈0.001）. The average PAR/SR was significantly lower （P=0.02） on the dusty days compared to the non-dust days. Water vapor in the atmosphere was shown to be the strongest factor in the variation of PAR/SR. This is the first study examining PAR/SR under a semi-arid condition in Mongolia.

关键词： clearness index dust storm photosynthetically active radiation total solar radiation water vapor pressure

Relationships between soil moisture and dust emissions in a bare sandy soil of Mongolia

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Particuology 2016年第5期14卷 131-137页

作者： Erdenebayar Munkhtsetseg masato Shinoda John A. Gillies Reiji Kimura James King George Nikolich National University of Mongolia Peace Avenue 14/3 Sukhbaatar District 8 Ulaanbaatar 14191 Mongolia Nagoya University Furo-cho Chikusa-ku Nagoya 464-8601 Nagoya Japan Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA Arid Land Research Center Tottori University Hamasaka 1390 Tottori 680-0001 Japan Departement de geographie Universite de Montreal Pavilion 520 chemin de la Cote-Sainte-Catherine Montreal QC H3 C 3J7 Canada Desert Research Institute 755 E. Flamingo Road Las Vegas NV 89119. USA

This study presents experimental results of the change in threshold friction velocity and dust emission strength as a function of soil moisture content. The dust and soil moisture data were obtained from irrigated plots of a bare, sandy soil （no vegetation） situated in the Mongolian steppe. Dust flux was measured using the PI-SWERL^（R） device, while soil moisture was measured using gravimetric methods. Our results demonstrate the strong controlling effects of soil moisture on both the threshold friction velocity and dust emission strengths. Threshold friction velocity increased from 0.44 m/s for dry soil （0.002 g/g） to 0.67 m/s for wet soil （0.06 g/g）, confirming the importance of soil moisture for controlling dust events. Dust emission strength was significantly depressed for wet soils, starting at a soil moisture value of 0.02 g/g. From these results, we developed a simple dust diagram that may be useful as part of a warning system to identify initial sensitivity to threshold conditions as well as conditions that could lead to potentially significant dust emissions. Overall, the research findings in this study could be used to provide foreknowledge of conditions that would be conducive to high dust emissions for this area of Mongolia.

关键词： Threshold friction velocity Simple dust diagram Dust emission Absence of vegetation Mini wind tunnel

Effects of grazing and precipitation variability on vegetation dynamics in a Mongolian dry steppe

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Journal of Plant Ecology 2016年第5期9卷 508-519页

作者： Tserenpurev Bat-Oyun masato Shinoda Yunxiang Cheng Yadamjav Purevdorj Arid Land Research Center Tottori UniversityHamasakaTottori 680-0001Japan Information and Research Institute of Meteorology Hydrology and EnvironmentUlaanbaatar 15160Mongolia Graduate School of Environmental Studies Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan College of Pastoral Agriculture Science and Technology Lanzhou UniversityLanzhou 730020China Department of Food Science and Human Wellness Rakuno Gakuen UniversityEbetsuHokkaido 069-8501Japan

Aims Grazing and water availability are the primary drivers of vegetation dynamics in grazing-dominated regions of Mongolia with a semi-arid climate and frequent *** animal husbandry still plays a large part in the economy of Mongolia,but more variable precipitation regime and increase in livestock number have severely affected grassland ecosystems through overgrazing,leading to pasture *** study aimed to examine the effects of grazing exclusion,interannual variation of plant-available precipitation(PAP)and their interaction on the aboveground biomass(AGB)of each dominant species,the AGB of annual species and the total AGB in a Mongolian dry steppe,using long-term field *** To detect the effect of grazing on vegetation dynamics,vegetation surveys were conducted in a non-grazed exclosure zone and a fully grazed area outside the *** assessed the effects of grazing,PAP and their interaction on AGB parameters using a generalized linear model.A detrended correspondence analysis(DCA)was used to visualize the effects of grazing and PAP on the AGB of each *** Findings Grazing,PAP and their interaction had significant effects on *** effect of grazing on AGB was larger with higher precipitation and higher amounts of AGB(***)while AGB was strongly limited in drought years,which resulted in a smaller grazing *** current year PAP had the highest impact(r=0.88,P<0.01)on *** dominance of annual species was characterized by the amount of PAP in the current and preceding years:annuals dominated in wet years that followed consecutive dry *** DCA Axis 1 reflected the variation of AGB with interannual variation of PAP while the DCA Axis 2 differentiated the grazing *** DCA scatter diagram based on species score illustrated that Artemisia adamsii(an unpalatable herb)was clearly linked to grazing disturbance whereas palatable perennials such as Agropyron cristatum,Stipa krylovii and Cleistogenes

关键词： aboveground biomass annual species drought grazing plant-available precipitation

Development of high stability hot mix asphalt concrete with hybrid binder

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Journal of Traffic and Transportation Engineering(English Edition) 2014年第6期1卷 424-431页

作者： Toshiaki Hirato masato Murayama Hirotaka Sasaki Toa Road Corporation TsukubaIbarakiJapan Kao Corporation SumidaTokyoJapan

Cost reduction of public works projects has been desired due to severe financial circumstances. Therefore, asphalt pavement has been requested to extend its life. Semi-flexible pavement or epoxy asphalt pavement, which has high rutting resistance and oil resistance, may be applied to the place where these performances are demanded. However, special technique is required in manufacturing and construction. In addition, these materials have also raised a problem that they cannot be recycled. Meanwhile, conventional asphalt pavement has several drawbacks. It is vulnerable to rutting caused by traffic load and damage caused by petroleum oils such as gasoline or motor oil. The materials used in asphalt mixtures were studied for improving the durability of asphalt mixture. A high stability asphalt concrete was developed which has equal or superior performance to semi-flexible pavement and epoxy asphalt pavement. In this paper, the process of selecting the substance and the characteristics evaluation of the developed mixtures are described. Furthermore, an inspection result as well as follow- up survey of the performance of the developed mixtures obtained from trial and actual construction is shown.

关键词： hot mix asphalt rutting resistance oil resistance semi-flexible pavement epoxy asphaltpavement

Synthesis and mesomorphic properties of 4-(4-bromopropyloxy)-4'-(4-alkyloxybenzylidene)anilines

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Chinese Chemical Letters 2012年第7期23卷 769-772页

作者： Guan-Yeow Yeap Yew-Hong Ooi Kenji Kubo masato M.Ito Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Department of Environmental Engineering for Symbiosis Faculty of EngineeringSoka UniversityTokyo 192-8577Japan

This article describes the preparation and liquid crystalline properties of a new homologous series of 4-（4-bromopropyloxy）-4＇- （4-alkyloxybenzylidene）anilines in which the phenyl ring is armed by a bromopropyloxy *** thermal behavior and mesomorphic properties of the synthesized compounds were studied with particular attention given to the correlation between their phase transition temperatures and anisotropic change influenced by molecular *** the members displayed enantiotropic smectic phase except for the homologue with the longest alkyloxy chain（R = C_（18）H_（37））,exhibiting only monotropic characteristic. The presence of bromine atom from the propyloxy side chain is found to be capable of altering and influencing the mesomorphic properties.

关键词： 4-(4-Bromopropyloxy)-4'-(4-alkyloxybenzylidene)anilines Mesomorphic properties Enantiotropic smectic DSC

Nonalcoholic fatty liver disease with advanced fibrosis as a multi-systemic disease: proceed with caution

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 170-172页

作者： masato Yoneda Yuji Ogawa Kento Imajo Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohamaJapan

Accompanying the current epidemics of metabolic syndrome(MS)and obesity caused by westernization of lifestyles,the incidences of non-alcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)have been increasing worldwide over the last few decades(1).Now,NAFLD has a global prevalence estimated at 25%of the world population,with some geographical;the highest prevalences are in the South America and Middle ***,NAFLD has become recognized as the most common liver disease worldwide(2).

关键词： NAFLD prevalence liver